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Nanomedicine Volume 19, 2024 - Issue 9
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Research Article

Ph-Sensitive Docetaxel-Loaded Chitosan/Thiolated Hyaluronic Acid Polymeric Nanoparticles for Colorectal Cancer

Sobia Noreen1 Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Punjab, 63100, Pakistan;2 Centre for Chemistry & Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, 6020, AustriaORCID Iconhttps://orcid.org/0000-0002-4407-6002
ORCID Icon,
Fahad Pervaiz1 Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Punjab, 63100, PakistanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1941-082X
ORCID Icon,
Muhammad Ijaz2 Centre for Chemistry & Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, 6020, Austria;3 COMSATS University Islamabad, Lahore Campus, Punjab, 54000, Pakistan
,
Muhammad Farhan Hanif1 Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Punjab, 63100, Pakistan
,
Jam Riyan Hamza4 Department of Chemistry & Biochemistry, University of Minnesota Duluth, MN55812, USA
,
Hassan Mahmood3 COMSATS University Islamabad, Lahore Campus, Punjab, 54000, Pakistan
,
Hina Shoukat1 Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Punjab, 63100, Pakistan
,
Irsah Maqbool1 Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Punjab, 63100, Pakistan
&
Muhammad Azeem Ashraf5 University of Management & Technology Lahore, Punjab, 54770, Pakistan
 show all
Pages 755-777 | Received 30 Oct 2023, Accepted 17 Jan 2024, Published online: 09 Feb 2024
Supplemental material

Supplementary Material 01

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Supplementary Table S1. Thiol group quantification assay

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Supplementary Table S2. Kinetic characteristics of DTX release from formulations of CS/SH-HA nanoparticles

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Supplementary Table S3. An acute oral toxicity investigation for SH-HA nanoparticles with clinical outcomes

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Supplementary Table S4. Stability study of the thiolated NP formulation at different storage conditions for three months

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