Are There Any Advantages of the Low Opioid Anaesthesia and Non-Opioid Postoperative Analgesia Protocol: A Clinical Observational Study

References

• Mulier JP, Hunter JM, de Boer HD. Seventy-five years since the birth of the Liverpool anaesthetic technique. Br J Anaesth. 2021;126(2):343–347. doi:10.1016/j.bja.2020.10.020
   PubMed Web of Science ®Google Scholar
• Robinson DH, Toledo AH. Historical development of modern anesthesia. J Invest Surg. 2012;25(3):141–149. doi:10.3109/08941939.2012.690328
   PubMed Web of Science ®Google Scholar
• Ellis TA 2nd, Narr BJ, Bacon DR. Developing a specialty: J.S. Lundy’s three major contributions to anesthesiology. J Clin Anesth. 2004;16(3):226–229. doi:10.1016/j.jclinane.2003.07.005
   PubMed Web of Science ®Google Scholar
• Brown EN, Pavone KJ, Naranjo M. Multimodal general anesthesia: theory and practice. AnesthAnalg. 2018;127(5):1246–1258. doi:10.1213/ANE.0000000000003668
   Google Scholar
• Rogobete AF, Sandesc D. General anesthesia as a multimodal individualized clinical concept. Medicina. 2022;58(7):956. doi:10.3390/medicina58070956
   PubMedGoogle Scholar
• Kosciuczuk U, Jakubow P, Tarnowska K, Rynkiewicz-Szczepanska E. Opioid therapy and implications for oxidative balance: a clinical study of Total Oxidative Capacity (TOC) and Total Antioxidative Capacity (TAC). J Clin Med. 2023;13(1):82. doi:10.3390/jcm13010082
   PubMed Web of Science ®Google Scholar
• Small C, Laycock H. Acute postoperative pain management. Br J Surg. 2020;107(2):e70–e80. doi:10.1002/bjs.11477
   PubMed Web of Science ®Google Scholar
• Frauenknecht J, Kirkham KR, Jacot-Guillarmod A, Albrecht E. Analgesic impact of intra-operative opioids vs. opioid-free anaesthesia: a systematic review and meta-analysis. Anaesthesia. 2019;74(5):651–662. doi:10.1111/anae.14582
   PubMed Web of Science ®Google Scholar
• de Boer HD, Detriche O, Forget P. Opioid-related side effects: postoperative ileus, urinary retention, nausea and vomiting, and shivering. A review of the literature. Best Pract Res Clin Anaesthesiol. 2017;31(4):499–504. doi:10.1016/j.bpa.2017.07.002
   PubMed Web of Science ®Google Scholar
• Kosciuczuk U, Knapp P, Lotowska-Cwiklewska AM. Opioid-induced immunosuppression and carcinogenesis promotion theories create the newest trend in acute and chronic pain pharmacotherapy. Clinics. 2020;75:e1554. doi:10.6061/clinics/2020/e1554
   PubMed Web of Science ®Google Scholar
• Kosciuczuk U, Jakubow P, Czyzewska J, Knapp P, Rynkiewicz-Szczepanska E. Plasma brain-derived neurotrophic factor and opioid therapy: Results of Pilot Cross-Sectional Study. Clin Med Res. 2022;20(4):195–203. doi:10.3121/cmr.2022.1731
   PubMed Web of Science ®Google Scholar
• Wei G, Moss J, Yuan CS. Opioid-induced immunosuppression: is it centrally mediated or peripherally mediated? Biochem Pharmacol. 2003;65(11):1761–1766. doi:10.1016/s0006-2952(03)00085-6
   PubMed Web of Science ®Google Scholar
• Bissell BD, Sturgill JL, Bruno MEC, Lewis ED. Assessment of opioid-induced immunomodulation in experimental and clinical sepsis. Crit Care Explor. 2023;5(1):e0849. doi:10.1097/CCE.0000000000000849
   PubMedGoogle Scholar
• Sacerdote P. Opioid-induced immunosuppression. CurrOpin Support Palliat Care. 2008;2(1):14–18. doi:10.1097/SPC.0b013e3282f5272e
   PubMedGoogle Scholar
