Transmission of Exosomal TPX2 Promotes Metastasis and Resistance of NSCLC Cells to Docetaxel

References

• Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7–33. doi:10.3322/caac.21708
   PubMed Web of Science ®Google Scholar
• Thai AA, Solomon BJ, Sequist LV, Gainor JF, Heist RS. Lung cancer. Lancet. 2021;398(10299):535–554. doi:10.1016/S0140-6736(21)00312-3
   PubMed Web of Science ®Google Scholar
• Hirsch FR, Scagliotti GV, Mulshine JL, et al. Lung cancer: current therapies and new targeted treatments. Lancet. 2017;389:299–311. doi:10.1016/S0140-6736(16)30958-8
   PubMed Web of Science ®Google Scholar
• Cortes JE, Pazdur R. Docetaxel. J Clin Oncol. 1995;13(10):2643–2655. doi:10.1200/JCO.1995.13.10.2643
   PubMed Web of Science ®Google Scholar
• Zhang E, Xing R, Liu S, Li P. Current advances in development of new docetaxel formulations. Expert Opin Drug Deliv. 2019;16(3):301–312. doi:10.1080/17425247.2019.1583644
   PubMed Web of Science ®Google Scholar
• Passaro A, Brahmer J, Antonia S, Mok T, Peters S. Managing resistance to immune checkpoint inhibitors in lung cancer: treatment and novel strategies. J Clin Oncol. 2022;40(6):598–610. doi:10.1200/JCO.21.01845
   PubMed Web of Science ®Google Scholar
• Chen Z, Shi T, Zhang L, et al. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: a review of the past decade. Cancer Lett. 2016;370(1):153–164. doi:10.1016/j.canlet.2015.10.010
   PubMed Web of Science ®Google Scholar
• Wadsworth P. TPX2. Curr Biol. 2015;25(24):R1156–R1158. doi:10.1016/j.cub.2015.10.003
   PubMed Web of Science ®Google Scholar
• Neumayer G, Belzil C, Gruss OJ, Nguyen MD. TPX2: of spindle assembly, DNA damage response, and cancer. Cell Mol Life Sci. 2014;71(16):3027–3047. doi:10.1007/s00018-014-1582-7
   PubMed Web of Science ®Google Scholar
• King MR, Petry S. Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation. Nat Commun. 2020;11(1):270. doi:10.1038/s41467-019-14087-0
   PubMed Web of Science ®Google Scholar
• Zou Z, Zheng B, Li J, et al. TPX2 level correlates with cholangiocarcinoma cell proliferation, apoptosis, and EMT. Biomed Pharmacother. 2018;107:1286–1293. doi:10.1016/j.biopha.2018.08.011
   PubMed Web of Science ®Google Scholar
• Gomes-Filho SM, Dos Santos EO, Bertoldi ERM, et al. Aurora A kinase and its activator TPX2 are potential therapeutic targets in KRAS-induced pancreatic cancer. Cell Oncol. 2020;43:445–460. doi:10.1007/s13402-020-00498-5
   Web of Science ®Google Scholar
• Wang F, Zhao W, Gao Y, et al. CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis. J Exp Clin Cancer Res. 2019;38(1):286. doi:10.1186/s13046-019-1297-6
   PubMedGoogle Scholar
• Wang X, Wang J, Shen H, Luo Z, Lu X. Downregulation of TPX2 impairs the antitumor activity of CD8+ T cells in hepatocellular carcinoma. Cell Death Dis. 2022;13(3):223. doi:10.1038/s41419-022-04645-8
   PubMed Web of Science ®Google Scholar
• Zeng H, Ji J, Song X, et al. Stemness related genes revealed by network analysis associated with tumor immune microenvironment and the clinical outcome in lung adenocarcinoma. Front Genet. 2020;11:549213. doi:10.3389/fgene.2020.549213
   PubMed Web of Science ®Google Scholar
• Wang H, Wang X, Xu L, Cao H, Zhang J. Nonnegative matrix factorization-based bioinformatics analysis reveals that TPX2 and SELENBP1 are two predictors of the inner sub-consensuses of lung adenocarcinoma. Cancer Med. 2021;10(24):9058–9077. doi:10.1002/cam4.4386
   PubMed Web of Science ®Google Scholar
• Huo C, Zhang M-Y, Li R, et al. Comprehensive analysis of TPX2-related ceRNA network as prognostic biomarkers in lung adenocarcinoma. Int J Med Sci. 2020;17(16):2427–2439. doi:10.7150/ijms.49053
   PubMed Web of Science ®Google Scholar
• Shah KN, Bhatt R, Rotow J, et al. Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. Nat Med. 2019;25(1):111–118. doi:10.1038/s41591-018-0264-7
   PubMed Web of Science ®Google Scholar
• Pegtel DM, Gould SJ. Exosomes. Annu Rev Biochem. 2019;88(1):487–514. doi:10.1146/annurev-biochem-013118-111902
   PubMed Web of Science ®Google Scholar
• Dai J, Su Y, Zhong S, et al. Exosomes: key players in cancer and potential therapeutic strategy. Signal Transduct Target Ther. 2020;5(1):145. doi:10.1038/s41392-020-00261-0
   PubMed Web of Science ®Google Scholar
