Role of free radicals in toxic hepatic injury II. Are free radicals the cause of toxin-Induced liver injury?

References

• Comporti M. Lipid peroxidation and cellular damage in toxic liver injury. Lab Invest 1985; 53: 599–623
   PubMed Web of Science ®Google Scholar
• Recknagel R O. Carbon tetrachloride hepatotoxicity. Pharmacol Rev 1967; 19: 145–208
   PubMed Web of Science ®Google Scholar
• Rubin E, Popper H. The evolution of human cirrhosis deduced from observations in experimental animals. Medicine 1967; 46: 163–183
   PubMed Web of Science ®Google Scholar
• Bagnasco F M, Stringer B, Muslim A M. Carbon tetrachloride poisoning. Radiographic findings. NY State J Med 1978; 78: 646–647
   PubMedGoogle Scholar
• Kalf G F, Post G B, Snyder R. Solvent toxicology. Recent advances in the toxicology of benzene, the glycol ethers, and carbon tetrachloride. Ann Rev Pharmacol Toxicol 1987; 27: 399–427
   PubMed Web of Science ®Google Scholar
• Barceloux D. Halogenated hazardous materials toxicology. Clinical Principles of Environmental Health, J B Sullivan, G Kreiger. Williams and Wilkins, Baltimore 1992; 732–747
   Google Scholar
• Thomas C E, Aust S D. Free radicals and environmental toxins. Ann Emerg Med 1986; 15: 1075–1083
   PubMed Web of Science ®Google Scholar
• Wright W H, Schaffer J M. Critical anthelmintic tests of chlorinated alkyl hydrocarbons and a correlation between the anthelmintic efficacy, chemical structure and physical properties. Am J Hyg 1932; 16: 325–428
   Google Scholar
• Ungemach F R. Pathobiochemical mechanisms of hepatocellular damage following lipid peroxidation. Chem Phys Lipids 1987; 45: 171–205
   PubMed Web of Science ®Google Scholar
• Berger M L, Bhatt H, Combes B, Estabrook R W. CCl4-induced toxicity in isolated hepatocytes: the importance of direct solvent injury. Hepatology 1986; 6: 36–45
   PubMed Web of Science ®Google Scholar
• Butler T C. Reduction of carbon tetrachloride in vivo and reduction of carbon tetrachloride and chloroform in vitro by tissues and tissue constituents. J Pharmacol Exp Ther 1961; 134: 311–319
   PubMed Web of Science ®Google Scholar
• Fowler J S. Carbon tetrachloride metabolism in the rabbit. Br J Pharmacol 1968; 37: 733–737
   Web of Science ®Google Scholar
• Farber J L. The biochemical pathology of toxic cell death. The Pathologist and the Environment, D G Scarpelli, J E Craighead, N Kaufman. Williams and Wilkins, Baltimore 1985; 19–30
   Google Scholar
• Klaassen C D, Plaa G L. Comparison of the biochemical alterations elicited in livers from rats treated with carbon tetrachloride, chloroform, 1,1,2-trichloroethane and 1,1,1-trichloroethane. Biochem Pharmacol 1969; 18: 2019–2027
   PubMed Web of Science ®Google Scholar
• Reynolds E S. Comparison of early injury to liver endoplasmic reticulum by halomethane, hexachloroethane, benzene, toluene, bromobenzene, ethionine, thioacetamide and dimethylnitrosamine. Biochem Pharmacol 1972; 21: 2555–2561
   PubMed Web of Science ®Google Scholar
• Reynolds E S, Moslen M T. Liver injury following halothane anesthesia in phenobarbital-pretreated rats. Biochem Pharmacol 1974; 23: 189–195
   PubMed Web of Science ®Google Scholar
• Slater T F. Free radical mechanisms in tissue injury. Pion Limited, London 1972
   Google Scholar
• Gordis E. Lipid metabolites of carbon tetrachloride. J Clin Invest 1969; 48: 203–209
   PubMed Web of Science ®Google Scholar
• Comporti M. Glutathione-depleting agents and lipid peroxidation. Chem Phys Lipids 1987; 45: 143–169
   PubMed Web of Science ®Google Scholar
