26
Views
0
CrossRef citations to date
0
Altmetric
Neuropathic Pain

Markers of Tissue Deterioration and Pain on Earth and in Space

ORCID Icon, , , , ORCID Icon, ORCID Icon, , , & ORCID Icon show all
Pages 1683-1692 | Received 16 Nov 2023, Accepted 25 Apr 2024, Published online: 08 May 2024

References

  • Sauer AK, Vigouroux M, Dougherty PM, Cata JP, Ingelmo PM. Pain experience and sensory changes in astronauts during and after short-lasting commercial spaceflight: a proof-of-concept study. J Pain Res. 2023;16:4253–4266. doi:10.2147/jpr.S440630
  • Willie BM, Zimmermann EA, Vitienes I, Main RP, Komarova SV. Bone adaptation: safety factors and load predictability in shaping skeletal form. Bone. 2020;131:115114. doi:10.1016/j.bone.2019.115114
  • Puntillo F, Giglio M, Paladini A, et al. Pathophysiology of musculoskeletal pain: a narrative review. Ther Adv Musculoskelet Dis. 2021;13:1759720x21995067. doi:10.1177/1759720x21995067
  • Lee PHU, Chung M, Ren Z, Mair DB, Kim DH. Factors mediating spaceflight-induced skeletal muscle atrophy. Am J Physiol Cell Physiol. 2022;322(3):C567–C580. doi:10.1152/ajpcell.00203.2021
  • Chang DG, Healey RM, Snyder AJ, et al. Lumbar spine paraspinal muscle and intervertebral disc height changes in astronauts after long-duration spaceflight on the international space station. Spine. 2016;41(24):1917–1924. doi:10.1097/brs.0000000000001873
  • Burkhart K, Allaire B, Bouxsein ML. Negative effects of long-duration spaceflight on paraspinal muscle morphology. Spine. 2019;44(12):879–886. doi:10.1097/brs.0000000000002959
  • Stavnichuk M, Mikolajewicz N, Corlett T, Morris M, Komarova SV. A systematic review and meta-analysis of bone loss in space travelers. NPJ Microgravity. 2020;6:13. doi:10.1038/s41526-020-0103-2
  • Nagy EE, Nagy-Finna C, Popoviciu H, Kovács B. Soluble biomarkers of osteoporosis and osteoarthritis, from pathway mapping to clinical trials: an update. Clin Interv Aging. 2020;15:501–518. doi:10.2147/cia.S242288
  • Akbik OS, Ban VS, MacAllister MC, Aoun SG, Bagley CA. Genetic and serum markers in adult degenerative scoliosis: a literature review. Spine Deform. 2022;10(3):479–488. doi:10.1007/s43390-021-00451-y
  • Zhou YQ, Liu Z, Liu ZH, et al. Interleukin-6: an emerging regulator of pathological pain. J Neuroinflammation. 2016;13(1):141. doi:10.1186/s12974-016-0607-6
  • Kwan Tat S, Padrines M, Théoleyre S, Heymann D, Fortun Y. IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology. Cytokine Growth Factor Rev. 2004;15(1):49–60. doi:10.1016/j.cytogfr.2003.10.005
  • DeVon HA, Piano MR, Rosenfeld AG, Hoppensteadt DA. The association of pain with protein inflammatory biomarkers: a review of the literature. Nurs Res. 2014;63(1):51–62. doi:10.1097/nnr.0000000000000013
  • Al-Rawaf HA, Gabr SA, Alghadir AH. Vitamin D deficiency and molecular changes in circulating MicroRNAs in older adults with lower back pain. Pain Res Manag. 2021;6662651. doi:10.1155/2021/6662651
  • Albertoni Giraldes AL, Salomao R, Leal PD, Brunialti MK, Sakata RK. Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of IL-1, IL-6 and IL-8 in patients with fibromyalgia: a randomized double-blind study. Int J Rheum Dis. 2016;19(10):946–953. doi:10.1111/1756-185X.12904
  • Alghadir AH, Gabr SA, Rizk AA. Plasmatic adipocyte biomarkers and foot pain associated with flatfoot in schoolchildren with obesity. Rev Assoc Med Bras. 2019;65(8):1061–1066. doi:10.1590/1806-9282.65.8.1061
  • Alstergren P, Kopp S. Insufficient endogenous control of tumor necrosis factor-alpha contributes to temporomandibular joint pain and tissue destruction in rheumatoid arthritis. J Rheumatol. 2006;33(9):1734–1739.
