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Inhalation Toxicology
International Forum for Respiratory Research
Volume 22, 2010 - Issue 10
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Research Article

Impact of variations in the chemical composition of vitreous mineral fibers on biopersistence in rat lungs and consequences for regulation

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Pages 817-827 | Received 09 Feb 2010, Accepted 01 Apr 2010, Published online: 21 May 2010

References

  • Bellmann B, Muhle H, Pott F. 1990. Untersuchung zur Beständigkeit chemisch unterschiedlicher Glasfasern in Rattenlungen. Zbl Hyg 190:310–314.
  • Bellmann B, Muhle H. 1997. Biopersistence of various types of mineral fibres in the rat lung after intratracheal application. Ann Occup Hyg 41(Suppl 1):298–303.
  • Bellmann B, Muhle H, Creutzenberg O, Ernst H, Brown RC, Sébastien P. 2001. Effects of nonfibrous particles on ceramic fiber (RCF1) toxicity in rats. Inhal Toxicol 13(10):877–901.
  • Bernstein DM, Morscheidt C, Grimm HG, Teichert U. 1996. The evaluation of soluble fibers using the inhalation biopersistence model, a nine fiber comparison. Inhal Toxicol 8:345–385.
  • Bernstein DM, Morscheidt C, De Meringo A, Schumm M, Grimm HG, Teichert U, Thevenaz P, Mellon L. 1997. The biopersistence of fibers following inhalation and intratracheal instillation exposure. Ann Occup Hyg 41(Suppl 1):224–230.
  • Bernstein DM, Riego-Sintes JM. 1999. Methods for the determination of the hazardous properties for human health of man made mineral fibers (MMMF), European Commission Joint Research Centre, Institute for Health and Consumer Protection, Unit: Toxicology and Chemical Substances. European Chemicals Bureau, 1–93. http://tsar.jrc.ec.europa.eu/documents/Testing-Methods/mmmfweb.pdf (Accessed April 27, 2010).
  • Bernstein DM, Riego Sintes JM, Ersboell BK, Kunert J. 2001a. Biopersistence of synthetic mineral fibers as a predictor of chronic inhalation toxicity in rats. Inhal Toxicol 13(10):823–849.
  • Bernstein DM, Riego Sintes JM, Ersboell BK, Kunert J. 2001b. Biopersistence of synthetic mineral fibers as a predictor of chronic intraperitoneal injection tumor response in rats. Inhal Toxicol 13(10):851–875.
  • Eastes W, Potter RM, Hadley JG. 2000. Estimating rock and slag wool fiber dissolution rate from composition. Inhal Toxicol 12(12):1127–1139.
  • Eastes W, Baron PA, Baier RE, Guldberg M, Potter R. 2007. Do vitreous fibers break in the lung? Inhal Toxicol 19(4):311–315.
  • European Commission. 1997. O.J. L 343/19 of 13 December 1997. Commission Directive 97/69/EC of 5 December 1997 adapting to technical progress for the 23rd time Council Directive 67/ 548/EEC on the approximation of the laws regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances. http://ecb.jrc.ec.europa.eu/documents/Classification-Labelling/DIRECTIVE_67-548-EEC/ATPS_OF_DIRECTIVE_67-548-EEC/23rd_ATP.pdf (Accessed April 27, 2010).
  • Gefahrstoffverordnung. 2008. German Hazardous Substances Ordinance of December 23, 2004 (last revised December 18, 2008). http://www.baua.de/nn_12292/de/Themen-von-A-Z/Gefahrstoffe/Rechtstexte/pdf/Gefahrstoffverordnung.pdf (Accessed April 27, 2010).
  • Guldberg M, Jensen SL, Knudsen T, Steenberg T, Kamstrup O. 2002. High-alumina low-silica HT stone wool fibers: A chemical compositional range with high biosolubility. Regul Toxicol Pharmacol 35(2 Pt 1):217–226.
  • Hesterberg TW, Miiller WC, Musselman RP, Kamstrup O, Hamilton RD, Thevenaz P. 1996. Biopersistence of man-made vitreous fibers and crocidolite asbestos in the rat lung following inhalation. Fundam Appl Toxicol 29(2):267–279.
