A Preservative-Free Approach – Effects on Dry Eye Signs and Symptoms After Cataract Surgery

References

• Rossi T, Romano MR, Iannetta D, et al. Cataract surgery practice patterns worldwide: a survey. BMJ Open Ophthalmol. 2021;6(1):e000464. doi:10.1136/bmjophth-2020-000464
   PubMed Web of Science ®Google Scholar
• Li XM, Hu L, Hu J, Wang W. Investigation of dry eye disease and analysis of the pathogenic factors in patients after cataract surgery. Cornea. 2007;26(9 Suppl 1):S16–S20. doi:10.1097/ICO.0b013e31812f67ca
   PubMed Web of Science ®Google Scholar
• Naderi K, Gormley J, O’Brart D. Cataract surgery and dry eye disease: a review. Eur J Ophthalmol. 2020;30(5):840–855. doi:10.1177/1120672120929958
   PubMed Web of Science ®Google Scholar
• Craig JP, Nichols KK, Akpek EK, et al. TFOS DEWS II definition and classification report. Ocul Surf. 2017;15(3):276–283. doi:10.1016/j.jtos.2017.05.008
   PubMed Web of Science ®Google Scholar
• Khanal S, Tomlinson A, Esakowitz L, et al. Changes in corneal sensitivity and tear physiology after phacoemulsification. Ophthalmic Physiol Opt. 2008;28(2):127–134. doi:10.1111/j.1475-1313.2008.00539.x
   PubMed Web of Science ®Google Scholar
• Zhao X, Xia S, Chen Y. Comparison of the efficacy between topical diquafosol and artificial tears in the treatment of dry eye following cataract surgery: a meta-analysis of randomized controlled trials. Medicine. 2017;96(39):e8174. doi:10.1097/md.0000000000008174
   PubMed Web of Science ®Google Scholar
• Kasetsuwan N, Satitpitakul V, Changul T, Jariyakosol S, Wedrich A. Incidence and pattern of dry eye after cataract surgery. PLoS One. 2013;8(11):e78657. doi:10.1371/journal.pone.0078657
   PubMed Web of Science ®Google Scholar
• Lu Q, Lu Y, Zhu X. Dry eye and phacoemulsification cataract surgery: a systematic review and meta-analysis. Front Med. 2021;8:649030. doi:10.3389/fmed.2021.649030
   Web of Science ®Google Scholar
• Wingert AM, Liu SH, Lin JC, Sridhar J. Non-steroidal anti-inflammatory agents for treating cystoid macular edema following cataract surgery. Cochrane Database Syst Rev. 2022;12(12):Cd004239. doi:10.1002/14651858.CD004239.pub4
   PubMedGoogle Scholar
• Kato K, Miyake K, Hirano K, Kondo M. Management of postoperative inflammation and dry eye after cataract surgery. Cornea. 2019;38(Suppl 1):S25–S33. doi:10.1097/ico.0000000000002125
   PubMedGoogle Scholar
• Goldstein MH, Silva FQ, Blender N, Tran T, Vantipalli S. Ocular benzalkonium chloride exposure: problems and solutions. Eye. 2022;36(2):361–368. doi:10.1038/s41433-021-01668-x
   PubMed Web of Science ®Google Scholar
• Zaleska-żmijewska A, Strzemecka E, Wawrzyniak ZM, Szaflik JP. Extracellular MMP-9-based assessment of ocular surface inflammation in patients with primary open-angle glaucoma. J Ophthalmol. 2019;2019:1240537. doi:10.1155/2019/1240537
   PubMed Web of Science ®Google Scholar
• Baudouin C, Labbé A, Liang H, Pauly A, Brignole-Baudouin F. Preservatives in eyedrops: the good, the bad and the ugly. Prog Retin Eye Res. 2010;29(4):312–334. doi:10.1016/j.preteyeres.2010.03.001
   PubMed Web of Science ®Google Scholar
