TEDOFA Trial Study Protocol: A Prospective Double-Blind, Randomized, Controlled Clinical Trial Comparing Opioid-Free versus Opioid Anesthesia on the Quality of Postoperative Recovery and Chronic Pain in Patients Receiving Thoracoscopic Surgery

References

• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2002. CA Cancer J Clin. 2020;70(1):7–30. doi:10.3322/caac.21590
   PubMed Web of Science ®Google Scholar
• Zheng RHSK, Zhang SW, Zeng HM, et al. Report of cancer epidemiology in China, 2015. Chin J Oncol. 2019;41:19–28.
   Google Scholar
• Van der Ploeg APT, Ayez N, Akkersdijk GP, van Rossem CC, de Rooij PD. Postoperative pain after lobectomy: robot-assisted, video-assisted and open thoracic surgery. J Robot Surg. 2020;14(1):131–136. doi:10.1007/s11701-019-00953-y
   PubMed Web of Science ®Google Scholar
• Lim E, Harris RA, McKeon HE, et al. Impact of video-assisted thoracoscopic lobectomy versus open lobectomy for lung cancer on recovery assessed using self-reported physical function: VIOLET RCT. Health Technol Assess. 2022;26(48):1–162. doi:10.3310/THBQ1793
   PubMed Web of Science ®Google Scholar
• Bendixen M, Jørgensen OD, Kronborg C, et al. Postoperative pain and quality of life after lobectomy via video-assisted thoracoscopic surgery or anterolateral thoracotomy for early stage lung cancer: a randomised controlled trial. Lancet Oncol. 2016;17(6):836–844. doi:10.1016/S1470-2045(16)00173-X
   PubMed Web of Science ®Google Scholar
• Tong Y, Wei P, Wang S, et al. Characteristics of Postoperative Pain After VATS and Pain-Related Factors: the Experience in National Cancer Center of China. J Pain Res. 2020;13(1861):2529–2530. doi:10.2147/JPR.S285650
   PubMedGoogle Scholar
• Chen WC, Bai YY, Zhang LH, et al. Prevalence and Predictors of Chronic Postsurgical Pain After Video-Assisted Thoracoscopic Surgery: a Systematic Review and Meta-analysis. Pain Ther. 2022;12(1):117–139. doi:10.1007/s40122-022-00439-0
   PubMed Web of Science ®Google Scholar
• Brown CHT, Laflam A, Max L, et al. Delirium After Spine Surgery in Older Adults: incidence, Risk Factors, and Outcomes. J Am Geriatr Soc. 2016;64(10):2101–2108. doi:10.1111/jgs.14434
   PubMed Web of Science ®Google Scholar
• Yan H, Chen W, Chen Y, et al. Opioid-Free Versus Opioid-Based Anesthesia on Postoperative Pain After Thoracoscopic Surgery: the Use of Intravenous and Epidural Esketamine. Anesth Analg. 2023;137(2):399–408. doi:10.1213/ANE.0000000000006547
   PubMed Web of Science ®Google Scholar
• Apfel CC, Läärä E, Koivuranta M, et al. A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers. Anesthesiology. 1999;91(3):693–700. doi:10.1097/00000542-199909000-00022
   PubMed Web of Science ®Google Scholar
• Paqueron X, Lumbroso A, Mergoni P, et al. Is morphine-induced sedation synonymous with analgesia during intravenous morphine titration? Br J Anaesth. 2002;89(5):697–701. doi:10.1093/bja/89.5.697
   PubMed Web of Science ®Google Scholar
• Gan TJ, Robinson SB, Oderda GM, et al. Impact of postsurgical opioid use and ileus on economic outcomes in gastrointestinal surgeries. Curr Med Res Opin. 2015;31(4):677–686. doi:10.1185/03007995.2015.1005833
   PubMed Web of Science ®Google Scholar
• Wang Y, Sands LP, Vaurio L, et al. The effects of postoperative pain and its management on postoperative cognitive dysfunction. Am J Geriatr Psychiatry. 2007;15(1):50–59. doi:10.1097/01.JGP.0000229792.31009.da
   PubMed Web of Science ®Google Scholar
• Lee LA, Caplan RA, Stephens LS, et al. Postoperative opioid-induced respiratory depression: a closed claims analysis. Anesthesiology. 2015;122(3):659–665. doi:10.1097/ALN.0000000000000564
   PubMed Web of Science ®Google Scholar
• Fletcher D, Martinez V. Opioid-induced hyperalgesia in patients after surgery: a systematic review and a meta-analysis. Br J Anaesth. 2014;112(6):991–1004. doi:10.1093/bja/aeu137