• Packer J E, Slater T F, Willson R L. Reactions of the carbon tetrachloride-related peroxy free radical (CCl302) with amino acids: pulse radiolysis evidence. Life Sci 1978; 23: 2617–2620
   PubMed Web of Science ®Google Scholar
• DeFerreyra E C, Castro J A, Diaz Gomez M I, et al. Prevention and treatment of carbon tetrachloride hepatotoxicity by cysteine: studies about its mechanism. Toxicol Appl Pharmacol 1974; 27: 558–571
   PubMed Web of Science ®Google Scholar
• Recknagel R O, Glende E A, Hruszkewycz A M. New data supporting an obligatory role for lipid peroxidation in carbon tetrachloride-induced loss of aminopyrine demethylase, cytochrome P-450 and glucose-6phosphatase. Biological Reactive Intermediates, Formation, Toxicity and Inactivation, D J Jollow, J J Kocsis, R Snyder, H Vaino. Plenum Press, New York and London 1977; 417–430
   Google Scholar
• Lindstrom T D, Anders M W, Remmer H. Effect of phenobarbital and diethyl maleate on carbon tetrachloride toxicity in isolated rat hepatocytes. Exp Mol Pathol 1978; 28: 48–57
   PubMed Web of Science ®Google Scholar
• DeGroot H, Hass W. Self-catalyzed 02 independent inactivation of NADPH- or dithionite-reduced macrosomal cytochrome P-450 by carbon tetrachloride. Biochem Pharmacol 1981; 30: 2343–2347
   PubMed Web of Science ®Google Scholar
• Glende E A. Carbon tetrachloride-induced protection against carbon tetrachloride toxicity. The role of the liver microsomal drug-metabolizing system. Biochem Pharmacol 1972; 21: 1697–1702
   PubMed Web of Science ®Google Scholar
• Benedetti A, Casini A F, Ferrali M. Red cells lysis coupled to the peroxidation of liver microsomal lipids. Compartmentalization of the hemolytic system. Res Commun Chem Pathol Pharmacol 1977; 17: 519–528
   PubMedGoogle Scholar
• Benedetti A, Casini A F, Ferrali M, Fulceri R, Comporti M. Cytotoxic effects of carbonyl compounds (4-Hydroxyalkenals) originating from the peroxidation of microsomal lipids. Lipid Peroxidation and Tissue Injury, T F Slater, A Garner. Brunel Printing Services, Uxbridge 1981; 56
   Google Scholar
• Benedetti A, Comporti M, Esterbauer H. Identification of 4-hydroxynoal as a cysteine product originating from the peroxidation of liver microsomal lipids. Biochem Biophys Acta 1980; 620: 281–296
   PubMed Web of Science ®Google Scholar
• Recknagel R O, Glende E A, Waller R L, Lowrey K. Lipid peroxidation: biochemistry, measurement, and significance in liver injury. Toxicology of the Liver, G Plaa, W R Hewitt. Raven Press, New York 1982; 213–241
   Google Scholar
• Slater T F. Biochemical studies on liver injury. Biochemical Mechanisms of Liver Injury, T F Slater. Academic Press, London 1978; 1–44
   Google Scholar
• Reynolds E S, Ree H J. Liver parenchymal cell injury. VII. Membrane denaturation following carbon tetrachloride. Lab Invest 1971; 25: 237–250
   Web of Science ®Google Scholar
• Siegers C P, Steffen B, Younes M. Antidotal effects of desferrioxamine in experimental liver injury – role of lipid peroxidation. Pharmacol Res Commun 1988; 20: 337–343
   PubMedGoogle Scholar
• Colby H D, Brogan H C, Miles P R. Carbon tetrachloride-induced changes in adrenal microsomal mixed-function oxidases and lipid peroxidation. Toxicol Appl Pharmacol 1981; 60: 492–499
   PubMed Web of Science ®Google Scholar
• Hruszkewycz A M, Glende E A, Recknagel R O. Destruction of microsomal cytochrome P-450 and glucose-6-phosphatase by lipids extracted from peroxidized microsomes. Toxicol Appl Pharmacol 1978; 46: 695–702
   PubMed Web of Science ®Google Scholar
• Moore L, Davenport G R, Landon E J. Calcium uptake of a rat liver microsomal subcellular fraction in response to in vivo administration of carbon tetrachloride. J Biol Chem 1976; 251: 1197–1201