• Actis AG, Rolle T. Ocular surface alterations and topical antiglaucomatous therapy: a review. Open Ophthalmol J. 2014;8(1):67–72. doi:10.2174/1874364101408010067
   PubMedGoogle Scholar
• Walsh K, Jones L. The use of preservatives in dry eye drops. Clin Ophthalmol. 2019;13:1409–1425. doi:10.2147/opth.S211611
   PubMed Web of Science ®Google Scholar
• Maca SM, Amon M, Findl O, Kahraman G, Barisani-Asenbauer T. Efficacy and tolerability of preservative-free and preserved diclofenac and preserved ketorolac eyedrops after cataract surgery. Am J Ophthalmol. 2010;149(5):777–784. doi:10.1016/j.ajo.2009.12.010
   PubMed Web of Science ®Google Scholar
• Ishibashi T, Yokoi N, Kinoshita S. Comparison of the short-term effects on the human corneal surface of topical timolol maleate with and without benzalkonium chloride. J Glaucoma. 2003;12(6):486–490. doi:10.1097/00061198-200312000-00008
   PubMed Web of Science ®Google Scholar
• Porela-Tiihonen S, Kokki H, Kaarniranta K, Kokki M. Recovery after cataract surgery. Acta Ophthalmol. 2016;94(Suppl 2):1–34. doi:10.1111/aos.13055
   PubMed Web of Science ®Google Scholar
• Baudouin C, Hamard P, Liang H, Creuzot-Garcher C, Bensoussan L, Brignole F. Conjunctival epithelial cell expression of interleukins and inflammatory markers in glaucoma patients treated over the long term. Ophthalmology. 2004;111(12):2186–2192. doi:10.1016/j.ophtha.2004.06.023
   PubMed Web of Science ®Google Scholar
• Rossi GC, Pasinetti GM, Scudeller L, Raimondi M, Lanteri S, Bianchi PE. Risk factors to develop ocular surface disease 
in treated glaucoma or ocular hypertension patients. Eur J Ophthalmol. 2013;23(3):296–302. doi:10.5301/ejo.5000220
   PubMed Web of Science ®Google Scholar
• Ha JY, Sung MS, Park SW. Effects of preservative on the meibomian gland in glaucoma patients treated with prostaglandin analogues. Chonnam Med J. 2019;55(3):156–162. doi:10.4068/cmj.2019.55.3.156
   PubMedGoogle Scholar
• Jones L, Downie LE, Korb D, et al. TFOS DEWS II management and therapy report. Ocul Surf. 2017;15(3):575–628. doi:10.1016/j.jtos.2017.05.006
   PubMed Web of Science ®Google Scholar
• Assil KK, Greenwood MD, Gibson A, Vantipalli S, Metzinger JL, Goldstein MH. Dropless cataract surgery: modernizing perioperative medical therapy to improve outcomes and patient satisfaction. Curr Opinion Ophthalmol. 2021;32(Suppl 1):S1–S12. doi:10.1097/icu.0000000000000708
   PubMedGoogle Scholar
• Rosin LM, Bell NP. Preservative toxicity in glaucoma medication: clinical evaluation of benzalkonium chloride-free 0.5% timolol eye drops. Clin Ophthalmol. 2013;7:2131–2135. doi:10.2147/opth.S41358
   PubMedGoogle Scholar
• Cagini C, Di Lascio G, Torroni G, et al. Dry eye and inflammation of the ocular surface after cataract surgery: effectiveness of a tear film substitute based on trehalose/hyaluronic acid vs hyaluronic acid to resolve signs and symptoms. J Cataract Refract Surg. 2021;47(11):1430–1435. doi:10.1097/j.jcrs.0000000000000652
   PubMed Web of Science ®Google Scholar
• Labiris G, Ntonti P, Sideroudi H, Kozobolis V. Impact of polyethylene glycol 400/propylene glycol/hydroxypropyl-guar and 0.1% sodium hyaluronate on postoperative discomfort following cataract extraction surgery: a comparative study. Eye Vis. 2017;4(1):13. doi:10.1186/s40662-017-0079-5