   PubMed Web of Science ®Google Scholar
• Afsharimani B, Cabot P, Parat MO. Morphine and tumor growth and metastasis. Cancer Metastasis Rev. 2011;30:225–238. doi:10.1007/s10555-011-9285-0
   PubMed Web of Science ®Google Scholar
• van Gulik L, Ahlers SJ, van de Garde EM, et al. Remifentanil during cardiac surgery is associated with chronic thoracic pain 1 yr after sternotomy. Br J Anaesth. 2012;109(4):616–622. doi:10.1093/bja/aes247
   PubMed Web of Science ®Google Scholar
• Nguyen J, Luk K, Vang D, et al. Morphine stimulates cancer progression and mast cell activation and impairs survival in transgenic mice with breast cancer. Br J Anaesth. 2014;113(suppl 1):i4–i13. doi:10.1093/bja/aeu090
   PubMedGoogle Scholar
• Baboli KM, Liu H, Poggio JL. Opioid-free postoperative analgesia: is it feasible? Curr Probl Surg. 2020;57(7):100794. doi:10.1016/j.cpsurg.2020.100794
   PubMed Web of Science ®Google Scholar
• Beloeil H. Opioid-free anesthesia. Best Pract Res Clin Anaesthesiol. 2019;33(3):353–360. doi:10.1016/j.bpa.2019.09.002
   PubMed Web of Science ®Google Scholar
• Kehlet H, Dahl JB. Anaesthesia, surgery, and challenges in postoperative recovery. Lancet. 2003;362(9399):1921–1928. doi:10.1016/S0140-6736(03)14966-5
   PubMed Web of Science ®Google Scholar
• Feld JM, Hoffman WE, Stechert MM, et al. Fentanyl or dexmedetomidine combined with desflurane for bariatric surgery. J Clin Anesth. 2006;18(1):24–28. doi:10.1016/j.jclinane.2005.05.009
   PubMed Web of Science ®Google Scholar
• Hofer RE, Sprung J, Sarr MG, et al. Anesthesia for a patient with morbid obesity using dexmedetomidine without narcotics. Can J Anaesth. 2005;52:176–180. doi:10.1007/BF03027725
   PubMed Web of Science ®Google Scholar
• Larue A, Jacquet-Lagrèze M, Ruste M, et al. Opioid-free anaesthesia for video-assisted thoracoscopic surgery: a retrospective cohort study with propensity score analysis. Anaesth Crit Care Pain Med. 2022;41(4):101089. doi:10.1016/j.accpm.2022.101089
   PubMed Web of Science ®Google Scholar
• Selim J, Jarlier X, Clavier T, et al. Impact of Opioid-free Anesthesia After Video-assisted Thoracic Surgery: a Propensity Score Study. Ann Thorac Surg. 2022;114(1):218–224. doi:10.1016/j.athoracsur.2021.09.014
   PubMed Web of Science ®Google Scholar
• An G, Zhang Y, Chen N, et al. Opioid-free anesthesia compared to opioid anesthesia for lung cancer patients undergoing video-assisted thoracoscopic surgery: a randomized controlled study. PLoS One. 2021;16(9):e0257279. doi:10.1371/journal.pone.0257279
   PubMed Web of Science ®Google Scholar
• Chen YK, Boden KA, Schreiber KL. The role of regional anaesthesia and multimodal analgesia in the prevention of chronic postoperative pain: a narrative review. Anaesthesia. 2021;76 Suppl 1(Suppl 1):8–17. doi:10.1111/anae.15256
   PubMedGoogle Scholar
• VanDenKerkhof EG, Hopman WM, Reitsma ML, et al. Chronic pain, healthcare utilization, and quality of life following gastrointestinal surgery. Can J Anaesth. 2012;59:670–80. 42. doi:10.1007/s12630-012-9712-x
   PubMed Web of Science ®Google Scholar
• Stark PA, Myles PS, Burke JA. Development and psychometric evaluation of a postoperative quality of recovery score: the QoR-15. Anesthesiology. 2013;118(6):1332–1340. doi:10.1097/ALN.0b013e318289b84b
   PubMed Web of Science ®Google Scholar
• Lehmann N, Joshi GP, Dirkmann D, et al. Development and longitudinal validation of the overall benefit of analgesia score: a simple multi-dimensional quality assessment instrument. Br J Anaesth. 2010;105(4):511–518. doi:10.1093/bja/aeq186
   PubMed Web of Science ®Google Scholar
• Myles PS, Myles DB. An Updated Minimal Clinically Important Difference for the QoR-15 Scale. Anesthesiology. 2021;135(5):934–935. doi:10.1097/ALN.0000000000003977
   PubMed Web of Science ®Google Scholar
• Bray F. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Ca a Cancer J Clinicians. 2018.
