Non-Invasive Treatment of Early Diabetic Macular Edema by Multiwavelength Photobiomodulation with the Valeda Light Delivery System

References

• Antonetti DA, Klein R, Gardner TW. Diabetic retinopathy. N Engl J Med. 2012;366(13):1227–1239. doi:10.1056/NEJMra1005073
   PubMed Web of Science ®Google Scholar
• Ding J, Wong TY. Current epidemiology of diabetic retinopathy and diabetic macular edema. Curr Diab Rep. 2012;12(4):346–354. doi:10.1007/s11892-012-0283-6
   PubMed Web of Science ®Google Scholar
• Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010;376(9735):124–136. doi:10.1016/S0140-6736(09)62124-3
   PubMed Web of Science ®Google Scholar
• Bullard KM, Cowie CC, Lessem SE, et al. Prevalence of Diagnosed Diabetes in Adults by Diabetes Type - United States, 2016. MMWR Morb Mortal Wkly Rep. 2018;67(12):359–361. doi:10.15585/mmwr.mm6712a2
   PubMed Web of Science ®Google Scholar
• Singh A, Stewart JM. Pathophysiology of diabetic macular edema. Int Ophthalmol Clin. 2009;49(2):1–11. doi:10.1097/IIO.0b013e31819fd164
   PubMedGoogle Scholar
• Shani M, Eviatar T, Komaneshter D, et al. Diabetic retinopathy -incidence and risk factors in a community setting- a longitudinal study. Scand J Prim Health Care. 2018;36(3):237–241.
   PubMed Web of Science ®Google Scholar
• Li JQ, Welchowski T, Schmid M, et al. Prevalence, incidence and future projection of diabetic eye disease in Europe: a systematic review and meta-analysis. Eur J Epidemiol. 2020;35(1):11–23. doi:10.1007/s10654-019-00560-z
   PubMed Web of Science ®Google Scholar
• Davidov E, Breitscheidel L, Clouth J, et al. Diabetic retinopathy and health-related quality of life. Graefes Arch Clin Exp Ophthalmol. 2009;247(2):267–272. doi:10.1007/s00417-008-0960-y
   PubMed Web of Science ®Google Scholar
• Ferris FL, Patz A. Macular edema. A complication of diabetic retinopathy. Surv Ophthalmol. 1984;28(Suppl):452–461. doi:10.1016/0039-6257(84)90227-3
   PubMed Web of Science ®Google Scholar
• Augustin A, Loewenstein A, Kuppermann BD. Macular edema. General pathophysiology. Dev Ophthalmol. 2010;47:10–26.
   PubMedGoogle Scholar
• Baker CW, Glassman AR, Beaulieu WT, et al. Effect of initial management with aflibercept vs laser photocoagulation vs observation on vision loss among patients with diabetic macular edema involving the center of the macula and good visual acuity: a randomized clinical trial. JAMA. 2019;321(19):1880–1894. doi:10.1001/jama.2019.5790
   PubMed Web of Science ®Google Scholar
• Heier JS, Korobelnik J-F, Brown DM, et al. Intravitreal aflibercept for diabetic macular edema: 148-week results from the vista and VIVID Studies. Ophthalmology. 2016;123(11):2376–2385. doi:10.1016/j.ophtha.2016.07.032
   PubMed Web of Science ®Google Scholar
• Brown DM, Nguyen QD, Marcus DM, et al. Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two Phase III trials: RISE and RIDE. Ophthalmology. 2013;120(10):2013–2022. doi:10.1016/j.ophtha.2013.02.034
   PubMed Web of Science ®Google Scholar
• Nguyen QD, Brown DM, Marcus DM, et al. Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE. Ophthalmology. 2012;119(4):789–801. doi:10.1016/j.ophtha.2011.12.039
   PubMed Web of Science ®Google Scholar
• Falavarjani KG, Nguyen QD. Adverse events and complications associated with intravitreal injection of anti-VEGF agents: a review of literature. Eye. 2013;27(7):787–794. doi:10.1038/eye.2013.107
   PubMed Web of Science ®Google Scholar
• Chung H, Dai T, Sharma SK, et al. The nuts and bolts of low-level laser (light) therapy. Ann Biomed Eng. 2012;40(2):516–533. doi:10.1007/s10439-011-0454-7
   PubMed Web of Science ®Google Scholar
• Hashmi JT, Huang -Y-Y, Osmani BZ, et al. Role of low-level laser therapy in neurorehabilitation. Pm r. 2010;2(12 Suppl 2):S292–305. doi:10.1016/j.pmrj.2010.10.013
   PubMedGoogle Scholar
• Tata DB, Waynant RW. Laser Therapy: a review of its mechanism of action and potential medical applications. Laser Photon Rev. 2010;5(1):1–12. doi:10.1002/lpor.200900032
   Web of Science ®Google Scholar
• Rojas JC, Gonzalaz-Lima F. Low level light therapy of the eye and brain. Dovepress. 2011;2011(3):49–67.
   Google Scholar
• Grossman N, Schneid N, Reuveni H, et al. 780 nm low power diode laser irradiation stimulates proliferation of keratinocyte cultures: involvement of reactive oxygen species. Lasers Surg Med. 1998;22(4):212–218. doi:10.1002/(SICI)1096-9101(1998)22:4<212::AID-LSM5>3.0.CO;2-S
   PubMed Web of Science ®Google Scholar
• Karu T, Pyatibrat L, Kalendo G. Irradiation with He-Ne laser increases ATP level in cells cultivated in vitro. J Photochem Photobiol B. 1995;27(3):219–223. doi:10.1016/1011-1344(94)07078-3
   PubMed Web of Science ®Google Scholar
• Karu TI, Kolyakov SF. Exact action spectra for cellular responses relevant to phototherapy. Photomed Laser Surg. 2005;23(4):355–361. doi:10.1089/pho.2005.23.355
   PubMed Web of Science ®Google Scholar
• Eells JT, Wong-Riley MTT, VerHoeve J, et al. Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy. Mitochondrion. 2004;4(5–6):559–567. doi:10.1016/j.mito.2004.07.033
   PubMed Web of Science ®Google Scholar
• Muste JC, Kalur A, Iyer A, et al. Photobiomodulation therapy in age-related macular degeneration. Curr Opin Ophthalmol. 2021;32(3):225–232. doi:10.1097/ICU.0000000000000742
   PubMed Web of Science ®Google Scholar
• Geneva II. Photobiomodulation for the treatment of retinal diseases: a review. Int J Ophthalmol. 2016;9(1):145–152.
