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Inhalation Toxicology
International Forum for Respiratory Research
Volume 22, 2010 - Issue 11
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Research Article

Pentoxifylline inhibits intercellular adhesion molecule-1 (ICAM-1) and lung injury in experimental phosgene-exposure rats

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Pages 889-895 | Received 17 Feb 2010, Accepted 11 May 2010, Published online: 22 Jun 2010

References

  • Abraham E. 2003. Neutrophils and acute lung injury. Crit Care Med 31:S195–S199.
  • Akgür FM, Zibari GB, McDonald JC, Granger DN, Brown MF. 1999. Effects of dextran and pentoxifylline on hemorrhagic shock-induced P-selectin expression. J Surg Res 87:232–238.
  • Albelda SM, Smith CW, Ward PA. 1994. Adhesion molecules and inflammatory injury. FASEB J 8:504–512.
  • Aldridge AJ. 2002. Role of the neutrophil in septic shock and the adult respiratory distress syndrome. Eur J Surg 168:204–214.
  • Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM. 1998. The American-European Consensus Conference on ARDS, part 2. Ventilatory, pharmacologic, supportive therapy, study design strategies and issues related to recovery and remodeling. Intensive Care Med 24:378–398.
  • Balázs C, Kiss E. 1994. Immunological aspects of the effect of pentoxifylline (Trental) (a brief review). Acta Microbiol Immunol Hung 41:121–126.
  • Bella J, Kolatkar PR, Marlor CW, Greve JM, Rossmann MG. 1999. The structure of the two amino-terminal domains of human intercellular adhesion molecule-1 suggests how it functions as a rhinovirus receptor. Virus Res 62:107–117.
  • Bessler H, Gilgal R, Djaldetti M, Zahavi I. 1986. Effect of pentoxifylline on the phagocytic activity, cAMP levels, and superoxide anion production by monocytes and polymorphonuclear cells. J Leukoc Biol 40:747–754.
  • Betsuyaku T, Nishimura M, Takeyabu K, Tanino M, Venge P, Xu S, Kawakami Y. 1999. Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema. Am J Respir Crit Care Med 159:1985–1991.
  • Bhatia M, Moochhala S. 2004. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol 202:145–156.
  • Boerma M, Roberto KA, Hauer-Jensen M. 2008. Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol. Int J Radiat Oncol Biol Phys 72:170–177.
  • Borak J, Diller WF. 2001. Phosgene exposure: mechanisms of injury and treatment strategies. J Occup Environ Med 43:110–119.
  • Crouch SP, Fletcher J. 1992. Effect of ingested pentoxifylline on neutrophil superoxide anion production. Infect Immun 60:4504–4509.
  • Currie MS, Rao KM, Padmanabhan J, Jones A, Crawford J, Cohen HJ. 1990. Stimulus-specific effects of pentoxifylline on neutrophil CR3 expression, degranulation, and superoxide production. J Leukoc Biol 47:244–250.
  • de Campos T, Deree J, Martins JO, Loomis WH, Shenvi E, Putnam JG, Coimbra R. 2008. Pentoxifylline attenuates pulmonary inflammation and neutrophil activation in experimental acute pancreatitis. Pancreas. 37:42–49.
  • D’Hellencourt CL, Diaw L, Cornillet P, Guenounou M. 1996. Differential regulation of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta, and IL-10 by pentoxifylline. Int J Immunopharmacol 18:739–748.
  • Diller WF. 1985. Pathogenesis of phosgene poisoning. Toxicol Ind Health 1:7–15.
  • Doggenweiler CF, Frenk S. 1965. Staining properties of lanthanum on cell membranes. Proc Natl Acad Sci USA 53:425–427.
