Asteroid Hyalosis: An Update on Prevalence, Risk Factors, Emerging Clinical Impact and Management Strategies

References

• Wand M, Smith TR, Cogan DG. Cholesterosis bulbi: the ocular abnormality known as synchysis scintillans. Am J Ophthalmol. 1975;80(2):177–183. doi:10.1016/0002-9394(75)90129-4
   PubMed Web of Science ®Google Scholar
• Mishra C, Tripathy K. Asteroid Hyalosis. StatPearls; 2022.
   Google Scholar
• Benson A. Diseases of the vitreous: a case of monocular asteroid hyalitis. Ophthalmol Soc. 1976;14(416):101–104.
   Google Scholar
• Khoshnevis M, Rosen S, Sebag J. Asteroid hyalosis-a comprehensive review. Surv Ophthalmol. 2019;64(4):452–462. doi:10.1016/j.survophthal.2019.01.008
   PubMed Web of Science ®Google Scholar
• Winkler J, Lünsdorf H. Ultrastructure and composition of asteroid bodies. Invest Ophthalmol Vis Sci. 2001;42(5):902–907.
   PubMed Web of Science ®Google Scholar
• Bergren RL, Brown GC, Duker JS. Prevalence and association of asteroid hyalosis with systemic diseases. Am J Ophthalmol. 1991;111(3):289–293. doi:10.1016/s0002-9394(14)72311-6
   PubMed Web of Science ®Google Scholar
• Kim JH, Roh MI, Byeon SH, Koh HJ, Lee SC, Kwon OW. Prevalence of and risk factors for asteroid hyalosis in Seoul, Korea. Retina. 2008;28(10):1515–1521. doi:10.1097/iae.0b013e318185ea3c
   PubMed Web of Science ®Google Scholar
• Mitchell P, Wang MY, Wang JJ. Asteroid hyalosis in an older population: the Blue Mountains Eye Study. Ophthalmic Epidemiol. 2003;10(5):331–335. doi:10.1076/opep.10.5.331.17324
   PubMed Web of Science ®Google Scholar
• Elbaz H, Schuster AK, Nickels S, et al. Epidemiologic analysis of asteroid hyalosis and associations: the Gutenberg Health Study. Ophthalmology. 2021;128(2):328–330. doi:10.1016/j.ophtha.2020.07.008
   PubMed Web of Science ®Google Scholar
• Duong R, Cai X, Ambati N, Shildkrot Y, Sieburth R. Prevalence of asteroid hyalosis and systemic risk factors in United States adults. Eye. 2022. doi:10.1038/s41433-022-02214-z 37 1678–1682
   PubMed Web of Science ®Google Scholar
• Zhang C, Shao L, Dong L, Da Zhou W, Zhang RH, Wei W. Prevalence and associations of asteroid hyalosis: the Beijing Eye Study. BMC Ophthalmol. 2022;22(1):360. doi:10.1186/s12886-022-02586-6
   PubMed Web of Science ®Google Scholar
• Fawzi AA, Vo B, Kriwanek R, et al. Asteroid hyalosis in an autopsy population: the University of California at Los Angeles (UCLA) experience. Arch Ophthalmol. 2005;123(4):486–490. doi:10.1001/archopht.123.4.486
   PubMedGoogle Scholar
• Moss SE, Klein R, Klein BE. Asteroid hyalosis in a population: the Beaver Dam eye study. Am J Ophthalmol. 2001;132(1):70–75. doi:10.1016/s0002-9394(01)00936-9
   PubMed Web of Science ®Google Scholar
• Malerbi FK, Dal Fabbro AL, Moises RCS, Vieira Filho JPB, Franco LJ. High frequency of asteroid hyalosis precludes diabetic retinopathy screening with smartphone-based retinal camera in Brazilian Xavante Indians. J Diabetes Sci Technol. 2020;14(5):974–975. doi:10.1177/1932296820929673
   PubMedGoogle Scholar
• Cheng C-Y, Da Soh Z, Majithia S, et al. Big data in ophthalmology. Asia-Pacific J Ophthalmol. 2020;9(4):291–298. doi:10.1097/APO.0000000000000304
   PubMed Web of Science ®Google Scholar
• Mather M, Jacobsen L, Pollard M. Aging in the United States. Popul Bull. 2015;70(2):245.
