Insights from a multi-year program designed to test the impact of ingredients on mainstream cigarette smoke toxicity

References

• Baker RR 1999. Smoke chemistry. In: Davis DL, Nielsen MT, eds. Tobacco: Production, Chemistry, and Technology. Oxford: Blackwell Science, pp. 398–439.
   Google Scholar
• Baker RR, Bishop LJ. 2004. The pyrolysis of tobacco ingredients. J Anal App Pyrol 71:223–311.
   Web of Science ®Google Scholar
• Baker RR, Massey ED, Smith G. 2004. An overview of the effects of tobacco ingredients on smoke chemistry and toxicity. Food Chem Toxicol 42 Suppl:S53–S83.
   Web of Science ®Google Scholar
• Burns DM, Dybing E, Gray N, Hecht S, Anderson C, Sanner T, O’Connor R, Djordjevic M, Dresler C, Hainaut P, Jarvis M, Opperhuizen A, Straif K 2008. Mandated lowering of toxicants in cigarette smoke: a description of the World Health Organization TobReg proposal. Tob Control 17:132–41.
   PubMed Web of Science ®Google Scholar
• Carmines EL. 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 1: cigarette design, testing approach, and review of results. Food Chem Toxicol 40:77–91.
   PubMed Web of Science ®Google Scholar
• Carmines EL, Gaworski CL. 2005. Toxicological evaluation of glycerin as a cigarette ingredient. Food Chem Toxicol 43:1521–1539.
   PubMed Web of Science ®Google Scholar
• Carmines EL, Lemus R, Gaworski CL. 2005. Toxicologic evaluation of licorice extract as a cigarette ingredient. Food Chem Toxicol 43:1303–1322.
   PubMed Web of Science ®Google Scholar
• Coggins CRE, Liu J, Merski JA, Werley MS, Oldham MJ 2011a. A comprehensive evaluation of the toxicology of cigarette ingredients: aliphatic and aromatic carboxylic acids. Inhal Toxicol.
   Web of Science ®Google Scholar
• Coggins CRE, Jerome AM, Edmiston JS, Oldham MJ 2011b. A comprehensive evaluation of the toxicology of cigarette ingredients: aliphatic carbonyl compounds. Inhal Toxicol.
   Web of Science ®Google Scholar
• Coggins CRE, Edmiston JS, Jerome AM, Langston TB, Sena EJ, Smith DC, Oldham MJ 2011c. A comprehensive evaluation of the toxicology of cigarette ingredients: essential oils and resins. Inhal Toxicol.
   Web of Science ®Google Scholar
• Counts ME, Morton MJ, Laffoon SW, Cox RH, Lipowicz PJ. 2005. Smoke composition and predicting relationships for international commercial cigarettes smoked with three machine-smoking conditions. Regul Toxicol Pharmacol 41:185–227.
   PubMed Web of Science ®Google Scholar
• DIN 2004. DIN-Fachbericht 133: Toxicological Evaluation of Additives for tobacco products—A Guide. Bestellnummer: 97615. Beuth Verlag GmbH, pp. 1–21.
   Google Scholar
• Djordjevic MV, Stellman SD, Zang E. 2000. Doses of nicotine and lung carcinogens delivered to cigarette smokers. J Natl Cancer Inst 92:106–111.
   PubMedGoogle Scholar
• Gaworski CL, Dozier MM, Heck JD, Gerhart JM, Rajendran N, David RM, Brennecke LH, Morrissey R. 1998. Toxicologic evaluation of flavor ingredients added to cigarette tobacco: 13-week inhalation exposures in rats. Inhal Toxicol 10:357–381.
   Web of Science ®Google Scholar
• Gaworski CL, Heck JD, Bennett MB, Wenk ML. 1999. Toxicologic evaluation of flavor ingredients added to cigarette tobacco: skin painting bioassay of cigarette smoke condensate in SENCAR mice. Toxicology 139:1–17.
