Comparison of realistic and idealized breathing patterns in computational models of airflow and vapor dosimetry in the rodent upper respiratory tract

References

• Appelman LM, Woutersen RA, Feron VJ. (1982). Inhalation toxicity of acetaldehyde in rats. I. Acute and subacute studies. Toxicology 23:293–307.
   PubMed Web of Science ®Google Scholar
• Bogdanffy MS, Randall HW, Morgan KT. (1986). Histochemical localization of aldehyde dehydrogenase in the respiratory tract of the Fischer-344 rat. Toxicol Appl Pharmacol 82:560–7.
   PubMed Web of Science ®Google Scholar
• Bogdanffy MS, Sarangapani R, Kimbell JS, et al. (1998). Analysis of vinyl acetate metabolism in rat and human nasal tissues by an in vitro gas uptake technique. Toxicol Sci 46:235–46.
   PubMed Web of Science ®Google Scholar
• Bogdanffy MS, Sarangapani R, Plowchalk DR, et al. (1999). A biologically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxicity. Toxicol Sci 51:19–35.
   PubMed Web of Science ®Google Scholar
• Carey RM, Wachowiak M. (2011). Effect of sniffing on the temporal structure of mitral/tufted cell output from the olfactory bulb. J Neurosci 31:10615–26.
   PubMed Web of Science ®Google Scholar
• Casanova-Schmitz M, David RM, Heck HdA. (1984). Oxidation of formaldehyde and acetaldehyde by NAD+-dependent dehydrogenases in rat nasal mucosal homogenates. Biochem Pharmacol 33:1137–42.
   PubMed Web of Science ®Google Scholar
• Corley RA, Kabilan S, Kuprat AP, et al. (2015). Comparative risks of aldehyde constituents in cigarette smoke using transient computational fluid dynamics/physiologically based pharmacokinetic models of the rat and human respiratory tracts. Toxicol Sci 146:65–88.
   PubMed Web of Science ®Google Scholar
• Corley RA, Kabilan S, Kuprat AP, et al. (2012). Comparative computational modeling of airflows and vapor dosimetry in the respiratory tracts of rat, monkey, and human. Toxicol Sci 128:500–16.
   PubMed Web of Science ®Google Scholar
• Courtiol E, Amat C, Thévenet M, et al. (2011a). Reshaping of bulbar odor response by nasal flow rate in the rat. PLoS One 6:e16445. doi:10.1371/journal.pone.0016445.
   Google Scholar
• Courtiol E, Hegoburu C, Litaudon P, et al. (2011b). Individual and synergistic effects of sniffing frequency and flow rate on olfactory bulb activity. J Neurophysiol 106:2813–24.
   PubMed Web of Science ®Google Scholar
• Dorman DC, Struve MF, Wong BA, et al. (2008). Derivation of an inhalation reference concentration based upon olfactory neuronal loss in male rats following subchronic acetaldehyde inhalation. Inhal Toxicol 20:245–56.
   PubMed Web of Science ®Google Scholar
• Inoue T, Strowbridge BW. (2008). Transient activity induces a long-lasting increase in the excitability of olfactory bulb interneurons. J Neurophysiol 99:187–99.
   PubMed Web of Science ®Google Scholar
• Ishikawa S, Nakayama T, Watanabe M, Matsuzawa T. (2009). Flow mechanisms in the human olfactory groove: numerical simulation of nasal physiological respiration during inspiration, expiration, and sniffing. Arch Otolaryngol Head Neck Surg 135:156–62.
   PubMedGoogle Scholar
• Kabilan S, Lin CL, Hoffman EA. (2007). Characteristics of airflow in a CT-based ovine lung: a numerical study. J Appl Physiol 102:1469–82.
   PubMed Web of Science ®Google Scholar
• Kuprat A, Khamayseh A, George D, Larkey L. (2001). Volume conserving smoothing for piecewise linear curves, surfaces, and triple lines. J Comput Phys 172:99–118.
   Web of Science ®Google Scholar
• Kuprat AP, Einstein DR. (2009). An anisotropic scale-invariant unstructured mesh generator suitable for volumetric imaging data. J Comput Phys 228:619–40.