  • Hesterberg TW, Hart GA, Chevalier J, Miiller WC, Hamilton RD, Bauer J, Thevenaz P. 1998a. The importance of fiber biopersistence and lung dose in determining the chronic inhalation effects of X607, RCF1, and chrysotile asbestos in rats. Toxicol Appl Pharmacol 153(1):68–82.
  • Hesterberg TW, Chase G, Axten C, Miller WC, Musselman RP, Kamstrup O, Hadley J, Morscheidt C, Bernstein DM, Thevenaz P. 1998b. Biopersistence of synthetic vitreous fibers and amosite asbestos in the rat lung following inhalation. Toxicol Appl Pharmacol 151:262–275.
  • International Life Sciences Institute (ILSI). 2005. Testing of fibrous particles: Short-term assays and strategies. Report of an ILSI Risk Science Institute Working Group. Inhal Toxicol 17:497–537.
  • Maxim LD, Hadley JG, Potter RM, Niebo R. 2006. The role of fiber durability/biopersistence of silica-based synthetic vitreous fibers and their influence on toxicology. Regul Toxicol Pharmacol 46(1):42–62.
  • Morgan A, Holmes A, Davison W. 1982. Clearance of sized glass fibres from the rat lung and their solubility in vivo. Ann Occup Hyg 25(3):317–331.
  • Morrow PE. 1988. Possible mechanisms to explain dust overloading of the lungs. Fundam Appl Toxicol 10(3):369–384.
  • Muhle H, Bellmann B, Pott F. 1994. Comparative investigations of the biodurability of mineral fibers in the rat lung. Environ Health Perspect 102(Suppl 5):163–168. http://ehp.niehs.nih.gov/members/1994/Suppl-5/muhle-full.html (Accessed April 27, 2010).
  • Muhle H, Bellmann B. 1995. Biopersistence of man-made vitreous fibres. Ann Occup Hyg 39(5):655–660.
  • Muhle H, Creutzenberg O, Bellmann B, Heinrich U, Mermelstein R. 1990. Dust overloading of lungs: Investigations of various materials, species differences, and irreversibility of effects. J Aerosol Med 3:S111–S128.
  • Muhle H, Bellmann B, Sebastian K, Böhm T. 1998. Persistenzuntersuchungen von Mineralfasern in vivo und in vitro und Entwicklung von Beurteilungskriterien für die Biobeständigkeit, In: BIA-Report 2/98: Fasern: Tests zur Abschätzung der Biobeständigkeit und zum Verstaubungsverhalten. Hauptverband der gewerblichen Berufsgenossenschaften: Sankt Augustin, Germany, pp. 29–272. http://www.dguv.de/ifa/de/pub/rep/pdf/rep02/biar0298/0298.pdf (Accessed April 27, 2010).
  • Potter RM, Mattson SM. 1991. Glass fiber dissolution in a physiological saline solution. Glastech Ber 64(1):16–28.
  • Schlesinger RB. 1995. Deposition and clearance of inhaled particles, In: McClellan RO, Henderson RF, editors. Concepts in Inhalation Toxicology. Washington DC, USA: Taylor and Francis, pp. 191–224.
  • Scholze H. 1991. Glass, Nature, Structure, and Properties, Springer-Verlag New York, Inc.
  • Technische Regeln für Gefahrstoffe (TRGS) 905. Bundesarbeitsblatt (8/9 2005). http://www.baua.de/nn_5846/de/Themen-von-A-Z/Gefahrstoffe/TRGS/pdf/TRGS-905.pdf (Amendment to TRGS 905. (2002). Text see at) http://www.baua.de/nn_17206/de/Themen-von-A-Z/Gefahrstoffe/TRGS/pdf/905/905-anorganische-fasern.pdf (Accessed April 27, 2010).
  • Snipes MB. 1995. Pulmonary retention of particles and fibers: Biokinetics and effects of exposure concentration, In: McClellan OO, Henderson RF, editors. Concepts in inhalation toxicology. Washington DC, USA: Taylor and Francis, pp. 225–255.
  • Wardenbach P. 1998. Wissenschaftlich fragwürdige EU-Richtlinie zur Einstufung von künstlichen Mineralfasern verabschiedet. AS 2.2-92112. Gefahrstoffe-Reinhalt Luft 58:81–84.
  • Yu CP, Dai YT, Boymel PM, Zoitos BK, Oberdörster G, Utell MJ. 1998. A clearance model of man-made vitreous fibers (MMVFs) in the rat lung. Inhal Toxicol 10:253–274.

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