Expert Opinion on Biological Therapy, Volume 18, Issue sup1 (2018)

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Expert Opinion on Biological Therapy, Volume 18, Issue sup1 (2018)

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Proceedings of the Fifth International Symposium on Thymosins in Health and Disease

Foreword

Editorial
Introduction for the Fifth International Symposium on Thymosins in Health and Disease
Allan L. Goldstein & Enrico Garaci
Pages: 1-3
Published online: 31 Jul 2018
First Page PreviewforIntroduction for the Fifth International Symposium on Thymosins in Health and Disease | Full Text | References | PDF (299.3 KB)
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Editorial

Editorial
Advancing biological therapies against a rising tide of American anti-science and other external threats
Peter J Hotez
Pages: 5-7
Published online: 31 Jul 2018
First Page PreviewforAdvancing biological therapies against a rising tide of American anti-science and other external threats | Full Text | References | PDF (349.7 KB)
  • 986 Views
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Editorial
From thymus to cystic fibrosis: the amazing life of thymosin alpha 1
Enrico Garaci
Pages: 9-11
Published online: 31 Jul 2018
First Page PreviewforFrom thymus to cystic fibrosis: the amazing life of thymosin alpha 1 | Full Text | References | PDF (327.3 KB)
  • 2717 Views
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Review

Review
Serum thymosin alpha 1 levels in normal and pathological conditions
Francesca Pica, Roberta Gaziano, Ida Antonia Casalinuovo, Gabriella Moroni, Cristina Buè, Dolores Limongi, Cartesio D’Agostini, Carlo Tomino, Roberto Perricone, Anna Teresa Palamara, Paola Sinibaldi Vallebona & Enrico Garaci
Pages: 13-21
Published online: 31 Jul 2018
AbstractforSerum thymosin alpha 1 levels in normal and pathological conditions | Full Text | References | PDF (719.1 KB)
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Original Research

Article
Deciphering cellular biological processes to clinical application: a new perspective for Tα1 treatment targeting multiple diseases
Claudia Matteucci, Ayele Argaw-Denboba, Emanuela Balestrieri, Alessandro Giovinazzo, Martino Miele, Cartesio D’Agostini, Francesca Pica, Sandro Grelli, Maurizio Paci, Antonio Mastino, Paola Sinibaldi Vallebona, Enrico Garaci & Carlo Tomino
Pages: 23-31
Published online: 31 Jul 2018
AbstractforDeciphering cellular biological processes to clinical application: a new perspective for Tα1 treatment targeting multiple diseases | Full Text | References | PDF (1.1 MB)
  • 162 Views
  • 9 CrossRef citations
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Review

Review
Potential mechanism of thymosin-α1-membrane interactions leading to pleiotropy: experimental evidence and hypotheses
Walter Mandaliti, Ridvan Nepravishta, Francesca Pica, Paola Sinibaldi Vallebona, Enrico Garaci & Maurizio Paci
Pages: 33-42
Published online: 31 Jul 2018
AbstractforPotential mechanism of thymosin-α1-membrane interactions leading to pleiotropy: experimental evidence and hypotheses | Full Text | References | PDF (1.2 MB)
  • 147 Views
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Review
Cellular proteostasis: a new twist in the action of thymosin α1
Claudia Stincardini, Giorgia Renga, Valeria Villella, Marilena Pariano, Vasilis Oikonomou, Monica Borghi, Marina M. Bellet, Luigi Sforna, Claudio Costantini, Allan L. Goldstein, Enrico Garaci & Luigina Romani
Pages: 43-48
Published online: 31 Jul 2018
AbstractforCellular proteostasis: a new twist in the action of thymosin α1 | Full Text | References | PDF (910.1 KB)
  • 458 Views
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Review
Unmet needs in cystic fibrosis
Bruce K. Rubin
Pages: 49-52
Published online: 31 Jul 2018
AbstractforUnmet needs in cystic fibrosis | Full Text | References | PDF (381.4 KB)
  • 305 Views
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Review
The effect of thymosin α1 for prevention of infection in patients with severe acute pancreatitis
Na Yang, Lu Ke, Zhihui Tong & Weiqin Li
Pages: 53-60
Published online: 31 Jul 2018
AbstractforThe effect of thymosin α1 for prevention of infection in patients with severe acute pancreatitis | Full Text | References | PDF (655.7 KB)
  • 124 Views
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Original Research

