Novel Autophagy-Related Blood Biomarkers Associated with Immune Cell Infiltration in Ankylosing Spondylitis

References

• Bond D. Ankylosing spondylitis: diagnosis and management. Royal College Nurs. 2013;28(16–18):52–9; quiz 60. doi:10.7748/ns2013.12.28.16.52.e7807
   Google Scholar
• Xiong Y, Cai M, Xu Y, et al. Joint together: the etiology and pathogenesis of ankylosing spondylitis. Front Immunol. 2022;13:996103. doi:10.3389/fimmu.2022.996103
   PubMed Web of Science ®Google Scholar
• Hanson A, Brown MA. Genetics and the causes of ankylosing spondylitis. Rheum Dis Clin North Am. 2017;43(3):401–414. doi:10.1016/j.rdc.2017.04.006
   PubMed Web of Science ®Google Scholar
• Nakamura A, Boroojeni SF, Haroon N. Aberrant antigen processing and presentation: key pathogenic factors leading to immune activation in Ankylosing spondylitis. Seminars Immunopathol. 2021;43(2):245–253. doi:10.1007/s00281-020-00833-w
   PubMed Web of Science ®Google Scholar
• Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. J Pathol. 2010;221(1):3–12. doi:10.1002/path.2697
   PubMed Web of Science ®Google Scholar
• Guo F, Liu X, Cai H, Le W. Autophagy in neurodegenerative diseases: pathogenesis and therapy. Brain Pathol. 2018;28(1):3–13. doi:10.1111/bpa.12545
   PubMed Web of Science ®Google Scholar
• Kanno H, Handa K, Murakami T, Aizawa T, Ozawa H. Chaperone-mediated autophagy in neurodegenerative diseases and acute neurological insults in the central nervous system. Cells. 2022;11(7):1205. doi:10.3390/cells11071205
   PubMed Web of Science ®Google Scholar
• Ferro F, Servais S, Besson P, Roger S, Dumas JF, Brisson L. Autophagy and mitophagy in cancer metabolic remodelling. Seminars Cell Develop Biol. 2020;98:129–138.
   PubMed Web of Science ®Google Scholar
• Zhu C, Shen S, Zhang S, Huang M, Zhang L, Chen X. Autophagy in bone remodeling: a regulator of oxidative stress. Front Endocrinol. 2022;13:898634. doi:10.3389/fendo.2022.898634
   PubMed Web of Science ®Google Scholar
• Nollet M, Santucci-Darmanin S, Breuil V, et al. Autophagy in osteoblasts is involved in mineralization and bone homeostasis. Autophagy. 2014;10(11):1965–1977. doi:10.4161/auto.36182
   PubMed Web of Science ®Google Scholar
• Trojani MC, Santucci-Darmanin S, Breuil V, Carle GF, Pierrefite-Carle V. Autophagy and bone diseases. Joint Bone Spine. 2022;89(3):105301. doi:10.1016/j.jbspin.2021.105301
   PubMed Web of Science ®Google Scholar
• Ciccia F, Haroon N. Autophagy in the pathogenesis of ankylosing spondylitis. Clin Rheumatol. 2016;35(6):1433–1436. doi:10.1007/s10067-016-3262-5
   PubMed Web of Science ®Google Scholar
• Park MC, Kim HW, Lee SW, Song JJ, Park YB. Defective autophagy activity and its association with spinal damage in patients with ankylosing spondylitis. Joint Bone Spine. 2017;84(5):583–587. doi:10.1016/j.jbspin.2016.09.005
   PubMed Web of Science ®Google Scholar
• Lin T, Chen W, Yang P, et al. Bioinformatics analysis and identification of genes and molecular pathways in steroid-induced osteonecrosis of the femoral head. J Orthop Surg Res. 2021;16(1):327. doi:10.1186/s13018-021-02464-9
   PubMed Web of Science ®Google Scholar
• Liang Y, Lin F, Huang Y. Identification of biomarkers associated with diagnosis of osteoarthritis patients based on bioinformatics and machine learning. J Immunol Res. 2022;2022:5600190. doi:10.1155/2022/5600190
   PubMed Web of Science ®Google Scholar
• Yang J, Fan Y, Liu S. ATF3 as a potential diagnostic marker of early-stage osteoarthritis and its correlation with immune infiltration through bioinformatics analysis. Bone Joint Res. 2022;11(9):679–689. doi:10.1302/2046-3758.119.BJR-2022-0075.R1
   PubMed Web of Science ®Google Scholar
• Lu K, Wang L, Fu Y, Li G, Zhang X, Cao M. Bioinformatics analysis identifies immune-related gene signatures and subtypes in diabetic nephropathy. Front Endocrinol. 2022;13:1048139. doi:10.3389/fendo.2022.1048139
   PubMed Web of Science ®Google Scholar
• Aran D. Cell-type enrichment analysis of bulk transcriptomes using xCell. Methods Mol Biol. 2020;2120:263–276.
