9
Views
7
CrossRef citations to date
0
Altmetric
Original Article

Differential Inhibitory Effects of Serine/Threonine Phosphatase Inhibitors and a Calmodulin Antagonist on Phosphoinositol/Calcium- and Cyclic Adenosine Monophosphate-Mediated Pancreatic Amylase Secretion

, , , , , & show all
Pages 384-391 | Received 12 Apr 1994, Accepted 10 Aug 1994, Published online: 08 Jul 2009

References

  • Schmidt W E, Seebeck J, Höcker M, Schwarzhoff R, Schäfer H, Fornefeld H, et al. PACAP and VIP stimulate enzyme secretion in rat pancreatic acini via interaction with VIP/PACAP-2 receptors: additive augmentation of CCK/carbachol-induced enzyme release. Pancreas 1993; 8: 476–87
  • Williams J A, Yule D I. Stimulus-secretion coupling in pancreatic acinar cells. The pancreas—biology, pathobiology and disease, V LW Go, E P Dimagno, J D Gardner, E Lebenthal, H A Rebcr, G A Scheele. Raven Press, New York 1993; 167–91
  • Cohen P. The role of protein phosphorylation in neural and hormonal control of cellular activity. Nature 1982; 296: 613–20
  • Burnham D B, Williams J A. Effects of carbachol, cholecystokinin and insulin on protein phosphorylation in isolated pancreatic acini. J Biol Chem 1982; 257: 10523–8
  • Burnham D B, Munowitz P, Hootmann S R, Williams J A. Regulation of protein phosphorylation in pancreatic acini. Biochem J 1986; 235: 125–31
  • Burnham D B, Sung C K, Munowitz P, Williams J A. Regulation of protein phosphorylation in pancreatic acini by cyclic AMP-mediated secretagogues: interaction with carbamylcholine. Biochem Biophys Acta 1988; 169: 33–9
  • Lutz M P, Pinon D I, Gates L K, Shenolikar S, Miller L J. Control of cholecystokinin receptor dephosphorylation in pancreatic acinar cells. J Biol Chem 1993; 268: 12136–2
  • Biolojan C, Takai A. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Biochem J 1988; 256: 283–90
  • Cohen P, Holmes C FB, Tsukitani Y. Okadaic acid: a new probe for the study of cellular regulation. TIBS 1990; 15: 98–102
  • Wagner A CC, Wishart M J, Yule D I, Williams J A. Effects of okadaic acid indicate a role for dephosphorylation in pancreatic stimulus-secretion coupling. Am J Physiol 1992; 263: C1172–80
  • Ishihara H, Martin B, Brantigan D L, Karaki H, Ozaki H, Kato Y, et al. Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem Biophys Res Commun 1989; 159: 871–7
  • Suganuma M, Fujiki H, Okabe S, Nishiwaki S, Brantigan D, Ingebritsen T, et al. Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity. Toxicon 1992; 30: 873–8
  • Wagner A CC, Schäfer C, Williams J A. Effects of calyculin A on amylase release in streptolysin-O permeabilized acinar cells. Biochem Biophys Res Commun 1993; 189: 1606–12
  • Liu J, Farmer J D, Lane W S, Friedman J, Weissman I, Schreiber S L. Calcineurin is a common target of cyclophilin-cyclosporine A and FKBP-FK506 complexes. Cell 1991; 66: 807–15
  • Waschulewski I H, Hall D V, Kern H F, Edwardson J M. Effect of the immunosuppressants cyclosporinc A and FK 506 on exocytosis in the rat exocrine pancreas in vitro. Br J Pharmacol 1993; 108: 892–900
  • Höcker M, Waschulewski I H, Domagk K, Schwarzhoff R, Kern H F, Fölsch U R, et al. Cyclosporinc A inhibits protein kinase C-mcdiated amylase release from isolated rat pancreatic acini. Digestion 1994; 55: 380–8
  • Tanaka T, Hidaka H. Calcium signalling of calcium-binding proteins and drug actions. Adv Exp Med Biol 1989; 255: 165–71
  • Ishiguro H, Hayakawa T, Kondo T, Shibata T, Kitagawa M, Sakai Y, et al. Effects of calmodulin inhibitors on amylase secretion from rat pancreatic acini. Digestion 1992; 53: 162–70
  • Hocker M, Schmidt W E, Creutzfeldt W, Roy Choudhury A, Nustede R, Schafmayer A, et al. Determination of plasma CCK concentrations by bioassay and specific radioimmunoassay in man. A critical evaluation. Regul Pept 1992; 37: 255–69