  • Ang DC, Moore MN, Hilligoss J, Tabbey R. MCP-1 and IL-8 as pain biomarkers in fibromyalgia: a pilot study. Pain Med. 2011;12(8):1154–1161. doi:10.1111/j.1526-4637.2011.01179.x
  • Bäckryd E, Ghafouri B, Larsson B, Gerdle B. Plasma pro-inflammatory markers in chronic neuropathic pain: a multivariate, comparative, cross-sectional pilot study. Scand J Pain. 2016;10:1–5. doi:10.1016/j.sjpain.2015.06.006
  • Barisic I, Ljutic D, Vlak T, Bekavac J, Jankovic S. Laboratory and sonographic findings in dialyzed patients with bilateral chronic knee pain versus dialyzed asymptomatic patients. Coll Antropol. 2007;31(2):489–494.
  • Brennan ML, Penn MS, Van Lente F, et al. Prognostic value of myeloperoxidase in patients with chest pain. N Engl J Med. 2003;349(17):1595–1604.
  • Cavusoglu E, Ruwende C, Chopra V, et al. Adiponectin is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction in patients presenting with chest pain. Eur Heart J. 2006;27(19):2300–2309.
  • de Queiroz BZ, Pereira DS, Lopes RA, et al. Association between the plasma levels of mediators of inflammation with pain and disability in the elderly with acute low back pain: data from the Back Complaints in the Elders (BACE)-Brazil Study. Spine. 2016;41(3):197–203. doi:10.1097/BRS.0000000000001214
  • Freidin MB, Wells HRR, Potter T, Livshits G, Menni C, Williams FMK. Metabolomic markers of fatigue: association between circulating metabolome and fatigue in women with chronic widespread pain. Biochim. 2018;1864(2):601–606. doi:10.1016/j.bbadis.2017.11.025
  • Guo H, Xu YM, Ye ZQ, Yu JH. [Levels of cytokines and heat-shock protein 70 in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome]. Zhonghua Nan Ke Xue. 2012;18(12):1088–1092. Chinese.
  • Jasim H. Topical review - salivary biomarkers in chronic muscle pain. Scand J Pain. 2023;23(1):3–13. doi:10.1515/sjpain-2022-0112
  • Jasim H, Carlsson A, Hedenberg-Magnusson B, Ghafouri B, Ernberg M. Saliva as a medium to detect and measure biomarkers related to pain. Sci Rep. 2018;8(1):3220. doi:10.1038/s41598-018-21131-4
  • Jasim H, Ghafouri B, Carlsson A, Hedenberg-Magnusson B, Ernberg M. Daytime changes of salivary biomarkers involved in pain. J Oral Rehabil. 2020;47(7):843–850. doi:10.1111/joor.12977
  • Jasim H, Ghafouri B, Gerdle B, Hedenberg-Magnusson B, Ernberg M. Altered levels of salivary and plasma pain related markers in temporomandibular disorders. J Headache Pain. 2020;21(1):105. doi:10.1186/s10194-020-01160-z
  • Kamieniak P, Bielewicz JM, Grochowski C, et al. IFN-gamma correlations with pain assessment, radiological findings, and clinical intercourse in patient after lumbar microdiscectomy: preliminary study. Dis Markers. 2020:1318930. doi:10.1155/2020/1318930
  • Khadra A, Fletcher P, Luzzi G, Shattock R, Hay P. Interleukin-8 levels in seminal plasma in chronic prostatitis/chronic pelvic pain syndrome and nonspecific urethritis. BJU Int. 2006;97(5):1043–1046.