   PubMedGoogle Scholar
• Ranganathan V, Gracey E, Brown MA, Inman RD, Haroon N. Pathogenesis of ankylosing spondylitis - recent advances and future directions. Nat Rev Rheumatol. 2017;13(6):359–367. doi:10.1038/nrrheum.2017.56
   PubMed Web of Science ®Google Scholar
• Golder V, Schachna L. Ankylosing spondylitis: an update. Aust Fam Physician. 2013;42(11):780–784.
   PubMedGoogle Scholar
• Liu L, Yuan Y, Zhang S, Xu J, Zou J. Osteoimmunological insights into the pathogenesis of ankylosing spondylitis. J Cellular Physiol. 2021;236(9):6090–6100. doi:10.1002/jcp.30313
   PubMed Web of Science ®Google Scholar
• Tan M, Zhang QB, Liu TH, et al. Autophagy dysfunction may be involved in the pathogenesis of ankylosing spondylitis. Exp Ther Med. 2020;20(4):3578–3586. doi:10.3892/etm.2020.9116
   PubMed Web of Science ®Google Scholar
• Zhai Y, Lin P, Feng Z, et al. TNFAIP3-DEPTOR complex regulates inflammasome secretion through autophagy in ankylosing spondylitis monocytes. Autophagy. 2018;14(9):1629–1643. doi:10.1080/15548627.2018.1458804
   PubMed Web of Science ®Google Scholar
• Wu J, Yan L, Chai K. Systemic immune-inflammation index is associated with disease activity in patients with ankylosing spondylitis. J Clin Lab Analysis. 2021;35(9):e23964. doi:10.1002/jcla.23964
   PubMed Web of Science ®Google Scholar
• Shani G, Fischer WH, Justice NJ, Kelber JA, Vale W, Gray PC. GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. Molecul Cell Biol. 2008;28(2):666–677. doi:10.1128/MCB.01716-07
   PubMed Web of Science ®Google Scholar
• Gomer CJ, Ferrario A, Rucker N, Wong S, Lee AS. Glucose regulated protein induction and cellular resistance to oxidative stress mediated by porphyrin photosensitization. Cancer Res. 1991;51(24):6574–6579.
   PubMed Web of Science ®Google Scholar
• Cha-Molstad H, Sung KS, Hwang J, et al. Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding. Nature Cell Biol. 2015;17(7):917–929. doi:10.1038/ncb3177
   PubMed Web of Science ®Google Scholar
• Kim SY, Kim HJ, Kim HJ, et al. HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer. Autophagy. 2018;14(3):385–403. doi:10.1080/15548627.2017.1414126
   PubMed Web of Science ®Google Scholar
• Han C, Xie K, Yang C, et al. HA15 alleviates bone loss in ovariectomy-induced osteoporosis by targeting HSPA5. Exp Cell Res. 2021;406(2):112781. doi:10.1016/j.yexcr.2021.112781
   PubMed Web of Science ®Google Scholar
• Bjørkøy G, Lamark T, Pankiv S, Øvervatn A, Brech A, Johansen T. Monitoring autophagic degradation of p62/SQSTM1. Methods enzymol. 2009;452:181–197.