   Google Scholar
• Møller-Lorentzen TB, Eckmann-Hansen C, Faber C, Larsen M, Subhi Y. Global prevalence of asteroid hyalosis and projection of its future burden: a systematic review and meta-analysis. Acta Ophthalmol. 2020;98(8):755–762. doi:10.1111/aos.14465
   PubMed Web of Science ®Google Scholar
• Anderson WBJ, Anderson WB. Asteroid hyalitis: a study of serum calcium levels in affected patients. South Med J. 1965;58:191–194. doi:10.1097/00007611-196502000-00010
   PubMed Web of Science ®Google Scholar
• Hatfield RE, Gastineau CF, Rucker CW. Asteroid bodies in the vitreous: relationship to diabetes and hypercholesterolemia. Proc Staff Meet Mayo Clin. 1962;37:513–514.
   PubMed Web of Science ®Google Scholar
• Ikeda Y, Hisatomi T, Murakami Y, et al. Retinitis pigmentosa associated with asteroid hyalosis. Retina. 2010;30(8):1278–1281. doi:10.1097/IAE.0b013e3181dcfc0a
   PubMed Web of Science ®Google Scholar
• Dev Borman A, Ocaka LA, Mackay DS, et al. Early onset retinal dystrophy due to mutations in LRAT: molecular analysis and detailed phenotypic study. Invest Ophthalmol Vis Sci. 2012;53(7):3927–3938. doi:10.1167/iovs.12-9548
   PubMed Web of Science ®Google Scholar
• Fantin A, Summers CG, Cameron JD. Neonatal asteroid hyalosis. J AAPOS. 1998;2(4):253–254. doi:10.1016/s1091-8531(98)90061-1
   PubMedGoogle Scholar
• Verhoeff FH. Microscopic findings in a case of asteroid hyalitis. Am J Ophthalmol. 1921;4(3):155–160. doi:10.5555/uri:pii:S0002939421911279
   Google Scholar
• Rodman HI, Johnson FB, Zimmerman LE. New histopathological and histochemical observations concerning asteroid hyalitis. Arch Ophthalmol. 1961;66(4):552–563. doi:10.1001/archopht.1961.00960010554019
   PubMedGoogle Scholar
• Topilow HW, Kenyon KR, Takahashi M, Freeman HM, Tolentino FI, Hanninen LA. Asteroid hyalosis. Biomicroscopy, ultrastructure, and composition. Arch Ophthalmol. 1982;100(6):964–968. doi:10.1001/archopht.1982.01030030972015
   PubMedGoogle Scholar
• March WF, Shoch D. Electron diffraction study of asteroid bodies. Invest Ophthalmol. 1975;14(5):399–400.
   PubMedGoogle Scholar
• Streeten BW. Vitreous asteroid bodies. Ultrastructural characteristics and composition. Arch Ophthalmol. 1982;100(6):969–975. doi:10.1001/archopht.1982.01030030977016
   PubMedGoogle Scholar
• Komatsu H, Kamura Y, Ishi K, Kashima Y. Fine structure and morphogenesis of asteroid hyalosis. Med electron Microsc. 2003;36(2):112–119. doi:10.1007/s00795-002-0211-y
   PubMedGoogle Scholar
• Kador PF, Wyman M. Asteroid hyalosis: pathogenesis and prospects for prevention. Eye. 2008;22(10):1278–1285. doi:10.1038/eye.2008.35
   PubMed Web of Science ®Google Scholar
• Rani PK, Prajapati RC. Role of OCT angiography in the detection of retinal vascular and macular abnormalities in subjects with asteroid hyalosis. Semin Ophthalmol. 2018:1–5. doi:10.1080/08820538.2018.1551497
   PubMed Web of Science ®Google Scholar
• Marlow E, Mikhail M, Faia L, Garretson B. Acute decreased vision in asteroid hyalosis due to posterior vitreous separation. Invest Ophthalmol Vis Sci. 2019;60(9):5782.