   PubMed Web of Science ®Google Scholar
• Chenery R, George M, Krishna G. The effect of ionophore A23187 and calcium on carbon tetrachloride-induced toxicity in cultured rat hepatocytes. Toxicol Appl Pharmacol 1981; 60: 241–252
   PubMed Web of Science ®Google Scholar
• Lowrey K, Glende E A, Recknagel R O. Destruction of liver microsomal calcium pump activity by carbon tetrachloride and bromotrichloromethane. Biochem Pharmacol 1981; 30: 135–140
   PubMed Web of Science ®Google Scholar
• Waller R J, Glende E A, Jr, Recknagel R O. Carbon tetrachloride and bromotrichloromethane toxicity. Dual role of covalent binding of metabolic cleavage products and lipid peroxidation in depression of microsomal calcium sequestration. Biochem Pharmacol 1983; 32: 1613–1617
   PubMed Web of Science ®Google Scholar
• DiLuzio N R. Influence of intravenously-administered hexahydrocoenzyme Q4 on liver injury. Life Sci 1966; 5: 1467–1478
   PubMedGoogle Scholar
• Younes M, Cornelius S, Siegers C P. Ferrous ion supported in vivo lipid peroxidation induced by paracetamol – its relation to hepatotoxicity. Res Commun Chem Pathol Pharmacol 1986; 51: 89–99
   PubMedGoogle Scholar
• LePage R N, Dorling P R. Plasma membranes in acute liver injury. Biochemical changes induced by carbon tetrachloride. Aust J Exp Biol Med Sci 1971; 49: 345–350
   PubMedGoogle Scholar
• Shanne F AX, Kane A B, Yound P E, Farber J L. Calcium dependence of toxic cell death: A final common pathway. Science 1979; 206: 700–702
   PubMed Web of Science ®Google Scholar
• Burk R F, Lane J M, Patel K. Relationship of oxygen and glutathione in protection against carbon tetrachloride-induced hepatic microsomal lipid peroxidation and covalent binding in the rat. Rationale for the use of hyperbaric oxygen to treat carbon tetrachloride ingestion. J Clin Invest 1984; 74: 1996–2001
   PubMed Web of Science ®Google Scholar
• Nastainczyk W, Ahr H J, Ullrich V. The reductive metabolism of halogenated alkanes by liver microsomal cytochrome P-450. Biochem Pharmacol 1982; 31: 391–396
   PubMed Web of Science ®Google Scholar
• Burk R F, Patel K, Lane J M. Reduced glutathione protection against rat liver microsomal injury by carbon tetrachloride: dependence on O2. Biochem J 1983; 215: 441–445
   PubMed Web of Science ®Google Scholar
• Uehleke H, Hellmer K, Tabarelli S. Binding of C14-carbon tetrachloride to microsomal proteins in vitro and formation of CHCl3 by reduced liver microsomes. Xenobiotica 1973; 3: 1–11
   PubMed Web of Science ®Google Scholar
• Ahr H J, King L J, Nastainczyk W, Ullrich V. The mechanism of chloroform and carbon monoxide formation from carbon tetrachloride by microsomal cytochrome P-450. Biochem Pharmacol 1980; 29: 2855–2861
   PubMed Web of Science ®Google Scholar
• Stacey N H, Ottenwilder H, Kappus G. CCl4-induced lipid peroxidation in isolated rat hepatocytes with different oxygen concentrations. Toxicol Appl Pharmacol 1982; 62: 421–427
   PubMed Web of Science ®Google Scholar
• Lubbers D W. Quantitative measurement and description of oxygen supply to the tissue. Oxygen and Physiologic Function, F F Jobsis. Professional Information Library, Dallas 1977; 254–276
   Google Scholar
• Marzella L, Muhvich K, Myers R A. Effect of hyperoxia on liver necrosis induced by hepatotoxins. Virchows Arch Cell Pathol 1986; 51: 497–507
   Google Scholar
• Truss C D, Kilenberg P G. Treatment of carbon tetrachloride poisoning with hyperbaric oxygen. Gastroenterology 1982; 82: 767–769
   PubMed Web of Science ®Google Scholar
