Diagnostic and Management Strategies of IgA Vasculitis Nephritis/Henoch-Schönlein Purpura Nephritis in Pediatric Patients: Current Perspectives

References

• Ozen S, Pistorio A, Iusan SM, et al. EULAR/PRINTO/PRES criteria for Henoch-Schonlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. part II: final classification criteria. Ann Rheum Dis. 2010;69(5):798–806. doi:10.1136/ard.2009.116657
   PubMed Web of Science ®Google Scholar
• Sestan M Contribution of the Whole Exome Sequencing in the Identification of Genetic Variants Associated With Childhood-Onset Systemic Lupus and IgA Vasculitis PhD [dissertation]. Zagreb: University of Zagreb School of Medicine; 2022. Available from: https://urn.nsk.hr/urn:nbn:hr:105:954607. Accessed February 27, 2023.
   Google Scholar
• Gardner-Medwin JM, Dolezalova P, Cummins C, Southwood TR. Incidence of Henoch-Schönlein purpura, Kawasaki disease, and rare vasculitides in children of different ethnic origins. Lancet. 2002;360:1197–1202.
   PubMed Web of Science ®Google Scholar
• Jennette JC, Falk RJ, Bacon PA, et al. 2012 revised international chapel hill consensus conference nomenclature of vasculitides. Arthritis Rheum. 2013;65:1–11.
   PubMed Web of Science ®Google Scholar
• Olson JC, Kelly KJ, Pan CG, Wortmann DW. Pulmonary disease with hemorrhage in Henoch-Schöenlein purpura. Pediatrics. 1992;89:1177–1181.
   PubMed Web of Science ®Google Scholar
• Reid-Adam J. Henoch-Schonlein purpura. Pediatr Rev. 2014;35:447–449.
   PubMedGoogle Scholar
• Trnka P. Henoch-Schönlein purpura in children. J Paediatr Child Health. 2013;49:995–1003.
   PubMed Web of Science ®Google Scholar
• Davin JC, Coppo R. Henoch-Schönlein purpura nephritis in children. Nat Rev Nephrol. 2014;10:563–573.
   PubMed Web of Science ®Google Scholar
• Davin JC, Ten Berge IJ, Weening JJ. What is the difference between IgA nephropathy and Henoch-Schönlein purpura nephritis? Kidney Int. 2001;59:823–834.
   PubMed Web of Science ®Google Scholar
• Davin J-C, Coppo R. Pitfalls in recommending evidence-based guidelines for a protean disease like Henoch–Schönlein purpura nephritis. Pediatr Nephrol. 2013;28(10):1897–1903. doi:10.1007/s00467-013-2550-4
   PubMed Web of Science ®Google Scholar
• Piram M, Maldini C, Biscardi S, et al. Incidence of IgA vasculitis in children estimated by four-source capture–recapture analysis: a population-based study. Rheumatology. 2017;56(8):1358–1366. doi:10.1093/rheumatology/kex158
   PubMed Web of Science ®Google Scholar
• Park SJ, Suh J-S, Lee JH, et al. Advances in our understanding of the pathogenesis of Henoch-Schönlein purpura and the implications for improving its diagnosis. Expert Rev Clin Immunol. 2013;9(12):1223–1238. doi:10.1586/1744666X.2013.850028
   PubMed Web of Science ®Google Scholar
• Sapina M, Frkovic M, Sestan M, et al. Geospatial clustering of childhood IgA vasculitis and IgA vasculitis-associated nephritis. Ann Rheum Dis. 2021;80(5):610–616. doi:10.1136/annrheumdis-2020-218649
   PubMed Web of Science ®Google Scholar
• Brogan P, Eleftheriou D, Dillon M. Small vessel vasculitis. Pediatr Nephrol. 2010;25(6):1025–1035. doi:10.1007/s00467-009-1317-4
   PubMed Web of Science ®Google Scholar
• Pohl M. Henoch–Schönlein purpura nephritis. Pediatr Nephrol. 2015;30(2):245–252. doi:10.1007/s00467-014-2815-6
   PubMed Web of Science ®Google Scholar