  • Kinfe TM, Muhammad S, Link C, Roeske S, Chaudhry SR, Yearwood TL. Burst spinal cord stimulation increases peripheral antineuroinflammatory interleukin 10 levels in failed back surgery syndrome patients with predominant back pain. Neuromodulation. 2017;20(4):322–330. doi:10.1111/ner.12586
  • Kovacs D, Eszlari N, Petschner P, et al. Interleukin-6 promoter polymorphism interacts with pain and life stress influencing depression phenotypes. J Neural Transm. 2016;123(5):541–548. doi:10.1007/s00702-016-1506-9
  • Lee E, Nelson OL, Puyana C, et al. Association between C-reactive protein and radiotherapy-related pain in a tri-racial/ethnic population of breast cancer patients: a prospective cohort study. Breast Cancer Res. 2019;21(1):70. doi:10.1186/s13058-019-1151-y
  • Li D, Song X, Huang H, Huang H, Ye Z. Association of Parkinson’s disease-related pain with plasma interleukin-1, interleukin-6, interleukin-10, and tumour necrosis factor-α. Neurosci Lett. 2018;683:181–184. doi:10.1016/j.neulet.2018.07.027
  • Liu YC, Hsiao HT, Wang JC, Wen TC, Chen SL. TGF-β1 in plasma and cerebrospinal fluid can be used as a biological indicator of chronic pain in patients with osteoarthritis. PLoS One. 2022;17(1):e0262074. doi:10.1371/journal.pone.0262074
  • McCann CJ, Glover BM, Menown IB, et al. Investigation of a multimarker approach to the initial assessment of patients with acute chest pain. Adv Ther. 2009;26(5):531–534. doi:10.1007/s12325-009-0032-7
  • Miller LJ, Fischer KA, Goralnick SJ, et al. Nerve growth factor and chronic prostatitis/chronic pelvic pain syndrome. Urology. 2002;59(4):603–608. doi:10.1016/s0090-4295(01)01597-7
  • Nieman DC, Shanely RA, Luo B, Dew D, Meaney MP, Sha W. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Nutr J. 2013;12(1):154. doi:10.1186/1475-2891-12-154
  • Penna G, Mondaini N, Amuchastegui S, et al. Seminal plasma cytokines and chemokines in prostate inflammation: interleukin 8 as a predictive biomarker in chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia. Europ Urology. 2007;51(2):524–533.
  • Ponniah S, Arah I, Alexander RB. PSA is a candidate self-antigen in autoimmune chronic prostatitis/chronic pelvic pain syndrome. Prostate. 2000;44(1):49–54. doi:10.1002/1097-0045(20000615)44:1<49::aid-pros7>3.0.co;2-7
  • Prada-Arias M, Gómez-Veiras J, Salgado-Barreira Á, Vázquez JL, Montero-Sánchez M, Fernández-Lorenzo JR. Value of fibrinogen to discriminate appendicitis from nonspecific abdominal pain in preschool children. Eur J Pediatr Surg. 2020;30(4):357–363. doi:10.1055/s-0039-1692166
  • Prada-Arias M, Vázquez JL, Salgado-Barreira Á, Gómez-Veiras J, Montero-Sánchez M, Fernández-Lorenzo JR. Diagnostic accuracy of fibrinogen to differentiate appendicitis from nonspecific abdominal pain in children. Am J Emerg Med. 2017;35(1):66–70. doi:10.1016/j.ajem.2016.10.003
  • Radojčić MR, Thudium CS, Henriksen K, et al. Biomarker of extracellular matrix remodelling C1M and proinflammatory cytokine interleukin 6 are related to synovitis and pain in end-stage knee osteoarthritis patients. Pain. 2017;158(7):1254–1263. doi:10.1097/j.pain.0000000000000908
  • Ramanathan S, Douglas SR, Alexander GM, et al. Exosome microRNA signatures in patients with complex regional pain syndrome undergoing plasma exchange. J Transl Med. 2019;17(1):81. doi:10.1186/s12967-019-1833-3
  • Reed JL, Strait RT, Kachelmeyer AM, Byczkowski TL, Ho ML, Huppert JS. Biomarkers to distinguish surgical etiologies in females with lower quadrant abdominal pain. Acad Emerg Med. 2011;18(7):686–691. doi:10.1111/j.1553-2712.2011.01108.x
  • Rhee KY, Goetzl L, Unal R, Cierny J, Flood P. The relationship between plasma inflammatory cytokines and labor pain. Anesth Analg. 2015;121(3):748–751. doi:10.1213/ane.0000000000000837