• Farber J L. Biochemical mechanisms of toxic cell injury. Klin Wochenschr 1986; 64: 142–143
   PubMedGoogle Scholar
• Casini A, Giorli M, Hyland R J, et al. Mechanisms of the killing of cultured hepatocytes by bromobenzene. J Biol Chem 1982; 257: 6721–6728
   PubMed Web of Science ®Google Scholar
• Casini A F, Pompella A, Comporti M. Liver glutathione depletion induced by bromobenzene, iodobenzene, and diethylmaleate poisoning and its relation to lipid peroxidation and necrosis. Am J Pathol 1985; 118: 225–237
   PubMed Web of Science ®Google Scholar
• Black I M. Acetaminophen hepatotoxicity. Gastroenterology 1980; 78: 382
   PubMed Web of Science ®Google Scholar
• Albano E, Poli G, Chiarpotto E, Biasi F, Dianzani M U. Paracetamol-stimulated lipid peroxidation in isolated rat and mouse hepatocytes. Chem Biol Interactions 1983; 47: 249–263
   PubMed Web of Science ®Google Scholar
• Reiter R, Wendel A. Drug-induced lipid peroxidation in mice-IV. In vitro hydrocarbon evolution. Reduction of oxygen and covalent binding of acetaminophen. Biochem Pharmacol 1983; 32: 665–670
   PubMed Web of Science ®Google Scholar
• van de Straat R, Bijloo G J, Vermeulen N P. Paracetamol, 3-monoalkyl- and 3,5-dialkyl-substituted derivatives. Antioxidant activity and relationship between lipid peroxidation and cytotoxicity. Biochem Pharmacol 1988; 37: 3473–3476
   PubMed Web of Science ®Google Scholar
• Wendel A. Measurement of in vivo lipid peroxidation and toxicological significance. Free Radiciol Med 1987; 3: 355–358
   PubMed Web of Science ®Google Scholar
• Mason R P, Fischer V. Free radicals of acetaminophen: their subsequent reactions and toxicological significance. Fed Proc 1986; 45: 2493–2499
   PubMedGoogle Scholar
• Porubek D J, Rundgren M, Harvison P J, Nelson S D, Moldeus P. Investigation of mechanisms of acetaminophen toxicity in isolated rat hepatocytes with the acetaminophen analogues 3,5-dimethyl-acetaminophen and 2,6-dimethylacetaminophen. Mol Pharmacol 1987; 31: 647–653
   PubMed Web of Science ®Google Scholar
• Burton G W, Ingold K U. Auto-oxidation of biological molecules: The antioxidant activity of vitamin E and related chain-breaking phenolic antioxidants in vitro. J Amer Chem Soc 1981; 103: 6472–6477
   Web of Science ®Google Scholar
• Bors W, Michel C, Saran M. Antioxidants: their functions and mechanism as radical scavengers. Oxy Radicals and Their Scavenger System, G Cohen, R A Greenwald. Elsevier, Amsterdam 1983; 38–43
   Google Scholar
• Rosen G M, Rauckman E J, Ellington S P, et al. Reduction and glutathione conjugation reactions of N-acetyl-p-benzoquinone- imine and two dimethylated analogues. Mol Pharmacol 1984; 25: 151–157
   PubMed Web of Science ®Google Scholar
• Blair I A, Boobis A R, Davies D S, Cresp R M. Paracetamol oxidation: Synthesis and reactivity of N-acetyl-p-benzoquinoneimine. Tetrahedron Lett 1980; 21: 4947–4950
   Web of Science ®Google Scholar
• Tee L BG, Davies D S, Seddon C E, Boobis A R. Species differences in the hepatotoxicity of paracetamol are due to differences in the rate of conversion to its cytotoxic metabolite. Biochem Pharmacol 1987; 36: 1041–1052
   PubMed Web of Science ®Google Scholar
• Rosen G M, Singletary W V, Rauckman E J, Killenberg P G. Acetaminophen hepatotoxicity. An alternative mechanism. Biochem Pharmacol 1983; 32: 2053–2059
   PubMed Web of Science ®Google Scholar
• West P, Harmen L S, Josephy P D, Mason R P. Acetaminophen: enzymatic formation of a transient phenoxyl free radical. Biochem Pharmacol 1984; 33: 2933–2936
   PubMed Web of Science ®Google Scholar
