Investigating the Impact of Gut Microbiota on Gout Through Mendelian Randomization

References

• Danve A, Sehra ST, Neogi T. Role of diet in hyperuricemia and gout. Best Pract Res Clin Rheumatol. 2021;35(4):101723. doi:10.1016/j.berh.2021.101723
   PubMed Web of Science ®Google Scholar
• Dehlin M, Jacobsson L, Roddy E. Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors. Nat Rev Rheumatol. 2020;16(7):380–390. doi:10.1038/s41584-020-0441-1
   PubMed Web of Science ®Google Scholar
• Dalbeth N, Merriman TR, Stamp LK. Gout. Lancet. 2016;388(10055):2039–2052. doi:10.1016/S0140-6736(16)00346-9
   PubMed Web of Science ®Google Scholar
• Bardin T, Richette P. Impact of comorbidities on gout and hyperuricaemia: an update on prevalence and treatment options. BMC Med. 2017;15(1):123. doi:10.1186/s12916-017-0890-9
   PubMed Web of Science ®Google Scholar
• Choi HK, McCormick N, Yokose C. Excess comorbidities in gout: the causal paradigm and pleiotropic approaches to care. Nat Rev Rheumatol. 2022;18(2):97–111.
   PubMed Web of Science ®Google Scholar
• Eckenstaler R, Benndorf RA. The role of ABCG2 in the pathogenesis of primary hyperuricemia and Gout-An Update. Int J Mol Sci. 2021;22(13):6678. doi:10.3390/ijms22136678
   PubMed Web of Science ®Google Scholar
• Wu ZD, Yang XK, He YS, et al. Environmental factors and risk of gout. Environ Res. 2022;212(Pt C):113377. doi:10.1016/j.envres.2022.113377
   PubMedGoogle Scholar
• Dalbeth N, Gosling AL, Gaffo A, Abhishek A. Gout. Lancet. 2021;397(10287):1843–1855. doi:10.1016/S0140-6736(21)00569-9
   PubMed Web of Science ®Google Scholar
• So AK, Martinon F. Inflammation in gout: mechanisms and therapeutic targets. Nat Rev Rheumatol. 2017;13(11):639–647. doi:10.1038/nrrheum.2017.155
   PubMed Web of Science ®Google Scholar
• Joosten LA, Netea MG, Mylona E, et al. Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. Arthritis Rheum. 2010;62(11):3237–3248. doi:10.1002/art.27667
   PubMedGoogle Scholar
• Abhishek A, Valdes AM, Doherty M. Low omega-3 fatty acid levels associate with frequent gout attacks: a case control study. Ann Rheum Dis. 2016;75(4):784–785. doi:10.1136/annrheumdis-2015-208767
   PubMed Web of Science ®Google Scholar
• Gentile CL, Weir TL. The gut microbiota at the intersection of diet and human health. Science. 2018;362(6416):776–780. doi:10.1126/science.aau5812
   PubMed Web of Science ®Google Scholar
• Yokose C, McCormick N, Rai SK, et al. Effects of low-fat, Mediterranean, or low-carbohydrate weight loss diets on serum urate and cardiometabolic risk factors: A secondary analysis of the dietary intervention randomized controlled trial (DIRECT). Diabetes Care. 2020;43(11):2812–2820. doi:10.2337/dc20-1002
   PubMed Web of Science ®Google Scholar
• Juraschek SP, Gelber AC, Choi HK, Appel LJ, Miller ER. Effects of the dietary approaches to stop hypertension (DASH) diet and sodium intake on serum uric acid. Arthrit Rheum. 2016;68(12):3002–3009. doi:10.1002/art.39813
   PubMed Web of Science ®Google Scholar
• Vieira AT, Galvão I, Macia LM, et al. Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice. J Leukoc Biol. 2017;101(1):275–284. doi:10.1189/jlb.3A1015-453RRR
   PubMed Web of Science ®Google Scholar
• Fan Y, Pedersen O. Gut microbiota in human metabolic health and disease. Nat Rev Microbiol. 2021;19(1):55–71. doi:10.1038/s41579-020-0433-9
   PubMed Web of Science ®Google Scholar
• Du L, Li Q, Yi H, Kuang T, Tang Y, Fan G. Gut microbiota-derived metabolites as key actors in type 2 diabetes mellitus. Biomed Pharmacother. 2022;149:112839. doi:10.1016/j.biopha.2022.112839
   PubMed Web of Science ®Google Scholar
• Rooks MG, Garrett WS. Gut microbiota, metabolites and host immunity. Nat Rev Immunol. 2016;16(6):341–352. doi:10.1038/nri.2016.42
   PubMed Web of Science ®Google Scholar
