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ORIGINAL RESEARCH

Transepithelial Accelerated Crosslinking for Progressive Keratoconus: A Critical Analysis of Medium-Term Treatment Outcomes

ORCID Icon, ORCID Icon, ORCID Icon, , ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 393-407 | Received 02 Dec 2023, Accepted 24 Jan 2024, Published online: 08 Feb 2024

References

  • Mas Tur V, MacGregor C, Jayaswal R, et al. A review of keratoconus: diagnosis, pathophysiology, and genetics. Surv Ophthalmol. 2017;62(6):770–783. doi:10.1016/j.survophthal.2017.06.009
  • Davidson AE, Hayes S, Hardcastle AJ, et al. The pathogenesis of keratoconus. Eye. 2014;28(2):189–195. doi:10.1038/eye.2013.278
  • Nakagawa T, Maeda N, Kosaki R, et al. Higher-order aberrations due to the posterior corneal surface in patients with keratoconus. Invest Ophthalmol Vis Sci. 2009;50(6):2660–2665. doi:10.1167/iovs.08-2754
  • Rabinowitz YS, Galvis V, Tello A, et al. Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus. Exp Eye Res. 2021;202:108328. doi:10.1016/j.exer.2020.108328
  • Bui AD, Truong A, Pasricha ND, et al. Keratoconus Diagnosis and Treatment: recent Advances and Future Directions. Clin Ophthalmol. 2023;17:2705–2718. doi:10.2147/OPTH.S392665
  • Galvis V, Tello A, Barrera R, et al. Inflammation in Keratoconus. Cornea. 2015;34(8):e22–3. doi:10.1097/ICO.0000000000000499
  • Elbeyli A, Kurtul BE. Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio levels are associated with keratoconus. Indian J Ophthalmol. 2021;69(7):1725–1729. doi:10.4103/ijo.IJO_3011_20
  • Loh IP, Sherwin T. Is Keratoconus an Inflammatory Disease? The Implication of Inflammatory Pathways. Ocul Immunol Inflamm. 2022;30(1):246–255. doi:10.1080/09273948.2020.1780271
  • Pinheiro-Costa J, Lima Fontes M, Luís C, et al. Serum inflammatory biomarkers are associated with increased choroidal thickness in keratoconus. Sci Rep. 2023;13(1):10862. doi:10.1038/s41598-023-37472-8
  • Santodomingo-Rubido J, Carracedo G, Suzaki A, et al. Keratoconus: an updated review. Cont Lens Anterior Eye. 2022;45(3):101559. doi:10.1016/j.clae.2021.101559
  • Salman A, Darwish T, Ghabra M, et al. Prevalence of Keratoconus in a Population-Based Study in Syria. J Ophthalmol. 2022;2022:6064533. doi:10.1155/2022/6064533
  • Ambrósio R, Lopes BT, Faria-Correia F, et al. Integration of Scheimpflug-Based Corneal Tomography and Biomechanical Assessments for Enhancing Ectasia Detection. J Refract Surg. 2017;33(7):434–443. doi:10.3928/1081597X-20170426-02
  • Duncan JK, Belin MW, Borgstrom M. Assessing progression of keratoconus: novel tomographic determinants. Eye Vis (Lond). 2016;3(1):6. doi:10.1186/s40662-016-0038-6
  • Jay JM, Akilesh G, Hans RV, et al. Progression of keratoconus in children and adolescents. Br J Ophthalmol. 2023;107(2):176. doi:10.1136/bjophthalmol-2020-316481
  • Gomes JA, Tan D, Rapuano CJ, et al. Global consensus on keratoconus and ectatic diseases. Cornea. 2015;34(4):359–369. doi:10.1097/ICO.0000000000000408
  • Ribeiro M, Barbosa C, Correia P, et al. Best Fit Sphere Back and Adjusted Maximum Elevation of Corneal Back Surface as Novel Predictors of Keratoconus Progression. Clin Ophthalmol. 2022;16:4239–4248. doi:10.2147/OPTH.S388614
  • Cunha AM, Correia PJ, Alves H, et al. Keratoconus enlargement as a predictor of keratoconus progression. Sci Rep. 2021;11(1):21079. doi:10.1038/s41598-021-00649-0