• Kiryluk K, Li Y, Sanna-Cherchi S, et al. Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis. PLoS Genet. 2012;8(6):e1002765. doi:10.1371/journal.pgen.1002765
   PubMed Web of Science ®Google Scholar
• Rigante D, Castellazzi L, Bosco A, Esposito S. Is there a crossroad between infections, genetics, and Henoch–Schönlein purpura? Autoimmun Rev. 2013;12(10):1016–1021. doi:10.1016/j.autrev.2013.04.003
   PubMed Web of Science ®Google Scholar
• Jelusic M, Sestan M. IgA vasculitis or Henoch-Schönlein purpura: genetics and beyond. Pediatr Nephrol. 2021;36(8):2149–2153. doi:10.1007/s00467-021-04987-z
   PubMed Web of Science ®Google Scholar
• Lopez-Mejias R, Carmona FD, Castaneda S, et al. A genome-wide association study suggests the HLA class II region as the major susceptibility locus for IgA vasculitis. Sci Rep. 2017;7(1):5088. doi:10.1038/s41598-017-03915-2
   PubMedGoogle Scholar
• Koskela M, Nihtilä J, Ylinen E, et al. HLA-DQ and HLA-DRB1 alleles associated with Henoch-Schönlein purpura nephritis in Finnish pediatric population: a genome-wide association study. Pediatr Nephrol. 2021;36(8):2311–2318. doi:10.1007/s00467-021-04955-7
   PubMed Web of Science ®Google Scholar
• Hastings MC, Rizk DV, Kiryluk K, et al. IgA vasculitis with nephritis: update of pathogenesis with clinical implications. Pediatr Nephrol. 2022;37(4):719–733. doi:10.1007/s00467-021-04950-y
   PubMed Web of Science ®Google Scholar
• Hwang HH, Lim IS, Choi B, Yi DY. Analysis of seasonal tendencies in pediatric Henoch–Schönlein purpura and comparison with outbreak of infectious diseases. Medicine. 2018;97(36):e12217. doi:10.1097/MD.0000000000012217
   PubMed Web of Science ®Google Scholar
• Weiss PF, Klink AJ, Luan X, et al. Temporal association of streptococcus, staphylococcus, and parainfluenza pediatric hospitalizations and hospitalized cases of Henoch-Schönlein purpura. The Journal of Rheumatology. 2010;37(12):2587–2594. doi:10.3899/jrheum.100364
   PubMed Web of Science ®Google Scholar
• Gonzalez LM, Janniger CK, Schwartz RA. Pediatric Henoch-Schönlein purpura. Int J Dermatol. 2009;48(11):1157–1165. doi:10.1111/j.1365-4632.2009.04162.x
   PubMed Web of Science ®Google Scholar
• Suzuki H, Raska M, Yamada K, et al. Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes. J Biol Chem. 2014;289(8):5330–5339. doi:10.1074/jbc.M113.512277
   PubMed Web of Science ®Google Scholar
• Heineke MH, Ballering AV, Jamin A, Ben Mkaddem S, Monteiro RC, Van Egmond M. New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura). Autoimmun Rev. 2017;16:1246–1253.
   PubMed Web of Science ®Google Scholar
• Pillebout E, Jamin A, Ayari H, et al. Biomarkers of IgA vasculitis nephritis in children. PLoS One. 2017;12:e0188718.
   PubMed Web of Science ®Google Scholar
• Chen JY, Mao JH. Henoch-Schönlein purpura nephritis in children: incidence, pathogenesis and management. World J Pediatr. 2015;11:29–34.
   PubMed Web of Science ®Google Scholar
• Jelusic M, Sestan M, Cimaz R, Ozen S. Different histological classifications for Henoch-Schönlein purpura nephritis: which one should be used? Pediatr Rheumatol Online J. 2019;17:10.
   PubMed Web of Science ®Google Scholar
• Goldstein AR, White RHR, Akuse R, Chantler C. Long-term follow-up of childhood Henoch-Schönlein nephritis. Lancet. 1992;339:280–282.
   PubMed Web of Science ®Google Scholar
• Oni L, Sampath S. Childhood IgA vasculitis (Henoch Schonlein purpura) - advances and knowledge gaps. Front Pediatr. 2019;7:257.