Article
Combination of entecavir with thymosin alpha-1 in HBV-related compensated cirrhosis: a prospective multicenter randomized open-label study
Xiaoning Wu, Yiwen Shi, Jialing Zhou, Yameng Sun, Hongxin Piao, Wei Jiang, Anlin Ma, Yongpeng Chen, Mingyi Xu, Wen Xie, Jun Cheng, Shibin Xie, Jia Shang, Jilin Cheng, Qing Xie, Huiguo Ding, Xuqing Zhang, Lang Bai, Mingxiang Zhang, Bingqiong Wang, Shuyan Chen, Hong Ma, Xiaojuan Ou, Jidong Jia & Hong You
Pages: 61-69
Published online: 31 Jul 2018
AbstractforCombination of entecavir with thymosin alpha-1 in HBV-related compensated cirrhosis: a prospective multicenter randomized open-label study | Full Text | References | PDF (983.7 KB) | Supplemental
  • 341 Views
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Review

Review
Thymosin alpha 1 treatment for patients with sepsis
Fei Pei, Xiangdong Guan & Jianfeng Wu
Pages: 71-76
Published online: 31 Jul 2018
AbstractforThymosin alpha 1 treatment for patients with sepsis | Full Text | References | PDF (628.9 KB)
  • 437 Views
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Original Research

Article
Long-term follow up of metastatic melanoma patients treated with Thymosin alpha-1: investigating immune checkpoints synergy
Riccardo Danielli, Filomena Cisternino, Diana Giannarelli, Luana Calabrò, Roberto Camerini, Vinno Savelli, Giovanni Bova, Rosella Dragonetti, Anna Maria Di Giacomo, Maresa Altomonte & Michele Maio
Pages: 77-83
Published online: 31 Jul 2018
AbstractforLong-term follow up of metastatic melanoma patients treated with Thymosin alpha-1: investigating immune checkpoints synergy | Full Text | References | PDF (856.9 KB)
  • 263 Views
  • 12 CrossRef citations
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Editorial

Editorial
Overlapping molecular signaling of IRX-2 and Ta1 resulting in synergistic biological activity
Paul H Naylor & Cartha W Naylor
Pages: 85-88
Published online: 31 Jul 2018
First Page PreviewforOverlapping molecular signaling of IRX-2 and Ta1 resulting in synergistic biological activity | Full Text | References | PDF (454.6 KB)
  • 529 Views
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Original Research

Article
Ecto-F0/F1 ATPase as a novel candidate of prothymosin α receptor
Hiroshi Ueda, Hayato Matsunaga, Yosuke Matsushita, Shiori Maeda, Ryusei Iwamoto, Shigeyuki Yokoyama & Mikako Shirouzu
Pages: 89-94
Published online: 31 Jul 2018
AbstractforEcto-F0/F1 ATPase as a novel candidate of prothymosin α receptor | Full Text | References | PDF (1 MB)
  • 100 Views
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Editorial

Editorial
Thymosin-induced immunoregulation: clinical potentials for allergy and asthma endotypes
Gailen Marshall Jr.
Pages: 95-97
Published online: 06 Mar 2018
First Page PreviewforThymosin-induced immunoregulation: clinical potentials for allergy and asthma endotypes | Full Text | References | PDF (309.5 KB)
  • 2963 Views
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Meeting Highlights

Thymosin beta 4 and the eye: the journey from bench to bedside
Gabriel Sosne
Pages: 99-104
Published online: 31 Jul 2018
AbstractforThymosin beta 4 and the eye: the journey from bench to bedside | Full Text | References | PDF (562.7 KB) | Supplemental
  • 293 Views
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Review

Review
The role of Thymosin β4 in angiotensin II-induced cardiomyocytes growth
Sudhiranjan Gupta & Li Li
Pages: 105-110
Published online: 31 Jul 2018
AbstractforThe role of Thymosin β4 in angiotensin II-induced cardiomyocytes growth | Full Text | References | PDF (1,002.4 KB)
  • 207 Views
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Review
Induced pluripotent stem cell derived cardiac models: effects of Thymosin β4
Tilman Ziegler, Rabea Hinkel & Christian Kupatt
Pages: 111-120
Published online: 31 Jul 2018
AbstractforInduced pluripotent stem cell derived cardiac models: effects of Thymosin β4 | Full Text | References | PDF (1 MB)
  • 305 Views
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Review
Thymosin β4-mediated protective effects in the heart
Rabea Hinkel, Katharina Klett, Andrea Bähr & Christian Kupatt
Pages: 121-129
Published online: 31 Jul 2018
AbstractforThymosin β4-mediated protective effects in the heart | Full Text | References | PDF (1.2 MB)
  • 317 Views
  • 7 CrossRef citations
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Review
Thymosin β4 and the vasculature: multiple roles in development, repair and protection against disease
Karina N. Dubé & Nicola Smart
Pages: 131-139
Published online: 31 Jul 2018
AbstractforThymosin β4 and the vasculature: multiple roles in development, repair and protection against disease | Full Text | References | PDF (800.5 KB)
  • 245 Views
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Review
Sources of variability in quantifying circulating thymosin beta-4: literature review and recommendations
Warren K. Y. Tan, Kristy Purnamawati, Leroy S. Pakkiri, Sock Hwee Tan, Xiaoxun Yang, Mark Y. Chan & Chester L. Drum
Pages: 141-147
Published online: 12 Mar 2018
AbstractforSources of variability in quantifying circulating thymosin beta-4: literature review and recommendations | Full Text | References | PDF (1.3 MB) | Supplemental
  • 188 Views
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Review
Thymosin β4 for the treatment of acute stroke: neurorestorative or neuroprotective?
Daniel C Morris, Zheng G Zhang & Michael Chopp
Pages: 149-158
Published online: 31 Jul 2018
AbstractforThymosin β4 for the treatment of acute stroke: neurorestorative or neuroprotective? | Full Text | References | PDF (1.2 MB)
  • 118 Views
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Original Research