• DeVries J. Hepatotoxic metabolic activation of paracetamol and its derivatives phenacetin and benorilate: oxygenation or electron transfer. Biochem Pharmacol 1981; 30: 399–402
   PubMed Web of Science ®Google Scholar
• Hinson J A, Pohl L R, Monks T J, Gillette J R, Guengerich F P. 3-Hydroxyacetaminophen: a microsomal metabolite of acetaminophen. Evidence against an epoxide as the reactive metabolite of acetaminophen. Drug Metab Dispos 1980; 8: 289–294
   PubMed Web of Science ®Google Scholar
• van de Straat R, Vromans R M, Bosman P, DeVries J, Vermeulen N P. Cytochrome P-450-mediated oxidation of substrates by electron-transfer; role of oxygen radicals and of 1- and 2- electron oxidation of paracetamol. Chem Biol Interact 1988; 64: 287–280
   Web of Science ®Google Scholar
• Bisby R H, Rabassum N. Properties of the radicals formed by one-electron oxidation of acetaminophen – a pulse radiolysis study. Biochem Pharmacol 1988; 17: 2734–2738
   Google Scholar
• Potter D W, Hinson J A. Mechanism of acetaminophen oxidation to N-acetyl-p-benzoquinone imine by horseradish peroxidase and cytochrome P-450. J Biol Chem 1987; 262: 966–973
   PubMed Web of Science ®Google Scholar
• Tee L B, Boobis A R, Huggett A C, Davies D S. Reversal of acetaminophen toxicity in isolated hamster hepatocytes by dithiothreitol. Toxicol Appl Pharmacol 1986; 83: 294–314
   PubMed Web of Science ®Google Scholar
• Hinson J A. Biochemical toxicology of acetaminophen. Rev Biochem Toxicol 1980; 2: 103–129
   Google Scholar
• Pumford N R, Hinson J A, Potter D W, et al. Immunochemical quantitation of 3-(cystein-S-yl) acetaminophen adducts in serum and liver proteins of acetaminophen-treated mice. J Pharmacol Exp Ther 1989; 248: 190–196
   PubMed Web of Science ®Google Scholar
• Piperno E, Berssenbruegge D A. Reversal of experimental paracetamol toxicosis with N-acetylcysteine. Lancet 1976; 2: 738–739
   PubMed Web of Science ®Google Scholar
• Piperno E, Mosher A H, Berssenbruegge D A, Winkler J D, Smith R B. Pathophysiology of acetaminophen overdosage toxicity: implications for management. Pediatrics 1978; 62: 880–889
   PubMed Web of Science ®Google Scholar
• Rumack B H, Peterson R C, Koch G G, Amara I A. Acetaminophen overdose. Arch Intern Med 1981; 14: 380–395
   Google Scholar
• Rumack B H, Peterson R G. Acetaminophen overdose: incidence, diagnosis, and management in 417 patients. Pediatrics 1978; 62: 893–903
   Web of Science ®Google Scholar
• Prescott L F, Newton R W, Swainson C S, et al. Successful treatment of severe paracetamol overdosage with cysteamine. Lancet 1974; 1: 588–592
   PubMed Web of Science ®Google Scholar
• Crome P, Volans C N, Vale J A, Widdop B, Goulding R. Oral methionine in the treatment of severe paracetamol (acetaminophen) overdosage. Lancet 1976; 2: 829–830
   PubMed Web of Science ®Google Scholar
• Labadarios D, Davis M, Portmann B, Williams R. Paracetamol-induced hepatic necrosis in the mouse – relationship between covalent binding, hepatic glutathione depletion and the protective effect of x-mercaptopropionylglycine. Biochem Pharmacol 1976; 26: 31–35
   Web of Science ®Google Scholar
• Lauterburg B H, Corcoran G B, Mitchell J R. Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. J Clin Invest 1983; 71: 980–991
   PubMed Web of Science ®Google Scholar
• Ziment I. Acetylcysteine: a drug with an interesting past and a fascinating future. Respiration 1986; 50: 26–30
   PubMed Web of Science ®Google Scholar
• Mitchell J R. Acetaminophen toxicity. N Engl J Med 1988; 319: 1601–1602
   PubMed Web of Science ®Google Scholar
• Wendel A, Feuerstein S. Drug-induced lipid peroxidation in mice I: modulation by monoxygenase activity, glutathione and selenium status. Biochem Pharmacol 1981; 30: 2513–2520