  • Ritz BW, Alexander GM, Nogusa S, et al. Elevated blood levels of inflammatory monocytes (CD14+ CD16+) in patients with complex regional pain syndrome. Clin Exp Immunol. 2011;164(1):108–117. doi:10.1111/j.1365-2249.2010.04308.x
  • Rocha AL, Vieira EL, Ferreira MC, Maia LM, Teixeira AL, Reis FM. Plasma brain-derived neurotrophic factor in women with pelvic pain: a potential biomarker for endometriosis? Biomarker Med. 2017;11(4):313–317. doi:10.2217/bmm-2016-0327
  • Sanchis J, Bosch X, Bodí V, et al. Combination of clinical risk profile, early exercise testing and circulating biomarkers for evaluation of patients with acute chest pain without ST-segment deviation or troponin elevation. Heart. 2008;94(3):311–315. doi:10.1136/hrt.2007.115626
  • Simon CB, Bishop MD, Wallace MR, et al. Circulating inflammatory biomarkers predict pain change following exercise-induced shoulder injury: findings from the biopsychosocial influence on shoulder pain preclinical trial. J Pain. 2023;24(8):1465–1477. doi:10.1016/j.jpain.2023.04.001
  • Thakkar B, Acevedo EO. BDNF as a biomarker for neuropathic pain: consideration of mechanisms of action and associated measurement challenges. Brain Behav. 2023;13(3):e2903. doi:10.1002/brb3.2903
  • Tofik R, Swärd P, Ekelund U, et al. Plasma pro-inflammatory cytokines, IgM-uria and cardiovascular events in patients with chest pain: a comparative study. Scand J Clin Lab Invest. 2015;75(8):638–645. doi:10.3109/00365513.2015.1057218
  • Wereszczynska-Siemiatkowska U, Dabrowski A, Siemiatkowski A, Mroczko B, Laszewicz W, Gabryelewicz A. Serum profiles of E-selectin, interleukin-10, and interleukin-6 and oxidative stress parameters in patients with acute pancreatitis and nonpancreatic acute abdominal pain. Pancreas. 2003;26(2):144–152. doi:10.1097/00006676-200303000-00010
  • Wu EB, Lumb P, Chambers JB, Crook MA. Plasma sialic acid and coronary artery atheromatous load in patients with stable chest pain. Atherosclerosis. 1999;145(2):261–266. doi:10.1016/s0021-9150(99)00074-x
  • Gerdle B, Bäckryd E, Falkenberg T, Lundström E, Ghafouri B. Changes in inflammatory plasma proteins from patients with chronic pain associated with treatment in an interdisciplinary multimodal rehabilitation program - an explorative multivariate pilot study. Scand J Pain. 2019;20(1):125–138. doi:10.1515/sjpain-2019-0088
  • Goode AP, Hu D, George SZ, et al. Biomarker clusters differentiate phenotypes of lumbar spine degeneration and low back pain: the Johnston County Osteoarthritis Project. Osteoarthr Cartil Open. 2022;4(3). doi:10.1016/j.ocarto.2022.100270
  • Jönsson M, Gerdle B, Ghafouri B, et al. The inflammatory profile of cerebrospinal fluid, plasma, and saliva from patients with severe neuropathic pain and healthy controls-a pilot study. The inflammatory profile of cerebrospinal fluid, plasma, and saliva from patients with severe neuropathic pain and healthy controls-a pilot study. BMC neuro. 2021;22:6. doi:10.1186/s12868-021-00608-5
  • Karppinen J, Koivisto K, Ketola J, et al. Serum biomarkers for Modic changes in patients with chronic low back pain. Eur Spine J. 2021;30(4):1018–1027. doi:10.1007/s00586-020-06713-z
  • Mann TN, Davis JH, Walzl G, et al. Candidate biomarkers to distinguish spinal tuberculosis from mechanical back pain in a tuberculosis endemic setting. Front Immunol. 2021;12:768040. doi:10.3389/fimmu.2021.768040
  • Paish HL, Baldock TE, Gillespie CS, et al. Chronic, active inflammation in patients with failed total knee replacements undergoing revision surgery. J Orthop Res. 2019;37(11):2316–2324. doi:10.1002/jor.24398
  • Sarchielli P, Alberti A, Vaianella L, et al. Chemokine levels in the jugular venous blood of migraine without aura patients during attacks. Comparative Study. Headache. 2004;44(10):961–968.
