Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 23, 2011 - Issue 5
1,594
Views
192
CrossRef citations to date
0
Altmetric
Research Article

Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice

, , , , , , , , & show all
Pages 257-267 | Received 09 Dec 2010, Accepted 22 Feb 2011, Published online: 20 Apr 2011

References

  • Aebi H. 1984. Catalase in vitro. Meth Enzymol 105:121–126.
  • André E, Stoeger T, Takenaka S, Bahnweg M, Ritter B, Karg E, Lentner B, Reinhard C, Schulz H, Wjst M. 2006. Inhalation of ultrafine carbon particles triggers biphasic pro-inflammatory response in the mouse lung. Eur Respir J 28:275–285.
  • Antonini JM, Taylor MD, Leonard SS, Lawryk NJ, Shi X, Clarke RW, Roberts JR. 2004. Metal composition and solubility determine lung toxicity induced by residual oil fly ash collected from different sites within a power plant. Mol Cell Biochem 255:257–265.
  • Bae S, Pan XC, Kim SY, Park K, Kim YH, Kim H, Hong YC. 2010. Exposures to particulate matter and polycyclic aromatic hydrocarbons and oxidative stress in schoolchildren. Environ Health Perspect 118:579–583.
  • Bates JH, Decramer M, Chartrand D, Zin WA, Boddener A, Milic-Emili J. 1985a. Volume-time profile during relaxed expiration in the normal dog. J Appl Physiol 59:732–737.
  • Bates JH, Rossi A, Milic-Emili J. 1985b. Analysis of the behavior of the respiratory system with constant inspiratory flow. J Appl Physiol 58:1840–1848.
  • Bates JH, Ludwig MS, Sly PD, Brown K, Martin JG, Fredberg JJ. 1988. Interrupter resistance elucidated by alveolar pressure measurement in open-chest normal dogs. J Appl Physiol 65:408–414.
  • Billet S, Garçon G, Dagher Z, Verdin A, Ledoux F, Cazier F, Courcot D, Aboukais A, Shirali P. 2007. Ambient particulate matter (PM2.5): Physicochemical characterization and metabolic activation of the organic fraction in human lung epithelial cells (A549). Environ Res 105:212–223.
  • Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254.
  • Braga AL, Zanobetti A, Schwartz J. 2002. The effect of weather on respiratory and cardiovascular deaths in 12 U.S. cities. Environ Health Perspect 110:859–863.
  • Brown DM, Stone V, Findlay P, MacNee W, Donaldson K. 2000. Increased inflammation and intracellular calcium caused by ultrafine carbon black is independent of transition metals or other soluble components. Occup Environ Med 57:685–691.
  • Caricchia AM, Chiavarini S, Pezza M. 1999. Polycyclic aromatic hydrocarbons in the urban atmospheric particulate matter in the city of Naples (Italy). Atmospheric Environ 33:3731–3738.
  • Castaño-Vinyals G, D’Errico A, Malats N, Kogevinas M. 2004. Biomarkers of exposure to polycyclic aromatic hydrocarbons from environmental air pollution. Occup Environ Med 61:e12.
  • Chauhan SS, Misra UK. 1991. Elevation of rat pulmonary, hepatic and lung surfactant lipids by fly ash inhalation. Biochem Pharmacol 41:191–198.
  • Clarke RW, Catalano PJ, Koutrakis P, Murthy GG, Sioutas C, Paulauskis J, Coull B, Ferguson S, Godleski JJ. 1999. Urban air particulate inhalation alters pulmonary function and induces pulmonary inflammation in a rodent model of chronic bronchitis. Inhal Toxicol 11:637–656.
  • CETESB. 2006. Relatório de qualidade do ar no Estado de São Paulo. <http://www.cetesb.sp.gov.br/Ar/relatorios.asp>.
  • CETESB. 2008. Material particulado inalável fino (MP2,5) e grosso (MP2,5–10) na atmosfera da região metropolitana de São Paulo (2000–2006). 1–24.