Article
Thymosin beta 4 induces significant changes in the plasma miRNA profile following severe traumatic brain injury in the rat lateral fluid percussion injury model
Jennifer Osei, William Kelly, Kathryn Toffolo, Kaitlynn Donahue, Bennet Levy, Jonathan Bard, Jianxin Wang, Elad Levy, Norma Nowak & David Poulsen
Pages: 159-164
Published online: 31 Jul 2018
AbstractforThymosin beta 4 induces significant changes in the plasma miRNA profile following severe traumatic brain injury in the rat lateral fluid percussion injury model | Full Text | References | PDF (707.1 KB)
  • 217 Views
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Review

Review
Anti-inflammatory potential of thymosin β4 in the central nervous system: implications for progressive neurodegenerative diseases
Marie-Christine Pardon
Pages: 165-169
Published online: 31 Jul 2018
AbstractforAnti-inflammatory potential of thymosin β4 in the central nervous system: implications for progressive neurodegenerative diseases | Full Text | References | PDF (561.4 KB)
  • 140 Views
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Review
Thymosin β4 limits inflammation through autophagy
Giorgia Renga, Vasilis Oikonomou, Claudia Stincardini, Marilena Pariano, Monica Borghi, Claudio Costantini, Andrea Bartoli, Enrico Garaci, Allan L. Goldstein & Luigina Romani
Pages: 171-175
Published online: 31 Jul 2018
AbstractforThymosin β4 limits inflammation through autophagy | Full Text | References | PDF (545.9 KB)
  • 378 Views
  • 17 CrossRef citations
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Original Research

Article
Thymosin β4 inhibits PDGF-BB induced activation, proliferation, and migration of human hepatic stellate cells via its actin-binding domain
Ruchi Shah, Karina Reyes-Gordillo & Marcos Rojkind
Pages: 177-184
Published online: 31 Jul 2018
AbstractforThymosin β4 inhibits PDGF-BB induced activation, proliferation, and migration of human hepatic stellate cells via its actin-binding domain | Full Text | References | PDF (1.4 MB)
  • 197 Views
  • 10 CrossRef citations
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Review

Review
Thymosin-β4: A key modifier of renal disease
Elisavet Vasilopoulou, Paul R. Riley & David A. Long
Pages: 185-192
Published online: 09 May 2018
AbstractforThymosin-β4: A key modifier of renal disease | Full Text | References | PDF (846.8 KB)
  • 354 Views
  • 12 CrossRef citations
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Review
Thymosin beta 4 regulation of actin in sepsis
Justin B. Belsky, Emanuel P. Rivers, Michael R. Filbin, Patty J. Lee & Daniel C. Morris
Pages: 193-197
Published online: 06 Mar 2018
AbstractforThymosin beta 4 regulation of actin in sepsis | Full Text | References | PDF (540.7 KB) | Supplemental
  • 279 Views
  • 7 CrossRef citations
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Original Research

Article
Thymosin fraction 5 re-evaluated after 35 years by high-resolution mass spectrometry
Ewald Hannappel, Federica Iavarone & Massimo Castagnola
Pages: 199-203
Published online: 31 Jul 2018
AbstractforThymosin fraction 5 re-evaluated after 35 years by high-resolution mass spectrometry | Full Text | References | PDF (1.1 MB) | Supplemental
  • 54 Views
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Review

Review
Icosahedral boron clusters as modifying entities for biomolecules
Tomasz M. Goszczyński, Krzysztof Fink & Janusz Boratyński
Pages: 205-213
Published online: 31 Jul 2018
AbstractforIcosahedral boron clusters as modifying entities for biomolecules | Full Text | References | PDF (1.1 MB)
  • 190 Views
  • 18 CrossRef citations
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