   PubMed Web of Science ®Google Scholar
• Gaworski CL, Lemus-Olalde R, Carmines EL. 2008. Toxicological evaluation of potassium sorbate added to cigarette tobacco. Food Chem Toxicol 46:339–351.
   PubMed Web of Science ®Google Scholar
• Gaworski CL, Oldham MJ, Coggins CR. 2010. Toxicological considerations on the use of propylene glycol as a humectant in cigarettes. Toxicology 269:54–66.
   PubMed Web of Science ®Google Scholar
• Gaworski CL, Oldham MJ, Wagner KA, Coggins CRE, Patskan GJ. 2011. An evaluation of the toxicity of 95 ingredients added individually to experimental cigarettes: approach and methods. Inhal Toxicol 23(S1):1–12.
   PubMed Web of Science ®Google Scholar
• Heck JD, Gaworski CL, Rajendran N, Morrissey RL. 2002. Toxicologic evaluation of humectants added to cigarette tobacco: 13-week smoke inhalation study of glycerin and propylene glycol in Fischer 344 rats. Inhal Toxicol 14:1135–1152.
   PubMed Web of Science ®Google Scholar
• Heck JD. 2010. A review and assessment of menthol employed as a cigarette flavoring ingredient. Food Chem Toxicol 48 Suppl 2:S1–38.
   Web of Science ®Google Scholar
• Hoffmann D, Djordjevic MV, Hoffmann I 1997. The changing cigarette. Prev Med 26:427–34.
   PubMed Web of Science ®Google Scholar
• Intorp M, Purkis S, Whittaker M, Wright W. 2009. Determination of “Hoffmann Analyties” in cigarette mainstream smoke. The CORESTA 2006 joint experiment. Beitr Tabakforsch Int 23:161–202.
   Google Scholar
• Johnson MD, Schilz J, Djordjevic MV, Rice JR, Shields PG. 2009. Evaluation of in vitro assays for assessing the toxicity of cigarette smoke and smokeless tobacco. Cancer Epidemiol Biomarkers Prev 18:3263–3304.
   PubMed Web of Science ®Google Scholar
• Lemus R, Carmines EL, Van Miert E, Coggins CR, Anskeit E, Gerstenberg B, Meisgen TJ, Schramke H, Stabbert R, Völkel H, Terpstra PM. 2007. Toxicological comparisons of cigarettes containing different amounts of vanillin. Inhal Toxicol 19:683–699.
   PubMed Web of Science ®Google Scholar
• Life Sciences Research Office 2004. Review of ingredients added to cigarettes: Phase one: The feasibility of testing ingredients added to cigarettes. ed. Daniel M., Byrd III. LSRO Bethesda, MD.
   Google Scholar
• Life Sciences Research Office 2006. Review of ingredients added to cigarettes: Phase two: Scientific criteria for the evaluation of ingredients added to cigarettes. eds. Daniel M., Byrd III, Kara Lewis Paula, Nixon, and Robin Feldman. LSRO Bethesda, MD.
   Google Scholar
• Morton MJ, Laffoon SW. 2008. Cigarette smoke chemistry market maps under Massachusetts Department of Public Health smoking conditions. Regul Toxicol Pharmacol 51:1–30.
   PubMed Web of Science ®Google Scholar
• NTP 1989. Toxicology and carcinogenicity studies of d-carvone (CAS No. 2244-16-8) in B6C3F1 mice and toxicology studies in F344/N rats (gavage studies). National Toxicology Program (NTP), Report Number:NTP/TR No.381. UD Department of Health and Human Services, National Institute of Health. available at: http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr381.pdf.
   Google Scholar
• Paschke T, Scherer G, Heller W-D. 2002. Effects of ingredients on cigarette smoke composition and biological activity: a literature review. Beitr Tabakforsch Int 20:107–247.