  • Jiménez-García M, Kreps EO, Nd S, et al. Determining the Most Suitable Tomography-Based Parameters to Describe Progression in Keratoconus. The Retrospective Digital Computer Analysis of Keratoconus Evolution Project. Eye Contact Lens. 2021;47(9):486–493. doi:10.1097/ICL.0000000000000800
  • Gustafsson I, Bergström A, Cardiakides A, et al. The Interday Repeatability of Parameters for the Assessment of Progressive Disease in Subjects With Less Advanced Keratoconus. Am J Ophthalmol. 2021;225:38–46. doi:10.1016/j.ajo.2020.12.028
  • Martínez-Abad A, Piñero DP. New perspectives on the detection and progression of keratoconus. J Cataract Refract Surg. 2017;43(9):1213–1227. doi:10.1016/j.jcrs.2017.07.021
  • Shajari M, Steinwender G, Herrmann K, et al. Evaluation of keratoconus progression. Br J Ophthalmol. 2019;103(4):551–557. doi:10.1136/bjophthalmol-2017-311651
  • Henriquez MA, Hernandez-Sahagun G, Camargo J, et al. Accelerated Epi-On Versus Standard Epi-Off Corneal Collagen Cross-Linking for Progressive Keratoconus in Pediatric Patients: five Years of Follow-Up. Cornea. 2020;39(12):1493–1498. doi:10.1097/ICO.0000000000002463
  • Al Fayez MF, Alfayez S, Alfayez Y. Transepithelial Versus Epithelium-Off Corneal Collagen Cross-Linking for Progressive Keratoconus: a Prospective Randomized Controlled Trial. Cornea. 2015;34(Suppl 10):S53–6. doi:10.1097/ICO.0000000000000547
  • Salman A, Ali A, Rafea S, et al. Long-term visual, anterior and posterior corneal changes after crosslinking for progressive keratoconus. Eur J Ophthalmol. 2022;32(1):50–58. doi:10.1177/11206721211052878
  • Salman AM, Darwish TR, Haddad YH, et al. Accelerated versus Standard Corneal Cross-linking for Progressive Keratoconus in Syria. J Ophthalmic Vis Res. 2021;16(3):338–348. doi:10.18502/jovr.v16i3.9430
  • Deshmukh R, Ong ZZ, Rampat R, et al. Management of keratoconus: an updated review. Front Med Lausanne. 2023;10:1212314. doi:10.3389/fmed.2023.1212314
  • Valera-Cornejo DA, Vega-Estrada A, Alio JL. Invasive Pharmacology Outcomes with Different Corneal Cross-Linking Protocols: a Review. J Ocul Pharmacol Ther. 2019;35(9):475–490. doi:10.1089/jop.2018.0144
  • Subasinghe SK, Ogbuehi KC, Dias GJ. Current perspectives on corneal collagen crosslinking (CXL). Graefes Arch Clin Exp Ophthalmol. 2018;256(8):1363–1384. doi:10.1007/s00417-018-3966-0
  • Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135(5):620–627. doi:10.1016/S0002-9394(02)02220-1
  • Heikal MA, Soliman TT, Fayed A, et al. Efficacy of transepithelial corneal collagen crosslinking for keratoconus: 12-month follow-up. Clin Ophthalmol. 2017;11:767–771. doi:10.2147/OPTH.S129037
  • Beckman KA, Gupta PK, Farid M, et al. Corneal crosslinking: current protocols and clinical approach. J Cataract Refract Surg. 2019;45(11):1670–1679. doi:10.1016/j.jcrs.2019.06.027
  • O’Brart DPS. Corneal collagen crosslinking for corneal ectasias: a review. Eur J Ophthalmol. 2017;27(3):253–269. doi:10.5301/ejo.5000916
  • Razmjoo H, Rahimi B, Kharraji M, et al. Corneal haze and visual outcome after collagen crosslinking for keratoconus: a comparison between total epithelium off and partial epithelial removal methods. Adv Biomed Res. 2014;3(1):221. doi:10.4103/2277-9175.145677
  • Hashemi H, Miraftab M, Hafezi F, et al. Matched comparison study of total and partial epithelium removal in corneal cross-linking. J Refract Surg. 2015;31(2):110–115. doi:10.3928/1081597X-20150122-06