  • Deneke SM, Fanburg BL. 1989. Regulation of cellular glutathione. Am J Physiol 257:L163–L173.
  • Ding LR, Wang K, Fahmy B, Shen HH, Cormier S. 2010. Airborne fine particulate matter induced pulmonary inflammation as well as oxidative stress in neonate rats. Chin Med J 123:2895–2900.
  • Donaldson K, Stone V. 2003. Current hypotheses on the mechanisms of toxicity of ultrafine particles. Ann Ist Super Sanita 39:405–410.
  • Donaldson K, Stone V, Clouter A, Renwick L, MacNee W. 2001. Ultrafine particles. Occup Environ Med 58:211–216.
  • Donaldson K, Tran CL. 2002. Inflammation caused by particles and fibers. Inhal Toxicol 14:5–27.
  • Draper HH, Hadley M. 1990. Malondialdehyde determination as index of lipid peroxidation. Meth Enzymol 186:421–431.
  • Dreher KL, Jaskot RH, Lehmann JR, Richards JH, McGee JK, Ghio AJ, Costa DL. 1997. Soluble transition metals mediate residual oil fly ash induced acute lung injury. J Toxicol Environ Health 50:285–305.
  • Dye JA, Lehmann JR, McGee JK, Winsett DW, Ledbetter AD, Everitt JI, Ghio AJ, Costa DL. 2001. Acute pulmonary toxicity of particulate matter filter extracts in rats: Coherence with epidemiologic studies in Utah Valley residents. Environ Health Perspect 109 Suppl 3:395–403.
  • Gardner SY, Lehmann JR, Costa DL. 2000. Oil fly ash-induced elevation of plasma fibrinogen levels in rats. Toxicol Sci 56:175–180.
  • Gavett SH, Haykal-Coates N, Copeland LB, Heinrich J, Gilmour MI. 2003. Metal composition of ambient PM2.5 influences severity of allergic airways disease in mice. Environ Health Perspect 111:1471–1477.
  • Ghio AJ, Devlin RB. 2001. Inflammatory lung injury after bronchial instillation of air pollution particles. Am J Respir Crit Care Med 164:704–708.
  • Ghio AJ, Stonehuerner J, Pritchard RJ, Piantadosi CA, Quigley DR, Dreher KL, Costa DL. 1996. Humic-like substances in air pollution particulates correlate with concentrations of transition metals and oxidant generation. Inhal Toxicol 8:479–494.
  • González-Flecha B. 2004. Oxidant mechanisms in response to ambient air particles. Mol Aspects Med 25:169–182.
  • Hiura TS, Kaszubowski MP, Li N, Nel AE. 1999. Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages. J Immunol 163:5582–5591.
  • Kodavanti UP, Schladweiler MC, Ledbetter AD, Hauser R, Christiani DC, McGee J, Richards JR, Costa DL. 2002. Temporal association between pulmonary and systemic effects of particulate matter in healthy and cardiovascular compromised rats. J Toxicol Environ Health Part A 65:1545–1569.
  • Kooter IM, Boere AJ, Fokkens PH, Leseman DL, Dormans JA, Cassee FR. 2006. Response of spontaneously hypertensive rats to inhalation of fine and ultrafine particles from traffic: Experimental controlled study. Part Fibre Toxicol 3:7.
  • Laks D, de Oliveira RC, de André PA, Macchione M, Lemos M, Faffe D, Saldiva PH, Zin WA. 2008. Composition of diesel particles influences acute pulmonary toxicity: An experimental study in mice. Inhal Toxicol 20:1037–1042.
  • Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberley T, Froines J, Nel A. 2003. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 111:455–460.
  • Li N, Venkatesan MI, Miguel A, Kaplan R, Gujuluva C, Alam J, Nel A. 2000. Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element. J Immunol 165:3393–3401.
  • Li N, Wang M, Oberley TD, Sempf JM, Nel AE. 2002. Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages. J Immunol 169:4531–4541.