• Malofoglia V, Ilari S, Vitiello L, et al. The interplay between chronic pain, opioids, and the immune system. Neuroscientist. 2022;28:613–627. doi:10.1177/10738584211030493
   PubMed Web of Science ®Google Scholar
• O’Neil A, Lirk P. Multimodal analgesia. Anesthesiol Clin. 2022;40(3):455–468. doi:10.1016/j.anclin.2022.04.002
   PubMedGoogle Scholar
• Egan TD. Are opioids indispensable for general anaesthesia? Br J Anaesth. 2019;122(6):e127–e135. doi:10.1016/j.bja.2019.02.018
   PubMed Web of Science ®Google Scholar
• Baboli KM, Liu H, Poggio JL. Opioid-free postoperative analgesia: is it feasible? Curr Prob Surg. 2020;57:100794. doi:10.1016/j.cpsurg.2020.100794
   PubMed Web of Science ®Google Scholar
• Carcamo-Cavazos V, Cannesson M. Opioid-free anesthesia: the pros and cons. Adv Anesth. 2022;40(1):149–166. doi. doi:10.1016/j.aan.2022.07.003
   PubMedGoogle Scholar
• Chou R, Gordon DB, de Leon-Casasola OA, et al. Management of postoperative pain: a clinical practice guideline from the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists’ Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain. 2016;17(2):131–157. doi:10.1016/j.jpain.2015.12.008
   PubMed Web of Science ®Google Scholar
• Vasilopoulos T, Wardhan R, Rashidi P, et al; Temporal Postoperative Pain Signatures (TEMPOS) Group. Patient and procedural determinants of postoperative pain trajectories. Anesthesiology. 2021;134(3):421–434. doi:10.1097/ALN.0000000000003681
   PubMed Web of Science ®Google Scholar
• Echeverria-Villalobos M, Stoicea N, Todeschini AB, et al. Enhanced Recovery After Surgery (ERAS): a perspective review of postoperative pain management under ERAS pathways and its role on opioid crisis in the United States. Clin J Pain. 2020;36(3):219–226. doi:10.1097/AJP.0000000000000792
   PubMed Web of Science ®Google Scholar
• Sultana A, Torres D, Schumann R. Special indications for opioid free anaesthesia and analgesia, patient and procedure related: including obesity, sleep apnoea, chronic obstructive pulmonary disease, complex regional pain syndromes, opioid addiction and cancer surgery. Best Pract Res Clin Anaesthesiol. 2017;31:547–560. doi:10.1016/j.bpa.2017.11.002
   PubMedGoogle Scholar
• Beverly A, Kaye AD, Ljungqvist O, Urman RD. Essential elements of multimodal analgesia in Enhanced Recovery After Surgery (ERAS) Guidelines. Anesthesiol Clin. 2017;35(2):e115–e143. doi:10.1016/j.anclin.2017.01.018
   PubMedGoogle Scholar
• Thota R, Ramkiran S, Garg R, Goswami J, Baxi V, Thomas M. Opioid free onco-anesthesia: is it time to convict opioids? A systematic review of literature. J Anaesth Clin Pharmacol. 2019;35:441–452. doi:10.4103/joacp.JOACP_128_19
   PubMed Web of Science ®Google Scholar
• Morgenstern C, Ramírez-Paesano C, Galcerán AJ, Morgenstern R. Thoracolumbar interfascial plane block results in opioid-free postoperative recovery after percutaneous/endoscopic transforaminal lumbar interbody fusion surgery. World Neurosurg. 2021;153:e473–e480. doi:10.1016/j.wneu.2021.06.152
   PubMed Web of Science ®Google Scholar
• Williams L, Iteld L. Moving toward opioid-free breast surgery: regional blocks and a novel technique. Clin Plast Surg. 2021;48(1):123–130. doi:10.1016/j.cps.2020.09.003
   PubMed Web of Science ®Google Scholar
