Expert Opinion on Biological Therapy, Volume 12, Issue sup1 (2012)

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Expert Opinion on Biological Therapy, Volume 12, Issue sup1 (2012)

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Foreword

Article
Circulating nucleic acids in plasma and serum: an intriguing phenomenon
Dolores C García-Olmo & Damián García-Olmo
Pages: S1-S2
Published online: 18 May 2012
AbstractforCirculating nucleic acids in plasma and serum: an intriguing phenomenon | Full Text | References | PDF (145 KB)
  • 197 Views
  • 4 CrossRef citations
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Original Research

Article
Quantitative analysis of free-circulating DNA in plasma of patients with resectable NSCLC
Adam Szpechcinski DMSc, Joanna Chorostowska-Wynimko, Wlodzimierz Kupis, Krystyna Maszkowska-Kopij, Maciej Dancewicz, Janusz Kowalewski & Tadeusz Orlowski
Pages: S3-S9
Published online: 05 May 2012
AbstractforQuantitative analysis of free-circulating DNA in plasma of patients with resectable NSCLC | Full Text | References | PDF (306.4 KB)
  • 387 Views
  • 22 CrossRef citations
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Article
A comparative study of cell-free apoptotic and genomic DNA using FISH and massive parallel sequencing
Evgeniy S Morozkin, Ekaterina M Loseva, Igor V Morozov, Alexander M Kurilshikov, Anna A Bondar, Elena Yu Rykova, Nikolay B Rubtsov, Valentin V Vlassov & Pavel P Laktionov
Pages: S11-S17
Published online: 16 Apr 2012
AbstractforA comparative study of cell-free apoptotic and genomic DNA using FISH and massive parallel sequencing | Full Text | References | PDF (420.1 KB)
  • 169 Views
  • 13 CrossRef citations
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Article
Non-invasive prenatal diagnosis of fetal aneuploidies using massively parallel sequencing-by-ligation and evidence that cell-free fetal DNA in the maternal plasma originates from cytotrophoblastic cells
Brigitte HW Faas PhD, Joep de Ligt MSc, Irene Janssen, Alex J Eggink MD PHD, Lia DE Wijnberger MD PhD, John MG van Vugt MD PhD, Lisenka Vissers PhD & Ad Geurts van Kessel PhD
Pages: S19-S26
Published online: 16 Apr 2012
AbstractforNon-invasive prenatal diagnosis of fetal aneuploidies using massively parallel sequencing-by-ligation and evidence that cell-free fetal DNA in the maternal plasma originates from cytotrophoblastic cells | Full Text | References | PDF (305.1 KB)
  • 750 Views
  • 105 CrossRef citations
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Article
Alterations in methylation status of immune response genes promoters in cell-free DNA during a hemodialysis procedure
Marie Korabecna PhD, Eva Pazourkova, Ales Horinek, Magdalena Mokrejsova & Vladimir Tesar
Pages: S27-S33
Published online: 16 Apr 2012
AbstractforAlterations in methylation status of immune response genes promoters in cell-free DNA during a hemodialysis procedure | Full Text | References | PDF (276 KB)
  • 179 Views
  • 5 CrossRef citations
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Article
Ku protein as the main cellular target of cell-surface-bound circulating DNA
Anna V Cherepanova, Alexander V Bushuev, Tatyana G Duzhak, Ivan A Zaporozhchenko, Valentin V Vlassov & Pavel P Laktionov
Pages: S35-S41
Published online: 16 Apr 2012
AbstractforKu protein as the main cellular target of cell-surface-bound circulating DNA | Full Text | References | PDF (332.2 KB)
  • 126 Views
  • 1 CrossRef citations
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Article
Unbiased approach to profile the variety of small non-coding RNA of human blood plasma with massively parallel sequencing technology
Dmitry V. Semenov, Dmitry N. Baryakin, Evgeny V. Brenner, Alexander M. Kurilshikov, Gennady V. Vasiliev, Leonid A. Bryzgalov, Elena D. Chikova, Julia A. Filippova, Elena V. Kuligina & Vladimir A. Richter
Pages: S43-S51
Published online: 18 Apr 2012
