Pain Experience and Sensory Changes in Astronauts During and After Short-Lasting Commercial Spaceflight: A Proof-of-Concept Study

References

• Fritsch-Yelle JM, Charles JB, Jones MM, Wood ML. Microgravity decreases heart rate and arterial pressure in humans. J Appl Physiol. 1996;80:910–914. doi:10.1152/jappl.1996.80.3.910
   PubMed Web of Science ®Google Scholar
• Roberge E. The gravity of it all: from osteoporosis to immunosuppression, exploring disease in a microgravity environment holds promise for better treatments on earth. IEEE Pulse. 2014;5:35–41. doi:10.1109/MPUL.2014.2321933
   PubMedGoogle Scholar
• Arone A, Ivaldi T, Loganovsky K, et al. The burden of space exploration on the mental health of astronauts: a narrative review. Clin Neuropsychiatry. 2021;18:237–246. doi:10.36131/cnfioritieditore20210502
   PubMed Web of Science ®Google Scholar
• Burkhart K, Allaire B, Bouxsein ML. Negative effects of long-duration spaceflight on paraspinal muscle morphology. Spine. 2019;44:879–886. doi:10.1097/BRS.0000000000002959
   PubMed Web of Science ®Google Scholar
• Chang DG, Healey RM, Snyder AJ, et al. Lumbar spine paraspinal muscle and intervertebral disc height changes in astronauts after long-duration spaceflight on the international space station. Spine. 2016;41:1917–1924. doi:10.1097/BRS.0000000000001873
   PubMed Web of Science ®Google Scholar
• Shackelford LC Musculoskeletal response to space flight. Principles of Clinical Medicine for Space Flight; 2019:581–607.
   Google Scholar
• Bailey JF, Miller SL, Khieu K, et al. From the international space station to the clinic: how prolonged unloading may disrupt lumbar spine stability. Spine J. 2018;18:7–14. doi:10.1016/j.spinee.2017.08.261
   PubMed Web of Science ®Google Scholar
• Treffel L, Navasiolava N, Mkhitaryan K, et al. DI-5-cuffs: lumbar intervertebral disc proteoglycan and water content changes in humans after five days of dry immersion to simulate microgravity. Int J Mol Sci. 2020;21. doi:10.3390/ijms21113748
   PubMed Web of Science ®Google Scholar
• Harrison MF, Garcia KM, Sargsyan AE, Ebert D, Riascos-Castaneda RF, Dulchavsky SA. Preflight, in-flight, and postflight imaging of the cervical and lumbar spine in astronauts. Aerosp Med Hum Perform. 2018;89:32–40. doi:10.3357/AMHP.4878.2018
   PubMed Web of Science ®Google Scholar
• Hides JA, Lambrecht G, Sexton CT, et al. The effects of exposure to microgravity and reconditioning of the lumbar multifidus and anterolateral abdominal muscles: implications for people with LBP. Spine J. 2021;21:477–491. doi:10.1016/j.spinee.2020.09.006
   PubMed Web of Science ®Google Scholar
• Hides JA, Lambrecht G, Stanton WR, Damann V. Changes in multifidus and abdominal muscle size in response to microgravity: possible implications for low back pain research. Eur Spine J. 2015;25:175–182. doi:10.1007/s00586-015-4311-5
   PubMed Web of Science ®Google Scholar
• Kim M-HY, George KA, Cucinotta FA. Evaluation of skin cancer risk for lunar and Mars missions. Adv Space Res. 2006;37:1798–1803. doi:10.1016/j.asr.2006.03.032
   Web of Science ®Google Scholar
• Delanian S, Lefaix J-L, Pradat P-F. Radiation-induced neuropathy in cancer survivors. Radiother Oncol. 2012;105:273–282. doi:10.1016/j.radonc.2012.10.012
   PubMed Web of Science ®Google Scholar