  • Galvis V, Tello A, Carreño NI, et al. Corneal Cross-Linking (with a Partial Deepithelization) in Keratoconus with Five Years of Follow-Up. Ophthalmol Eye Dis. 2016;8:17–21. doi:10.4137/OED.S38364
  • Henriquez MA, Rodríguez AM, Izquierdo L. Accelerated Epi-On Versus Standard Epi-Off Corneal Collagen Cross-Linking for Progressive Keratoconus in Pediatric Patients. Cornea. 2017;36(12):1503–1508. doi:10.1097/ICO.0000000000001366
  • Zaheryani SMS, Movahedan H, Salouti R, et al. Corneal Collagen Cross-Linking Using Epithelium Disruptor Instrument in Progressive Keratoconus. J Curr Ophthalmol. 2020;32(3):256–262. doi:10.4103/JOCO.JOCO_59_20
  • Li W, Wang B. Efficacy and safety of transepithelial corneal collagen crosslinking surgery versus standard corneal collagen crosslinking surgery for keratoconus: a meta-analysis of randomized controlled trials. BMC Ophthalmol. 2017;17(1):262. doi:10.1186/s12886-017-0657-2
  • Napolitano P, Tranfa F, D’Andrea L, et al. Topographic Outcomes in Keratoconus Surgery: epi-on versus Epi-off Iontophoresis Corneal Collagen Cross-Linking. J Clin Med. 2022;11(7):1785. doi:10.3390/jcm11071785
  • Medeiros CS, Giacomin NT, Bueno RL, et al. Accelerated corneal collagen crosslinking: technique, efficacy, safety, and applications. J Cataract Refract Surg. 2016;42(12):1826–1835. doi:10.1016/j.jcrs.2016.11.028
  • Cunha AM, Sardinha T, Torrão L, et al. Transepithelial Accelerated Corneal Collagen Cross-Linking: two-Year Results. Clin Ophthalmol. 2020;14:2329–2337. doi:10.2147/OPTH.S252940
  • Ng AL, Chan TC, Lai JS, et al. Comparison of the Central and Peripheral Corneal Stromal Demarcation Line Depth in Conventional Versus Accelerated Collagen Cross-Linking. Cornea. 2015;34(11):1432–1436. doi:10.1097/ICO.0000000000000626
  • Hersh PS, Stulting RD, Muller D, et al. United States Multicenter Clinical Trial of Corneal Collagen Crosslinking for Keratoconus Treatment. Ophthalmology. 2017;124(9):1259–1270. doi:10.1016/j.ophtha.2017.03.052
  • Gordon MO, Steger-May K, Szczotka-Flynn L, et al. Baseline factors predictive of incident penetrating keratoplasty in keratoconus. Am J Ophthalmol. 2006;142(6):923–930. doi:10.1016/j.ajo.2006.07.026
  • Matthaei M, Sandhaeger H, Hermel M, et al. Changing Indications in Penetrating Keratoplasty: a Systematic Review of 34 Years of Global Reporting. Int J Med. 2017;101(6):1387–1399. doi:10.1097/TP.0000000000001281
  • Cifariello F, Minicucci M, Di Renzo F, et al. Epi-Off versus Epi-On Corneal Collagen Cross-Linking in Keratoconus Patients: a Comparative Study through 2-Year Follow-Up. J Ophthalmol. 2018;2018:4947983. doi:10.1155/2018/4947983
  • Sun L, Li M, Zhang X, et al. Transepithelial accelerated corneal collagen cross-linking with higher oxygen availability for keratoconus: 1-year results. Int Ophthalmol. 2018;38(6):2509–2517. doi:10.1007/s10792-017-0762-5
  • Tian M, Jian W, Sun L, et al. One-year follow-up of accelerated transepithelial corneal collagen cross-linking for progressive pediatric keratoconus. BMC Ophthalmol. 2018;18(1):75. doi:10.1186/s12886-018-0739-9
  • Akbar B, Intisar-Ul-Haq R, Ishaq M, et al. Transepithelial corneal crosslinking in treatment of progressive keratoconus: 12 months’ clinical results. Pak J Med Sci. 2017;33(3):570–575. doi:10.12669/pjms.333.11907
