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Journal of Biopharmaceutical Statistics Volume 34, 2024 - Issue 3

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Research Article

Optimal biological dose selection in dose-finding trials with model-assisted designs based on efficacy and toxicity: a simulation study

Yusuke Yamaguchia Astellas Pharma Global Development, Inc, Northbrook, Illinois, USACorrespondence[email protected]

https://orcid.org/0000-0002-8589-5303 View further author information

Kentaro Takedaa Astellas Pharma Global Development, Inc, Northbrook, Illinois, USA

https://orcid.org/0000-0002-8584-0521 View further author information

Satoshi Yoshidab Data Science, Astellas Pharma Inc, Tokyo, JapanView further author information

Kazushi Maruoc Department of Biostatistics, University of Tsukuba, Tsukuba, Japan

https://orcid.org/0000-0002-3093-0386 View further author information

Pages 379-393 | Received 18 Nov 2022, Accepted 06 Apr 2023, Published online: 28 Apr 2023

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https://doi.org/10.1080/10543406.2023.2202259
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