   Web of Science ®Google Scholar
• Kumar S. Cholesterol crystals in the anterior chamber. Br J Ophthalmol. 1963;47(5):295–299. doi:10.1136/bjo.47.5.295
   PubMedGoogle Scholar
• Brodsky MC. Synchysis scintillans in a child. JAMA Ophthalmol. 2015;133(7):e150793–e150793. doi:10.1001/jamaophthalmol.2015.0793
   PubMed Web of Science ®Google Scholar
• Hwang JC, Barile GR, Schiff WM, et al. Optical coherence tomography in asteroid hyalosis. Retina. 2006;26(6):661–665. doi:10.1097/01.iae.0000224502.33905.66
   PubMed Web of Science ®Google Scholar
• Dammacco R, Merlini G, Lisch W, et al. Amyloidosis and ocular involvement: an overview. Semin Ophthalmol. 2020;35(1):7–26. doi:10.1080/08820538.2019.1687738
   PubMed Web of Science ®Google Scholar
• Kawaji T, Ando Y, Hara R, Tanihara H. Novel therapy for transthyretin-related ocular amyloidosis: a pilot study of retinal laser photocoagulation. Ophthalmology. 2010;117(3):552–555. doi:10.1016/j.ophtha.2009.07.042
   PubMed Web of Science ®Google Scholar
• AAO. Retina and vitreous. In: Basic and Clinical Science Course. AAO; 2022.
   Google Scholar
• Coupland SE, Damato B. Understanding intraocular lymphomas. Clin Experiment Ophthalmol. 2008;36(6):564–578. doi:10.1111/j.1442-9071.2008.01843.x
   PubMed Web of Science ®Google Scholar
• Scott DAR, Møller-Lorentzen TB, Faber C, Wied J, Grauslund J, Subhi Y. Spotlight on asteroid hyalosis: a clinical perspective. Clin Ophthalmol. 2021;15:2537–2544. doi:10.2147/OPTH.S272333
   PubMed Web of Science ®Google Scholar
• Noda S, Hayasaka S, Setogawa T. Patients with asteroid hyalosis and visible floaters. Jpn J Ophthalmol. 1993;37(4):452–455.
   PubMed Web of Science ®Google Scholar
• Lambrou FHJ, Sternberg PJ, Meredith TA, Mines J, Fine SL. Vitrectomy when asteroid hyalosis prevents laser photocoagulation. Ophthalmic Surg. 1989;20(2):100–102.
   PubMedGoogle Scholar
• Yokoyama S, Kojima T, Kaga T, Ichikawa K. Increased internal higher-order aberrations as a useful parameter for indication of vitrectomy in three asteroid hyalosis cases. BMJ Case Rep. 2015; 2015:bcr2015211704. doi:10.1136/bcr-2015-211704
   PubMedGoogle Scholar
• Sato T, Koh S, Mori R, Korehisa H, Hayashi K. Impact of asteroid hyalosis on internal higher-order aberrations in eyes with cataract accompanied by acoustic shadows on swept-source optical coherence tomography examination. J Cataract Refract Surg. 2020;46(12):e1–e4. doi:10.1097/j.jcrs.0000000000000303
   PubMed Web of Science ®Google Scholar
• Parnes RE, Zakov ZN, Novak MA, Rice TA. Vitrectomy in patients with decreased visual acuity secondary to asteroid hyalosis. Am J Ophthalmol. 1998;125(5):703–704. doi:10.1016/s0002-9394(98)00031-2
   PubMed Web of Science ®Google Scholar
• Yamaguchi T, Inoue M, Ishida S, Shinoda K. Detecting vitreomacular adhesions in eyes with asteroid hyalosis with triamcinolone acetonide. Graefes Arch Clin Exp Ophthalmol. 2007;245(2):305–308. doi:10.1007/s00417-005-0236-8
   PubMed Web of Science ®Google Scholar
• Ikeda T, Sawa H, Koizumi K, Yasuhara T, Kinoshita S, Tano Y. Vitrectomy for proliferative diabetic retinopathy with asteroid hyalosis. Retina. 1998;18(5):410–414. doi:10.1097/00006982-199805000-00004
   PubMed Web of Science ®Google Scholar
• Mochizuki Y, Hata Y, Kita T, et al. Anatomical findings of vitreoretinal interface in eyes with asteroid hyalosis. Graefes Arch Clin Exp Ophthalmol. 2009;247(9):1173–1177. doi:10.1007/s00417-009-1095-5
   PubMed Web of Science ®Google Scholar
• Hampton GR, Nelsen PT, Hay PB. Viewing through the asteroids. Ophthalmology. 1981;88(7):669–672. doi:10.1016/s0161-6420(81)34969-0