   Google Scholar
• Potts RJ, Bombick BR, Meckley DR, Ayres PH, Pence DH. 2010. A summary of toxicological and chemical data relevant to the evaluation of cast sheet tobacco. Exp Toxicol Pathol 62:117–126.
   PubMedGoogle Scholar
• Purkis SW, Hill CA, Bailey IA. 2003. Current measurement reliability of selected smoke analytes. Beitr Tabakforsch Int 20:314–324.
   Google Scholar
• Renne RA, Yoshimura H, Yoshino K, Lulham G, Minamisawa S, Tribukait A, Dietz DD, Lee KM, Westerberg RB. 2006. Effects of flavoring and casing ingredients on the toxicity of mainstream cigarette smoke in rats. Inhal Toxicol 18:685–706.
   PubMed Web of Science ®Google Scholar
• Roemer E, Stabbert R, Rustemeier K, Veltel DJ, Meisgen TJ, Reininghaus W, Carchman RA, Gaworski CL, Podraza KF. 2004. Chemical composition, cytotoxicity and mutagenicity of smoke from US commercial and reference cigarettes smoked under two sets of machine smoking conditions. Toxicology 195:31–52.
   PubMed Web of Science ®Google Scholar
• Roemer E, Tewes FJ, Meisgen TJ, Veltel DJ, Carmines EL. 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 3: in vitro genotoxicity and cytotoxicity. Food Chem Toxicol 40:105–111.
   PubMed Web of Science ®Google Scholar
• Rustemeier K, Stabbert R, Haussmann HJ, Roemer E, Carmines EL. 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 2: chemical composition of mainstream smoke. Food Chem Toxicol 40:93–104.
   PubMed Web of Science ®Google Scholar
• Secretary of State for Health. 1997 Voluntary Agreement on the Approval and Use of New Additives in Tobacco Products in the UK.
   Google Scholar
• Shields PG 2002. Tobacco smoking, harm reduction, and biomarkers. J Nat Cancer Inst 94:1435–44.
   PubMedGoogle Scholar
• Stavanja MS, Ayres PH, Meckley DR, Bombick BR, Pence DH, Borgerding MF, Morton MJ, Mosberg AT, Swauger JE. 2003. Toxicological evaluation of honey as an ingredient added to cigarette tobacco. J Toxicol Environ Health Part A 66:1453–1473.
   PubMed Web of Science ®Google Scholar
• Stavanja MS, Curtin GM, Ayres PH, Bombick ER, Borgerding MF, Morgan WT, Garner CD, Pence DH, Swauger JE. 2008. Safety assessment of diammonium phosphate and urea used in the manufacture of cigarettes. Exp Toxicol Pathol 59:339–353.
   PubMedGoogle Scholar
• Thun MJ, Henley SJ, Calle EE 2002. Tobacco use and cancer: an epidemiologic perspective for geneticists. Oncogene, 21:7307–25.
   PubMed Web of Science ®Google Scholar
• Tso TC. 1999. Seed to smoke in tobacco: production chemistry and technology. eds. DL Davis, and MT Nielsen, Blackwell Science Ltd, Oxford, UK.
   Google Scholar
• Vanscheeuwijck PM, Teredesai A, Terpstra PM, Verbeeck J, Kuhl P, Gerstenberg B, Gebel S, Carmines EL. 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 4: subchronic inhalation toxicity. Food Chem Toxicol 40:113–131.
   PubMed Web of Science ®Google Scholar
• Vleeming W, Schenk E, Opperhuizen A. 2004. Letter to the editor. Food Chem Toxicol 42:865–6; author reply 867.
   PubMed Web of Science ®Google Scholar
• White JL, Conner BT, Perfetti TA, Bombick BR, Avalos JT, Fowler KW, Smith CJ, Doolittle DJ. 2001. Effect of pyrolysis temperature on the mutagenicity of tobacco smoke condensate. Food Chem Toxicol 39:499–505.
   PubMed Web of Science ®Google Scholar