Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 23, 2011 - Issue 7
141
Views
25
CrossRef citations to date
0
Altmetric
Research Article

Pathological features of rat lung following inhalation and intratracheal instillation of C60 fullerene

, , , , , , , , , , , , , , , , , & show all
Pages 407-416 | Received 06 Dec 2010, Accepted 05 Apr 2011, Published online: 03 Jun 2011

References

  • Baker GL, Gupta A, Clark ML, Valenzuela BR, Staska LM, Harbo SJ, Pierce JT, Dill JA. 2008. Inhalation toxicity and lung toxicokinetics of C60 fullerene nanoparticles and microparticles. Toxicol Sci 101:122–131.
  • David WIF, Ibberson RM, Matsuo T. 1993. High resolution neutron powder diffraction: a case study of the structure of C60. Proc R Soc Lond A 442:129–146.
  • Endoh S, Uchida K. 2008. Preparation of suspension of nano-sized particle for toxicology test. International symposium on the risk assessment of manufactured nanomaterials. NEDO-AIST-OECD symposium in Tokyo. Tokyo, pp. 36–40.
  • Fujita K, Morimoto Y, Ogami A, Myojyo T, Tanaka I, Shimada M, Wang WN, Endoh S, Uchida K, Nakazato T, Yamamoto K, Fukui H, Horie M, Yoshida Y, Iwahashi H, Nakanishi J. 2009. Gene expression profiles in rat lung after inhalation exposure to C60 fullerene particles. Toxicology 258:47–55.
  • Geiser M, Rothen-Rutishauser B, Kapp N, Schürch S, Kreyling W, Schulz H, Semmler M, Im Hof V, Heyder J, Gehr P. 2005. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 113:1555–1560.
  • Johnston HJ, Hutchison GR, Christensen FM, Aschberger K, Stone V. 2009. The biological mechanisms and physicochemical characteristics responsible for driving fullerene toxicity. Toxicol Sci 114:162–182.
  • Kaewamatawong T, Kawamura N, Okajima M, Sawada M, Morita T, Shimada A. 2005. Acute pulmonary toxicity caused by exposure to colloidal silica: particle size dependent pathological changes in mice. Toxicol Pathol 33:743–749.
  • Kroto H. 1988. Space, stars, c60, and soot. Science 242:1139–1145.
  • Morimoto Y, Hirohashi M, Ogami A, Oyabu T, Myojo T, Nishi K, Kadoya C, Todoroki M, Yamamoto M, Murakami M, Shimada M, Wang WN, Yamamoto K, Fujita K, Endoh S, Uchida K, Shinohara N, Nakanishi J, Tanaka I. 2010a. Inflammogenic effect of well-characterized fullerenes in inhalation and intratracheal instillation studies. Part Fibre Toxicol 7:4.
  • Morimoto Y, Kobayashi N, Shinohara N, Myojo T, Tanaka I, Nakanishi J. 2010b. Hazard assessments of manufactured nanomaterials. J Occup Health. 52(6):325–334.
  • Myojo T, Oyabu T, Ogami A, Hirohashi M, Murakami M, Yamamoto M, Todoroki M, Kadoya C, Nishi K, Yamasaki S, Morimoto Y, Tanaka I, Shimada M, Endoh S. 2010. Monitoring of C60 aerosol concentrations during 4-week inhalation study using a carbon aerosol analyzer with adjusted analytical protocol. J Nanopart Res (in press). Published online, 25 May 2010, DOI 10.1007/s11051-010-9961-y.
  • Naota M, Shimada A, Morita T, Inoue K, Takano H. 2009. Translocation pathway of the intratracheally instilled C60 fullerene from the lung into the blood circulation in the mouse: possible association of diffusion and caveolae-mediated pinocytosis. Toxicol Pathol 37:456–462. Published online, 25 May 2010, DOI 10.1007/s11051-010-9961-y.
  • Oberdörster G, Oberdörster E, Oberdörster J. 2005. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839.
  • Ogami A, Morimoto Y, Myojo T, Oyabu T, Murakami M, Nishi K, Kadoya C, Tanaka I. 2007. Histopathological changes in rat lung following intratracheal instillation of silicon carbide whiskers and potassium octatitanate whiskers. Inhal Toxicol 19:753–758.
  • Ogami A, Morimoto Y, Myojo T, Oyabu T, Murakami M, Todoroki M, Nishi K, Kadoya C, Yamamoto M, Tanaka I. 2009. Pathological features of different sizes of nickel oxide following intratracheal instillation in rats. Inhal Toxicol 21:812–818.
  • Ogami A, Morimoto Y, Yamato H, Oyabu T, Kajiwara T, Tanaka I. 2004. Patterns of histopathological change determined by the point counting method and its application for the hazard assessment of respirable dust. Inhal Toxicol 16:793–800.
  • Park EJ, Kim H, Kim Y, Yi J, Choi K, Park K. 2010. Carbon fullerenes (C60s) can induce inflammatory responses in the lung of mice. Toxicol Appl Pharmacol 244:226–233.
  • Pauluhn J. 2009. Pulmonary toxicity and fate of agglomerated 10 and 40 nm aluminum oxyhydroxides following 4-week inhalation exposure of rats: toxic effects are determined by agglomerated, not primary particle size. Toxicol Sci 109:152–167.
  • Sayes CM, Marchione AA, Reed KL, Warheit DB. 2007. Comparative pulmonary toxicity assessments of C60 water suspensions in rats: few differences in fullerene toxicity in vivo in contrast to in vitro profiles. Nano Lett 7:2399–2406.
  • Shimada M, Wang WN, Okuyama K, Myojo T, Oyabu T, Morimoto Y, Tanaka I, Endoh S, Uchida K, Ehara K, Sakurai H, Yamamoto K, Nakanishi J. 2009. Development and evaluation of an aerosol generation and supplying system for inhalation experiments of manufactured nanoparticles. Environ Sci Technol 43:5529–5534.
  • Shinohara N, Gamo M, Nakanishi J. 2009a. Risk assessment of manufactured nanomaterials—fullerene (C60). In Nakanishi J, Gamo M, eds., NEDO project “Research and Development of Nanoparticle Characterization Methods” (P06041). Tsukuba: National Institute of Advanced Industrial Science (AIST).
  • Shinohara N, Matsumoto K, Endoh S, Maru J, Nakanishi J. 2009b. In vitro and in vivo genotoxicity tests on fullerene C60 nanoparticles. Toxicol Lett 191:289–296.
  • Shinohara N, Nakazato T, Tamura M, Endoh S, Fukui H, Morimoto Y, Myojo T, Shimada M, Yamamoto K, Tao H, Yoshida Y, Nakanishi J. 2010. Clearance kinetics of fullerene C60 nanoparticles from rat lungs after intratracheal C60 instillation and inhalation C60 exposure. Toxicol Sci 118:564–573.
  • Warheit DB, Webb TR, Reed KL. 2006. Pulmonary toxicity screening studies in male rats with TiO2 particulates substantially encapsulated with pyrogenically deposited, amorphous silica. Part Fibre Toxicol 3:3.
  • Yang MJ, Yang YS, Sung JH, Kim JS, Cho KH, Lim CW, Chung YH, Kim HY, Yang JS, Yu IJ, Song CW. 2009. Recurrent exposure to welding fumes induces insufficient recovery from inflammation. Inhal Toxicol 21:337–346.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.