AbstractforUnbiased approach to profile the variety of small non-coding RNA of human blood plasma with massively parallel sequencing technology | Full Text | References | PDF (317.8 KB)
  • 415 Views
  • 23 CrossRef citations
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Article
Prognostic impact of circulating miR-21 and miR-375 in plasma of patients with esophageal squamous cell carcinoma
Shuhei Komatsu, Daisuke Ichikawa MD PhD, Hiroki Takeshita, Hirotaka Konishi, Hiroaki Nagata, Shoji Hirajima, Tsutomu Kawaguchi, Tomohiro Arita, Atsushi Shiozaki, Hitoshi Fujiwara, Kazuma Okamoto & Eigo Otsuji
Pages: S53-S59
Published online: 23 Apr 2012
AbstractforPrognostic impact of circulating miR-21 and miR-375 in plasma of patients with esophageal squamous cell carcinoma | Full Text | References | PDF (343.1 KB) | Supplemental
  • 397 Views
  • 66 CrossRef citations
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Article
Oncogenic transformation induced by cell-free nucleic acids circulating in plasma (genometastasis) remains after the surgical resection of the primary tumor: a pilot study
Damián García-Olmo, Dolores C García-Olmo, Carolina Domínguez-Berzosa, Hector Guadalajara, Luz Vega & Mariano García-Arranz
Pages: S61-S68
Published online: 08 May 2012
AbstractforOncogenic transformation induced by cell-free nucleic acids circulating in plasma (genometastasis) remains after the surgical resection of the primary tumor: a pilot study | Full Text | References | PDF (301.1 KB)
  • 264 Views
  • 9 CrossRef citations
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Article
Plasma hTERT mRNA discriminates between clinically localized and locally advanced disease and is a predictor of recurrence in prostate cancer patients
José A March-Villalba MD, José M Martínez-Jabaloyas MD PhD, María J Herrero PhD, José Santamaría MD, Salvador F Aliño MD PhD & Francisco Dasí PhD
Pages: S69-S77
Published online: 05 May 2012
AbstractforPlasma hTERT mRNA discriminates between clinically localized and locally advanced disease and is a predictor of recurrence in prostate cancer patients | Full Text | References | PDF (416.4 KB)
  • 176 Views
  • 13 CrossRef citations
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Article
Assessment of diabetic retinopathy by measuring retina-specific mRNA in blood
A Butt, MS Ahmad, J Powrie & R Swaminathan
Pages: S79-S84
Published online: 18 May 2012
AbstractforAssessment of diabetic retinopathy by measuring retina-specific mRNA in blood | Full Text | References | PDF (243.8 KB)
  • 193 Views
  • 8 CrossRef citations
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Article
Extracellular DNA oxidation stimulates activation of NRF2 and reduces the production of ROS in human mesenchymal stem cells
Polina Loseva, S Kostyuk PhD, E Malinovskaya PhD, N Clement, CA Dechesne PhD, C Dani, T Smirnova PhD, K Glebova PhD, G Baidakova PhD, A Baranova PhD, V Izhevskaia, E Ginter & N Veiko PhD
Pages: S85-S97
Published online: 18 May 2012
AbstractforExtracellular DNA oxidation stimulates activation of NRF2 and reduces the production of ROS in human mesenchymal stem cells | Full Text | References | PDF (605.7 KB)
  • 352 Views
  • 36 CrossRef citations
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Article
Extracellular GC-rich DNA activates TLR9- and NF-kB-dependent signaling pathways in human adipose-derived mesenchymal stem cells (haMSCs)
Svetlana Kostjuk PhD, Polina Loseva, Oksana Chvartatskaya, Elizaveta Ershova PhD, Tatyana Smirnova, Elena Malinovskaya PhD, Olga Roginko, Vladimir Kuzmin, Vera Izhevskaia, Ancha Baranova, Evgeny Ginter & Natalia Veiko
Pages: S99-S111
Published online: 18 May 2012
AbstractforExtracellular GC-rich DNA activates TLR9- and NF-kB-dependent signaling pathways in human adipose-derived mesenchymal stem cells (haMSCs) | Full Text | References | PDF (656.4 KB)
  • 193 Views
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Reviews