   PubMed Web of Science ®Google Scholar
• Belenje A, Rani PK. Role of wide-angle optical coherence tomography angiography in detection of proliferative diabetic retinopathy in a patient with dense asteroid hyalosis. BMJ Case Rep. 2020;13(9). doi:10.1136/bcr-2020-237248
   Google Scholar
• Motiani MV, McCannel CA, Almanzor R, McCannel TA. Diagnosis of choroidal melanoma in dense asteroid hyalosis. Semin Ophthalmol. 2017;32(2):257–259. doi:10.3109/08820538.2015.1053627
   PubMed Web of Science ®Google Scholar
• Gross JG, Glassman AR, Liu D, et al. Five-year outcomes of panretinal photocoagulation vs intravitreous ranibizumab for proliferative diabetic retinopathy: a randomized clinical trial. JAMA Ophthalmol. 2018;136(10):1138–1148. doi:10.1001/jamaophthalmol.2018.3255
   PubMed Web of Science ®Google Scholar
• Azad AD, Chen EM, Hinkle J, et al. Anti-vascular endothelial growth factor and panretinal photocoagulation use after protocol S for proliferative diabetic retinopathy. Ophthalmol Retin. 2021;5(2):151–159. doi:10.1016/j.oret.2020.07.018
   PubMedGoogle Scholar
• Wong SCK, Sampath R. Erroneous automated refraction in a case of asteroid hyalosis. J Cataract Refract Surg. 2002;28(9):1707–1708. doi:10.1016/s0886-3350(01)01224-x
   PubMed Web of Science ®Google Scholar
• Allison KL, Price J, Odin L. Asteroid hyalosis and axial length measurement using automated biometry. J Cataract Refract Surg. 1991;17(2):181–186. doi:10.1016/s0886-3350(13)80248-9
   PubMed Web of Science ®Google Scholar
• Martin RG, Safir A. Asteroid hyalosis affecting the choice of intraocular lens implant. J Cataract Refract Surg. 1987;13(1):62–65. doi:10.1016/s0886-3350(87)80014-7
   PubMed Web of Science ®Google Scholar
• Hartstein I, Barke RM. Axial length measurement discrepancies in asteroid hyalosis. Br J Ophthalmol. 1991;75(3):191. doi:10.1136/bjo.75.3.191
   PubMed Web of Science ®Google Scholar
• Erkin EF, Tarhan S, Oztürk F. Axial length measurement and asteroid hyalosis. J Cataract Refract Surg. 1999;25(10):1400–1403. doi: 10.1016/S0886-3350(99)00214-X
   PubMed Web of Science ®Google Scholar
• Moshirfar M, Martin DJ, Jensen JL, Payne CJ. Light adjustable intraocular lenses: an updated platform for cataract surgery. Curr Opin Ophthalmol. 2023;34(1):78–83. doi:10.1097/ICU.0000000000000911
   PubMed Web of Science ®Google Scholar
• Ochi R, Sato B, Morishita S, et al. Case of asteroid hyalosis that developed severely reduced vision after cataract surgery. BMC Ophthalmol. 2017;17(1):68. doi:10.1186/s12886-017-0467-6
   PubMed Web of Science ®Google Scholar
• Doshi S, Pathengay A, Sane S, Saldanha M. Asteroid hyalosis prolapse in the anterior chamber after cataract surgery. BMJ Case Rep. 2019;12(4). doi:10.1136/bcr-2019-230076 e230076
   PubMedGoogle Scholar
• Stringham J, Werner L, Monson B, Theodosis R, Mamalis N. Calcification of different designs of silicone intraocular lenses in eyes with asteroid hyalosis. Ophthalmology. 2010;117(8):1486–1492. doi:10.1016/j.ophtha.2009.12.032
   PubMed Web of Science ®Google Scholar
• Espandar L, Mukherjee N, Werner L, Mamalis N, Kim T. Diagnosis and management of opacified silicone intraocular lenses in patients with asteroid hyalosis. J Cataract Refract Surg. 2015;41(1). 222–225 doi:10.1016/j.jcrs.2014.11.009
   PubMed Web of Science ®Google Scholar
• Leysen I, Bartholomeeusen E, Coeckelbergh T, Tassignon M. Surgical outcomes of intraocular lens exchange: five-year study. J Cataract Refract Surg. 2009;35(6). 1013–1018 doi:10.1016/j.jcrs.2009.01.024
   PubMed Web of Science ®Google Scholar