  • Li XY, Gilmour PS, Donaldson K, MacNee W. 1996. Free radical activity and pro-inflammatory effects of particulate air pollution (PM10) in vivo and in vitro. Thorax 51:1216–1222.
  • Liu M, Wang L, Li E, Enhorning G. 1996. Pulmonary surfactant given prophylactically alleviates an asthma attack in guinea-pigs. Clin Exp Allergy 26:270–275.
  • Lopes FD, Pinto TS, Arantes-Costa FM, Moriya HT, Biselli PJ, Ferraz LF, Lichtenfels AJ, Saldiva PH, Mauad T, Martins MA. 2009. Exposure to ambient levels of particles emitted by traffic worsens emphysema in mice. Environ Res 109:544–551.
  • Mantecca P, Farina F, Moschini E, Gallinotti D, Gualtieri M, Rohr A, Sancini G, Palestini P, Camatini M. 2010. Comparative acute lung inflammation induced by atmospheric PM and size-fractionated tire particles. Toxicol Lett 198:244–254.
  • Martin S, Fernandez-Alanis E, Delfosse V, Evelson P, Yakisich JS, Saldiva PH, Tasat DR. 2010. Low doses of urban air particles from Buenos Aires promote oxidative stress and apoptosis in mice lungs. Inhal Toxicol 22:1064–1071.
  • Mauad T, Rivero DH, de Oliveira RC, Lichtenfels AJ, Guimarães ET, de Andre PA, Kasahara DI, Bueno HM, Saldiva PH. 2008. Chronic exposure to ambient levels of urban particles affects mouse lung development. Am J Respir Crit Care Med 178:721–728.
  • Mazzoli-Rocha F, Magalhães CB, Malm O, Saldiva PH, Zin WA, Faffe DS. 2008. Comparative respiratory toxicity of particles produced by traffic and sugar cane burning. Environ Res 108:35–41.
  • Oberdörster G, Ferin J, Gelein R, Soderholm SC, Finkelstein J. 1992. Role of the alveolar macrophage in lung injury: Studies with ultrafine particles. Environ Health Perspect 97:193–199.
  • Ohyama M, Otake T, Adachi S, Kobayashi T, Morinaga K. 2007. A comparison of the production of reactive oxygen species by suspended particulate matter and diesel exhaust particles with macrophages. Inhal Toxicol 19 Suppl 1:157–160.
  • Park S, Nam H, Chung N, Park JD, Lim Y. 2006. The role of iron in reactive oxygen species generation from diesel exhaust particles. Toxicol In Vitro 20:851–857.
  • Pereira CE, Heck TG, Saldiva PH, Rhoden CR. 2007. Ambient particulate air pollution from vehicles promotes lipid peroxidation and inflammatory responses in rat lung. Braz J Med Biol Res 40:1353–1359.
  • Powell CV, Nash AA, Powers HJ, Primhak RA. 1994. Antioxidant status in asthma. Pediatr Pulmonol 18:34–38.
  • Prahalad AK, Inmon J, Dailey LA, Madden MC, Ghio AJ, Gallagher JE. 2001. Air pollution particles mediated oxidative DNA base damage in a cell free system and in human airway epithelial cells in relation to particulate metal content and bioreactivity. Chem Res Toxicol 14:879–887.
  • Rahman I, Kode A, Biswas SK. 2006. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat Protoc 1:3159–3165.
  • Rahman Q, Abidi P, Afaq F, Schiffmann D, Mossman BT, Kamp DW, Athar M. 1999. Glutathione redox system in oxidative lung injury. Crit Rev Toxicol 29:543–568.
  • Risom L, Møller P, Loft S. 2005. Oxidative stress-induced DNA damage by particulate air pollution. Mutat Res 592:119–137.
  • Rivero DH, Soares SR, Lorenzi-Filho G, Saiki M, Godleski JJ, Antonangelo L, Dolhnikoff M, Saldiva PH. 2005. Acute cardiopulmonary alterations induced by fine particulate matter of São Paulo, Brazil. Toxicol Sci 85:898–905.
