Mast Cells and Their Related Gene HK-1 are Closely Associated with Discogenic Low Back Pain: A Bioinformatics and Clinical Sample Study

References

• Wang L, He T, Liu J, et al. Revealing the immune infiltration landscape and identifying diagnostic biomarkers for lumbar disc herniation. Front Immunol. 2021;12:666355. doi:10.3389/fimmu.2021.666355
   PubMed Web of Science ®Google Scholar
• Ou-Yang DC, Kleck CJ, Ackert-Bicknell CL. Genetics of intervertebral disc degeneration. Curr Osteoporosis Rep. 2023;21(1):56–64. doi:10.1007/s11914-022-00769-0
   PubMed Web of Science ®Google Scholar
• Torgerson WR, Dotter WE. Comparative roentgenographic study of the asymptomatic and symptomatic lumbar spine. J Bone Joint Surg Am. 1976;58(6):850–853.
   PubMed Web of Science ®Google Scholar
• Isa ILM, Teoh SL, Nor NHM, Mokhtar SA. Discogenic low back pain: anatomy, pathophysiology and treatments of intervertebral disc degeneration. Int J Mol Sci. 2023;24(1):208. doi:10.3390/ijms24010208
   Web of Science ®Google Scholar
• Arnbak B, Jensen RK, Manniche C, et al. Identification of subgroups of inflammatory and degenerative MRI findings in the spine and sacroiliac joints: a latent class analysis of 1037 patients with persistent low back pain. Arthritis Res Therapy. 2016;18(1). doi:10.1186/s13075-016-1131-x
   PubMedGoogle Scholar
• Wang Y, Che M, Xin J, Zheng Z, Li J, Zhang S. The role of IL-1β and TNF-α in intervertebral disc degeneration. Biomed Pharmacother. 2020;131:110660. doi:10.1016/j.biopha
   PubMed Web of Science ®Google Scholar
• Lyu F-J, Cui H, Pan H, et al. Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions. Bone Res. 2021;9(1):7. doi:10.1038/s41413-020-00125-x
   PubMed Web of Science ®Google Scholar
• Johnson ZI, Schoepflin ZR, Choi H, Shapiro IM, Risbud MV. Disc in flames: roles of TNF-alpha and IL-1beta in intervertebral disc degeneration. Eur Cell Mater. 2015;30:104–116; discussion 116–107. doi:10.22203/eCM.v030a08
   Web of Science ®Google Scholar
• Yan M, Song Z, Kou H, et al. New progress in basic research of macrophages in the pathogenesis and treatment of low back pain. Front Cell Dev Biol. 2022;10:866857. doi:10.3389/fcell.2022.866857
   PubMed Web of Science ®Google Scholar
• Abdel Fattah IO, Nasr El-Din WA. Granulocyte-colony stimulating factor improves intervertebral disc degeneration in experimental adult male rats: a microscopic and radiological study. Anat Rec. 2021;304(4):787–802. doi:10.1002/ar.24519
   Google Scholar
• Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinf. 2008;9(1):559. doi:10.1186/1471-2105-9-559
   PubMed Web of Science ®Google Scholar
• Zhou Y, Zhou B, Pache L, et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019;10(1):1523. doi:10.1038/s41467-019-09234-6
   PubMed Web of Science ®Google Scholar
• Roughley PJ. Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix. Spine. 2004;29(23):2691–2699. doi:10.1097/01.brs.0000146101.53784.b1
   PubMed Web of Science ®Google Scholar
• Novais EJ, Tran VA, Johnston SN, et al. Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice. Nat Commun. 2021;12(1):5213. doi:10.1038/s41467-021-25453-2
   PubMed Web of Science ®Google Scholar
• Ou X, Ying J, Bai X, Wang C, Ruan D. Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration. Int J Mol Med. 2020;46(3):1074–1084. doi:10.3892/ijmm.2020.4668