• Zhang Y, Chen S, Yuan M, Xu Y, Xu H. Gout and Diet: A comprehensive review of mechanisms and management. Nutrients. 2022;14(17):3525. doi:10.3390/nu14173525
   PubMed Web of Science ®Google Scholar
• Chu Y, Sun S, Huang Y, et al. Metagenomic analysis revealed the potential role of gut microbiome in gout. NPJ Biofilms Microb. 2021;7(1):66. doi:10.1038/s41522-021-00235-2
   PubMed Web of Science ®Google Scholar
• Wang Y, Wei J, Zhang W, et al. Gut dysbiosis in rheumatic diseases: a systematic review and meta-analysis of 92 observational studies. EBioMed. 2022;80:104055. doi:10.1016/j.ebiom.2022.104055
   PubMed Web of Science ®Google Scholar
• Wrigley R, Phipps-Green AJ, Topless RK, et al. Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout. Arthritis Res Ther. 2020;22(1):45. doi:10.1186/s13075-020-2136-z
   PubMed Web of Science ®Google Scholar
• Yu Y, Liu Q, Li H, Wen C, He Z. Alterations of the Gut microbiome associated with the treatment of hyperuricaemia in male rats. Front Microbiol. 2018;9:2233. doi:10.3389/fmicb.2018.02233
   PubMed Web of Science ®Google Scholar
• Aron-Wisnewsky J, Vigliotti C, Witjes J, et al. Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders. Nat Rev Gastroenterol Hepatol. 2020;17(5):279–297. doi:10.1038/s41575-020-0269-9
   PubMed Web of Science ®Google Scholar
• Huang C, Shi G. Smoking and microbiome in oral, airway, gut and some systemic diseases. J Transl Med. 2019;17(1):225. doi:10.1186/s12967-019-1971-7
   PubMed Web of Science ®Google Scholar
• Zhou X, Zhang B, Zhao X, et al. Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis. Food Funct. 2021;12(12):5637–5649. doi:10.1039/D0FO03199B
   PubMed Web of Science ®Google Scholar
• Burgess S, Timpson NJ, Ebrahim S, Davey Smith G. Mendelian randomization: where are we now and where are we going. Int J Epidemiol. 2015;44(2):379–388. doi:10.1093/ije/dyv108
   PubMed Web of Science ®Google Scholar
• Inamo J. Non-causal association of gut microbiome on the risk of rheumatoid arthritis: a Mendelian randomisation study. Ann Rheum Dis. 2021;80(7):e103. doi:10.1136/annrheumdis-2019-216565
   PubMed Web of Science ®Google Scholar
• Long Y, Tang L, Zhou Y, Zhao S, Zhu H. Causal relationship between gut microbiota and cancers: A two-sample Mendelian randomisation study. BMC Med. 2023;21(1):66. doi:10.1186/s12916-023-02761-6
   PubMed Web of Science ®Google Scholar
• Kurilshikov A, Medina-Gomez C, Bacigalupe R, et al. Large-scale association analyses identify host factors influencing human gut microbiome composition. Nat Genet. 2021;53(2):156–165. doi:10.1038/s41588-020-00763-1
   PubMed Web of Science ®Google Scholar
• Burgess S, Thompson SG. Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol. 2011;40(3):755–764. doi:10.1093/ije/dyr036
   PubMed Web of Science ®Google Scholar
• Curtin F, Schulz P. Multiple correlations and Bonferroni’s correction. Biol Psychiatry. 1998;44(8):775–777. doi:10.1016/S0006-3223(98)00043-2
   PubMed Web of Science ®Google Scholar
• Lin S, Zhang T, Zhu L, et al. Characteristic dysbiosis in gout and the impact of a uric acid-lowering treatment, febuxostat on the gut microbiota. J Genet Genomics. 2021;48(9):781–791. doi:10.1016/j.jgg.2021.06.009
   PubMed Web of Science ®Google Scholar
• Zhou D, Liu Y, Zhang X, et al. Functional polymorphisms of the ABCG2 gene are associated with gout disease in the Chinese Han male population. Int J Mol Sci. 2014;15(5):9149–9159. doi:10.3390/ijms15059149
   PubMed Web of Science ®Google Scholar
• Neogi T. Clinical practice. Gout N Engl J Med. 2011;364(5):443–452. doi:10.1056/NEJMcp1001124
   PubMed Web of Science ®Google Scholar
• Stewart S, Rome K, Eason A, et al. Predictors of activity limitation in people with gout: a prospective study. Clin Rheumatol. 2018;37(8):2213–2219. doi:10.1007/s10067-018-4110-6
   PubMed Web of Science ®Google Scholar
