Predicting Prognosis Based on Regional Prevalence, Ulcer Morphology and Treatment Strategy in Vision-Threatening Pythium insidiosum Keratitis

References

• Gaastra W, Lipman LJ, De Cock AW, et al. Pythium insidiosum: an overview. Vet Microbiol. 2010;146(1–2):1–16. doi:10.1016/j.vetmic.2010.07.019
   PubMed Web of Science ®Google Scholar
• Nam B, Choi YJ. Phytopythium and Pythium species (Oomycota) isolated from freshwater environments of Korea. Mycobiology. 2019;47(3):261–272. doi:10.1080/12298093.2019.1625174
   PubMed Web of Science ®Google Scholar
• Gurnani B, Christy J, Narayana S, Rajkumar P, Kaur K, Gubert J. Retrospective multifactorial analysis of Pythium keratitis and review of literature. Indian J Ophthalmol. 2021;69(5):1095–1101. doi:10.4103/ijo.IJO_1808_20
   PubMed Web of Science ®Google Scholar
• Gurnani B, Kaur K. Pythium Keratitis. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022.
   Google Scholar
• Hasika R, Lalitha P, Radhakrishnan N, Rameshkumar G, Prajna NV, Srinivasan M. Pythium keratitis in South India: incidence, clinical profile, management, and treatment recommendation. Indian J Ophthalmol. 2019;67(1):42–47. doi:10.4103/ijo.IJO_445_18
   PubMed Web of Science ®Google Scholar
• Thianprasit M, Chaiprasert A, Imwidthaya P. Human pythiosis. Curr Top Med Mycol. 1996;7(1):43–54.
   PubMedGoogle Scholar
• Chitasombat MN, Jongkhajornpong P, Lekhanont K, Krajaejun T. Recent update in diagnosis and treatment of human pythiosis. Peer J. 2020;8:e8555. doi:10.7717/peerj.8555
   PubMed Web of Science ®Google Scholar
• Agarwal S, Iyer G, Srinivasan B, et al. Clinical profile, risk factors and outcome of medical, surgical and adjunct interventions in patients with Pythiuminsidiosum keratitis. Br J Ophthalmol. 2019;103(3):296–300. doi:10.1136/bjophthalmol-2017-311804
   PubMed Web of Science ®Google Scholar
• Puangsricharern V, Chotikkakamthorn P, Tulvatana W, et al. Clinical characteristics, histopathology, and treatment outcomes of pythium keratitis: a retrospective cohort study. Clin Ophthalmol. 2021;15:1691–1701. doi:10.2147/OPTH.S303721
   PubMed Web of Science ®Google Scholar
• Mittal R, Jena SK, Desai A, Agarwal S. Pythium insidiosum keratitis: histopathology and rapid novel diagnostic staining technique. Cornea. 2017;36(9):1124–1132. doi:10.1097/ICO.0000000000001244
   PubMed Web of Science ®Google Scholar
• Bagga B, Sharma S, Madhuri Guda SJ, et al. Leap forward in the treatment of Pythium insidiosum keratitis. Br J Ophthalmol. 2018;102(12):1629–1633. doi:10.1136/bjophthalmol-2017-311360
   PubMed Web of Science ®Google Scholar
• Permpalung N, Worasilchai N, Chindamporn A. Human pythiosis: emergence of fungal-like organism. Mycopathologia. 2020;185(5):801–812. doi:10.1007/s11046-019-00412-0
   PubMed Web of Science ®Google Scholar
• Sathapatayavongs B, Leelachaikul P, Prachaktam R, et al. Human pythiosis associated with thalassemia hemoglobinopathy syndrome. J Infect Dis. 1989;159(2):274–280. doi:10.1093/infdis/159.2.274
   PubMed Web of Science ®Google Scholar
• Krajaejun T, Sathapatayavongs B, Pracharktam R, et al. Clinical and epidemiological analyses of human pythiosis in Thailand. Clin Infect Dis. 2006;43(5):569–576. doi:10.1086/506353
   PubMed Web of Science ®Google Scholar
• Permpalung N, Worasilchai N, Plongla R, et al. Treatment outcomes of surgery, antifungal therapy and immunotherapy in ocular and vascular human pythiosis: a retrospective study of 18 patients. J Antimicrob Chemother. 2015;70(6):1885–1892. doi:10.1093/jac/dkv008
   PubMed Web of Science ®Google Scholar
• Sane SS, Madduri B, Mohan N, Mittal R, Raghava JV, Fernandes M. Improved outcome of pythium keratitis with a combined triple drug regimen of linezolid and azithromycin. Cornea. 2021;40(7):888–893. doi:10.1097/ICO.0000000000002503
   PubMed Web of Science ®Google Scholar
• Gurnani B, Narayana S, Christy J, Rajkumar P, Kaur K, Gubert J. Successful management of pediatric pythium insidiosum keratitis with cyanoacrylate glue, linezolid, and azithromycin: rare case report. Eur J Ophthalmol. 2022;32(5):NP87–NP91. doi:10.1177/11206721211006564
   PubMed Web of Science ®Google Scholar
• Hou H, Wang Y, Tian L, Wang F, Sun Z, Chen Z. Pythium insidiosum keratitis reported in China, raising the alertness to this fungus-like infection: a case series. J Med Case Rep. 2021;15(1):619. doi:10.1186/s13256-021-03189-3
   PubMedGoogle Scholar
• Badenoch PR, Mills RA, Chang JH, Sadlon TA, Klebe S, Coster DJ. Pythium insidiosum keratitis in an Australian child. Clin Exp Ophthalmol. 2009;37(8):806–809. doi:10.1111/j.1442-9071.2009.02135.x