   PubMed Web of Science ®Google Scholar
• de Schepper EI, Damen J, van Meurs JB, et al. The association between lumbar disc degeneration and low back pain: the influence of age, gender, and individual radiographic features. Spine. 2010;35(5):531–536. doi:10.1097/BRS.0b013e3181aa5b33
   PubMed Web of Science ®Google Scholar
• Zhu Z, He Z, Tang T, et al. Integrative bioinformatics analysis revealed mitochondrial dysfunction-related genes underlying intervertebral disc degeneration. Oxid Med Cell Longev. 2022;2022:1372483. doi:10.1155/2022/1372483
   PubMed Web of Science ®Google Scholar
• Ramachandran R. Neurogenic inflammation and its role in migraine. Semin Immunopathol. 2018;40(3):301–314. doi:10.1007/s00281-018-0676-y
   PubMed Web of Science ®Google Scholar
• Gao J, Xiong T, Grabauskas G, Owyang C. Mucosal serotonin reuptake transporter expression in irritable bowel syndrome is modulated by gut microbiota via mast cell-prostaglandin E2. Gastroenterology. 2022;162(7):1962–1974 e1966. doi:10.1053/j.gastro.2022.02.016
   PubMed Web of Science ®Google Scholar
• Zhou S, Lu H, Xiong M. Identifying immune cell infiltration and effective diagnostic biomarkers in rheumatoid arthritis by bioinformatics analysis. Front Immunol. 2021;12:726747. doi:10.3389/fimmu.2021.726747
   PubMed Web of Science ®Google Scholar
• Zhao X, Younis S, Shi H, et al. RNA-seq characterization of histamine-releasing mast cells as potential therapeutic target of osteoarthritis. Clin Immunol. 2022;244:109117. doi:10.1016/j.clim.2022.109117
   PubMed Web of Science ®Google Scholar
• Borbely E, Helyes Z. Role of hemokinin-1 in health and disease. Neuropeptides. 2017;64:9–17. doi:10.1016/j.npep.2016.12.003
   PubMed Web of Science ®Google Scholar
• Sumpter TL, Ho CH, Pleet AR, et al. Autocrine hemokinin-1 functions as an endogenous adjuvant for IgE-mediated mast cell inflammatory responses. J Allergy Clin Immunol. 2015;135(4):1019–1030 e1018. doi:10.1016/j.jaci.2014.07.036
   PubMed Web of Science ®Google Scholar
• Borbely E, Hunyady A, Pohoczky K, et al. Hemokinin-1 as a mediator of arthritis-related pain via direct activation of primary sensory neurons. Front Pharmacol. 2020;11:594479. doi:10.3389/fphar.2020.594479
   PubMed Web of Science ®Google Scholar
• Tsilioni I, Russell IJ, Stewart JM, Gleason RM, Theoharides TC, Neuropeptides CRH. SP, HK-1, and inflammatory cytokines IL-6 and TNF are increased in serum of patients with fibromyalgia syndrome, implicating mast cells. J Pharmacol Exp Ther. 2016;356(3):664–672. doi:10.1124/jpet.115.230060
   PubMed Web of Science ®Google Scholar
• Hamza T, Barnett JB, Li B. Interleukin 12 a key immunoregulatory cytokine in infection applications. Int J Mol Sci. 2010;11(3):789–806. doi:10.3390/ijms11030789
   PubMed Web of Science ®Google Scholar
• Anandarajah A, Ritchlin CT. Treatment update on spondyloarthropathy. Curr Opin Rheumatol. 2005;17(3):247–256. doi:10.1097/01.bor.0000159926.42761.dd
   PubMed Web of Science ®Google Scholar
• Nees TA, Rosshirt N, Zhang JA, et al. Synovial cytokines significantly correlate with osteoarthritis-related knee pain and disability: inflammatory mediators of potential clinical relevance. J Clin Med. 2019;8(9):1343. doi:10.3390/jcm8091343
   PubMed Web of Science ®Google Scholar