• Darmawikarta D, Sourour M, Couban R, et al. Opioid-free analgesia for supratentorial craniotomies: a systematic review. Can J Neurol Sci. 2019;46(4):415–422. doi:10.1017/cjn.2019.57
   PubMed Web of Science ®Google Scholar
• Chia PA, Cannesson M, Bui CCM. Opioid free anesthesia: feasible? Curr Opin Anaesthesiol. 2020;33(4):512–517. doi:10.1097/ACO.0000000000000878
   PubMed Web of Science ®Google Scholar
• Beloeil H. Opioid-free anesthesia. Best Pract Res Clin Anaesthesiol. 2019;33(3):353–360. doi:10.1016/j.bpa.2019.09.002
   PubMed Web of Science ®Google Scholar
• Jiang B, Ye S. Pharmacotherapeutic pain management in patients undergoing laparoscopic cholecystectomy: a review. Adv Clin Exp Med. 2022;31(11):1275–1288. doi:10.17219/acem/151995
   PubMed Web of Science ®Google Scholar
• Bugada D, Lorini LF, Lavand’homme P. Opioid free anesthesia: evidence for short and long-term outcome. Minerva Anestesiol. 2021;87(2):230–237. doi:10.23736/S0375-9393.20.14515-2
   PubMed Web of Science ®Google Scholar
• Salomé A, Harkouk H, Fletcher D, Martinez V. Opioid-free anesthesia benefit-risk balance: a systematic review and meta-analysis of randomized controlled trials. J Clin Med. 2021;10(10):2069. doi:10.3390/jcm10102069
   PubMed Web of Science ®Google Scholar
• Forget P. Why and how? A contextual analysis. Anaesth Crit Care Pain Med. 2019;38(2):169–172. doi:10.1016/j.accpm.2018.05.002
   PubMed Web of Science ®Google Scholar
• Toleska M, Dimitrovski A, Toleska-Dmitrovska N. Postoperative nausea and vomiting in opioid-free anesthesia versus opioid based anesthesia in laparoscopic cholecystectomy. Pril. 2022;43(3):101–108. doi:10.2478/prilozi-2022-0042
   PubMedGoogle Scholar
• Toleska M, Dimitrovski A. Is opioid-free general anesthesia more superior for postoperative pain versus opioid general anesthesia in laparoscopic cholecystectomy? Pril. 2019;40(2):81–87. doi:10.2478/prilozi-2019-0018
   PubMedGoogle Scholar
• Mulier JP. Is opioid-free general anesthesia for breast and gynecological surgery a viable option? Curr Opin Anaesthesiol. 2019;3: 257-262. Available from: https://www.researchgate.net/publication/356169952_OFAM_opioid_free_general_anesthesia_mixture_Mulimix_Multimodal_anaesthesia_developed. Accessed February 27, 2024.
   Google Scholar
• Sadowska D, Bialka S, Palaczynski P, et al. Opioid-free anaesthesia effectiveness in thoracic surgery—objective measurement with a skin conductance algesimeter: a randomized controlled trial. Int J Environ Res Public Health. 2022;19(21):14358. doi:10.3390/ijerph192114358
   PubMed Web of Science ®Google Scholar
• An G, Zhang Y, Chen N, Fu J, Zhao B, Zhao X. Opioid-free anesthesia compared to opioid anesthesia for lung cancer patients undergoing video-assisted thoracoscopic surgery: a randomized controlled study. PLoS One. 2021;16(9):e0257279. doi:10.1371/journal.pone.0257279
   PubMed Web of Science ®Google Scholar
• Ziemann-Gimmel P, Goldfarb AA, Koppman J, Marema RT. Opioid-free total intravenous anaesthesia reduces postoperative nausea and vomiting in bariatric surgery beyond triple prophylaxis. Br J Anaesth. 2014;112(5):906–911. doi:10.1093/bja/aet551
   PubMed Web of Science ®Google Scholar
• Ibrahim M, Elnabtity AM, Hegab A, Alnujaidi OA, El Sanea O. Combined opioid free and loco-regional anaesthesia enhances the quality of recovery in sleeve gastrectomy done under ERAS protocol: a randomized controlled trial. BMC Anesthesiol. 2022;22(1):29. doi:10.1186/s12871-021-01561-w