• Wang Z, Li Y, Liao W, et al. Gut microbiota remodeling: a promising therapeutic strategy to confront hyperuricemia and gout. Front Cell Infect Microbiol. 2022;12:935723. doi:10.3389/fcimb.2022.935723
   PubMed Web of Science ®Google Scholar
• Guo Z, Zhang J, Wang Z, et al. Intestinal Microbiota Distinguish Gout Patients from Healthy Humans. Sci Rep. 2016;6:20602. doi:10.1038/srep20602
   PubMed Web of Science ®Google Scholar
• Chiaro TR, Soto R, Zac Stephens W, et al. A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice. Sci Transl Med. 2017;9(380):eaaf9044. doi:10.1126/scitranslmed.aaf9044
   PubMed Web of Science ®Google Scholar
• Zhu L, Wu Q, Deng C, et al. Adaptive evolution to a high purine and fat diet of carnivorans revealed by gut microbiomes and host genomes. Environ Microbiol. 2018;20(5):1711–1722. doi:10.1111/1462-2920.14096
   PubMed Web of Science ®Google Scholar
• Singh V, Yeoh BS, Walker RE, et al. Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation. Gut. 2019;68(10):1801–1812. doi:10.1136/gutjnl-2018-316250
   PubMed Web of Science ®Google Scholar
• Zhang YZ, Sui XL, Xu YP, Gu FJ, Zhang AS, Chen JH. NLRP3 inflammasome and lipid metabolism analysis based on UPLC-Q-TOF-MS in gouty nephropathy. Int J Mol Med. 2019;44(1):172–184. doi:10.3892/ijmm.2019.4176
   PubMed Web of Science ®Google Scholar
• Zhao J, Wei K, Jiang P, et al. Inflammatory response to regulated cell death in Gout and its functional implications. Front Immunol. 2022;13:888306. doi:10.3389/fimmu.2022.888306
   PubMed Web of Science ®Google Scholar
• Maslowski KM, Vieira AT, Ng A, et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature. 2009;461(7268):1282–1286. doi:10.1038/nature08530
   PubMed Web of Science ®Google Scholar
• Vasquez R, Oh JK, Song JH, Kang DK. Gut microbiome-produced metabolites in pigs: a review on their biological functions and the influence of probiotics. J Anim Sci Technol. 2022;64(4):671–695. doi:10.5187/jast.2022.e58
   PubMed Web of Science ®Google Scholar
• Wu YL, Zhang CH, Teng Y, et al. Propionate and butyrate attenuate macrophage pyroptosis and osteoclastogenesis induced by CoCrMo alloy particles. Mil Med Res. 2022;9(1):46. doi:10.1186/s40779-022-00404-0
   PubMed Web of Science ®Google Scholar
• Bian X, Wu W, Yang L, et al. Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice. Front Microbiol. 2019;10:2259. doi:10.3389/fmicb.2019.02259
   PubMed Web of Science ®Google Scholar
• Dong L, Du H, Zhang M, et al. Anti-inflammatory effect of Rhein on ulcerative colitis via inhibiting PI3K/Akt/mTOR signaling pathway and regulating gut microbiota. Phytother Res. 2022;36(5):2081–2094. doi:10.1002/ptr.7429
   PubMed Web of Science ®Google Scholar
• Hosomi K, Saito M, Park J, et al. Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota. Nat Commun. 2022;13(1):4477. doi:10.1038/s41467-022-32015-7
   PubMed Web of Science ®Google Scholar
• Sun B, Vatanen T, Jayasinghe TN, McKenzie E, Murphy R, O’Sullivan JM. Desacetyl-α-MSH and α-MSH have sex specific interactions with diet to influence mouse gut morphology, metabolites and microbiota. Sci Rep. 2020;10(1):18957. doi:10.1038/s41598-020-75786-z
   PubMed Web of Science ®Google Scholar
• Yang Y, Dai D, Jin W, et al. Microbiota and metabolites alterations in proximal and distal gastric cancer patients. J Transl Med. 2022;20(1):439. doi:10.1186/s12967-022-03650-x
   PubMed Web of Science ®Google Scholar
• Miyagi Y, Higashiyama M, Gochi A, et al. Plasma free amino acid profiling of five types of cancer patients and its application for early detection. PLoS One. 2011;6(9):e24143. doi:10.1371/journal.pone.0024143
   PubMed Web of Science ®Google Scholar
• Yü TF, Adler M, Bobrow E, Gutman AB. Plasma and urinary amino acids in primary gout, with special reference to glutamine. J Clin Invest. 1969;48(5):885–894. doi:10.1172/JCI106047