  • Scholl B, Bersinger NA, Kuhn A, Mueller MD. Correlation between symptoms of pain and peritoneal fluid inflammatory cytokine concentrations in endometriosis. Gynecol Endocrinol. 2009;25(11):701–706. doi:10.3109/09513590903159680
  • Sedighi M, Haghnegahdar A. Role of vitamin D3 in treatment of lumbar disc herniation--pain and sensory aspects: study protocol for a randomized controlled trial. Trials. 2014;15:373. doi:10.1186/1745-6215-15-373
  • Slouma M, Kharrat L, Tezegdenti A, et al. Pro-inflammatory cytokines in patients with low back pain: a comparative study. Reumatol Clin. 2023;19(5):244–248. doi:10.1016/j.reumae.2022.07.002
  • Sugimoto C, Konno T, Wakao R, Fujita H, Fujita H, Wakao H. Mucosal-associated invariant T cell is a potential marker to distinguish fibromyalgia syndrome from arthritis. PLoS One. 2015;10(4):e0121124. doi:10.1371/journal.pone.0121124
  • Tay ML, Bolam SM, Monk AP, McGlashan SR, Young SW, Matthews BG. Better post-operative outcomes at 1-year follow-up are associated with lower levels of pre-operative synovitis and higher levels of IL-6 and VEGFA in unicompartmental knee arthroplasty patients. Knee Surg Sports Traumatol Arthrosc. 2023;31(10):4109–4116. doi:10.1007/s00167-023-07503-y
  • Jiang YH, Jhang JF, Hsu YH, Ho HC, Wu YH, Kuo HC. Urine cytokines as biomarkers for diagnosing interstitial cystitis/bladder pain syndrome and mapping its clinical characteristics. Am J Physiol Renal Physiol. 2020;318(6):F1391–F1399. doi:10.1152/ajprenal.00051.2020
  • Yücel Ç, Fırat Oğuz E, Er S, Balamir İ, Turhan T, Tez M. Diagnostic value of GCP-2/CXCL-6 and hs-CRP in the diagnosis of acute appendicitis. Ulus Travma Acil Cerrahi Derg. 2020;26(2):191–196. doi:10.14744/tjtes.2019.26270
  • Andersen T, Ueland T, Aukrust P, et al. Procollagen type 1 N-terminal propeptide is associated with adverse outcome in acute chest pain of suspected coronary origin. Front Cardiovasc Med. 2023;10:1191055. doi:10.3389/fcvm.2023.1191055
  • Aslam I, Perjar I, Shi XA, et al. Associations between biomarkers of joint metabolism, hand osteoarthritis, and hand pain and function: the Johnston County Osteoarthritis Project. J Rheumatol. 2014;41(5):938–944. doi:10.3899/jrheum.130904
  • Bihlet AR, Byrjalsen I, Bay-Jensen AC, et al. Associations between biomarkers of bone and cartilage turnover, gender, pain categories and radiographic severity in knee osteoarthritis. Arthritis Res Ther. 2019;21(1):203. doi:10.1186/s13075-019-1987-7
  • Bolgla LA, Gordon R, Sloan G, Pretlow LG, Lyon M, Fulzele S. Comparison of patella alignment and cartilage biomarkers in young adult females with and without patellofemoral pain: a Pilot Study. Int J Sports Phys Ther. 2019;14(1):46–54. doi:10.26603/ijspt20190046
  • Chahal J, Gomez-Aristizabal A, Shestopaloff K, et al. Bone marrow mesenchymal stromal cell treatment in patients with osteoarthritis results in overall improvement in pain and symptoms and reduces synovial inflammation. Stem Cells Transl Med. 2019;8(8):746–757. doi:10.1002/sctm.18-0183
  • Forni GL, Perrotta S, Giusti A, et al. Neridronate improves bone mineral density and reduces back pain in beta-thalassaemia patients with osteoporosis: results from a Phase 2, randomized, parallel-arm, open-label study. Brit J Haematol. 2012;158(2):274–282. doi:10.1111/j.1365-2141.2012.09152.x
  • Garcia-Alvarado FJ, Gonzalez-Martinez MDR, Jaramillo-Rodriguez Y, Delgado-Aguirre HA. Increased urinary concentration of C-terminal telopeptide of type ii collagen and pain by radiographic grade in women with knee osteoarthritis in Northeastern Mexico: a cross-sectional study. Biores Open Access. 2020;9(1):7–12. doi:10.1089/biores.2019.0003
  • Ghaffari S, Yaghoubi A, Baghernejad R, Sepehrvand N, Sokhanvar S, Haghjou AG. The value of serum osteoprotegerin levels in patients with angina like chest pain undergoing diagnostic coronary angiography. Cardiol J. 2013;20(3):261–267. doi:10.5603/CJ.2013.0071