  • Kruse-Jarres J D, Kaiser C, Hafkenscheid J C, Hohenwallner W, Stein W, Bohner J, et al. Evaluation of a new alpha-amylase assay using 4.6-ethylidene-(G7)-1–4-nitrophenyl-(G1)-alpha-D-maltoheptasoide as substrate. J Clin Chem Clin Biochem 1989; 27: 103–7
  • Schäfer H, Schwarzhoff R, Creutzfeldt W, Schmidt W E. Characterization of a G-protein coupled receptor for pituitary adenlyate cyclase activating peptide on plasma membranes from rat brain. Eur J Biochem 1991; 202: 951–8
  • Grynkiewicz G, Poenie M, Tsien R Y. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985; 260: 3440–50
  • Theodorsson-Norheim E. Friedman and Quade tests: basic computer program to perform nonparametric two-way analysis of variance and multiple comparisons on ranks of several related samples. Comp Biol Med 1987; 17: 85–99
  • Davidson H W, McGowan C H, Balch W E. Evidence for the regulation of exocytotic transport by protein phosphorylation. J Cell Biol 1992; 116: 1343–55
  • Doi R, Inoue K, Chowdhury P, Rayford P L. Biochemical characterization of the effects of FK 506 on signal transduction in exocytotic function of rat pancreatic acini. J Pharmacol Exp Ther 1993; 264: 873–8
  • Botana L M, MacGlashan D W, Jr. Effect of okadaic acid on human basophil secretion. Biochem Pharmacol 1993; 45: 2311–5
  • Yanagihara N, Toyohira Y, Koda Y, Wada A, Izumi F. Inhibitory effect of okadaic acid on carbachol-evoked secretion of catecholamines in cultered bovine adrenal medullary cells. Biochem Biophys Res Commun 1991; 174: 77–83
  • Takuma T, Ichida T. Okadaic acid inhibits amylase exocytosis from parotid acini stimulated by cyclic AMP. FEBS Lett 1991; 285: 124–6
  • Meyer-Alber A, Fetz I, Waschulewski I H, Höcker M, Fölsch U R, Schmidt W E. Calyculin A, okadaic acid and W-7 interfere with a distal step in pancreatic acinar signal transduction. Biochem Biophys Res Commun 1994; 201: 1470–6
  • Hultsch T, Albers M W, Schreiber S L, Hohmann R J. Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription. Proc Natl Acad Sci USA 1991; 88: 6229–33
  • Vandermeers A, Vandermeers-Piret M C, Rathe J, Jutzner R, Delforge A, Christophe J. A calcium dependent protein activator of guanosin 3′:5′-monophosphate phosphodiesterase in bovine and rat pancreas. Eur J Biochem 1977; 81: 379–86
  • Ingebritsen T S, Cohen P. The protein phosphatases involved in cellular regulation. I. Classification and substrate specificities. Eur J Biochem 1983; 132: 255–61
  • Tallant E A, Cheung W Y. Calmodulin-dependent protein phosphatase: a developmental study. Biochemistry 1983; 22: 3630–5
  • Wood J G, Wallace P W, Whitaker J W, Cheung W Y. Immunocytochemical localization of calmodulin binding protein (Cam-BP80) in basal ganglia of mouse brain. J Cell Biol 1980; 84: 66–76
  • Bartelt D C, Wolff D J, Scheele G A. Calmodulin-binding proteins and calmodulin-regulated enzymes in dog pancreas. Biochem J 1986; 240: 753–63
  • MacLean C M, Marciniak S J, Hall D V, Edwardson J M. Involvement of a phosphoprotein on the zymogen granule membrane in the control of regulated exocytosis in the exocrine pancreas. J Cell Sci 1993; 106: 663–70
  • MacLean C M, Marciniak S J, Waschulewski I H, Kern H F, Edwardson J M. A phosphoprotein on the zymogen granule membrane is involved in the control of exocytosis in the exocrine pancreas. Digestion 1993; 54: 292
  • Höcker M, Fornefeld H, Fetz I, Meyer-Alber A, Waschulewski I H, Agricola B, et al. Phosphatase 2b inhibitor okadaic acid inhibits cAMP- and IP3/CA2+ -mediated amylase release of isolated rat pancreatic acini. Digestion 1993; 54: 283
  • Meyer-Alber A, Waschulewski I H, Höcker M, Fetz I, Fornefeld H, Fölsch U R, et al. Differential inhibitory effects of serine/threonine phosphatase inhibitors and a calmodulin antagonist in Ca2+/IP3- and cAMP-mediated acinar amylase secretion. Gastroenterology 1994; 106: A307

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.