   PubMed Web of Science ®Google Scholar
• DuBois P R, Hill K E, Burk R F. Antioxidant effect of acetaminophen in rat liver. Biochem Pharmacol 1983; 32: 2621–2622
   PubMed Web of Science ®Google Scholar
• Anundi I, Hogberg J, Stead A H. Glutathione depletion in isolated hepatocytes: its relation to lipid peroxidation and cell damage. Acta Pharmacol Toxicol 1979; 45: 45–51
   PubMedGoogle Scholar
• Wendel A, Jaeschke H, Kleinwaechter C. Xenobiotic-induced lipid peroxidation and glutathione status in mouse liver. Lipid Peroxidation in Biological Systems. Amer Oil Chem Soc, Champagne, Illinois 1988; 71–83
   Google Scholar
• Kyle M E, Miccadei S, Nakae D, Farber J L. Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen. Biochem Biophys Res Commun 1987; 149: 889–896
   PubMed Web of Science ®Google Scholar
• Younes M, Siegers C P. The role of iron in the paracetamol and CCl4-induced lipid peroxidation and hepatotoxicity. Chem Biol Interact 1985; 55: 327–334
   PubMed Web of Science ®Google Scholar
• Devalia J L, Ogilvie R C, McLean A EM. Dissociation of cell death from covalent binding of paracetamol by flavones in a hepatocyte system. Biochem Pharmacol 1982; 31: 3745–3749
   PubMed Web of Science ®Google Scholar
• Comporti M, Benedetti A, Chieli E. Studies on in vitro peroxidation of liver lipids in ethanol-treated rats. Lipids 1973; 8: 498–502
   PubMed Web of Science ®Google Scholar
• Fernandez V, Videla L A. Effect of acute and chronic ethanol ingestion on the content of reduced glutathione of various tissues of the rat. Experimentia 1981; 37: 392–394
   PubMedGoogle Scholar
• Shaw S, Jayatilleke E, Ross W A, Gordon E R, Lieber C S. Ethanol-induced lipid peroxidation: potentiation by long-term alcohol feeding and attenuation by methionine. J Lab Clin Med 1981; 98: 417–424
   PubMed Web of Science ®Google Scholar
• Takada A, Ikegami F, Okumura Y, et al. Effect of alcohol on the liver of rats. III. The use of lipid peroxidation and sulfhydryl compounds in ethanol-induced liver injury. Lab Invest 1970; 23: 421–428
   PubMed Web of Science ®Google Scholar
• Videla L A, Fernandez V, Ugarte G, Valenzuela A. Effect of acute ethanol intoxication of the concent of reduced glutathional of the liver in relation to its lipoperoxidative capacity in the rat. FEBS Lett 1980; 111: 6–10
   PubMed Web of Science ®Google Scholar
• Gillette J R. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I. Correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity. Biochem Pharmacol 1974; 23: 2785–2794
   PubMed Web of Science ®Google Scholar
• Ghoshal A K, Recknagel R O. Positive evidence of acceleration of lipoperoxidation rat liver by carbon tetrachloride: in vitro experiments. Life Sci 1965; 4: 1521–1530
   PubMedGoogle Scholar
• Ghoshal A K, Recknagel R O. On the mechanism of carbon tetrachloride hepatotoxicity: coincidence of loss of glucose-6- phosphatase activity with peroxidation of microsomal lipid. Life Sci 1965; 4: 2195–2209
   Google Scholar
• Glende E A, Jr. On the mechanism of carbon tetrachloride toxicity: coincidence of loss or drug-metabolizing activity with peroxidation of microsomal lipid. Biochem Pharmacol 1972; 21: 2131–2138
   PubMed Web of Science ®Google Scholar
• Morton S, Mitchell M C. Effects of chronic alcohol feeding on glutathione turnover in the rat. Biochem Pharmacol 1985; 34: 1559–1563
   PubMed Web of Science ®Google Scholar
• Shaw S, Rubin K, Lieber C S. Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease: evidence of lipid peroxidation. Dig Dis Sci 1983; 28: 585–589