   PubMedGoogle Scholar
• Mencucci R, Boccalini C, Caputo R, Favuzza E. Effect of a hyaluronic acid and carboxymethylcellulose ophthalmic solution on ocular comfort and tear-film instability after cataract surgery. J Cataract Refract Surg. 2015;41(8):1699–1704. doi:10.1016/j.jcrs.2014.12.056
   PubMed Web of Science ®Google Scholar
• Jee D, Park M, Lee HJ, Kim MS, Kim EC. Comparison of treatment with preservative-free versus preserved sodium hyaluronate 0.1% and fluorometholone 0.1% eyedrops after cataract surgery in patients with preexisting dry-eye syndrome. J Cataract Refract Surg. 2015;41(4):756–763. doi:10.1016/j.jcrs.2014.11.034
   PubMed Web of Science ®Google Scholar
• Graae Jensen P, Gundersen M, Nilsen C, et al. Prevalence of dry eye disease among individuals scheduled for cataract surgery in a Norwegian Cataract Clinic. Clin Ophthalmol. 2023;17:1233–1243. doi:10.2147/opth.S407805
   PubMed Web of Science ®Google Scholar
• Nilsen C, Graae Jensen P, Gundersen M, et al. The significance of inter-eye osmolarity difference in dry eye diagnostics. Clin Ophthalmol. 2023;17:829–835. doi:10.2147/opth.S402556
   PubMed Web of Science ®Google Scholar
• de Monchy I, Gendron G, Miceli C, Pogorzalek N, Mariette X, Labetoulle M. Combination of the Schirmer I and phenol red thread tests as a rescue strategy for diagnosis of ocular dryness associated with Sjögren’s syndrome. Invest Ophthalmol Vis Sci. 2011;52(8):5167–5173. doi:10.1167/iovs.10-6671
   PubMed Web of Science ®Google Scholar
• Osmolarity system - user manual. San Diego, CA, USA: TearLab Corporation; 2017.
   Google Scholar
• Craig JP, Nelson JD, Azar DT, et al. TFOS DEWS II Report Executive Summary. Ocul Surf. 2017;15(4):802–812. doi:10.1016/j.jtos.2017.08.003
   PubMed Web of Science ®Google Scholar
• Asiedu K, Kyei S, Mensah SN, Ocansey S, Abu LS, Kyere EA. Ocular Surface Disease Index (OSDI) versus the Standard Patient Evaluation of Eye Dryness (SPEED): a study of a nonclinical sample. Cornea. 2016;35(2):175–180. doi:10.1097/ico.0000000000000712
   PubMed Web of Science ®Google Scholar
• Tian L, Qu J, Zhang X and Sun X. Repeatability and reproducibility of noninvasive keratograph 5M measurements in patients with dry eye disease. J Ophthalmol. 2016;2016:6. doi:10.1155/2016/8013621
   Web of Science ®Google Scholar
• Herbaut A, Liang H, Denoyer A, Baudouin C, Labbé A. Tear film analysis and evaluation of optical quality: a review of the literature. J Fr Ophtalmol. 2019;42(2):e21–e35. doi:10.1016/j.jfo.2018.12.001
   PubMed Web of Science ®Google Scholar
• Finis D, Pischel N, Schrader S, Geerling G. Evaluation of lipid layer thickness measurement of the tear film as a diagnostic tool for Meibomian gland dysfunction. Cornea. 2013;32(12):1549–1553. doi:10.1097/ICO.0b013e3182a7f3e1
   PubMed Web of Science ®Google Scholar
• Bron AJ, Evans VE, Smith JA. Grading of corneal and conjunctival staining in the context of other dry eye tests. Cornea. 2003;22(7):640–650. doi:10.1097/00003226-200310000-00008
   PubMed Web of Science ®Google Scholar
