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Inhalation Toxicology
International Forum for Respiratory Research
Volume 22, 2010 - Issue 7
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Research Article

Metered-dose inhaler efficiency enhancement: A case study and novel design

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Pages 601-609 | Received 26 Oct 2009, Accepted 06 Jan 2010, Published online: 13 Apr 2010

References

  • Barry PW, O’Callaghan C. 1997. In vitro comparison of the amount of salbutamol available for inhalation from different formulations used with different spacer devices. Eur Respir J 10:1345–1348.
  • Bowes SM, Swift DL. 1989. Deposition of Inhaled particles in the oral airway during oronasal breathing. Aerosol Sci Technol 11:157–167.
  • Brocklebank D, Ram F, Wright J, Barry P, Cates C, Davies L, Douglas G, Muers M, Smith D, White J. 2001. Comparison of the effectiveness of inhaler devices in asthma and chronic obstruction airway disease. Health Technol Assess 5:1–149.
  • Chan TL, Lippmann M. 1980. Experimental measurement and empirical modeling of the regional deposition of inhaled particles in human. J Independ Hyg Assoc 41:399–409.
  • Cheng YS, Zhou Y, Chen B. 1999. Particle deposition in a cast of human oral airways. Aerosol Sci Technol 31:286–300.
  • Cheng YS, Fu CS, Yazzie D, Zhou Y. 2001. Respiratory deposition patterns of salbutamol pMDI with CFC and HFA-134a formulation in a human airway replica. J Aerosol Med 14:255–266.
  • Davis SS, Hardy JG, Newman SP, Wilding IR. 1992. Gamma scintigraphy in the evaluation of pharmaceutical dosage forms. Eur J Nucl Med Mol Imag 19:971–986.
  • Dehaan W, Finlay W. 2001. In In vitro Monodisperse aerosol deposition in a month and throat with six different inhalation devices. J Aerosol Med 14:361–367.
  • Dehaan W, Finlay W. 2004. Predicting extrathoracic deposition from dry powder inhalers. J Aerosol Sci 35:309–331.
  • Emmett PC, Aitken RJ, Hannan WJ. 1982. Measurements of total and regional deposition of inhaled particles in the human respiratory tract. J Aerosol Science 13:549–560.
  • Foord N, Black A, Walsh M. 1978. Regional Deposition of 2.5 – 7.5 μm Diameter Inhaled Particles in Healthy Male Non-Smokers. Journal of Aerosol Sci 9:283–390.
  • Fadl A, Wang J, Yang P, Zhang Z, Cheng Y. 2007a. Balloon based in vitro MDI aerosol deposition experiments on the effects of mouthpiece diameter. J Inhal Toxicol 19:505–515.
  • Fadl A, Wang J, Zhang Z, Cheng Y. 2007b. Effects of MDI spray angle on aerosol penetration efficiency through an oral airway cast. Int J Aerosol Sci 38:853–864.
  • Grgic B, Finlay WH, Heenan AF. 2004. Regional aerosol deposition and flow measurements in idealized mouth and throat. J Aerosol Sci 35:21–23.
  • Heenan AF, Finlay WH, Matida EA, Pollard A. 2003. Experimental measurements and computational modeling of the flow in an idealized extrathoracic airway. Exp Fluids 35:70–84.
  • Hochrainer D, Hölz H, Kreher C, Scaffidi L, Spallek M, Wachtel H. 2005. Comparison of the aerosol velocity and spray duration of Respimat® Soft Mist™ inhaler and pressurized metered dose inhalers. J Aerosol Med 18:273–282.
  • Johnson K. 1995. Inhalation drug delivery: Principles techniques and applications to product development. Notes for AAPS Short Course, Miami Beach, FL.
  • Kim CS, Garcia L. 1993. Delivery characteristics of albuterol powder aerosol by rotahaler. J Aerosol Med 2:199–211.
  • Lipmann M, Albert RE. 1969. The effect of particle size on the regional deposition of inhaled aerosol in the human respiratory tract. J Independ Hyg Assoc 30:257–275.
  • Lin T, Breysse P, Laube B, Swift D. 2001. Mouthpiece diameter affects deposition efficiency in cast models of human oral airway. J Aerosol Med 14:335–341.
  • Newman SP. 1985. Aerosol deposition considerations in inhalation therapy. Chest 88:125–160.
  • Newman SP, Clarke SW. 1983. Therapeutic aerosols. 1—Physical and practical considerations [editorial]. Thorax 38:881–886.
  • Newman SP, Clark AR, Talaee N, Clarks SW. 1989. Pressurized aerosol deposition in the human lung with and without an “open” spacer device. Thorax 44:706–710.
  • Newman SP, Brown J, Steed KP, Reader SJ, Kladders H. 1998. Lung deposition of fenoterol and flunisolide delivered using a novel device for inhaled medicines comparison of RESPIMAT with conventional metered-dose inhalers with and without spacer devices. Chest 113:957–963.
  • Stahilofen W, Gebhart J, Heyder J. 1980. Experimental determination of the regional deposition of aerosol in the human respiratory tract. J Independ Hyg Assoc 41:385–395.
  • Stahilofen W, Gebhart J, Heyder J, Scheuch G. 1983. New regional deposition date of the human respiratory tract. J Aerosol Med 2:285–308.
  • Swift DL. 1989. Design of aerosol delivery system to optimize regional deposition and agent utilization. J Aerosol Med 2:211–220.
  • Yu CP, Diu CK. 1983. Total and regional deposition of inhaled aerosol in humans. J Aerosol Sci 14:599–609.
  • Yue G, Fadl A, Barek T, Major J, Zhang Z. 2009. Experimental study of aerosol deposition in pulsating balloon structures. J Inhal Toxicol 21:215–222.
  • Zhang Y, Chia TL, Finlay WH, 2006. Experimental measurements and numerical study of particle deposition in highly idealized mouth-throat models. Aerosol Sci Technol 40:361–372.

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