Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 25, 2013 - Issue 6
202
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Nitrogen dioxide is genotoxic in urban concentrations

, , , , , , , & show all
Pages 341-347 | Received 24 Jan 2013, Accepted 17 Mar 2013, Published online: 23 May 2013

References

  • Alberg T, Nilsen A, Hansen JS, et al. (2011). Nitrogen dioxide: no influence on allergic sensitization in an intranasal mouse model with ovalbumin and diesel exhaust particles. Inhal Toxicol 23:268–76
  • Ayyagari VN, Januszkiewicz A, Nath J. (2007). Effects of nitrogen dioxide on the expression of intercellular adhesion molecule-1, neutrophil adhesion, and cytotoxicity: studies in human bronchial epithelial cells. Inhal Toxicol 19:181–94
  • Azad N, Rojanasakul Y, Vallyathan V. (2008). Inflammation and lung cancer: roles of reactive oxygen/nitrogen species. J Toxicol Environ Health B Crit Rev 11:1–15
  • Bakand S, Winder C, Khalil C, Hayes A. (2006a). An experimental in vitro model for dynamic direct exposure of human cells to airborne contaminants. Toxicol Lett 165:1–10
  • Bakand S, Winder C, Khalil C, Hayes A. (2006b). A novel in vitro exposure technique for toxicity testing of selected volatile organic compounds. J Environ Monit 8:100–5
  • Brandsma CA, Hylkema MN, Luinge MA, et al. (2008). Nitrogen dioxide exposure attenuates cigarette smoke-induced cytokine production in mice. Inhal Toxicol 20:183–9
  • Fehrenbach H, Zimmermann G, Starke E, et al. (2007). Nitrogen dioxide induces apoptosis and proliferation but not emphysema in rat lungs. Thorax 62:438–46
  • Ginzkey C, Kampfinger K, Friehs G, et al. (2009). Nicotine induces DNA damage in human salivary glands. Toxicol Lett 184:1–4
  • Grisham MB, Jourd’Heuil D, Wink DA. (2000). Review article: chronic inflammation and reactive oxygen and nitrogen metabolism – implications in DNA damage and mutagenesis. Aliment Pharmacol Ther 14:3–9
  • Han M, Guo Z, Li G, Sang N. (2013). Nitrogen dioxide inhalation induces genotoxicity in rats. Chemosphere 90:2737--42
  • Hansel NN, Breysse PN, McCormack MC, et al. (2008). A longitudinal study of indoor nitrogen dioxide levels and respiratory symptoms in inner-city children with asthma. Environ Health Perspect 116:1428–32
  • Jerrett M, Finkelstein MM, Brook JR, et al. (2009). A cohort study of traffic-related air pollution and mortality in Toronto, Ontario, Canada. Environ Health Perspect 117:772–7
  • Jerrett M, Shankardass K, Berhane K, et al. (2008). Traffic-related air pollution and asthma onset in children: a prospective cohort study with individual exposure measurement. Environ Health Perspect 116:1433–8
  • Kalpaklioglu AF, Kalkan IK. (2012). Comparison of orally exhaled nitric oxide in allergic versus nonallergic rhinitis. Am J Rhinol Allergy 26:e50–4
  • Kienast K, Knorst M, Riechelmann H, et al. (1993). In vitro studies of the beat frequency of ciliary cell cultures after short-term exposure to SO2 and NO2. Med Klin 88:520–4
  • Kleinsasser NH, Harreus UA, Gamarra F, et al. (2009). Cytochrome P4502A6 stability in a mini organ culture model of human nasal mucosa for genotoxicology studies as detected by flow cytometry. Eur Archiv Otorhinolaryngol 266:385–9
  • Kleinsasser NH, Juchhoff J, Wallner BC, et al. (2004). The use of mini-organ cultures of human upper aerodigestive tract epithelia in ecogenotoxicology. Mutat Res 561:63–73
  • Kleinsasser NH, Schmid K, Sassen AW, et al. (2006). Cytotoxic and genotoxic effects of resin monomers in human salivary gland tissue and lymphocytes as assessed by the single cell microgel electrophoresis (Comet) assay. Biomaterials 27:1762–70
  • Koehler C, Ginzkey C, Friehs G, et al. (2010). Aspects of nitrogen dioxide toxicity in environmental urban concentrations in human nasal epithelium. Toxicol Appl Pharmacol 245:219–25
  • Koehler C, Ginzkey C, Friehs G, et al. (2011). Ex vivo toxicity of nitrogen dioxide in human nasal epithelium at the WHO defined 1-h limit value. Toxicol Lett 207:89–95
  • Newland N, Baxter A, Hewitt K, Minet E. (2011). CYP1A1/1B1 and CYP2A6/2A13 activity is conserved in cultures of differentiated primary human tracheobronchial epithelial cells. Toxicol In Vitro 25:922–9
  • Olive PL, Durand RE, Le Riche J, et al. (1993). Gel electrophoresis of individual cells to quantify hypoxic fraction in human breast cancers. Cancer Res 53:733–6
  • Pedersen M, Wichmann J, Autrup H, et al. (2009). Increased micronuclei and bulky DNA adducts in cord blood after maternal exposures to traffic-related air pollution. Environ Res 109:1012–20
  • Singh NP, McCoy MT, Tice RR, Schneider EL. (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res, 175:184–91
  • Spitale N, Popat N, McIvor A. (2012). Update on exhaled nitric oxide in pulmonary disease. Expert Rev Respir Med 6:105–15
  • Szabo C, Ohshima H. (1997). DNA damage induced by peroxynitrite: subsequent biological effects. Nitric Oxide 1:373–85
  • Tice RR, Agurell E, Anderson D, et al. (2000). Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35:206–21
  • Villarini M, Moretti M, Fatigoni C, et al. (2008). Evaluation of primary DNA damage, cytogenetic biomarkers and genetic polymorphisms for CYP1A1 and GSTM1 in road tunnel construction workers. J Toxicol Environ Health A 71:1430–9
  • WHO. (2000). Air quality guidelines, 2nd edon. WHO Regional Publications, European Series, No. 91
  • WHO. (2005). Air quality guidelines global update 2005. WHO Regional Publications, European Series
  • Wiseman H, Halliwell B. (1996). Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J 313:17–29
  • Wolz L, Krause G, Scherer G, et al. (2002). In vitro genotoxicity assay of sidestream smoke using a human bronchial epithelial cell line. Food Chem Toxicol 40:845–50

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.