• Cialdai F, Vignali L, Morbidelli L, et al. Modeled microgravity affects fibroblast functions related to wound healing. Microgravity Sci Technol. 2017;29:121–132. doi:10.1007/s12217-016-9532-7
   Web of Science ®Google Scholar
• Loesberg WA, Walboomers XF, Bronkhorst EM, van Loon JJWA, Jansen JA. The effect of combined simulated microgravity and microgrooved surface topography on fibroblasts. Cell Motil Cytoskelet. 2007;64:174–185. doi:10.1002/cm.20174
   PubMed Web of Science ®Google Scholar
• Clement JQ, Lacy SM, Wilson BL. Gene expression profiling of human epidermal keratinocytes in simulated microgravity and recovery cultures. Genom Proteom Bioinform. 2008;6:8–28. doi:10.1016/S1672-0229(08)60017-0
   PubMedGoogle Scholar
• Gaudry E, Vagg P, Spielberger CD. Validation of the state-trait distinction in anxiety research. Multivariate Behav Res. 1975;10:331–341. doi:10.1207/s15327906mbr1003_6
   PubMed Web of Science ®Google Scholar
• Sullivan MJL, Bishop SR, Pivik J. The pain catastrophizing scale: development and validation. Psychol Assess. 1995;7:524–532. doi:10.1037/1040-3590.7.4.524
   Web of Science ®Google Scholar
• Ware JE, Kosinski M, Keller SD. A 12-item short-form health survey. Med Care. 1996;34:220–233. doi:10.1097/00005650-199603000-00003
   PubMed Web of Science ®Google Scholar
• Kopec JA, Esdaile JM, Abrahamowicz M, et al. The Quebec back pain disability scale: conceptualization and development. J Clin Epidemiol. 1996;49:151–161. doi:10.1016/0895-4356(96)00526-4
   PubMed Web of Science ®Google Scholar
• Melzack R, Raja Srinivasa N. The McGill pain questionnaire. Anesthesiology. 2005;103:199–202. doi:10.1097/00000542-200507000-00028
   PubMed Web of Science ®Google Scholar
• Neergaard MA, Olesen F, Andersen RS, Sondergaard J. Qualitative description – the poor cousin of health research? BMC Med Res Methodol. 2009;9. doi:10.1186/1471-2288-9-52
   PubMed Web of Science ®Google Scholar
• Milne J, Oberle K. Enhancing rigor in qualitative description. J Wound Ostomy Cont Nurs. 2005;32:413–420. doi:10.1097/00152192-200511000-00014
   PubMed Web of Science ®Google Scholar
• Patton MQ. Qualitative Research & Evaluation Methods: Integrating Theory and Practice. 4th ed. Thousand Oaks, California: SAGE Publications, Inc.; 2015.
   Google Scholar
• Ocay DD, Larche CL, Betinjane N, et al. Phenotyping chronic musculoskeletal pain in male and female adolescents: psychosocial profiles, somatosensory profiles and pain modulatory profiles. J Pain Res. 2022;15:591–612. doi:10.2147/JPR.S352607
   PubMed Web of Science ®Google Scholar
• Ocay DD, Ross BD, Moscaritolo L, et al. The psychosocial characteristics and somatosensory function of children and adolescents who meet the criteria for chronic nociplastic pain. J Pain Res. 2023;16:487–500. doi:10.2147/JPR.S397829
   PubMed Web of Science ®Google Scholar
• Teles AR, Ocay DD, Bin Shebreen A, et al. Evidence of impaired pain modulation in adolescents with idiopathic scoliosis and chronic back pain. Spine J. 2019;19:677–686. doi:10.1016/j.spinee.2018.10.009
   PubMed Web of Science ®Google Scholar
• Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain. 2009;10:895–926. doi:10.1016/j.jpain.2009.06.012
   PubMed Web of Science ®Google Scholar