   PubMed Web of Science ®Google Scholar
• Lin CL, Tawhai MH, Hoffman EA. (2013). Multiscale image-based modeling and simulation of gas flow and particle transport in the human lungs. Wiley Interdiscip Rev Syst Biol Med 5:643–55.
   PubMed Web of Science ®Google Scholar
• Lloyd S. (1982). Least squares quantization in PCM. IEEE Trans Inf Theory 28:129–37.
   Web of Science ®Google Scholar
• Lorensen WE, Cline HE. 1987. Marching cubes: a high resolution 3D surface construction algorithm. In: Proceedings of the 14th Annual Conference on Computer Graphics and Interactive Techniques, SIGGRAPH ’87. New York, NY: ACM, 163–9.
   Google Scholar
• Luo HY, Liu Y. (2008). Modeling the bifurcating flow in a CT-scanned human lung airway. J Biomech 41:2681–88.
   PubMed Web of Science ®Google Scholar
• Morgan KT, Monticello TM. (1990). Airflow, gas deposition, and lesion distribution in the nasal passages. Environ Health Perspect 85:209–18.
   PubMed Web of Science ®Google Scholar
• Morris JB. (1997). Uptake of acetaldehyde vapor and aldehyde dehydrogenase levels in the upper respiratory tracts of the mouse, rat, hamster, and guinea pig. Fundam Appl Toxicol 35:91–100.
   PubMedGoogle Scholar
• Morris JB, Blanchard KT. (1992). Upper respiratory tract deposition of inspired acetaldehyde. Toxicol Appl Pharmacol 114:140–6.
   PubMed Web of Science ®Google Scholar
• Overton JH, Graham RC, Miller FJ. (1987). A model of the regional uptake of gaseous pollutants in the lung: II. The sensitivity of ozone uptake in laboratory animal lungs to anatomical and ventilatory parameters. Toxicol Appl Pharmacol 88:418–32.
   PubMed Web of Science ®Google Scholar
• Plowchalk DR, Andersen ME, Bogdanffy MS. (1997). Physiologically based modeling of vinyl acetate uptake, metabolism, and intracellular pH changes in the rat nasal cavity. Toxicol Appl Pharmacol 142:386–400.
   PubMed Web of Science ®Google Scholar
• Schneider CA, Rasband WS, Eliceiri KW. (2012). NIH Image to ImageJ: 25 years of image analysis. Nat Methods 9:671–5.
   PubMed Web of Science ®Google Scholar
• Schroeter JD, Campbell J, Kimbell JS, et al. (2014). Effects of endogenous formaldehyde in nasal tissues on inhaled formaldehyde dosimetry predictions in the rat, monkey, and human nasal passages. Toxicol Sci 138:412–24
   PubMed Web of Science ®Google Scholar
• Schroeter JD, Kimbell JS, Gross EA, et al. (2008). Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acrolein. Inhal Toxicol 20:227–43.
   PubMed Web of Science ®Google Scholar
• Teeguarden JG, Bogdanffy MS, Covington TR, et al. (2008). A PBPK model for evaluating the impact of aldehyde dehydrogenase polymorphisms on comparative rat and human nasal tissue acetaldehyde dosimetry. Inhal Toxicol 20:375–90.
   PubMed Web of Science ®Google Scholar
• Wachowiak M. (2011). All in a sniff: olfaction as a model for active sensing. Neuron 71:962–73.
   PubMed Web of Science ®Google Scholar
• Wei Z, Xu Z, Li B, Xu F. (2013). Numerical simulation of airway dimension effects on airflow patterns and odorant deposition patterns in the rat nasal cavity. PLoS One 8:0077570. doi:10.1371/journal.pone.0077570.
   Web of Science ®Google Scholar
• Yin Y, Choi J, Hoffman EA, et al. (2013). A multiscale MDCT image-based breathing lung model with time-varying regional ventilation. J Comput Phys 244:168–92.
   PubMed Web of Science ®Google Scholar