  • Sabaitis CP, Leong BK, Rop DA, Aaron CS. 1999. Validation of intratracheal instillation as an alternative for aerosol inhalation toxicity testing. J Appl Toxicol 19:133–140.
  • Saldiva PH, King M, Delmonte VL, Macchione M, Parada MA, Daliberto ML, Sakae RS, Criado PM, Silveira PL, Zin WA, et al. 1992a. Respiratory alterations due to urban air pollution: An experimental study in rats. J Appl Physiol 57:19–33.
  • Saldiva PH, Zin WA, Santos RL, Eidelman DH, Milic-Emili J. 1992b. Alveolar pressure measurement in open-chest rats. J Appl Physiol 72:302–306.
  • Schwartz J. 2001. Air pollution and blood markers of cardiovascular risk. Environ Health Perspect 109 Suppl 3:405–409.
  • Seaton A, Soutar A, Crawford V, Elton R, McNerlan S, Cherrie J, Watt M, Agius R, Stout R. 1999. Particulate air pollution and the blood. Thorax 54:1027–1032.
  • Shukla A, Timblin C, BeruBe K, Gordon T, McKinney W, Driscoll K, Vacek P, Mossman BT. 2000. Inhaled particulate matter causes expression of nuclear factor (NF)-kappaB-related genes and oxidant-dependent NF-kappaB activation in vitro. Am J Respir Cell Mol Biol 23:182–187.
  • Sicinska P, Bukowska B, Michalowicz J, Duda W. 2006. Damage of cell membrane and antioxidative system in human erythrocytes incubated with microcystin-LR in vitro. Toxicon 47:387–397.
  • Sørensen M, Autrup H, Møller P, Hertel O, Jensen SS, Vinzents P, Knudsen LE, Loft S. 2003. Linking exposure to environmental pollutants with biological effects. Mutat Res 544:255–271.
  • Sørensen M, Schins RP, Hertel O, Loft S. 2005. Transition metals in personal samples of PM2.5 and oxidative stress in human volunteers. Cancer Epidemiol Biomarkers Prev 14:1340–1343.
  • Soukup JM, Ghio AJ, Becker S. 2000. Soluble components of Utah Valley particulate pollution alter alveolar macrophage function in vivo and in vitro. Inhal Toxicol 12:401–414.
  • Srivastava PK, Misra UK. 1986. Phosphatidylcholine metabolism in lung microsomes and lung surfactant of rats exposed intratracheally to coal fly ash. J Toxicol Environ Health 18:471–481.
  • Stohs SJ, Bagchi D. 1995. Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 18:321–336.
  • Stone PH, Godleski JJ. 1999. First steps toward understanding the pathophysiologic link between air pollution and cardiac mortality. Am Heart J 138:804–807.
  • Suzuki K, Ota H, Sasagawa S, Sakatani T, Fujikura T. 1983. Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Anal Biochem 132:345–352.
  • Terashima T, Wiggs B, English D, Hogg JC, van Eeden SF. 1997. Phagocytosis of small carbon particles (PM10) by alveolar macrophages stimulates the release of polymorphonuclear leukocytes from bone marrow. Am J Respir Crit Care Med 155:1441–1447.
  • Weibel ER. 1990. Morphometry: Stereological theory and practical methods. In: Models of Lung Disease—Microscopy and Structural Methods. Ed. Gil, J. Marcel Dekker. New York. 47, pp. 199–247.
  • Weng D, Lu Y, Wei Y, Liu Y, Shen P. 2007. The role of ROS in microcystin-LR-induced hepatocyte apoptosis and liver injury in mice. Toxicology 232:15–23.
  • Wolff RK, Griffith WC, Henderson RF, Hahn FF, Harkema JR, Rebar AH, Eidson AF, McClellan RO. 1989. Effects of repeated inhalation exposures to 1-nitropyrene, benzo[a]pyrene, Ga2O3 particles, and SO2 alone and in combinations on particle clearance, bronchoalveolar lavage fluid composition, and histopathology. J Toxicol Environ Health 27:123–138.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.