• Zhang L, Yu D. Exosomes in cancer development, metastasis, and immunity. Biochim Biophys Acta Rev Cancer. 2019;1871:455–468. doi:10.1016/j.bbcan.2019.04.004
   PubMed Web of Science ®Google Scholar
• Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367(6478):eaau6977. doi:10.1126/science.aau6977
   PubMed Web of Science ®Google Scholar
• Zhou Y, Zhang Y, Gong H, Luo S, Cui Y. The role of exosomes and their applications in cancer. Int J Mol Sci. 2021;22(22):12204. doi:10.3390/ijms222212204
   PubMed Web of Science ®Google Scholar
• Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29:e45. doi:10.1093/nar/29.9.e45
   PubMed Web of Science ®Google Scholar
• Lobb RJ, Becker M, Wen SW, et al. Optimized exosome isolation protocol for cell culture supernatant and human plasma. J Extracell Vesicles. 2015;4:27031. doi:10.3402/jev.v4.27031
   PubMed Web of Science ®Google Scholar
• Zhou F, Wang M, Aibaidula M, et al. TPX2 promotes metastasis and serves as a marker of poor prognosis in non-small cell lung cancer. Med Sci Monit. 2020;26:e925147-1–e925147-15. doi:10.12659/MSM.925147
   Web of Science ®Google Scholar
• Xu K, Zhang C, Du T, et al. Progress of exosomes in the diagnosis and treatment of lung cancer. Biomed Pharmacother. 2021;134:111111. doi:10.1016/j.biopha.2020.111111
   PubMed Web of Science ®Google Scholar
• Jiang C, Zhang N, Hu X, Wang H. Tumor-associated exosomes promote lung cancer metastasis through multiple mechanisms. Mol Cancer. 2021;20:117. doi:10.1186/s12943-021-01411-w
   PubMed Web of Science ®Google Scholar
• Rohrberg J, Van de Mark D, Amouzgar M, et al. MYC dysregulates mitosis, revealing cancer vulnerabilities. Cell Rep. 2020;30:3368–3382.e7. doi:10.1016/j.celrep.2020.02.041
   PubMed Web of Science ®Google Scholar
• Pérez de Castro I, Malumbres M. Mitotic stress and chromosomal instability in cancer: the case for TPX2. Genes Cancer. 2012;3:721–730. doi:10.1177/1947601912473306
   PubMedGoogle Scholar
• Liu Q, Tu K, Zhang H, Zheng X, Yao Y, Liu Q. TPX2 as a novel prognostic biomarker for hepatocellular carcinoma. Hepatol Res. 2015;45:906–918. doi:10.1111/hepr.12428
   PubMed Web of Science ®Google Scholar
• Wei P, Zhang N, Xu Y, et al. TPX2 is a novel prognostic marker for the growth and metastasis of colon cancer. J Transl Med. 2013;11(1):313. doi:10.1186/1479-5876-11-313
   PubMedGoogle Scholar
• Huang Y, Guo W, Kan H. TPX2 is a prognostic marker and contributes to growth and metastasis of human hepatocellular carcinoma. Int J Mol Sci. 2014;15(10):18148–18161. doi:10.3390/ijms151018148
   PubMed Web of Science ®Google Scholar
• Schneider MA, Christopoulos P, Muley T, et al. AURKA, DLGAP5, TPX2, KIF11 and CKAP5: five specific mitosis-associated genes correlate with poor prognosis for non-small cell lung cancer patients. Int J Oncol. 2017;50(2):9058–9077. doi:10.1002/cam4.4386
   Web of Science ®Google Scholar
• Shen Y, Tang X, Zhou X, et al. Screening of key prognosis genes of lung adenocarcinoma based on expression analysis on TCGA database. J Oncol. 2022;2022:4435092. doi:10.1155/2022/4435092
   PubMed Web of Science ®Google Scholar
• Liang B, Zheng W, Fang L, et al. Overexpressed targeting protein for Xklp2 (TPX2) serves as a promising prognostic marker and therapeutic target for gastric cancer. Cancer Biol Ther. 2016;17:824–832. doi:10.1080/15384047.2016.1195046
   PubMed Web of Science ®Google Scholar
• Huang D-H, Jian J, Li S, Zhang Y, Liu L-Z. TPX2 silencing exerts anti‑tumor effects on hepatocellular carcinoma by regulating the PI3K/AKT signaling pathway. Int J Mol Med. 2019;44:2113–2122. doi:10.3892/ijmm.2019.4371
   PubMed Web of Science ®Google Scholar
• Sawada J-I, Matsuno K, Ogo N, Asai A. Various effects of two types of kinesin-5 inhibitors on mitosis and cell proliferation. Biochem Pharmacol. 2021;193:114789. doi:10.1016/j.bcp.2021.114789
   PubMed Web of Science ®Google Scholar
• Hsu P-K, Chen H-Y, Yeh Y-C, et al. TPX2 expression is associated with cell proliferation and patient outcome in esophageal squamous cell carcinoma. J Gastroenterol. 2014;49(8):1231–1240. doi:10.1007/s00535-013-0870-6
   PubMed Web of Science ®Google Scholar
• Wang K, Zhang M, Wang J, et al. Identifies key regulators involved in cell proliferation and potential drugs for the treatment of human lung adenocarcinoma. Front Oncol. 2021;11:737152. doi:10.3389/fonc.2021.737152
   PubMed Web of Science ®Google Scholar