  • Domínguez-Jiménez C, Sancho D, Nieto M, Montoya MC, Barreiro O, Sánchez-Madrid F, González-Amaro R. 2002. Effect of pentoxifylline on polarization and migration of human leukocytes. J Leukoc Biol 71:588–596.
  • Folch-Puy E. 2007. [Markers of severity in acute pancreatitis]. Med Clin (Barc) 128:417–418.
  • Golias C, Tsoutsi E, Matziridis A, Makridis P, Batistatou A, Charalabopoulos K. 2007. Review. Leukocyte and endothelial cell adhesion molecules in inflammation focusing on inflammatory heart disease. In Vivo 21:757–769.
  • Grainge C, Brown R, Jugg BJ, Smith AJ, Mann TM, Jenner J, Rice P, Parkhouse DA. 2009. Early treatment with nebulised salbutamol worsens physiological measures and does not improve survival following phosgene induced acute lung injury. J R Army Med Corps 155:105–109.
  • Gray KD, Simovic MO, Chapman WC, Blackwell TS, Christman JW, May AK, Parman KS, Stain SC. 2003. Endotoxin potentiates lung injury in cerulein-induced pancreatitis. Am J Surg 186:526–530.
  • Hammerschmidt DE, Kotasek D, McCarthy T, Huh PW, Freyburger G, Vercellotti GM. 1988. Pentoxifylline inhibits granulocyte and platelet function, including granulocyte priming by platelet activating factor. J Lab Clin Med 112:254–263.
  • Han J, Huez G, Beutler B. 1991. Interactive effects of the tumor necrosis factor promoter and 3′-untranslated regions. J Immunol 146:1843–1848.
  • Helenmae Clark Robert, J, Gorlin D. 1958. On the use of a modified fifteen-minute hematoxylin and eosin tissue stain. Oral Surgery, Oral Medicine, Oral Pathology.11: 431–432.
  • Heller S, Weber K, Heller A, Urbaschek R, Koch T. 1999. Pentoxifylline improves bacterial clearance during hemorrhage and endotoxemia. Crit Care Med 27:756–763.
  • Hill J, Lindsay T, Valeri CR, Shepro D, Hechtman HB. 1993. A CD18 antibody prevents lung injury but not hypotension after intestinal ischemia-reperfusion. J Appl Physiol 74:659–664.
  • Huang Q, Shao L, He M, Chen H, Liu D, Luo Y, Dai Y. 2005. Inhibitory effects of sasanquasaponin on over-expression of ICAM-1 and on enhancement of capillary permeability induced by burns in rats. Burns 31:637–642.
  • Inoue S, Nakao A, Kishimoto W, Murakami H, Harada A, Nonami T, Takagi H. 1996. LFA-1 (CD11a/CD18) and ICAM-1 (CD54) antibodies attenuate superoxide anion release from polymorphonuclear leukocytes in rats with experimental acute pancreatitis. Pancreas 12:183–188.
  • Lee WL, Downey GP. 2001. Neutrophil activation and acute lung injury. Curr Opin Crit Care 7:1–7.
  • Li WL, Hai CX, Liang X, Zhang XD, Chen HL, Qin XJ, Liu R, He W, Wang P, Li B. 2006. Apoptosis of ATII cells in mice induced by phosgene. Inhal Toxicol 18:71–77.
  • Marcus BC, Hynes KL, Gewertz BL. 1997. Loss of endothelial barrier function requires neutrophil adhesion. Surgery 122:420–6; discussion 426.
  • Matthay MA, Martin TR. 2005. Pulmonary edema and acute lung injury, In: Mason (Ed.), Murray & Nadel’s Textbook of Respiratory Medicine, 4th ed. Saunders.
  • National Toxicology Program. 2001. Chemical health and safety data. http://ntp-server.niehs.nih.gov/Main Pages/Chem-HS.html.
  • Parsey MV, Tuder RM, Abraham E. 1998. Neutrophils are major contributors to intraparenchymal lung IL-1 beta expression after hemorrhage and endotoxemia. J Immunol 160:1007–1013.
  • Rao KM, Crawford J, Currie MS, Cohen HJ. 1988. Actin depolymerization and inhibition of capping induced by pentoxifylline in human lymphocytes and neutrophils. J Cell Physiol 137:577–582.
