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Inhalation Toxicology
International Forum for Respiratory Research
Volume 4, 1992 - Issue 1
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Research Article

Effects of Acute Exposure to O3 On Rats: Sequence of Epithelial and Inflammatory Changes in the Distal Airways

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Pages 17-31 | Published online: 27 Sep 2008

References

  • Abraham W. M., Delehunt J. C., Yerger L., Marchette B., Oliver W., Jr. Changes in airway permeability and responsiveness after exposure to ozone. Environ. Res. 1984; 34: 110–119
  • Barr B. C., Hyde D. M., Plopper C. G., Dungworth D. L. Distal airway remodeling in rats chronically exposed to ozone. Am. Rev. Respir. Dis. 1988; 137: 924–938
  • Barry B. E., Mercer R. R., Miller F. J., Crapo J. D. Effects of inhalation of 0.25 ppm ozone on the terminal bronchioles of juvenile and adult rats. Exp. Lung Res. 1988; 14: 225–245
  • Barry B. E., Miller F. J., Crapo J. D. Effects of inhalation of 0.12 and 0.25 parts per million ozone on the proximal alveolar region of juvenile and adult rats. Lab. Invest. 1985; 53(6)692–704
  • Bassett D. J.P., Bowen-Kelly E., Brewster E. L., Elbon C. L., Reichenbaugh S. S., Bunton T., Kerr J. S. A reversible model of acute lung injury based on ozone exposure. Lung 1988; 166: 355–369
  • Bhalla D. K., Crocker T. T. Pulmonary epithelial permeability in rats exposed to O3. J. Toxicol. Environ. Health 1987; 21: 73–87
  • Bhalla D. K., Daniels D. S. Suppression of O3, effect on airway permeability by cyclophosphamide, FPL 55712 and indomethacin. Am. Rev. Respir. Dis. 1991; 143(4), A698
  • Bhalla D. K., Mannix R. C., Kleinman M. T., Crocker T. T. Relative permeability of nasal, tracheal, and bronchoalveolar mucosa to macromolecules in rats exposed to ozone. J. Toxicol. Environ. Health 1986; 17: 269–283
  • Bhalla D. K., Mannix R. C., Lavan S. M., Phalen R. F., Kleinman M. T., Crocker T. T. Tracheal and bronchoalveolar permeability changes in rats inhaling oxidant atmospheres during rest or exercise. J. Toxicol Environ. Health 1987; 22: 417–437
  • Bils R. F., Christie B. R. The experimental pathology of oxidant and air pollutant inhalation. Int. Rev. Exp. Pathol. 1980; 21: 195–293
  • Bils R. F., Christie B. R., Hackney J. D. Toxic effects of low concentration of ozone on squirrel monkey lungs. Fed. Proc. 1976; 35: 504
  • Boatman E. S., Sata S., Frank R. Acute effects of ozone on cat lungs. II. Structural. Am. Rev. Respir Dis. 1974; 110: 157–169
  • Braude S., Nolop K. B., Hughes J. M.B., Barnes P. J., Royston D. Comparison of lung vascular and epithelial permeability indices in the adult respiratory distress syndrome. Am. Rev. Respir. Dis. 1986; 133: 1002–1005
  • Castleman W. L., Tyler W. S., Dungworth D. L. Lesions in respiratory bronchioles and conducting airways of monkeys exposed to ambient levels of ozone. Exp. Mol. Pathol. 1977; 26: 384–400
  • Devlin R. B., McDonnell W. F., Mann R., Becker S., House D. E., Schreinemachers D., Koren H. S. Exposure of humans to ambient levels of ozone for 6.6 hours causes cellular and biochemical changes in the lung. Am. J. Respir. Cell Mol. Biol. 1991; 4: 72–81
  • Dungworth D. L., Cross C. E., Gillespie J. R., Plopper C. G. The effects of ozone on animals. Ozone Chemistry and Technology A Review of the Literature, 1961–1974, J. S. Murphy, J. R. Orr. Franklin Institute, Philadelphia 1975; 29–54
  • Esterline R. L., Bassett D. J.P., Trush M. A. Characterization of the oxidant generation by inflammatory cells lavaged from rat lungs following acute exposure to ozone. Toxicol. Appl. Pharmacol. 1989; 99: 229–239
  • Evans M. I. Oxidant gases. Environ. Health Perspect. 1984; 55: 85–95
  • Evans M. J., Dekker N. P., Cabral-Anderson L. J., Shami S. G. Morphological basis of tolerance to ozone. Exp. Mol. Pathol. 1985; 42: 366
  • Fabbri L. M., Aizawa H., Alpert S. E., Walters E. H., O'Byrne P. M., Gold B. D., Nadel J. A., Holtzman M. J. Airway hyperresponsiveness and changes in cell counts in bronchoalveolar lavage after ozone exposure in dogs. Am. Rev. Respir. Dis. 1984; 129: 288–291
  • Flick M. R., Perel A., Staub N. C. Leukocytes are required for increased lung microvascular permeability after microembolizaton in sheep. Circ. Res. 1981; 48: 344–351
  • Holtzman J. J., Fabbri L. M., O'Byrne P. M., Gold B. D., Aizawa H., Walters E. H., Alpert S. E., Nadel J. A. Importance of airway inflammation for hyperresponsiveness induced by ozone. Am. Rev. Respir. Dis. 1983; 127: 686–690