   PubMed Web of Science ®Google Scholar
• Ishikawa T, Aw W, Kaneko K. Metabolic interactions of purine derivatives with human ABC Transporter ABCG2: Genetic testing to assess gout risk. Pharmaceuticals. 2013;6(11):1347–1360. doi:10.3390/ph6111347
   Google Scholar
• Mahbub MH, Yamaguchi N, Takahashi H, et al. Alteration in plasma free amino acid levels and its association with gout. Environ Health Prev Med. 2017;22(1):7. doi:10.1186/s12199-017-0609-8
   PubMed Web of Science ®Google Scholar
• Tavella T, Rampelli S, Guidarelli G, et al. Elevated gut microbiome abundance of Christensenellaceae, Porphyromonadaceae and Rikenellaceae is associated with reduced visceral adipose tissue and healthier metabolic profile in Italian elderly. Gut Microbes. 2021;13(1):1–19. doi:10.1080/19490976.2021.1880221
   PubMed Web of Science ®Google Scholar
• Lin H, Meng L, Sun Z, et al. Yellow Wine Polyphenolic Compound Protects Against Doxorubicin-Induced Cardiotoxicity by Modulating the Composition and Metabolic Function of the Gut Microbiota. Circ Heart Fail. 2021;14(10):e008220. doi:10.1161/CIRCHEARTFAILURE.120.008220
   PubMed Web of Science ®Google Scholar
• Lan Y, Sun Q, Ma Z, et al. Seabuckthorn polysaccharide ameliorates high-fat diet-induced obesity by gut microbiota-SCFAs-liver axis. Food Funct. 2022;13(5):2925–2937. doi:10.1039/D1FO03147C
   PubMed Web of Science ®Google Scholar
• Cipolletta E, Tata LJ, Nakafero G, Avery AJ, Mamas MA, Abhishek A. Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout. JAMA. 2022;328(5):440–450. doi:10.1001/jama.2022.11390
   PubMed Web of Science ®Google Scholar
• Henke MT, Kenny DJ, Cassilly CD, Vlamakis H, Xavier RJ, Clardy J. Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn’s disease, produces an inflammatory polysaccharide. Proc Natl Acad Sci U S A. 2019;116(26):12672–12677. doi:10.1073/pnas.1904099116
   PubMed Web of Science ®Google Scholar
• Azzouz D, Omarbekova A, Heguy A, et al. Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal. Ann Rheum Dis. 2019;78(7):947–956. doi:10.1136/annrheumdis-2018-214856
   PubMed Web of Science ®Google Scholar
• Breban M, Tap J, Leboime A, et al. Faecal microbiota study reveals specific dysbiosis in spondyloarthritis. Ann Rheum Dis. 2017;76(9):1614–1622. doi:10.1136/annrheumdis-2016-211064
   PubMed Web of Science ®Google Scholar
• Yan H, Qin Q, Chen J, et al. Gut Microbiome Alterations in Patients With Visceral Obesity Based on Quantitative Computed Tomography. Front Cell Infect Microbiol. 2021;11:823262. doi:10.3389/fcimb.2021.823262
   PubMed Web of Science ®Google Scholar
• Ruuskanen MO, Erawijantari PP, Havulinna AS, et al. Gut Microbiome Composition Is Predictive of Incident Type 2 Diabetes in a Population Cohort of 5572 Finnish Adults. Diabetes Care. 2022;45(4):811–818. doi:10.2337/dc21-2358
   PubMed Web of Science ®Google Scholar
• Shao T, Shao L, Li H, Xie Z, He Z, Wen C. Combined Signature of the Fecal Microbiome and Metabolome in Patients with Gout. Front Microbiol. 2017;8:268. doi:10.3389/fmicb.2017.00268
   PubMed Web of Science ®Google Scholar
• Wang M, Fan J, Huang Z, Zhou D, Wang X. Causal relationship between Gut microbiota and Gout: A Two-sample Mendelian randomization study. Nutrients. 2023;15(19):4260. doi:10.3390/nu15194260
   PubMed Web of Science ®Google Scholar
• Lou Y, Liu B, Jiang Z, et al. Assessing the causal relationships of gut microbial genera with hyperuricemia and gout using two-sample Mendelian randomization. Nutr Metab Cardiovasc Dis. 2024;34(4):1028–1035. doi:10.1016/j.numecd.2024.01.021
   PubMedGoogle Scholar
• Hou T, Dai H, Wang Q, et al. Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: a large-scale bidirectional Mendelian randomization. Front Immunol. 2023;14:1148591. doi:10.3389/fimmu.2023.1148591
   PubMedGoogle Scholar