  • Russell D, Blain PG, Rice P. 2006. Clinical management of casualties exposed to lung damaging agents: a critical review. Emerg Med J 23:421–424.
  • Schneider W, Diller W. 1989. Phosgene. In: Ullmann’s Encyclopedia of industrial chemistry. 5th ed. Vol. A 19:411–420. Weinheim, Germany: VCH Verlag.
  • Sciuto AM, Hurt HH. 2004. Therapeutic treatments of phosgene-induced lung injury. Inhal Toxicol 16:565–580.
  • Sciuto AM. 2000. Posttreatment with ETYA protects against phosgene-induced lung injury by amplifying the glutathione to lipid peroxidation ratio. Inhal Toxicol 12:347–356.
  • Sciuto AM, Stotts RR, Hurt HH. 1996. Efficacy of ibuprofen and pentoxifylline in the treatment of phosgene-induced acute lung injury. J Appl Toxicol 16:381–384.
  • Seiffge D, Bissinger T, Kremer E, Laux V, Schleyerbach R. 1995. Inhibitory effects of pentoxifylline on LPS-induced leukocyte adhesion and macromolecular extravasation in the microcirculation. Inflamm Res 44:281–286.
  • Shenkar R, Abraham E. 1999. Mechanisms of lung neutrophil activation after hemorrhage or endotoxemia: roles of reactive oxygen intermediates, NF-kappa B, and cyclic AMP response element binding protein. J Immunol 163:954–962.
  • Smith A, Brown R, Jugg B, Platt J, Mann T, Masey C, Jenner J, Rice P. 2009. The effect of steroid treatment with inhaled budesonide or intravenous methylprednisolone on phosgene-induced acute lung injury in a porcine model. Mil Med 174:1287–1294.
  • Strohschneider T, Kling D, Betz E. 1988. The effect of pentoxifylline on endothelial permeability of rabbit carotid artery wall. Eur J Pharmacol 150:287–293.
  • Sullivan GW, Carper HT, Novick WJ Jr, Mandell GL. 1988. Inhibition of the inflammatory action of interleukin-1 and tumor necrosis factor (alpha) on neutrophil function by pentoxifylline. Infect Immun 56:1722–1729.
  • Szinicz L. 2005. History of chemical and biological warfare agents. Toxicology 214:167–181.
  • Teresa Krakauer. 2000. Pentoxifylline inhibits ICAM-1 expression and chemokine production induced by proinflammatory cytokines in human pulmonary epithelial cells. Immunopharmacology. 46:253–261.
  • Torkunov PA, Shabanov PD. 2009. [Using NO-synthase inhibitors derived from L-arginine for preventing acute experimental lung edema development in mice]. Eksp Klin Farmakol 72:44–46.
  • Torkunov PA, Zemlianoi AV, Shabanov PD. 2007. [Antiedematous effect of diphenyliodinium salts on experimental toxic lung edema]. Eksp Klin Farmakol 70:36–40.
  • van de Stolpe A, van der Saag PT. 1996. Intercellular adhesion molecule-1. J Mol Med 74:13–33.
  • Voisin L, Breuillé D, Ruot B, Rallière C, Rambourdin F, Dalle M, Obled C. 1998. Cytokine modulation by PX differently affects specific acute phase proteins during sepsis in rats. Am J Physiol 275:R1412–R1419.
  • Ware LB, Matthay MA. 2000. The acute respiratory distress syndrome. N Engl J Med 342:1334–1349.
  • Weinberg JB, Mason SN, Wortham TS. 1992. Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin-induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation. Blood 79:3337–3343.
  • Zhang XD, Hai CX, Cai FL, Liang X, Liu R, Chen HL, Qin XJ, Feng AJ. 2008. Time course for expression of VEGF and its receptor and regulator levels of contraction and relaxation in increased vascular permeability of lung induced by phosgene. Inhal Toxicol 20:805–812.

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