• Chao C, Stapleton F, Badarudin E, Golebiowski B. Ocular surface sensitivity repeatability with Cochet-Bonnet esthesiometer. Optom Vis Sci. 2015;92(2):183–189. doi:10.1097/opx.0000000000000472
   PubMed Web of Science ®Google Scholar
• Stonecipher K, Abell TG, Chotiner B, Chotiner E, Potvin R. Combined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction. Clin Ophthalmol. 2019;13:993–999. doi:10.2147/opth.S213664
   PubMed Web of Science ®Google Scholar
• Juthani VV, Clearfield E, Chuck RS. Non-steroidal anti-inflammatory drugs versus corticosteroids for controlling inflammation after uncomplicated cataract surgery. Cochrane Database Syst Rev. 2017;7(7):Cd010516. doi:10.1002/14651858.CD010516.pub2
   PubMedGoogle Scholar
• Singer DD, Kennedy J, Wittpenn JR. Topical NSAIDs effect on corneal sensitivity. Cornea. 2015;34(5):541–543. doi:10.1097/ico.0000000000000309
   PubMed Web of Science ®Google Scholar
• Isawi H, Dhaliwal DK. Corneal melting and perforation in Stevens Johnson syndrome following topical bromfenac use. J Cataract Refract Surg. 2007;33(9):1644–1646. doi:10.1016/j.jcrs.2007.04.041
   PubMed Web of Science ®Google Scholar
• Rolando M, Barabino S, Alongi S, Calabria G. Topical non-preserved diclofenac therapy for keratoconjunctivitis sicca. Adv Exp Med Biol. 2002;506(Pt B):1237–1240. doi:10.1007/978-1-4615-0717-8_177
   PubMedGoogle Scholar
• Pinto-Fraga J, López-Miguel A, González-García MJ, et al. Topical fluorometholone protects the ocular surface of dry eye patients from desiccating stress: a randomized controlled clinical trial. Ophthalmology. 2016;123(1):141–153. doi:10.1016/j.ophtha.2015.09.029
   PubMed Web of Science ®Google Scholar
• Lin T, Gong L. Topical fluorometholone treatment for ocular dryness in patients with Sjögren syndrome: a randomized clinical trial in China. Medicine. 2015;94(7):e551. doi:10.1097/md.0000000000000551
   PubMed Web of Science ®Google Scholar
• Avunduk AM, Avunduk MC, Varnell ED, Kaufman HE. The comparison of efficacies of topical corticosteroids and nonsteroidal anti-inflammatory drops on dry eye patients: a clinical and immunocytochemical study. Am J Ophthalmol. 2003;136(4):593–602. doi:10.1016/s0002-9394(03)00326-x
   PubMed Web of Science ®Google Scholar
• Donthineni PR, Shanbhag SS, Basu S. An evidence-based strategic approach to prevention and treatment of dry eye disease, a modern global epidemic. Healthcare. 2021;9(1):89. doi:10.3390/healthcare9010089
   Web of Science ®Google Scholar
• Sánchez MA, Arriola-Villalobos P, Torralbo-Jiménez P, et al. The effect of preservative-free HP-Guar on dry eye after phacoemulsification: a flow cytometric study. Eye. 2010;24(8):1331–1337. doi:10.1038/eye.2010.24
   PubMed Web of Science ®Google Scholar
• Rossi GCM, Tinelli C, Milano G, et al. Randomised, single blind, controlled, three-month clinical trial on the evaluation and treatment of the ocular surface damage following phacoemulsification. Vision. 2022;6(3):42. doi:10.3390/vision6030042
   Google Scholar
• Fraunfelder FT, Sciubba JJ, Mathers WD. The role of medications in causing dry eye. J Ophthalmol. 2012;2012:285851. doi:10.1155/2012/285851
   PubMed Web of Science ®Google Scholar
