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ORIGINAL RESEARCH

The Feasibility of C-Reactive Protein Point-of-Care Testing to Reduce Overuse of Antibiotics in Children with Acute Respiratory Tract Infections in Rural Kyrgyzstan: A Pilot Study

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Pages 67-76 | Received 06 Jul 2023, Accepted 30 Dec 2023, Published online: 12 Feb 2024

References

  • van Gageldonk-Lafeber AB, van der Sande MAB, Heijnen MLA, Peeters MF, Bartelds AIM, Wilbrink B. Risk factors for acute respiratory tract infections in general practitioner patients in The Netherlands: a case-control study. BMC Infect Dis. 2007;7:1–8. doi:10.1186/1471-2334-7-35
  • Shalabayeva BS, Asheraliyev MY, Kabylova ET, Cherikchiyeva AB. Standardized approaches in the diagnosis and therapy of children with acute diseases of the respiratory and gastrointestinal tract in conditions of short-stay departments. Med J West Kazakhstan. 2018;3(59):34–39.
  • Hug L, Sharrow D, You DL. Trends in child mortality. New York; 2017. Available from: http://www.childmortality.org/files_v21/download/IGMEreport.2017.child.mortality.final.pdf. Accessed January 31, 2024.
  • Liu L, Oza S, Hogan D, et al. Global, regional, and national causes of child mortality in 2000 – 13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet. 2015;385:430–440. doi:10.1016/S0140-6736(14)61698-6
  • Nurmatov ZS. Assessment of the costs associated with outpatient and inpatient treatment of ARVI and influenza and its complications. Epidemiol Vaccinal Prev. 2015;14(5):26–30. doi:10.31631/2073-3046-2015-14-5-26-30
  • Nurmatov Z. Influenza and ARVI in Kyrgyzstan. Russ J Infect Immun. 2015;4:365–374. doi:10.15789/2220-7619-2014-4-365-374
  • Ibraimova A, Akkazieva B, Ibraimov A, Manzhieva E, Rechel B. Kyrgyzstan: health system review. Health Syst Transit. 2011;13:3.
  • World Health Organization. Regional Office for Europe and Policies, Health care systems in transition: Kyrgyzstan. Copenhagen PP - Copenhagen: World Health Organization. Regional Office for Europe; 2000. Available from: https://apps.who.int/iris/handle/10665/108323. Accessed January 31, 2024.
  • Østergaard MS, Kaplan A. Recurrent lower respiratory illnesses among young children in rural Kyrgyzstan: overuse of antibiotics and possible under-diagnosis of asthma. A qualitative FRESH AIR study. NPJ Prim Care Respir Med. 2018;28:1. doi:10.1038/s41533-018-0081-y
  • Smith B. Promoting Rational Use of Antibiotics in the Kyrgyz Republic. In: Marquez LR, editor. Improv Heal. Care Low- Middle-Income Ctries. A Case B. Springer International Publishing; 2020. Available from: https://www.ncbi.nlm.nih.gov/books/NBK565742/. Accessed January 31, 2024.
  • World Health Organization. (2015) Global action plan on antimicrobial resistance; 2017. Available from: www.who.int/antimicrobial-resistance/publications/global-action-plan/en/. Accessed January 31, 2024.
  • Klein EY, Van Boeckel TP, Martinez EM, et al. Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proc Natl Acad Sci U S A. 2018;115(15):E3463–E3470. doi:10.1073/pnas.1717295115
  • Baktygul K, Marat B, Ashirali Z, Harun-Or-rashid M, Sakamoto J. An assessment of antibiotics prescribed at the secondary health-care level in the Kyrgyz Republic. Nagoya J Med Sci. 2011;73(3–4):157–168.
  • Fridkin SK, Hageman J, McDougal LK, et al. Vancomycin-Intermediate Staphylococcus aureus Epidemiology Study Group. Epidemiological and microbiological characterization of infections caused by Staphylococcus aureus with reduced susceptibility to vancomycin, United States, 1997–2001. Clin Infect Dis. 2003;36:429–439. doi:10.1086/346207
  • Long SW, Olsen RJ, Mehta SC, et al. PBP2a mutations causing high-level Ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates. Antimicrob Agents Chemother. 2014;58:6668–6674. doi:10.1128/AAC.03622-14
  • Sproston NR, Ashworth JJ. Role of C-reactive protein at sites of inflammation and infection. Front Immunol. 2018;9:1–11. doi:10.3389/fimmu.2018.00754
  • Bernstein D, Coster D, Berliner S, et al. C-reactive protein velocity discriminates between acute viral and bacterial infections in patients who present with relatively low CRP concentrations. BMC Infect Dis. 2021;21(1):1–7. doi:10.1186/s12879-021-06878-y
  • Lelubre C, Anselin S, Zouaoui Boudjeltia K, Biston P, Piagnerelli M. Interpretation of c-reactive protein concentrations in critically Ill patients. BioMed Res Int. 2013;2013:1–11. doi:10.1155/2013/124021