   PubMed Web of Science ®Google Scholar
• Lamark T, Svenning S, Johansen T. Regulation of selective autophagy: the p62/SQSTM1 paradigm. Essays biochemist. 2017;61(6):609–624. doi:10.1042/EBC20170035
   PubMed Web of Science ®Google Scholar
• Bjørkøy G, Lamark T, Brech A, et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol. 2005;171(4):603–614. doi:10.1083/jcb.200507002
   PubMed Web of Science ®Google Scholar
• Jeong SJ, Zhang X, Rodriguez-Velez A, Evans TD, Razani B. p62/SQSTM1 and selective autophagy in cardiometabolic diseases. Antioxid Redox Signal. 2019;31(6):458–471. doi:10.1089/ars.2018.7649
   PubMed Web of Science ®Google Scholar
• Rea SL, Majcher V, Searle MS, Layfield R. SQSTM1 mutations--bridging Paget disease of bone and ALS/FTLD. Exp Cell Res. 2014;325(1):27–37. doi:10.1016/j.yexcr.2014.01.020
   PubMed Web of Science ®Google Scholar
• Visconti MR, Langston AL, Alonso N, et al. Mutations of SQSTM1 are associated with severity and clinical outcome in Paget disease of bone. J Bone Mineral Res. 2010;25(11):2368–2373. doi:10.1002/jbmr.132
   PubMed Web of Science ®Google Scholar
• Mauro D, Thomas R, Guggino G, Lories R, Brown MA, Ciccia F. Ankylosing spondylitis: an autoimmune or autoinflammatory disease? Nature Rev Rheumatol. 2021;17(7):387–404. doi:10.1038/s41584-021-00625-y
   PubMed Web of Science ®Google Scholar
• Rezaiemanesh A, Abdolmaleki M, Abdolmohammadi K, et al. Immune cells involved in the pathogenesis of ankylosing spondylitis. Biomed Pharmacot Biomed Pharmacot. 2018;100:198–204. doi:10.1016/j.biopha.2018.01.108
   PubMed Web of Science ®Google Scholar
• Jiang J, Zhan X, Qu H, et al. Upregulated of ANXA3, SORL1, and neutrophils may be key factors in the progressionof ankylosing spondylitis. Front Immunol. 2022;13:861459. doi:10.3389/fimmu.2022.861459
   PubMed Web of Science ®Google Scholar
• Ren C, Li M, Zheng Y, et al. Single-cell RNA-seq reveals altered NK cell subsets and reduced levels of cytotoxic molecules in patients with ankylosing spondylitis. J Cell Mol Med. 2022;26(4):1071–1082. doi:10.1111/jcmm.17159
   PubMed Web of Science ®Google Scholar
• Gracey E, Yao Y, Qaiyum Z, Lim M, Tang M, Inman RD. Altered cytotoxicity profile of CD8+ T cells in ankylosing spondylitis. Arthritis Rheumatol. 2020;72(3):428–434. doi:10.1002/art.41129
   PubMed Web of Science ®Google Scholar
• Liao HT, Tsai CY. Cytokines and regulatory T cells in ankylosing spondylitis. Bone Joint Res. 2023;12(2):133–137. doi:10.1302/2046-3758.122.BJR-2022-0195.R1
   PubMed Web of Science ®Google Scholar
• Wen JT, Zhang DH, Fang PF, Li MH, Wang RJ, Li SH. Role of Th1/Th2 cytokines in the diagnosis and prognostic evaluation of ankylosing spondylitis. Genet Molecul Res. 2017;16(1). doi:10.4238/gmr16019322
   Google Scholar