• Sarkar J, Chaudhary S, Namavari A, et al. Corneal neurotoxicity due to topical benzalkonium chloride. Invest Ophthalmol Vis Sci. 2012;53(4):1792–1802. doi:10.1167/iovs.11-8775
   PubMed Web of Science ®Google Scholar
• Hwang HB, Kim HS. Phototoxic effects of an operating microscope on the ocular surface and tear film. Cornea. 2014;33(1):82–90. doi:10.1097/ico.0000000000000001
   PubMed Web of Science ®Google Scholar
• Yang CQ, Sun W, Gu YS. A clinical study of the efficacy of topical corticosteroids on dry eye. J Zhejiang Univ Sci B. 2006;7(8):675–678. doi:10.1631/jzus.2006.B0675
   PubMedGoogle Scholar
• Garg P, Gupta A, Tandon N, Raj P. Dry eye disease after cataract surgery: study of its determinants and risk factors. Turk J Ophthalmol. 2020;50(3):133–142. doi:10.4274/tjo.galenos.2019.45538
   PubMedGoogle Scholar
• Prinz J, Maffulli N, Fuest M, Walter P, Bell A, Migliorini F. Efficacy of topical administration of corticosteroids for the management of dry eye disease: systematic review and meta-analysis. Life. 2022;12(11):1932. doi:10.3390/life12111932
   PubMedGoogle Scholar
• Kohli P, Arya SK, Raj A, Handa U. Changes in ocular surface status after phacoemulsification in patients with senile cataract. Int Ophthalmol. 2019;39(6):1345–1353. doi:10.1007/s10792-018-0953-8
   PubMed Web of Science ®Google Scholar
• Sahu PK, Das GK, Malik A, Biakthangi L. Dry eye following phacoemulsification surgery and its relation to associated intraoperative risk factors. Middle East Afr J Ophthalmol. 2015;22(4):472–477. doi:10.4103/0974-9233.151871
   PubMed Web of Science ®Google Scholar
• Malmin A, Thomseth VM, Førland PT, et al. Associations between serial intravitreal injections and dry eye. Ophthalmology. 2023;130(5):509–515. doi:10.1016/j.ophtha.2023.01.009
   PubMed Web of Science ®Google Scholar
• Cetinkaya S, Mestan E, Acir NO, Cetinkaya YF, Dadaci Z, Yener HI. The course of dry eye after phacoemulsification surgery. BMC Ophthalmol. 2015;15(1):68. doi:10.1186/s12886-015-0058-3
   PubMed Web of Science ®Google Scholar
• Cung LX, Nga NTT, Nga DM, Hiep NX, Pham DT. Kataraktchirurgie destabilisiert vorübergehend die Benetzung der Augenoberflä che [Cataract surgery destabilises temporary the tear film of the ocular surface]. Klin Monbl Augenheilkd. 2021;238(3):282–287. German. doi:10.1055/a-1179-0373.
   PubMedGoogle Scholar
• Kim JH, Kim EJ, Kim YH, et al. In vivo effects of preservative-free and preserved prostaglandin analogs: mouse ocular surface study. Korean j Ophthalmol. 2015;29(4):270–279. doi:10.3341/kjo.2015.29.4.270
   PubMedGoogle Scholar
• Ghosh S, O’Hare F, Lamoureux E, Vajpayee RB, Crowston JG. Prevalence of signs and symptoms of ocular surface disease in individuals treated and not treated with glaucoma medication. Clin Exp Ophthalmol. 2012;40(7):675–681. doi:10.1111/j.1442-9071.2012.02781.x
   PubMed Web of Science ®Google Scholar
• Jun I, Choi S, Lee GY, et al. Effects of preservative-free 3% diquafosol in patients with pre-existing dry eye disease after cataract surgery: a randomized clinical trial. Sci Rep. 2019;9(1):12659. doi:10.1038/s41598-019-49159-0
   PubMedGoogle Scholar