   PubMed Web of Science ®Google Scholar
• Allemani C, Matsuda T, Carlo VD, et al. Global surveillance of trends in cancer survival: analysis of individual records for 37,513,025 patients diagnosed with one of 18 cancers during 2000–2014 from 322 population-based registries in 71 countries (Concord-3). Lancet. 2018;391(10125):1023–1075. doi:10.1016/S0140-6736(17)33326-3
   PubMed Web of Science ®Google Scholar
• Wildgaard K, Ravn J, Nikolajsen L, Jakobsen E, Jensen TS, Kehlet H. Consequences of persistent pain after lung cancer surgery: a nationwide questionnaire study. Acta Anaesth Scand. 2011;55:60–68. doi:10.1111/j.1399-6576.2010.02357.x
   PubMed Web of Science ®Google Scholar
• Rizk NP, Ghanie A, Hsu M, et al. A Prospective Trial Comparing Pain and Quality of Life Measures After Anatomic Lung Resection Using Thoracoscopy or Thoracotomy. Ann Thorac Surg. 2014;98(4):1160–1166. doi:10.1016/j.athoracsur.2014.05.028
   PubMed Web of Science ®Google Scholar
• Su X, Wang DX. Improve postoperative sleep: what can we do? Curr Opin Anaesthesiol. 2018;31(1):83–88. doi:10.1097/ACO.0000000000000538
   PubMed Web of Science ®Google Scholar
• Kjolhede P, Langstrom P, Nilsson P, Wodlin NB, Nilsson L. The impact of quality of sleep on recovery from fast-track abdominal hysterectomy. J Clin Sleep Med. 2012;8(4):395–402. doi:10.5664/jcsm.2032
   PubMed Web of Science ®Google Scholar
• Gan TJ. Poorly controlled postoperative pain: prevalence, consequences, and prevention. J Pain Res. 2017;10:2287–2298. doi:10.2147/JPR.S144066
   PubMed Web of Science ®Google Scholar
• Khademi H, Kamangar F, Brennan P, et al. Opioid therapy and its side effects: a review. Arch Iran Med. 2016;19:870–876.
   PubMed Web of Science ®Google Scholar
• Bello M, Oger S, Bedon-Carte S, et al. Effect of opioid-free anaesthesia on postoperative epidural ropivacaine requirement after thoracic surgery: a retrospective unmatched case-control study. Anaesth Crit Care Pain Med. 2019;38(5):499–505. doi:10.1016/j.accpm.2019.01.013
   PubMed Web of Science ®Google Scholar
• Bugada D, Lorini LF, Lavand’homme P. Opioid free anesthesia: evidence for short and long-term outcome. Minerva Anestesiol. 2021;87(2):230–237. doi:10.23736/S0375-9393.20.14515-2
   PubMed Web of Science ®Google Scholar
• Selim J, Jarlier X, Clavier T, et al. Impact of Opioid-free Anesthesia After Video-assisted Thoracic Surgery: a Propensity Score Study. Ann Thorac Surg. 2022;114(1):218–224.
   PubMed Web of Science ®Google Scholar
• Sacerdote P. Opioid-induced immunosuppression. Curr Opin Support Palliat Care. 2008;2(1):14–18. doi:10.1097/SPC.0b013e3282f5272e
   PubMedGoogle Scholar