   PubMed Web of Science ®Google Scholar
• Apfel CC, Läärä E, Koivuranta M, Greim CA, Roewer N. A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers. Anesthesiology. 1999;91(3):693–700. doi:10.1097/00000542-199909000-00022
   PubMed Web of Science ®Google Scholar
• Darvall J, Handscombe M, Maat B, So K, Suganthirakumar A, Leslie K. Interpretation of the four risk factors for postoperative nausea and vomiting in the Apfel simplified risk score: an analysis of published studies. Can J Anaesth. 2021;68(7):1057–1063. doi:10.1007/s12630-021-01974-8
   PubMed Web of Science ®Google Scholar
• Gan TJ, Belani KG, Bergese S, et al. Fourth consensus guidelines for the management of postoperative nausea and vomiting. AnesthAnalg. 2020;131(2):411–448. doi:10.1213/ANE.0000000000004833
   Google Scholar
• Langevin S, Lessard MR, Trépanier CA, Baribault JP. Alfentanil causes less postoperative nausea and vomiting than equipotent doses of fentanyl or sufentanil in outpatients. Anesthesiology. 1999;91(6):1666–1673. doi:10.1097/00000542-199912000-00019
   PubMed Web of Science ®Google Scholar
• Apfel CC, Heidrich FM, Jukar-Rao S, et al. Evidence-based analysis of risk factors for postoperative nausea and vomiting. Br J Anaesth. 2012;109(5):742–753. doi:10.1093/bja/aes276
   PubMed Web of Science ®Google Scholar
• Rajan N, Joshi GP. Management of postoperative nausea and vomiting in adults: current controversies. Curr Opin Anaesthesiol. 2021;34(6):695–702. doi:10.1097/ACO.0000000000001063
   PubMed Web of Science ®Google Scholar
• Yayla A, Ilgin VE, Kılınç T, et al. Nausea and vomiting after laparoscopic cholecystectomy: analysis of predictive factors. J Perianesth Nurs. 2022;37(6):834–841. doi:10.1016/j.jopan.2022.01.002
   PubMed Web of Science ®Google Scholar
• Naemi AR, Kashanitabar V, Kamali A, Shiva A. Comparison of the effects of haloperidol, metoclopramide, dexmedetomidine and ginger on postoperative nausea and vomiting after laparoscopic cholecystectomy. J Med Life. 2020;13(2):206–210. doi:10.25122/jml-2019-0070
   PubMedGoogle Scholar
• Shahiri TS, Richebé P, Richard-Lalonde M, Gélinas C. Description of the validity of the Analgesia Nociception Index (ANI) and Nociception Level Index (NOL) for nociception assessment in anesthetized patients undergoing surgery: a systematized review. J Clin Monit Comput. 2022;36(3):623–635. doi:10.1007/s10877-021-00772-3
   PubMed Web of Science ®Google Scholar
• Ledowski T. Objective monitoring of nociception: a review of current commercial solutions. Br J Anaesth. 2019;123(2):e312–e321. doi:10.1016/j.bja.2019.03.024
   PubMed Web of Science ®Google Scholar
• von Dincklage F, Ledowski T. Monitoring of nociception: is more always more? Br J Anaesth. 2021;126(2):352–354. doi:10.1016/j.bja.2020.11.014
   PubMed Web of Science ®Google Scholar
• Chapman CR, Vierck CJ. The transition of acute postoperative pain to chronic pain: an integrative overview of research on mechanisms. J Pain. 2017;18(4):359.e1–359.e38. doi:10.1016/j.jpain.2016.11.004
   PubMedGoogle Scholar
• Glare P, Aubrey KR, Myles PS. Transition from acute to chronic pain after surgery. Lancet. 2019;393(10180):1537–1546. doi:10.1016/S0140-6736(19)30352-6
   PubMed Web of Science ®Google Scholar