Review Article
Circulating nucleic acids and evolution
Philippe Anker PhD & Maurice Stroun PhD
Pages: S113-S117
Published online: 28 Feb 2012
AbstractforCirculating nucleic acids and evolution | Full Text | References | PDF (180.9 KB)
  • 239 Views
  • 9 CrossRef citations
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Review Article
Implementing noninvasive prenatal fetal sex determination using cell-free fetal DNA in the United Kingdom
Melissa Hill, Celine Lewis, Lucy Jenkins, Stephanie Allen, Rob G Elles & Lyn S Chitty
Pages: S119-S126
Published online: 16 Apr 2012
AbstractforImplementing noninvasive prenatal fetal sex determination using cell-free fetal DNA in the United Kingdom | Full Text | References | PDF (251.3 KB)
  • 317 Views
  • 37 CrossRef citations
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Review Article
Continuous adaptation through genetic communication – a putative role for cell-free DNA
Dimetrie L Peters & Piet J Pretorius
Pages: S127-S132
Published online: 05 May 2012
AbstractforContinuous adaptation through genetic communication – a putative role for cell-free DNA | Full Text | References | PDF (235.5 KB)
  • 199 Views
  • 11 CrossRef citations
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Review Article
Horizontal transmission of malignancy by cell–cell fusion
David M Goldenberg ScD MD
Pages: S133-S139
Published online: 14 Apr 2012
AbstractforHorizontal transmission of malignancy by cell–cell fusion | Full Text | References | PDF (674.9 KB)
  • 275 Views
  • 23 CrossRef citations
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Review Article
Cell-free and cell-bound circulating nucleic acid complexes: mechanisms of generation, concentration and content
Elena Y Rykova, Evgeniy S Morozkin, Anastasia A Ponomaryova, Ekaterina M Loseva, Ivan A Zaporozhchenko, Nadezhda V Cherdyntseva, Valentin V Vlassov & Pavel P Laktionov
Pages: S141-S153
Published online: 14 Apr 2012
AbstractforCell-free and cell-bound circulating nucleic acid complexes: mechanisms of generation, concentration and content | Full Text | References | PDF (471.8 KB)
  • 888 Views
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Review Article
A new non-invasive prenatal diagnosis of Down syndrome through epigenetic markers and real-time qPCR
Philippos C Patsalis, Evdokia Tsaliki, George Koumbaris, Alex Karagrigoriou, Voula Velissariou & Elisavet A Papageorgiou
Pages: S155-S161
Published online: 14 Apr 2012
AbstractforA new non-invasive prenatal diagnosis of Down syndrome through epigenetic markers and real-time qPCR | Full Text | References | PDF (375.5 KB)
  • 359 Views
  • 11 CrossRef citations
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Review Article
Circulating nucleic acids and protease activities in blood of tumor patients
Heidi Schwarzenbach PhD
Pages: S163-S169
Published online: 16 Apr 2012
AbstractforCirculating nucleic acids and protease activities in blood of tumor patients | Full Text | References | PDF (184 KB)
  • 196 Views
  • 5 CrossRef citations
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Review Article
Noninvasive prenatal diagnosis of monogenic disorders
Marta Rodríguez de Alba, Ana Bustamante-Aragonés PhD, Sara Perlado, María José Trujillo-Tiebas PhD, Joaquín Díaz-Recasens MD PhD, Javier Plaza-Arranz MD PhD & Carmen Ramos PhD
Pages: S171-S179
Published online: 16 Apr 2012
AbstractforNoninvasive prenatal diagnosis of monogenic disorders | Full Text | References | PDF (522.1 KB)
  • 417 Views
  • 11 CrossRef citations
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Review Article
Fetal DNA in maternal plasma: a noninvasive tool for prenatal diagnosis of beta-thalassemia
Silvia Galbiati, Angela Brisci, Francesco Damin, Barbara Gentilin, Cristina Curcio, Gabriella Restagno, Laura Cremonesi & Maurizio Ferrari
Pages: S181-S187
Published online: 16 Apr 2012
AbstractforFetal DNA in maternal plasma: a noninvasive tool for prenatal diagnosis of beta-thalassemia | Full Text | References | PDF (266 KB)
  • 611 Views
  • 8 CrossRef citations
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Review Article
Exosomal RNA as biomarkers and the therapeutic potential of exosome vectors
Cecilia Lässer
Pages: S189-S197
Published online: 16 Apr 2012
AbstractforExosomal RNA as biomarkers and the therapeutic potential of exosome vectors | Full Text | References | PDF (267 KB)
  • 1277 Views
  • 96 CrossRef citations
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Review Article
Transformation of non-tumor host cells during tumor progression: theories and evidence
Dolores C García-Olmo, María G Picazo & Damián García-Olmo
Pages: S199-S207
Published online: 18 Apr 2012
AbstractforTransformation of non-tumor host cells during tumor progression: theories and evidence | Full Text | References | PDF (207.7 KB)
  • 190 Views
  • 21 CrossRef citations
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Review Article
The importance of examining the proportion of circulating DNA originating from tumor, microenvironment and normal cells in colorectal cancer patients
Florent Mouliere & Alain R Thierry
Pages: S209-S215
Published online: 18 May 2012
AbstractforThe importance of examining the proportion of circulating DNA originating from tumor, microenvironment and normal cells in colorectal cancer patients | Full Text | References | PDF (310.8 KB)
  • 1216 Views
  • 72 CrossRef citations
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Review Article
Circulating nucleosomes and biomarkers of immunogenic cell death as predictive and prognostic markers in cancer patients undergoing cytotoxic therapy
Oliver J Stoetzer, Christin Wittwer, Julia Lehner, Yvonne N Fahmueller, Nikolaus Kohles, Debora MI Fersching, Gloria Leszinski, Juliane Roessner & Stefan Holdenrieder MD
Pages: S217-S224
Published online: 24 May 2012
AbstractforCirculating nucleosomes and biomarkers of immunogenic cell death as predictive and prognostic markers in cancer patients undergoing cytotoxic therapy | Full Text | References | PDF (424.2 KB)
  • 479 Views
  • 18 CrossRef citations
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Letter to Editor

Letter
Circulating nucleic acids and Darwin's gemmules
Yongsheng Liu
Pages: S225-S226
Published online: 21 Apr 2012
CitationforCirculating nucleic acids and Darwin's gemmules | Full Text | References | PDF (140 KB)
  • 530 Views
  • 3 CrossRef citations
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