• La JH, Chung JM. Peripheral afferents and spinal inhibitory system in dynamic and static mechanical allodynia. Pain. 2017;158:2285–2289. doi:10.1097/j.pain.0000000000001055
   PubMed Web of Science ®Google Scholar
• Herrero JF, Laird JM, Lopez-Garcia JA. Wind-up of spinal cord neurones and pain sensation: much ado about something? Prog Neurobiol. 2000;61:169–203. doi:10.1016/S0301-0082(99)00051-9
   PubMed Web of Science ®Google Scholar
• Clarke RW, Eves S, Harris J, Peachey JE, Stuart E. Interactions between cutaneous afferent inputs to a withdrawal reflex in the decerebrated rabbit and their control by descending and segmental systems. Neuroscience. 2002;112:555–571. doi:10.1016/S0306-4522(02)00093-3
   PubMed Web of Science ®Google Scholar
• Mücke M, Cuhls H, Radbruch L, et al. Quantitative sensory testing (QST). English version. Schmerz. 2016;35:153–160. doi:10.1007/s00482-015-0093-2
   Google Scholar
• Kunz M, Bunk SF, Karmann AJ, Bar KJ, Lautenbacher S. Conditioned Pain Modulation (CPM) effects captured in facial expressions. J Pain Res. 2021;14:793–803. doi:10.2147/JPR.S300313
   PubMed Web of Science ®Google Scholar
• Cata JP, Weng HR, Burton AW, Villareal H, Giralt S, Dougherty PM. Quantitative sensory findings in patients with bortezomib-induced pain. J Pain. 2007;8:296–306. doi:10.1016/j.jpain.2006.09.014
   PubMed Web of Science ®Google Scholar
• Tousignant-Laflamme Y, Pagé S, Goffaux P, Marchand S. An experimental model to measure excitatory and inhibitory pain mechanisms in humans. Brain Res. 2008;1230:73–79. doi:10.1016/j.brainres.2008.06.120
   PubMed Web of Science ®Google Scholar
• Laughlin MS, Murray JD, Wear ML, Van Baalen M Post-flight back pain following international space station missions: evaluation of spaceflight risk factors; 2016 Human Research program Investigator’s Workshop; February 8, 2016; Galveston, TX.
   Google Scholar
• Johnston SL, Campbell MR, Scheuring R, Feiveson AH. Risk of herniated nucleus pulposus among U.S. astronauts. Aviat Space Environ Med. 2010;81:566–574. doi:10.3357/ASEM.2427.2010
   PubMedGoogle Scholar
• Pool-Goudzwaard AL, Belavý DL, Hides JA, Richardson CA, Snijders CJ. Low back pain in microgravity and bed rest studies. Aerosp Med Hum Perform. 2015;86:541–547. doi:10.3357/AMHP.4169.2015
   PubMed Web of Science ®Google Scholar
• McHugh RK, Kneeland ET, Edwards RR, Jamison R, Weiss RD. Pain catastrophizing and distress intolerance: prediction of pain and emotional stress reactivity. J Behav Med. 2020;43:623–629. doi:10.1007/s10865-019-00086-5
   PubMed Web of Science ®Google Scholar
• Michaelides C, Nguyen TN, Chiappa KH, Kwolek CJ, Simon MV. Cerebral embolism during elective carotid endarterectomy treated with tissue plasminogen activator: utility of intraoperative EEG monitoring. Clin Neurol Neurosurg. 2010;112:446–449. doi:10.1016/j.clineuro.2010.01.009
   PubMed Web of Science ®Google Scholar
• Dougherty PM, Cata JP, Cordella JV, Burton A, Weng HR. Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients. Pain. 2004;109:132–142. doi:10.1016/j.pain.2004.01.021
   PubMed Web of Science ®Google Scholar
• González‐Duarte A, Lem‐Carrillo M, Guerrero‐Torres L. Normative values of quantitative sensory testing in Hispanic Latino population. Brain Behav. 2016;6:e00466. doi:10.1002/brb3.466
   PubMed Web of Science ®Google Scholar
