Progerin Inhibits the Proliferation and Migration of Melanoma Cells by Regulating the Expression of Paxillin

References

• Ahmadi KF, Ramezanpour A. Clustering trends of melanoma incidence and mortality: a worldwide assessment from 1995 to 2019. Australas J Dermatol. 2022;63:e206–e17. doi:10.1111/ajd.13882
   PubMed Web of Science ®Google Scholar
• Lopes-Paciencia S, Saint-Germain E, Rowell MC, Ruiz AF, Kalegari P, Ferbeyre G. The senescence-associated secretory phenotype and its regulation. Cytokine. 2019;117:15–22. doi:10.1016/j.cyto.2019.01.013
   PubMed Web of Science ®Google Scholar
• Loo TM, Miyata K, Tanaka Y, Takahashi A. Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer. Cancer Sci. 2020;111(2):304–311. doi:10.1111/cas.14266
   PubMed Web of Science ®Google Scholar
• Ullrich NJ, Kieran MW, Miller DT, et al. Neurologic features of Hutchinson-Gilford progeria syndrome after lonafarnib treatment. Neurology. 2013;81(5):427–430. doi:10.1212/WNL.0b013e31829d85c0
   PubMed Web of Science ®Google Scholar
• Eriksson M, Brown WT, Gordon LB, et al. Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature. 2003;423(6937):293–298. doi:10.1038/nature01629
   PubMed Web of Science ®Google Scholar
• De Sandre-Giovannoli A, Bernard R, Cau P, et al. Lamin a truncation in Hutchinson-Gilford progeria. Science. 2003;300(5628):2055. doi:10.1126/science.1084125
   PubMed Web of Science ®Google Scholar
• Gonzalo S, Coll-Bonfill N. Genomic instability and innate immune responses to self-DNA in progeria. Geroscience. 2019;41(3):255–266. doi:10.1007/s11357-019-00082-2
   PubMed Web of Science ®Google Scholar
• Piekarowicz K, Machowska M, Dzianisava V, Rzepecki R. Hutchinson-Gilford Progeria Syndrome-Current Status and Prospects for Gene Therapy Treatment. Cells. 2019;9(1):8. doi:10.3390/cells9010008
   PubMedGoogle Scholar
• Gordon LB, Rothman FG, Lopez-Otin C, Misteli T. Progeria: a paradigm for translational medicine. Cell. 2014;156(3):400–407. doi:10.1016/j.cell.2013.12.028
   PubMed Web of Science ®Google Scholar
• Prokocimer M, Barkan R, Gruenbaum Y. Hutchinson-Gilford progeria syndrome through the lens of transcription. Aging Cell. 2013;12(4):533–543. doi:10.1111/acel.12070
   PubMed Web of Science ®Google Scholar
• Gonzalo S, Kreienkamp R. DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome. Curr Opin Cell Biol. 2015;34:75–83. doi:10.1016/j.ceb.2015.05.007
   PubMed Web of Science ®Google Scholar
• Kubben N, Misteli T. Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases. Nat Rev Mol Cell Biol. 2017;18(10):595–609. doi:10.1038/nrm.2017.68
   PubMed Web of Science ®Google Scholar
• Chang BD, Broude EV, Dokmanovic M, et al. A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res. 1999;59(15):3761–3767.
   PubMed Web of Science ®Google Scholar
• Acosta JC, Gil J. Senescence: a new weapon for cancer therapy. Trends Cell Biol. 2012;22(4):211–219. doi:10.1016/j.tcb.2011.11.006
   PubMed Web of Science ®Google Scholar
• Alpha KM, Xu W, Turner CE. Paxillin family of focal adhesion adaptor proteins and regulation of cancer cell invasion. Int Rev Cell Mol Biol. 2020;355:1–52. doi:10.1016/bs.ircmb.2020.05.003
   PubMed Web of Science ®Google Scholar
• Lopez-Colome AM, Lee-Rivera I, Benavides-Hidalgo R, Lopez E. Paxillin: a crossroad in pathological cell migration. J Hematol Oncol. 2017;10(1):50. doi:10.1186/s13045-017-0418-y
   PubMedGoogle Scholar
• Cai H, Zhang T, Tang WX, Li SL. Expression of paxillin in breast cancer cell with high and low metastatic potentiality. Sichuan Da Xue Xue Bao Yi Xue Ban. 2010;41(1):91–94.
   PubMedGoogle Scholar
• Chen DL, Wang ZQ, Ren C, et al. Abnormal expression of paxillin correlates with tumor progression and poor survival in patients with gastric cancer. J Transl Med. 2013;11(1):277. doi:10.1186/1479-5876-11-277
   PubMedGoogle Scholar
• Yang HJ, Chen JZ, Zhang WL, Ding YQ. Focal adhesion plaque associated cytoskeletons are involved in the invasion and metastasis of human colorectal carcinoma. Cancer Invest. 2010;28(2):127–134. doi:10.3109/07357900903147184
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhao H, Xiao Y, et al. Pan-cancer analysis reveals an immunological role and prognostic potential of PXN in human cancer. Aging (Albany NY). 2021;13(12):16248–16266. doi:10.18632/aging.203154
   PubMedGoogle Scholar
• Hu XT, Song HC, Yu H, Wu ZC, Liu XG, Chen WC. Overexpression of Progerin Results in Impaired Proliferation and Invasion of Non-Small Cell Lung Cancer Cells. Onco Targets Ther. 2020;13:2629–2642. doi:10.2147/OTT.S237016
   PubMed Web of Science ®Google Scholar
• Huang Y, Hong W, Wei X. The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis. J Hematol Oncol. 2022;15.