  • Hu P. C., Miller F. J., Daniels M. J., Hatch G. E., Graham J. A., Cardner D. E., Selgrade M. K. Protein accumulation in lung lavage fluid following ozone exposure. Environ. Res. 1982; 29: 377–388
  • Johnson K. I., Fantone J. C., III, Kaplan J., Ward P. A. In vivo damage of rat lungs by oxygen metabolites. J. Clin. Invest. 1981; 67: 983–993
  • Kehrl H. R., Vincent L. M., Kowalsky R. J., Horstman D. H., O'Neil J. J., McCartney W. H., Bromberg P. A. Ozone exposure increases respiratory epithelial permeability in humans. Am. Rev. Respir. Dis. 1987; 135: 1124–1128
  • Koren H. S., Devlin R. B., Graham D. E., Mann R., McCee M. P., Horstman D. H., Kozumbo W. J., Becker S., House D. E., McDonnell W. F., Bromberg P. A. Ozone-induced inflammation in the lower airways of human subjects. Am. Rev. Respir. Dis. 1989; 139: 407–415
  • Macy E., Kemeny M., Saxon A. Enhanced ELISA: How to measure less than 10 picograms of a specific protein (immunoglobulin) in less than 8 hours. FASEB J. 1988; 2: 3003–3009
  • Mautz W. J., McClure T. R., Reischl P., Phalen R. F., Crocker T. T. Enhancement of ozone-induced lung injury by exercise. J. Toxicol. Environ. Health 1985; 16: 841–854
  • Menzel D. B. Ozone: An Overview of its toxicity in man and animals. Fundamentals of Extrapolation Modeling of Inhaled Toxicants: Ozone and Nitrogen Dioxide, F. J. Miller, D. B. Menzel. Hemisphere., New York 1984; 183–204
  • Menzel D. B. Toxicity of ozone, oxygen, and radiation. Annu. Rev. Pharrnacol. 1970; 10: 379–394
  • Mudd J. B., Freeman B. A. Reaction of ozone with biological membranes. Biochemical Effects of Environmental Pollutants, S. D. Lee. Ann Arbor Science Publishers, Inc, Ann Arbor, Mich 1980; 97–133
  • Murlas C. G., Roum J. H. Sequence of pathologic changes in the airway mucosa of guinea pigs during ozone-induced bronchial hyperreactivity. Am. Rev. Respir. Dis. 1985; 131: 314–320
  • Ohki S., Hanyu T., Imaki K., Nakazawa N., Hirata F. Radioimmunoassays of prostaglandin F2α and prostaglandin F2α-main urinary metabolite with prosta- glandin-125I-yrosine methylester arnide. Prostaglandins 1974; 6: 137–148
  • Patterson C. E., Barnard J. W., Lafuze J. E., Hull M. T., Baldwin S. J., Rhoades R. A. The role of activation of neutrophils and microvascular pressure in acute pulmonary edema. Am. Rev. Respir. Dis. 1989; 140: 1052–1062
  • Plopper C. G., Dungworth D. L., Tyler W. S. Pulmonary lesions in rats exposed to ozone. A correlated light and electron microscopic study. Am. J. Pathol. 1973; 71: 373–394
  • Plopper C. G., Dungworth D. L., Tyler W. S., Chow C. K. Pulmonary alterations in rats exposed to 0.2 and 0.1 ppm ozone: A correlated morphological and biochemical study. Arch. Environ. Health 1979; 34(6)390–395
  • Schlesinger R. B., Driscoll K. E., Cunnison A. F., Zelikoff J. T. Pulmonary arachidonic acid metabolism following acute exposures to ozone and nitrogen dioxide. J. Toxicol. Environ. Health 1990; 31: 275–290
  • Schlesinger R. B., Weideman P. A., Zelikoff J. T. Effects of repeated exposures to ozone and nitrogen dioxide on respiratory tract prostanoids. Inhal. Toxicol. 1991; 3: 27–36
  • Schwerer B., Bach M., Bernheimer H. ELISA for determination of albumin in the nanogram range: assay in cerebrospinal fluid and comparison with radial immunodiffusion. Clin. Chim. Acta 1987; 163: 237–244
  • Seltzer J., Bigby B. G., Stulbarg M., Holtzman M. J., Nadel J. A., Ueki I. F., Leikauf G. D., Goetzl E. J., Boushey H. A. O3 induced change in bronchial reactivity to methacholine and airway inflammation in humans. J. Appl. Physiol. 1986; 60(4)1321–1326
  • Skrinska V., Lucas F. V. Isolations of prostacyclin from whole blood. Prostaglandin 1981; 22: 365–375
  • Smith P. K., Krohn R. I., Hermanson G. T., Mallia A. K., Gartner F. H., Provenzano M. D., Fujimoto E. K., Coeke N. M., Olson B. I., Klenk D. C. Measurement of protein using bicinchoninic acid. Anal. Biochem. 1985; 150: 76–85
  • Su W. Y., Gordon I., Chen L. C., Amdur M. Is the protein leakage into the alveolar space after toxic injury size dependent or protein specific?. Toxicologist 1991; 11(1)88
  • Weiss S. J. Tissue destruction by neutrophils. N. Engl. J. Med. 1989; 320: 365–376
  • Young C., Bhalla D. K. Time course of PMN influx in rat trachea and correlation to permeability following O3 exposure. Toxicologist 1991; 11(1)89

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