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Inhalation Toxicology
International Forum for Respiratory Research
Volume 4, 1992 - Issue 4
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Research Article

Extrapolation Modeling of Aerosol Deposition in Human and Laboratory Rat Lungs

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Pages 303-324 | Published online: 27 Sep 2008

References

  • Baldshby I., Hofmann W., Martonen T. B. Inspiratory particle deposition in airway bifurcation models. J. Aerosol Sci. 1991; 22: 15–30
  • Chan T. L., Lippmann M. Experimental measurements and empirical modeling of the regional deposition of inhaled particles in humans. Am. Ind. Hyg. Assoc. J. 1980; 41: 399–409
  • Chan T. L., Schreck R. M., Lippmann M. Effect of the laryngeal jet on particle deposition in the human trachea and upper bronchial airways. J. Aerosol Sci. 1980; 11: 447–459
  • Cheng Y. S., Yamada Y., Yeh H. C., Swift D. L. Diffusional deposition of ultrafine aerosols in a human nasal cast. J. Aerosol Sci. 1988; 19: 741–751
  • Costa D. L., Tepper J. S. Approaches to lung function assessment in small mammals. Toxicology of the Lung, D. E. Gardner, J. D. Crapo, E. J. Massaro. Raven Press, New York 1988; 147–174
  • Folinsbee L. J., Raven P. B. Exercise and air pollution. J. Sports Med. 1984; 2: 57–75
  • Foster M. Is 24 hour lung retention an index of alveolar deposition?. J. Aerosol Med. 1988; 1: 1–9
  • Gradon L., Yu C. P. Diffusional particle deposition in the human nose and mouth. Aerosol Sci. Technol. 1989; 11: 213–220
  • Heyder J., Rudolf G. Deposition of aerosol particles in the human nose. lnhaled Particles /V, W. H. Walton. Pergamon Press, Oxford 1977; 107–126
  • Heyder J., Gebhart J., Rudolf C., Schiller C. F., Stahlhofen W. Deposition of particles in the human respiratory tract in the size range 0.005–15 μm. J. Aerosol Sci. 1986; 17: 811–825
  • Hofmann W., Martonen T. B., Graham R. C. Predicted deposition of nonhygroscopic aerosols in the human lung as a function of subject age. J. Aerosol Med. 1989; 2: 49–68
  • International Commission on Radiological Protection. Report of the Task Group on Reference Man. ICRP Publication No. 23., Pergamon Press, Oxford 1975
  • Martonen T. B. Analytical model of hygroscopic particle behavior in human airways. Bull. Math. Biol. 1982; 44: 425–442
  • Martonen T. B. Deposition of inhaled particulate matter in the upper respiratory tract, larynx, and bronchial airways: A mathematical description. J. Toxicol. Environ. Health 1983; 12: 787–800
  • Martonen T. B. Surrogate experimental models for studying particle deposition in the human respiratory tract: An overview. 2nd U.S. Dutch International Symposium: Aerosols. Elsevier, New York 1986; 547–568
  • Martonen T. B. Development of surrogate lung systems with controlled thermodynamic environments to study hygroscopic particles: Air pollutants and pharmacologic drugs. Partic. Sci. Technol. 1990; 8: 1–20
  • Martonen T. B. Aerosol therapy implications of particle deposition patterns in simulated human airways. J. Aerosol Med. 1991; 42: 5–40
  • Martonen T. B., Graham R. C. Hygroscopic growth: Its effect on aerosol therapy and inhalation toxicology. Deposition and Clearance of Aerosols in the Hurnan Respiratory Tract, W. Hofmann. Facultas Universitatverlag Ges. m.b.H., Vienna 1987a; 200–206
  • Martonen T. B., Graham R. C. The effect of hygroscopic growth upon the regional dispersion of particulates in human airways. International Society for Aerosols in Medicine, Proceedings of the 6th Congress, J. M. Aiache, C. Molina. Librarie Lavoisier, Paris 1987b; 221–227
  • Martonen T. B., Lowe J. Assessment of aerosol deposition patterns in human respiratory tract casts. Aerosols in the Mining and Industrial Work Environments, V. A. Marple, B. Y.H. Liu. Ann Arbor Science., Ann Arbor, Mich. 1983; 151–164
  • Martonen T. B., Miller F. J. Dosimetry and species sensitivity: Key factors in hazard evaluation using animal exposure data. J. Aerosol Sci. 1986; 17: 316–319
  • Martonen T. B., Zhang Z. Comments on recent data for particle deposition data in human nasal passages. J. Aerosol Sci., in press
  • Martonen T. B., Barnett A. E., Miller F. J. Ambient sulfate aerosol deposition in man: Modelling the influence of hygroscopicity. Environ. Health Perspect. 1985; 63: 11–24
  • McMahon T. A., Brain J. D., Lemott S. Species differences in aerosol deposition. lnhaled Particles IV, W. H. Walton. Pergamon Press, Oxford 1977; 23–33
  • Miller F. I., Martonen T. B., Menache M. G., Graham R. C., Spektor D. M., Lippmann M. Influence of breathing mode and activity level on the regional deposition of inhaled particles and implications for regulatory standards. Inhaled Particles VI, J. Dodgson, R. I. McCallum, M. R. Bailey. Pergamon Press, Oxford 1988; 3–10, and D. R. Fisher
