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Editorial

Futuristic Senolytic Drug Incorporated Nanomedicine Therapy to Treat Osteoarthritis

ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 837-840 | Received 02 Dec 2023, Accepted 15 Feb 2024, Published online: 01 Mar 2024

References

  • Di Micco R , KrizhanovskyV , BakerD , D’addaDi Fagagna F. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat. Rev. Mol. Cell Biol.22(2), 75–95 (2021).
  • Campisi J . Aging, cellular senescence, and cancer. Annu. Rev. Physiol.75, 685–705 (2013).
  • Onishi K , UtturkarA , ChangE , PanushR , HataJ , Perret-KarimiD. Osteoarthritis: a critical review. Crit. Rev. Phys Rehabil. Med.24(3–4), 251–264 (2012).
  • Astrike-Davis EM , CoryellP , LoeserRF. Targeting cellular senescence as a novel treatment for osteoarthritis. Curr. Opin. Pharmacol.64, 102213 (2022).
  • Mcculloch K , LitherlandGJ , RaiTS. Cellular senescence in osteoarthritis pathology. Aging Cell16(2), 210–218 (2017).
  • Acosta JC , BanitoA , WuestefeldTet al. A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat. Cell Biol.15(8), 978–990 (2013).
  • Pfander D , KörtjeD , ZimmermannRet al. Vascular endothelial growth factor in articular cartilage of healthy and osteoarthritic human knee joints. Ann. Rheum. Dis.60(11), 1070–1073 (2001).
  • Hashimoto S , Creighton-AchermannL , TakahashiK , AmielD , CouttsRD , LotzM. Development and regulation of osteophyte formation during experimental osteoarthritis. Osteoarthr. Cartil.10(3), 180–187 (2002).
  • Philipot D , GueritD , PlatanoDet al. p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis. Arthritis Res. Ther.16(1), R58 (2014).
  • Neuhold LA , KillarL , ZhaoWet al. Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. J. Clin. Invest.107(1), 35–44 (2001).
  • Farr JN , FraserDG , WangHet al. Identification of senescent cells in the bone microenvironment. J. Bone Miner. Res.31(11), 1920–1929 (2016).
  • Jeon OH , DavidN , CampisiJ , ElisseeffJH. Senescent cells and osteoarthritis: a painful connection. J. Clin. Invest.128(4), 1229–1237 (2018).
  • Shane Anderson A , LoeserRF. Why is osteoarthritis an age-related disease?Best Pract. Res. Clin. Rheumatol.24(1), 15–26 (2010).
  • Kirkland JL , TchkoniaT. Senolytic drugs: from discovery to translation. J. Int. Med.288(5), 518–536 (2020).
  • Jha SK , ImranM , PaudelKR , MohammedY , HansbroP , DuaK. Treating primary lymphoma of the brain in AIDS patients via multifunctional oral nanoparticulate systems. Nanomedicine17(7), 425–429 (2022).
  • Maharjan R , PangeniR , JhaSKet al. Anti-angiogenic effect of orally available pemetrexed for metronomic chemotherapy. Pharmaceutics11(7), 1–22 (2019).
  • Xiao L , CuiJ , SunZ , LiuY , ZhengJ , DongY. Therapeutic potential of nanotechnology-based approaches in osteoarthritis. Front. Pharmacol.13, 920824 (2022).
  • Munoz-Espin D , RoviraM , GalianaIet al. A versatile drug delivery system targeting senescent cells. EMBO Mol. Med.10(9), 1–18 (2018).
  • Xu T , CaiY , ZhongXet al. β-Galactosidase instructed supramolecular hydrogelation for selective identification and removal of senescent cells. Chem. Commun.55(50), 7175–7178 (2019).
  • Ge M , HuL , AoH , ZiM , KongQ , HeY. Senolytic targets and new strategies for clearing senescent cells. Mech. Ag. Dev.195, 111468 (2021).
  • Amor C , FeuchtJ , LeiboldJet al. Senolytic CAR T cells reverse senescence-associated pathologies. Nature583(7814), 127–132 (2020).
  • Rabiei M , KashanianS , SamavatiSS , DerakhshankhahH , JamasbS , McinnesSJ. Nanotechnology application in drug delivery to osteoarthritis (OA), rheumatoid arthritis (RA), and osteoporosis (OSP). J. Drug Deliv. Sci. Technol.61, 102011 (2021).
  • Robbins PD , JurkD , KhoslaSet al. Senolytic drugs: reducing senescent cell viability to extend health span. Annu. Rev. Pharmacol. Toxicol.61, 779–803 (2021).
  • Jha SK , KumarB , PaudelKR , BandyopadhyayA. The application of bioglass to treat osteoarthritis. EXCLI J.22, 1232–1234 (2023).

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