   PubMed Web of Science ®Google Scholar
• Sestan M, Srsen S, Kifer N, et al. Persistence and severity of cutaneous manifestations in IgA vasculitis is associated with development of IgA vasculitis nephritis in children. Dermatology. 2022;238:340–346.
   PubMed Web of Science ®Google Scholar
• Sestan M, Kifer N, Frkovic M, et al. Gastrointestinal involvement and its association with the risk for nephritis in IgA vasculitis. Ther Adv Musculoskelet Dis. 2021;13:1759720X211024828.
   PubMed Web of Science ®Google Scholar
• Rajagopala S, Shobha V, Devaraj U, D’Souza G, Garg I. Pulmonary hemorrhage in Henoch-Schönlein purpura: case report and systematic review of the English literature. Semin Arthritis Rheum. 2013;42:391–400.
   PubMed Web of Science ®Google Scholar
• Ozen S, Marks SD, Brogan P, et al. European consensus-based recommendations for diagnosis and treatment of immunoglobulin A vasculitis-the SHARE initiative. Rheumatology. 2019;58:1607–1616.
   PubMed Web of Science ®Google Scholar
• Jelusic M, Sestan M, Giani T, Cimaz R. New insights and challenges associated with IgA vasculitis and IgA vasculitis with nephritis-is it time to change the paradigm of the most common systemic vasculitis in childhood? Front Pediatr. 2022;10:853724.
   PubMed Web of Science ®Google Scholar
• Counahan R, Winterborn MH, White RH, et al. Prognosis of Henoch-Schonlein nephritis in children. BMJ. 1977;2:11–14.
   PubMedGoogle Scholar
• Haas M. IgA nephropathy and Henoch-Schönlein Purpura nephritis. In: Jennette JC, Olson JC, Schwartz MM, Silva FG, editors. Heptinstall’s Pathology of the Kidney. Philadelphia: Lippincott, Williams & Wilkins; 2007:423–486.
   Google Scholar
• Trimarchi H, Barratt J, Cattran DC, et al. Oxford classification of IgA nephropathy 2016: an update from the IgA nephropathy classification working group. Kidney Int. 2017;91:1014–1021.
   PubMed Web of Science ®Google Scholar
• Haas M. Histologic subclassification of IgA nephropathy: a clinicopathologic study of 244 cases. Am J Kidney Dis. 1997;29:829–842.
   PubMed Web of Science ®Google Scholar
• Koskela M, Ylinen E, Ukonmaanaho E-M, et al. The ISKDC classification and a new semiquantitative classification for predicting outcomes of Henoch-Schönlein purpura nephritis. Pediatr Nephrol. 2017;32:1201–1209.
   PubMed Web of Science ®Google Scholar
• Davin JC. Henoch-Schönlein Purpura nephritis: pathophysiology, treatment, and future strategy. Clin J Am Soc Nephrol. 2011;6:679–689.
   PubMed Web of Science ®Google Scholar
• Yu B, Shi S, Hou W, et al. Evaluation of the Oxford classification in immunoglobulin A vasculitis with nephritis: a cohort study and meta-analysis. Clin Kidney J. 2020;14:516–525.
   PubMed Web of Science ®Google Scholar
• Kifer N, Bulimbasic S, Sestan M, et al. SQC and Oxford classifications predict poor renal outcome better than ISKDC and Haas in patients with IgAV nephritis: a multicenter study. J Nephrol. 2022;2022:1.
   Google Scholar
• Brogan P, Eleftheriou D. Vasculitis update: pathogenesis and biomarkers. Pediatr Nephrol. 2018;33:187–198.
   PubMed Web of Science ®Google Scholar
• Williams CEC, Toner A, Wright RD, Oni L. A systematic review of urine biomarkers in children with IgA vasculitis nephritis. Pediatr Nephrol. 2021;36:3033–3044.
   PubMedGoogle Scholar
• Fang X, Wu H, Lu M, et al. Urinary proteomics of Henoch-Schönlein purpura nephritis in children using liquid chromatography-tandem mass spectrometry. Clin Proteomics. 2020;17:10.