  • Muhle H., Bellmann B. Pulmonary clearance of inhaled particles in dependence of particle size. J. Aerosol Sci. 1986; 27: 346–349
  • Niinimaa V., Cole P., Mintz S., Shepard R. J. Oronasal distribution of respiratory airflow. Respir. Physiol. 1981; 43: 69–75
  • Olson D. E., Sudlow M. F., Horsfield K., Filley G. F. Convective patterns of flow during inspiration. Arch. Intern. Med. 1973; 131: 51–57
  • Pedley T. J., Schroter R. C., Sudlow M. F. Gas flow and mixing in the airways. Bioengineering Aspects of the Lung, J. B. West. Marcel Dekker, New York 1979; 163–265
  • Phalen R. F., Kenoyer J. L., Crocker T. T., McClure T. R. Effects of sulfate aerosols in combination with ozone on elimination of tracer particles inhaled by rats. J. Toxicol. Environ. Health 1980; 6: 797–810
  • Proctor D. F., Andersen I., Lundquist G. Nasal mucociliary function in humans. Respiratory Defense Mechanisms, Part I, J. D. Brain, D. F. Proctor, L. M. Reid. Marcel Dekker, New York 1977; 63–93
  • Raabe O. G. Deposition and clearance of inhaled aerosols. Mechanisms in Respiratory Toxicology, H. Witchi, P. Nettesheim. CRC Press, Boca Raton, Fla 1982; 27–76
  • Raabe O. G., Yeh H. C., Newton G. J., Phalen R. F., Velasquez D. J. Deposition of inhaled monodisperse aerosols in small rodents. Inhaled Particles IV, W. H. Walton. Pergamon Press, Oxford 1977; 3–21
  • Raabe O. G., Al-Bayati M. A., Teague S. V., Rasolt A. Regional deposition of inhaled monodisperse coarse and fine mode aerosol particles in small laboratory animals. Inhaled Particles W, J. Dodgson, R. I. McCallum, M. R. Bailey, D. R. Fisher. Pergamon Press, Oxford 1988; 53–63
  • Schlesinger R. B., Lippmann M. Particle deposition in the trachea: In vivo and in hollow casts. Thorax 1976; 31: 678–684
  • Schlesinger R. B., Bohning D. E., Chan T. L., Lippmann M. Particle deposition in a hollow cast of the human tracheobronchial tree. J. Aerosol Sci. 1977; 8: 429–445
  • Schreider J. P., Raabe O. C. Anatomy of the nasal-pharyngeal airway of experimental animals. Anat. Rec. 1981; 200: 195–205
  • Schroter R. L., Sudlow M. F. Flow patterns in models of the human bronchial airways. Respir. Physiol. 1969; 7: 341–355
  • Smaldone G. C., Perry R. J., Bennett W. D., Messina M. S., Zwang I., Ilowite J. Interpretation of “24 hour lung retention” in studies of mucociliary clearance. J. Aerosol Med. 1988; 1: 11–20
  • Soong T. T., Nicolaides P., Yu C. P., Soong S. C. A statistical description of the human tracheobronchial tree geometry. Respir. Physiol. 1979; 37: 161–172
  • Stahlhofen W., Gebhart J., Heyder J. Experimental determination of the regional deposition of aerosol particles in the human respiratory tract. Am. Ind. Hyg. Assoc. J. 1980; 41: 385–398
  • Stahlhofen W., Gebhart J., Heyder J., Scheuch G., Juraske P. Particle deposition in extrathoracic airways of healthy subjects and of patients with early stages of laryngeal carcinoma. J. Aerosol Sci. 1984; 15: 215–217
  • Stahlhofen W., Rudolf G., James A. C. Intercomparison of experimental regional aerosol deposition data. J. Aerosol Med. 1989; 2: 81–87
  • Sudlow M. F., Olson D. E., Schroter R. C. Fluid mechanics of bronchial air-flow. Inhaled Particles III, W. H. Walton. Unwin Bros., Old Woking, SurreyEngland 1970; 19–31
  • Task Group on Lung Dynamics. Deposition and retention models for internal dosimetry of the human respiratory tract. Health Phys. 1966; 12: 173–207
  • Tepper J. S., Wiester M. J., King M. E., Weber M. F., Costa D. L. Use of carbon dioxide challenge to detect toxicant-induced changes in cardiopulmonary function of awake rats. Inhal. Toxicol. 1988; 79–95, Premier lssue:
  • Weibel E. R. Morphometry of the Human Lung. Springer Verlag, Berlin 1963
  • Xu G. B., Yu C. P. Deposition of diesel exhaust particles in mammalian lungs: A comparison between rodents and man. Aerosol Sci. Technol. 1987; 71: 17–123
  • Yarnada Y., Cheng Y. W., Yeh H.-C., Swift D. L. lnspiratory and expiratory deposition of ultrafine particles in a human nasal cast. Inhal. Toxicol. Premier Issue. 1988; 1–22
  • Yeh H. C., Schum G. M., Duggan M. T. Anatomic models of the tracheobronchial and pulmonary regions of the rat. Anat. Rec. 1979; 195: 483–492
  • Yu C. P., Diu C. K., Soong T. T. Statistical analysis of aerosol deposition in nose and mouth. Am. Ind. Hyg. Assoc. J. 1981; 42: 726–733
  • Yu C. P., Xu G. B. Predictive models for deposition of diesel exhaust particulates in human and rat lungs. Aerosol Sci. Technol. 1986; 5: 337–347

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