  • Hider SL, Konstantinou K, Hay EM, Glossop J, Mattey DL. Inflammatory biomarkers do not distinguish between patients with sciatica and referred leg pain within a primary care population: results from a nested study within the ATLAS cohort. BMC Musculoskelet Disord. 2019;20(1):202. doi:10.1186/s12891-019-2604-2
  • Husain SF, Lam RWM, Hu T, et al. Locating the site of neuropathic pain in vivo using MMP-12-targeted magnetic nanoparticles. Pain Res Manag. 2019:9394715. doi:10.1155/2019/9394715
  • Ishijima M, Watari T, Naito K, et al. Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis. Arthritis Res Ther. 2011;13(1):R22. doi:10.1186/ar3246
  • Jacobs CA, Vranceanu AM, Thompson KL, Lattermann C. Rapid progression of knee pain and osteoarthritis biomarkers greatest for patients with combined obesity and depression: data from the osteoarthritis initiative. Cartilage. 2020;11(1):38–46. doi:10.1177/1947603518777577
  • Kalahasthi R, Bagepally BS, Barman T. Association between musculoskeletal pain and bone turnover markers in long-term Pb-exposed workers. J Res Health Sci. 2021;21(3):e00522. doi:10.34172/jrhs.2021.55
  • Leung YY, Huebner JL, Haaland B, Wong SBS, Kraus VB. Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain. Osteoarthritis Cartilage. 2017;25(9):1420–1427. doi:10.1016/j.joca.2017.04.001
  • Li H, Wang B, He L, Tao R, Shang S. Application of bone metabolic parameters in the diagnosis of growing pains. J Clin Lab Anal. 2022;36(2):e24184. doi:10.1002/jcla.24184
  • Meehan RT, Gill MT, Hoffman ED, et al. Ultrasound-guided injections of HYADD4 for knee osteoarthritis improves pain and functional outcomes at 3, 6, and 12 months without changes in measured synovial fluid, serum collagen biomarkers, or most synovial fluid biomarker proteins at 3 months. J Clin Med. 2023;12(17):25. doi:10.3390/jcm12175541
  • Port H, Nielsen SH, Madsen SF, et al. Extracellular matrix protein turnover markers are associated with axial spondyloarthritis-a comparison with postpartum women and other non-axial spondyloarthritis controls with or without back pain. Arthritis Res Ther. 2022;24(1):152. doi:10.1186/s13075-022-02839-1
  • Roy R, Stephens AJ, Daisy C, et al. Association of longitudinal changes in symptoms and urinary biomarkers in patients with urological chronic pelvic pain syndrome: a MAPP Research Network Study. J Urol. 2021;205(2):514–523. doi:10.1097/JU.0000000000001391
  • Ruff KJ, Morrison D, Duncan SA, Back M, Aydogan C, Theodosakis J. Beneficial effects of natural eggshell membrane versus placebo in exercise-induced joint pain, stiffness, and cartilage turnover in healthy, postmenopausal women. Clin Interv Aging. 2018;13:285–295. doi:10.2147/CIA.S153782
  • Selistre LFA, Goncalves GH, Vasilceac FA, et al. The relationship between urinary C-Telopeptide fragments of type II collagen, knee joint load, pain, and physical function in individuals with medial knee osteoarthritis. Braz J Phys Ther. 2021;25(1):62–69. doi:10.1016/j.bjpt.2020.02.002
  • Stakos DA, Tziakas DN, Chalikias G, Mitrousi K, Tsigalou C, Boudoulas H. Chest pain in patients with arterial hypertension, angiographically normal coronary arteries and stiff aorta: the aortic pain syndrome. Hellenic J Cardiol. 2013;54(1):25–31.
  • van Berkel AC, van Spil WE, Schiphof D, et al. Associations between biomarkers of matrix metabolism and inflammation with pain and fatigue in participants suspected of early Hip and or knee osteoarthritis: data from the CHECK study. Osteoarthritis Cartilage. 2022;30(12):1640–1646. doi:10.1016/j.joca.2022.08.013
  • Zhou K, Li YJ, Soderblom EJ, et al. A “best-in-class” systemic biomarker predictor of clinically relevant knee osteoarthritis structural and pain progression. Sci Adv. 2023;9(4):eabq5095. doi:10.1126/sciadv.abq5095
  • Le Roy B, Martin-Krumm C, Pinol N, Dutheil F, Trousselard M. Human challenges to adaptation to extreme professional environments: a systematic review. Neurosci Biobehav Rev. 2023;146:105054. doi:10.1016/j.neubiorev.2023.105054