• Yarnitsky D, Sprecher E, Zaslansky R, Hemli JA. Heat pain thresholds: normative data and repeatability. Pain. 1995;60:329–332. doi:10.1016/0304-3959(94)00132-X
   PubMed Web of Science ®Google Scholar
• Rolke R, Baron R, Maier C, et al. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain. 2006;123:231–243. doi:10.1016/j.pain.2006.01.041
   PubMed Web of Science ®Google Scholar
• Yarnitsky D, Bouhassira D, Drewes AM, et al. Recommendations on practice of conditioned pain modulation (CPM) testing. Eur J Pain. 2015;19:805–806. doi:10.1002/ejp.605
   PubMed Web of Science ®Google Scholar
• Suzuki H, Tahara S, Mitsuda M, et al. Current concept of quantitative sensory testing and pressure pain threshold in neck/shoulder and low back pain. Healthcare (Basel). 2022;10(8):1485. doi:10.3390/healthcare10081485
   PubMedGoogle Scholar
• Mancini F, Bauleo A, Cole J, et al. Whole-body mapping of spatial acuity for pain and touch. Ann Neurol. 2014;75:917–924. doi:10.1002/ana.24179
   PubMed Web of Science ®Google Scholar
• Jürgens TP, Sawatzki A, Henrich F, Magerl W, May A. An improved model of heat-induced hyperalgesia--repetitive phasic heat pain causing primary hyperalgesia to heat and secondary hyperalgesia to pinprick and light touch. PLoS One. 2014;9:e99507. doi:10.1371/journal.pone.0099507
   PubMed Web of Science ®Google Scholar
• Urban JPG, Holm S, Maroudas A, Nachemson A. Nutrition of the intervertebral disc. Clin Orthop Relat Res. 1982;170. doi:10.1097/00003086-198210000-00039
   Google Scholar
• Groh AMR, Fournier DE, Battié MC, Séguin CA. Innervation of the human intervertebral disc: a scoping review. Pain Med. 2021;22:1281–1304. doi:10.1093/pm/pnab070
   PubMed Web of Science ®Google Scholar
• Zhang F, Huan L, Xu T, et al. Inflammatory macrophages facilitate mechanical stress-induced osteogenesis. Aging. 2020;12:3617–3625. doi:10.18632/aging.102833
   PubMedGoogle Scholar
• Chen J, Liu Z, Zhong G, et al. Cyclic stretch enhances apoptosis in human lumbar ligamentum flavum cells via the induction of reactive oxygen species generation. J Spinal Cord Med. 2016;39:450–454. doi:10.1080/10790268.2016.1141470
   PubMed Web of Science ®Google Scholar
• Stavnichuk M, Mikolajewicz N, Corlett T, Morris M, Komarova SV. A systematic review and meta-analysis of bone loss in space travelers. Microgravity. 2020;6. doi:10.1038/s41526-020-0103-2
   Google Scholar
• Abdelaziz DM, Stone LS, Komarova SV. Osteolysis and pain due to experimental bone metastases are improved by treatment with rapamycin. Breast Cancer Res Treat. 2014;143:227–237. doi:10.1007/s10549-013-2799-0
   PubMed Web of Science ®Google Scholar
• Thornton W, Hoffler G, Rummel J Anthropometric changes and fluid shifts. Biomedical results from Skylab. Scientific and Technical Information Office. National Aeronautics and Space Administration:[for sale by the Supt of Docs, US Govt Print Off]; 1976:330–339.
   Google Scholar
• Clement G, Wood SJ. Rocking or rolling--perception of ambiguous motion after returning from space. PLoS One. 2014;9:e111107. doi:10.1371/journal.pone.0111107
   PubMed Web of Science ®Google Scholar
• Green DA, Scott JPR. Spinal health during unloading and reloading associated with spaceflight. Front Physiol. 2017;8:1126. doi:10.3389/fphys.2017.01126
   PubMed Web of Science ®Google Scholar