   PubMed Web of Science ®Google Scholar
• Eells JT, Gopalakrishnan S, Valter K. Near-Infrared Photobiomodulation in Retinal Injury and Disease. Adv Exp Med Biol. 2016;854:437–441.
   PubMed Web of Science ®Google Scholar
• Tang J, Herda AA, Kern TS. Photobiomodulation in the treatment of patients with non-center-involving diabetic macular oedema. Br J Ophthalmol. 2014;98(8):1013–1015. doi:10.1136/bjophthalmol-2013-304477
   PubMed Web of Science ®Google Scholar
• Shen W, Teo KYC, Wood JPM, et al. Preclinical and clinical studies of photobiomodulation therapy for macular oedema. Diabetologia. 2020;63(9):1900–1915. doi:10.1007/s00125-020-05189-2
   PubMed Web of Science ®Google Scholar
• Nonarath HJ. 670nm photobiomodulation modulates bioenergetics and oxidative stress, in rat Müller cells challenged with high glucose. PLoS One. 2021;16(12):e0260968.
   PubMed Web of Science ®Google Scholar
• Burton B, Parodi MB, Jürgens I, et al. LIGHTSITE II randomized multicenter trial: evaluation of multiwavelength photobiomodulation in non-exudative age-related macular degeneration. Ophthalmol Therap. 2023;12(2):953–968. doi:10.1007/s40123-022-00640-6
   PubMed Web of Science ®Google Scholar
• Markowitz SN, Devenyi RG, Munk MR, et al. A double-masked, randomized, sham-controlled, single-center study with photobiomodulation for the treatment of dry age-related macular degeneration. Retina. 2020;40(8):1471–1482. doi:10.1097/IAE.0000000000002632
   PubMed Web of Science ®Google Scholar
• German Society of Ophthalmology (DOG) geschaeftsstelle@ dog. org, German Retina Society (RG), Professional Association of Ophthalmologists in Germany (BVA). Statement of the German Ophthalmological Society, the German Retina Society, and the Professional Association of Ophthalmologists in Germany on treatment of diabetic macular edema: dated August 2019. Ophthalmologe. 2021;118(Suppl 1):40–67. doi:10.1007/s00347-020-01244-w
   PubMed Web of Science ®Google Scholar
• Schmidt-Erfurth U, Garcia-Arumi J, Bandello F, et al. Guidelines for the management of diabetic macular edema by the European Society of Retina Specialists (EURETINA). Ophthalmologica. 2017;237(4):185–222. doi:10.1159/000458539
   PubMed Web of Science ®Google Scholar
• Michaelides M, Kaines A, Hamilton RD, et al. A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2. Ophthalmology. 2010;117(6):1078–1086.e2. doi:10.1016/j.ophtha.2010.03.045
   PubMed Web of Science ®Google Scholar
• Brown DM, Schmidt-Erfurth U, Do DV, et al. Intravitreal aflibercept for diabetic macular edema: 100-week results from the vista and VIVID Studies. Ophthalmology. 2015;122(10):2044–2052. doi:10.1016/j.ophtha.2015.06.017
   PubMed Web of Science ®Google Scholar
• Ao J, Chidlow G, Wood JPM, et al. Safety profile of slit-lamp-delivered retinal laser photobiomodulation. Transl Vis Sci Technol. 2020;9(4):22. doi:10.1167/tvst.9.4.22
   PubMed Web of Science ®Google Scholar
• Funatsu H, Noma H, Mimura T, et al. Association of vitreous inflammatory factors with diabetic macular edema. Ophthalmology. 2009;116(1):73–79. doi:10.1016/j.ophtha.2008.09.037
   PubMed Web of Science ®Google Scholar
• Vujosevic S, Micera A, Bini S, et al. Aqueous humor biomarkers of Müller cell activation in diabetic eyes. Invest Ophthalmol Vis Sci. 2015;56(6):3913–3918. doi:10.1167/iovs.15-16554
   PubMed Web of Science ®Google Scholar
• Hillier RJ, Ojaimi E, Wong DT, et al. Aqueous humor cytokine levels as biomarkers of disease severity in diabetic macular edema. Retina. 2017;37(4):761–769. doi:10.1097/IAE.0000000000001210
   PubMed Web of Science ®Google Scholar
• Bensadoun RJ. Photobiomodulation or low-level laser therapy in the management of cancer therapy-induced mucositis, dermatitis and lymphedema. Curr Opin Oncol. 2018;30(4):226–232. doi:10.1097/CCO.0000000000000452
   PubMed Web of Science ®Google Scholar
• Merry GF, Munk MR, Dotson RS, et al. Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age-related macular degeneration. Acta Ophthalmol. 2017;95(4):e270–e277. doi:10.1111/aos.13354
   PubMed Web of Science ®Google Scholar
• Perich L, Improvement of visual function and electroretinography following photobiomodulation (Valeda) treatment in dry age-related macular degeneration subjects (ELECTROLIGHT); 2021.
   Google Scholar