  • Huang J, Shen Y, Jian W, et al. Two-year topographic and densitometric outcomes of accelerated (45 mW/cm(2)) transepithelial corneal cross-linking for keratoconus: a case-control study. BMC Ophthalmol. 2018;18(1):337. doi:10.1186/s12886-018-0999-4
  • Zhang X, Sun L, Chen Y, et al. One-year Outcomes of Pachymetry and Epithelium Thicknesses after Accelerated (45 mW/cm(2)) Transepithelial Corneal Collagen Cross-linking for Keratoconus Patients. Sci Rep. 2016;6:32692. doi:10.1038/srep32692
  • Kır MB, Türkyılmaz K, Öner V. Transepithelial High-Intensity Cross-Linking for the Treatment of Progressive Keratoconus: 2-year Outcomes. Curr Eye Res. 2017;42(1):28–31. doi:10.3109/02713683.2016.1148742
  • Zhang X, Sun L, Tian M, et al. Accelerated (45 mW/cm(2)) Transepithelial Corneal Cross-Linking for Progressive Keratoconus Patients: long-Term Topographical and Clinical Outcomes. Front Med Lausanne. 2020;7:283. doi:10.3389/fmed.2020.00283
  • Tian M, Jian W, Zhang X, et al. Three-year follow-up of accelerated transepithelial corneal cross-linking for progressive paediatric keratoconus. Br J Ophthalmol. 2020;104(11):1608–1612. doi:10.1136/bjophthalmol-2019-315260
  • Ziaei M, Vellara H, Gokul A, et al. Prospective 2-year study of accelerated pulsed transepithelial corneal crosslinking outcomes for Keratoconus. Eye. 2019;33(12):1897–1903. doi:10.1038/s41433-019-0502-3
  • Aixinjueluo W, Usui T, Miyai T, et al. Accelerated transepithelial corneal cross-linking for progressive keratoconus: a prospective study of 12 months. Br J Ophthalmol. 2017;101(9):1244–1249. doi:10.1136/bjophthalmol-2016-309775
  • Madeira C, Vasques A, Beato J, et al. Transepithelial accelerated versus conventional corneal collagen crosslinking in patients with keratoconus: a comparative study. Clin Ophthalmol. 2019;13:445–452. doi:10.2147/OPTH.S189183
  • D’Oria F, Palazón A, Alio JL. Corneal collagen cross-linking epithelium-on vs. epithelium-off: a systematic review and meta-analysis. Eye Vis (Lond). 2021;8(1):34. doi:10.1186/s40662-021-00256-0
  • Wen D, Song B, Li Q, et al. Comparison of Epithelium-Off Versus Transepithelial Corneal Collagen Cross-Linking for Keratoconus: a Systematic Review and Meta-Analysis. Cornea. 2018;37(8):1018–1024. doi:10.1097/ICO.0000000000001632
  • Meiri Z, Keren S, Rosenblatt A, et al. Efficacy of Corneal Collagen Cross-Linking for the Treatment of Keratoconus: a Systematic Review and Meta-Analysis. Cornea. 2016;35(3):417–428. doi:10.1097/ICO.0000000000000723
  • Buzzonetti L, Petrocelli G, Valente P, et al. Iontophoretic Transepithelial Collagen Cross-Linking Versus Epithelium-Off Collagen Cross-Linking in Pediatric Patients: 3-Year Follow-Up. Cornea. 2019;38(7):859–863. doi:10.1097/ICO.0000000000001965
  • Shalchi Z, Wang X, Nanavaty MA. Safety and efficacy of epithelium removal and transepithelial corneal collagen crosslinking for keratoconus. Eye. 2015;29(1):15–29. doi:10.1038/eye.2014.230
  • Barbara R, Barbara A, Castillo J, et al. Keratoconus Expert Meeting, London, 2014. Int J Keratoconus Ectatic Corneal Dis. 2014;3:141–158. doi:10.5005/ijkecd-3-3-141
  • Choi JA, Kim MS. Progression of keratoconus by longitudinal assessment with corneal topography. Invest Ophthalmol Vis Sci. 2012;53(2):927–935. doi:10.1167/iovs.11-8118
  • Perez-Straziota C, Gaster RN, Rabinowitz YS. Corneal Cross-Linking for Pediatric Keratcoconus Review. Cornea. 2018;37(6):802–809. doi:10.1097/ICO.0000000000001579