   PubMed Web of Science ®Google Scholar
• Sun L, Xie B, Zhang Q, et al. Biomarkers identification by a combined clinical and metabonomics analysis in Henoch-Schonlein purpura nephritis children. Oncotarget. 2017;8:114239–114250.
   PubMedGoogle Scholar
• Demir S, Kaplan O, Celebier M, et al. Predictive biomarkers of IgA vasculitis with nephritis by metabolomic analysis. Semin Arthritis Rheum. 2020;50:1238–1244.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Lai LY, Cai YY, et al. Serum-urine matched metabolomics for predicting progression of Henoch-Schonlein purpura nephritis. Front Med. 2021;8:657073.
   Web of Science ®Google Scholar
• Bhimma R, Nandlal L. Henoch-Schonlein Purpura (IgA Vasculitis). Available from: https://emedicine.medscape.com/article/984105-overview. Accessed February 27, 2023.
   Google Scholar
• Dolezalova P, Price-Kuehne FE, Özen S, et al. Disease activity assessment in childhood vasculitis: development and preliminary validation of the Paediatric Vasculitis Activity Score (PVAS). Ann Rheum Dis. 2013;72:1628–1633.
   PubMed Web of Science ®Google Scholar
• Dolezalova P, Wilkinson N, Brogan PA, et al. SAT0286 Paediatric vasculitis damage index: a new tool for standardised disease assessment. Ann Rheum Dis. 2014;73:696.
   Web of Science ®Google Scholar
• Peruzzi L, Coppo R. IgA vasculitis nephritis in children and adults: one or different entities? Pediatr Nephrol. 2021;36:2615–2625.
   PubMed Web of Science ®Google Scholar
• Abu-Zaid MH, Salah S, Lotfy HM, et al. Consensus evidence-based recommendations for treat-to-target management of immunoglobulin A vasculitis. Ther Adv Musculoskelet Dis. 2021;13:1759720X211059610.
   PubMed Web of Science ®Google Scholar
• Ronkainen J, Nuutinen M, Koskimies O. The adult kidney 24 years after childhood Henoch-Schonlein purpura: a retrospective cohort study. Lancet. 2002;360:666–670.
   PubMed Web of Science ®Google Scholar
• Radhakrishnan J, Cattran DC. The KDIGO practice guideline on glomerulonephritis: reading between the (guide) lines–application to the individual patient. Kidney Int. 2012;82:840–856.
   PubMed Web of Science ®Google Scholar
• Crayne CB, Eloseily E, Mannion ML, et al. Rituximab treatment for chronic steroid dependent Henoch-Schonlein purpura: 8 cases and a review of the literature. Pediatr Rheumatol Online J. 2018;16:71.
   PubMed Web of Science ®Google Scholar
• Fellström BC, Barratt J, Cook H, et al. Targeted-release budesonide versus placebo in patients with IgA nephropathy (NEFIGAN): a double-blind, randomised, placebo-controlled phase 2b trial. Lancet. 2017;389:2117–2127.
   PubMed Web of Science ®Google Scholar
• Van de Perre E, Smith RM, Bardsley V, Crawley C, Willcocks LC, Jayne DR. Successful outcome using bortezomib in adult refractory IgA vasculitis: a case report. Rheumatology. 2016;55:2089–2091.
   PubMed Web of Science ®Google Scholar
• Hernández-Rodríguez J, Carbonell C, Mirón-Canelo JA, Diez-Ruiz S, Marcos M, Chamorro AJ. Rituximab treatment for IgA vasculitis: a systematic review. Autoimmun Rev. 2020;19:102490.
   PubMed Web of Science ®Google Scholar
• Rizk DV, Maillard N, Julian BA, et al. The emerging role of complement proteins as a target for therapy of IgA nephropathy. Front Immunol. 2019;10:504.
   PubMed Web of Science ®Google Scholar
• McAdoo SP, Prendecki M, Tanna A, et al. Spleen tyrosine kinase inhibition is an effective treatment for established vasculitis in a pre-clinical model. Kidney Int. 2020;97:1196–1207.
   PubMed Web of Science ®Google Scholar