   PubMed Web of Science ®Google Scholar
• Liu W, Huang X, Luo W, Liu X, Chen W. The Role of Paxillin Aberrant Expression in Cancer and Its Potential as a Target for Cancer Therapy. Int J Mol Sci. 2023;24. doi:10.3390/ijms25010024
   PubMedGoogle Scholar
• Fernandez P, Scaffidi P, Markert E, Lee JH, Rane S, Misteli T. Transformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4. Cell Rep. 2014;9:248–260. doi:10.1016/j.celrep.2014.08.069
   PubMed Web of Science ®Google Scholar
• de la Rosa J, Freije JM, Cabanillas R, et al. Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion. Nat Commun. 2013;4(1):2268. doi:10.1038/ncomms3268
   PubMed Web of Science ®Google Scholar
• Lionetti FM, La Porta CAM. Nuclear biophysical changes during human melanoma plasticity. Cells Tissues Organs. 2022.
   PubMed Web of Science ®Google Scholar
• Cao H, Xu E, Liu H, Wan L, Lai M. Epithelial-mesenchymal transition in colorectal cancer metastasis: a system review. Pathol Res Pract. 2015;211(8):557–569. doi:10.1016/j.prp.2015.05.010
   PubMed Web of Science ®Google Scholar
• Mizukoshi K, Okazawa Y, Haeno H, et al. Metastatic seeding of human colon cancer cell clusters expressing the hybrid epithelial/mesenchymal state. Int, J, Cancer. 2020;146(9):2547–2562. doi:10.1002/ijc.32672
   PubMed Web of Science ®Google Scholar
• Matthews HK, Bertoli C, de Bruin RAM. Cell cycle control in cancer. Nat Rev Mol Cell Biol. 2022;23(1):74–88. doi:10.1038/s41580-021-00404-3
   PubMed Web of Science ®Google Scholar
• Mousson A, Legrand M, Steffan T, et al. Inhibiting FAK-Paxillin Interaction Reduces Migration and Invadopodia-Mediated Matrix Degradation in Metastatic Melanoma Cells. Cancers (Basel);2021. 13. doi:10.3390/cancers14010013
   PubMed Web of Science ®Google Scholar
• Wj CS, Wu Q, Qian J, Yang C, Bo P. Genistein inhibits the growth and regulates the migration and invasion abilities of melanoma cells via the FAK/paxillin and MAPK pathways. Oncotarget. 2017;8:21674–21691. doi:10.18632/oncotarget.15535
   PubMedGoogle Scholar
• Athanasopoulou A, Aroukatos P, Nakas D, Repanti M, Papadaki H, Bravou V. Decreased ezrin and paxillin expression in human urothelial bladder tumors correlate with tumor progression. Urol Oncol. 2013;31(6):836–842. doi:10.1016/j.urolonc.2011.07.003
   PubMed Web of Science ®Google Scholar
• Cai FF, Xu HR, Yu SH, et al. ADT-OH inhibits malignant melanoma metastasis in mice via suppressing CSE/CBS and FAK/Paxillin signaling pathway. Acta Pharmacol Sin. 2022;43(7):1829–1842. doi:10.1038/s41401-021-00799-x
   PubMed Web of Science ®Google Scholar
• Yoo SM, Latifkar A, Cerione RA, Antonyak MA. Cool-associated Tyrosine-phosphorylated Protein 1 Is Required for the Anchorage-independent Growth of Cervical Carcinoma Cells by Binding Paxillin and Promoting AKT Activation. J Biol Chem. 2017;292(9):3947–3957. doi:10.1074/jbc.M116.769190
   PubMed Web of Science ®Google Scholar
• Xie J, Guo T, Zhong Z, et al. ITGB1 Drives Hepatocellular Carcinoma Progression by Modulating Cell Cycle Process Through PXN/YWHAZ/AKT Pathways. Front Cell Dev Biol. 2021;9:711149. doi:10.3389/fcell.2021.711149
   PubMed Web of Science ®Google Scholar
• Wang Z, Xie W, Guan H. The diagnostic, prognostic role and molecular mechanism of miR-328 in human cancer. Biomed Pharmacother. 2023;157:114031. doi:10.1016/j.biopha.2022.114031
   PubMed Web of Science ®Google Scholar
• Liu X, Xu D, Xu X, Xue Q, Gao X, Tang C. MiR-216b regulates the tumorigenesis of gastric cancer by targeting PXN. Pathol Res Pract. 2021;218:153325. doi:10.1016/j.prp.2020.153325
   PubMed Web of Science ®Google Scholar
• Chen DL, Wang DS, Wu WJ, et al. Overexpression of paxillin induced by miR-137 suppression promotes tumor progression and metastasis in colorectal cancer. Carcinogenesis. 2013;34:803–811. doi:10.1093/carcin/bgs400
   PubMed Web of Science ®Google Scholar
• Jiang H, Zhang H, Hu X, Li W. Knockdown of long non-coding RNA XIST inhibits cell viability and invasion by regulating miR-137/PXN axis in non-small cell lung cancer. Int J Biol Macromol. 2018;111:623–631. doi:10.1016/j.ijbiomac.2018.01.022
   PubMed Web of Science ®Google Scholar
• Ashapkin VV, Kutueva LI, Kireev II. Are There Common Mechanisms Between the Hutchinson-Gilford Progeria Syndrome and Natural Aging? Front Genet. 2019;10:455. doi:10.3389/fgene.2019.00455
   PubMed Web of Science ®Google Scholar
• Frankel D, Delecourt V, Novoa-Del-Toro EM, et al. miR-376a-3p and miR-376b-3p overexpression in Hutchinson-Gilford progeria fibroblasts inhibits cell proliferation and induces premature senescence. iScience. 2022;25:103757. doi:10.1016/j.isci.2022.103757
   PubMed Web of Science ®Google Scholar