   PubMed Web of Science ®Google Scholar
• Comporti M, DiLuzio N R. Effects of ethanol administration on the peroxidation of liver lipids. Physiologist 1966; 9: 157
   Google Scholar
• Comporti M, Hartman A, DiLuzio N R. Effect of in vivo and in vitro ethanol administration on liver lipid peroxidation. Lab Invest 1967; 16: 616–624
   PubMed Web of Science ®Google Scholar
• DiLuzio N R. The role of lipid peroxidation and antioxidants in ethanol-induced lipid alterations. Exp Mol Pathol 1968; 8: 394
   PubMed Web of Science ®Google Scholar
• Shaw S, Jayatilleke E, Lieber C S. Lipid peroxidation as a mechanism of alcoholic liver injury: role of iron mobilization and microsomal induction. Alcohol 1988; 5: 135–140
   PubMed Web of Science ®Google Scholar
• Lai C S, Grover T A, Piette L H. Hydroxyl radical production in a purified NADPH-cytochrome c (P-450) reductase system. Arch Biochem Biophys 1979; 193: 373–378
   PubMed Web of Science ®Google Scholar
• Mishin V, Pokrovsky A, Lyakhovich V V. Interactions of some acceptors with superoxide anion radicals formed by the NADPH-specific flavoprotein in rat liver microsomal fractions. Biochem J 1976; 154: 307–310
   PubMed Web of Science ®Google Scholar
• Koes M, Ward T, Pennington S. Lipid peroxidation in chronic ethanol-treated rats: in vitro uncoupling of peroxidation from reduced nicotine adenosine dinucleotide phosphate oxidation. Lipids 1974; 9: 889–904
   Web of Science ®Google Scholar
• Kera Y, Ohbora Y, Komura S. The metabolism of acetaldehyde and not acetaldehyde itself is responsible for in vivo ethanol-induced lipid peroxidation in rats. Biochem Pharmacol 1988; 31: 3033–3038
   Google Scholar
• Popper H, Lieber C S. Histogenesis of alcoholic fibrosis and cirrhosis in the baboon. Am J Pathol 1980; 98: 695–716
   PubMed Web of Science ®Google Scholar
• Bradley S E. Handbook of Physiology, Section 22: Circulation. Williams and Wilkins, Baltimore 1963; Vol II: 1387–1438
   Google Scholar
• Reinke L A, Lai E K, DuBose C M, McKay P B. Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: correlation with radical formation in vitro. Proc Natl Acad Sci USA 1987; 84: 9223–9227
   PubMed Web of Science ®Google Scholar
• Albano E, Tomasi A, Goria-Gatti L, Dianzani M U. Spin trapping of free radical species produced during the microsomal metabolism of ethanol. Chem Biol Interactions 1988; 65: 223–234
   PubMed Web of Science ®Google Scholar
• Reinke L A, Rau J M, McKay P B. Possible roles of free radicals in alcoholic tissue damage. Free Radic Res Commun 1990; 9: 205–211
   PubMed Web of Science ®Google Scholar
• Ahmad F F, Cowan D L, Sun A Y. Potentiation of ethanol-induced lipid peroxidation of biological membranes in vitamin C. Life Sci 1988; 43: 1169–1176
   PubMed Web of Science ®Google Scholar
• Smith C V. Evidence for participation of lipid peroxidation and iron in diquat-induced hepatic necrosis in vivo. Mol Pharmacol 1987; 32: 417–422
   PubMed Web of Science ®Google Scholar
• Younes M, Cornelius S, Siegers C P. Fe2+-supported in vivo lipid peroxidation induced by compounds undergoing redox cycling. Chem Biol Interact 1985; 54: 97–103
   PubMed Web of Science ®Google Scholar
• Kehrer J P, Mossman B T, Sevanian A, Trush M A, Smith M T. Contemporary issues in toxicology: Free radical mechanisms in chemical pathogenesis. Toxicol Appl Pharmacol 1988; 95: 349–362
   PubMed Web of Science ®Google Scholar
• Sandy M S, Di Monte D, Smith M T. Relationships between intracellular vitamin E, lipid peroxidation, and chemical toxicity in hepatocytes. Toxicol Appl Pharmacol 1988; 93: 288–297
   PubMed Web of Science ®Google Scholar