   PubMed Web of Science ®Google Scholar
• Murdoch D, Parr D. Pythium insidiosum keratitis. Aust NZ J Ophthalmol. 1997;25(2):177–179. doi:10.1111/j.1442-9071.1997.tb01304.x
   PubMedGoogle Scholar
• Gurnani B, Kaur K, Agarwal S, et al. Pythium insidiosum Keratitis: past, Present, and Future. Ophthalmol Ther. 2022;11(5):1629–1653. doi:10.1007/s40123-022-00542-7
   PubMedGoogle Scholar
• Tanhehco TY, Stacy RC, Mendoza L, Durand ML, Jakobiec FA, Colby KA. Pythium insidiosum keratitis in Israel. Eye Contact Lens. 2011;37(2):96–98. doi:10.1097/ICL.0b013e3182043114
   PubMed Web of Science ®Google Scholar
• Maeno S, Oie Y, Sunada A, et al. Successful medical management of Pythium insidiosum keratitis using a combination of minocycline, linezolid, and chloramphenicol. Am J Ophthalmol Case Rep. 2019;15:100498. doi:10.1016/j.ajoc.2019.100498
   PubMedGoogle Scholar
• Vishwakarma P, Mohanty A, Kaur A, et al. Pythium keratitis: clinical profile, laboratory diagnosis, treatment, and histopathology features post-treatment at a tertiary eye care center in Eastern India. Indian J Ophthalmol. 2021;69(6):1544–1552. doi:10.4103/ijo.IJO_2356_20
   PubMed Web of Science ®Google Scholar
• Agarwal S, Srinivasan B, Janakiraman N, et al. Role of topical ethanol in the treatment of pythium insidiosum keratitis-A proof of concept. Cornea. 2020;39(9):1102–1107. doi:10.1097/ICO.0000000000002370
   PubMedGoogle Scholar
• Kwon-Chung KJ. Phylogenetic spectrum of fungi that are pathogenic to humans. Clin Infect Dis. 1994;19(Suppl 1):S1–S7. doi:10.1093/clinids/19.supplement_1.s1
   PubMedGoogle Scholar
• Kunavisarut S, Nimvorapan T, Methasiri S. Pythium corneal ulcer in Ramathibodi Hospital. J Med Assoc Thai. 2003;86(4):338–342.
   PubMedGoogle Scholar
• Ahirwar LK, Kalra P, Sharma S, et al. Linezolid shows high safety and efficacy in the treatment of Pythium insidiosum keratitis in a rabbit model. Exp Eye Res. 2021;202:108345. doi:10.1016/j.exer.2020.108345
   PubMed Web of Science ®Google Scholar
• Thanathanee O, Enkvetchakul O, Rangsin R, Waraasawapati S, Samerpitak K, Suwan-apichon O. Outbreak of Pythium keratitis during rainy season: a case series. Cornea. 2013;32(2):199–204. doi:10.1097/ICO.0b013e3182535841
   PubMed Web of Science ®Google Scholar
• He H, Liu H, Chen X, Wu J, He M, Zhong X. Diagnosis and treatment of pythium insidiosum corneal ulcer in a Chinese child: a case report and literature review. Am J Case Rep. 2016;17:982–988. doi:10.12659/ajcr.901158
   PubMedGoogle Scholar
• Ramappa M, Nagpal R, Sharma S, Chaurasia S. Successful medical management of presumptive pythium insidiosum keratitis. Cornea. 2017;36(4):511–514. doi:10.1097/ICO.0000000000001162
   PubMedGoogle Scholar
• Nonpassopon M, Jongkhajornpong P, Aroonroch R, Koovisitsopit A, Lekhanont K. Predisposing factors, clinical presentations, and outcomes of contact lens-related pythium keratitis. Cornea. 2021;40(11):1413–1419. doi:10.1097/ICO.0000000000002651
   PubMed Web of Science ®Google Scholar
• Thanathanee O, Bhoomibunchoo C, Anutarapongpan O, Suwan-Apichon O, Charoensuk K, Chindamporn A. Role of Immunotherapy in Pythium insidiosum Keratitis. Am J Trop Med Hyg. 2022;107(1):110–112. doi:10.4269/ajtmh.22-0015
   PubMedGoogle Scholar
• Jones DB. Decision-making in the management of microbial keratitis. Ophthalmology. 1981;88(8):814–820. doi:10.1016/s0161-6420(81)34943-4
   PubMed Web of Science ®Google Scholar
• Agarwal S, Iyer G, Srinivasan B, Agarwal M, Panchalam Sampath Kumar S, Therese LK. Clinical profile of pythium keratitis: perioperative measures to reduce risk of recurrence. Br J Ophthalmol. 2018;102(2):153–157. doi:10.1136/bjophthalmol-2017-310604
   PubMed Web of Science ®Google Scholar
• Raghavan A, Bellamkonda P, Mendoza L, Rammohan R. Pythium insidiosum and Acanthamoeba keratitis in a contact lens user. BMJ Case Rep. 2018;11(1):bcr2018226386. doi:10.1136/bcr-2018-226386
   PubMedGoogle Scholar
• Kate A, Bagga B, Ahirwar LK, Mishra DK, Sharma S. Unusual presentation of Pythium keratitis as peripheral ulcerative keratitis: clinical dilemma. Ocul Immunol Inflamm. 2022;30(7–8):2023–2026. doi:10.1080/09273948.2021.1952276
   PubMed Web of Science ®Google Scholar
• Lelievre L, Borderie V, Garcia-Hermoso D, et al. Imported Pythium insidiosum keratitis after a swim in Thailand by a contact lens-wearing traveler. Am J Trop Med Hyg. 2015;92(2):270–273. doi:10.4269/ajtmh.14-0380
   PubMed Web of Science ®Google Scholar