• Lee YJ, Han SB. Laser treatment of silicone intraocular lens opacification associated with asteroid hyalosis. Taiwan J Ophthalmol. 2019;9(1):49–52. doi:10.4103/tjo.tjo_65_18
   PubMedGoogle Scholar
• Mehta N, Goldberg RA, Shah CP. Treatment of dystrophic calcification on a silicone intraocular lens with pars plana vitrectomy. Clin Ophthalmol. 2014;8:1291–1293. doi:10.2147/OPTH.S62108
   PubMedGoogle Scholar
• Ullman DI, Gupta S. Pars plana vitrectomy for dystrophic calcification of a silicone intraocular lens in association with asteroid hyalosis. J Cataract Refract Surg. 2014;40(7):1228–1231. doi:10.1016/j.jcrs.2014.04.022
   PubMed Web of Science ®Google Scholar
• Rainsbury PG, Lochhead J. Pars plana vitrectomy for posterior surface calcification in a silicone intraocular lens in asteroid hyalosis - a report of mistaken identity? Clin Ophthalmol. 2014;8:2239–2241. doi:10.2147/OPTH.S74532
   PubMedGoogle Scholar
• Platt SM, Iezzi R, Mahr MA, Erie JC. Surgical removal of dystrophic calcification on a silicone intraocular lens in association with asteroid hyalosis. J Cataract Refract Surg. 2017;43(12). 1608–1610 doi:10.1016/j.jcrs.2017.09.026
   PubMed Web of Science ®Google Scholar
• Ambati NR, Duong RT, Zhang A, Shildkrot Y. Mechanical removal of calcifications on a silicone intraocular lens with a shielded light pipe in asteroid hyalosis. J Ophthalmic Surg. 2022;5(1):82–84. doi:10.36959/587/607
   Google Scholar
• Zapata MA, Royo-Fibla D, Font O, et al. Artificial intelligence to identify retinal fundus images, quality validation, laterality evaluation, macular degeneration, and suspected glaucoma. Clin Ophthalmol. 2020;14:419–429. doi:10.2147/OPTH.S235751
   PubMed Web of Science ®Google Scholar
• Grzybowski A, Brona P, Lim G, et al. Artificial intelligence for diabetic retinopathy screening: a review. Eye. 2020;34(3):451–460. doi:10.1038/s41433-019-0566-0
   PubMed Web of Science ®Google Scholar
• Ipp E, Liljenquist D, Bode B, et al. Pivotal evaluation of an artificial intelligence system for autonomous detection of referrable and vision-threatening diabetic retinopathy. JAMA Netw Open. 2021;4(11):e2134254–e2134254. doi:10.1001/jamanetworkopen.2021.34254
   PubMed Web of Science ®Google Scholar
• Shi C, Lee J, Wang G, Dou X, Yuan F, Zee B. Assessment of image quality on color fundus retinal images using the automatic retinal image analysis. Sci Rep. 2022;12(1):10455. doi:10.1038/s41598-022-13919-2
   PubMed Web of Science ®Google Scholar
• Jain A, Krishnan R, Rogye A, Natarajan S. Use of offline artificial intelligence in a smartphone-based fundus camera for community screening of diabetic retinopathy. Indian J Ophthalmol. 2021;69(11):3150–3154. doi:10.4103/ijo.IJO_3808_20
   PubMed Web of Science ®Google Scholar
• Yoo TK, Choi JY, Kim HK. CycleGAN-based deep learning technique for artifact reduction in fundus photography. Graefes Arch Clin Exp Ophthalmol. 2020;258(8):1631–1637. doi:10.1007/s00417-020-04709-5
   PubMed Web of Science ®Google Scholar
• Chee R-I, Darwish D, Fernandez-Vega A, et al. Retinal telemedicine. Curr Ophthalmol Rep. 2018;6(1):36–45. doi:10.1007/s40135-018-0161-8
   PubMedGoogle Scholar
• Kim JE, Tomkins-Netzer O, Elman MJ, et al. Evaluation of a self-imaging SD-OCT system designed for remote home monitoring. BMC Ophthalmol. 2022;22(1):261. doi:10.1186/s12886-022-02458-z
   PubMed Web of Science ®Google Scholar
• Chen H, Pan X, Yang J, et al. Application of 5G technology to conduct real-time teleretinal laser photocoagulation for the treatment of diabetic retinopathy. JAMA Ophthalmol. 2021;139(9):975–982. doi:10.1001/jamaophthalmol.2021.2312
   PubMed Web of Science ®Google Scholar