  • Smedemark SA, Aabenhus R, Llor C, Fournaise A, Olsen O, Jørgensen KJ. Biomarkers as point-of-care tests to guide prescription of antibiotics in people with acute respiratory infections in primary care. Cochrane Database Syst Rev. 2022;10(10):CD010130. doi:10.1002/14651858.CD010130.pub3
  • Cooke J, Llor C, Hopstaken R, Dryden M, Butler C. Respiratory tract infections (RTIs) in primary care: narrative review of C reactive protein (CRP) point-of-care testing (POCT) and antibacterial use in patients who present with symptoms of RTI. BMJ Open Respir Res. 2020;7:1. doi:10.1136/bmjresp-2020-000624
  • Wakeman M, Cork T, Watwood D. Point-of-care C-reactive protein testing in community pharmacy to deliver appropriate interventions in respiratory tract infections. Clin Pharm CP. 2018;10:5. doi:10.1211/PJ.2018.20204635
  • Martínez-González NA, Keizer E, Plate A, et al. Point-of-care C-reactive protein testing to reduce antibiotic prescribing for respiratory tract infections in primary care: systematic review and meta-analysis of randomised controlled trials. Antibiotics. 2020;9:9. doi:10.3390/antibiotics9090610
  • Althaus T, Greer RC, Swe MMM, et al. Effect of point-of-care C-reactive protein testing on antibiotic prescription in febrile patients attending primary care in Thailand and Myanmar: an open-label, randomised, controlled trial. Lancet Glob Heal. 2019;7(1):e119–e131. doi:10.1016/S2214-109X(18)30444-3
  • Samet JM, Wipfli H, Platz EA, Bhavsar N. A dictionary of epidemiology, fifth edition: edited by Miquel Porta. Am J Epidemiol. 2009;170(11):1449–1451. doi:10.1093/aje/kwp322
  • Isaeva E, Bloch J, Poulsen A, et al. C reactive protein-guided prescription of antibiotics for children under 12 years with respiratory symptoms in Kyrgyzstan: protocol for a randomised controlled clinical trial with 14 days follow-up. BMJ Open. 2023;13(4):e066806. doi:10.1136/bmjopen-2022-066806
  • Sealed Envelope Ltd. Simple randomisation service; 2022. Available from: https://www.sealedenvelope.com/simple-randomiser/v1/. Accessed May 1, 2023.
  • Nabulsi M, Khalil Y, Makhoul J. Parental attitudes towards and perceptions of their children’s participation in clinical research: a developing-country perspective. J Med Ethics. 2011;37(7):420–423. doi:10.1136/jme.2010.035899
  • Hardy V, Thompson M, Keppel GA, et al. Qualitative study of primary care clinicians’ views on point-of-care testing for C-reactive protein for acute respiratory tract infections in family medicine. BMJ Open. 2017;7(1):1–6. doi:10.1136/bmjopen-2016-012503
  • Jenish N. ICT-driven technological and industrial upgrading in Afghanistan, Kyrgyzstan and Tajikistan: current realities and opportunities. SSRN Electron J. 2021. doi:10.2139/ssrn.3807763
  • Huang Y, Chen R, Wu T, Wei X, Guo A. Association between point-of-care CRP testing and antibiotic prescribing in respiratory tract infections: a systematic review and meta-analysis of primary care studies. Br J Gen Pract. 2013;63(616):787–794. doi:10.3399/bjgp13X674477
  • Yebyo H, Medhanyie AA, Spigt M, Hopstaken R. C-reactive protein point-of-care testing and antibiotic prescribing for acute respiratory tract infections in rural primary health centres of North Ethiopia: a cross-sectional study. NPJ Prim Care Respir Med. 2016;26:15076. doi:10.1038/npjpcrm.2015.76
  • Joshi A, Perin DP, Gehle A, Nsiah-Kumi PA. Feasibility of using C-reactive protein for point-of-care testing. Technol Heal Care off J Eur Soc Eng Med. 2013;21(3):233–240. doi:10.3233/THC-130720
  • Jakobsen KA, Melbye H, Kelly MJ, et al. Influence of CRP testing and clinical findings on antibiotic prescribing in adults presenting with acute cough in primary care. Scand J Prim Health Care. 2010;28(4):229–236. doi:10.3109/02813432.2010.506995
  • Melbye H, Stocks N. Point of care testing for C-reactive protein - A new path for Australian GPs? Aust Fam Physician. 2006;35(7):513–517.
  • Marquez LR. Improving health care in low- and middle-income countries. Cham. 2020. doi:10.1007/978-3-030-43112-9
  • Zh.Ysykeeva NA. Medicine Prices, Availability, Affordability in Kyrgyz Republic Report of a survey conducted September to October 2015 MeTA Project in Kyrgyzstan (Medicines Transparency Alliance) Bishkek; 2015.
  • Dyson MP, Shave K, Gates A, et al. Which outcomes are important to patients and families who have experienced paediatric acute respiratory illness? Findings from a mixed methods sequential exploratory study. BMJ open. 2017;7(12):e018199. doi:10.1136/bmjopen-2017-018199