Expert Opinion on Drug Discovery, Volume 12, Issue 10 (2017)

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Expert Opinion on Drug Discovery, Volume 12, Issue 10 (2017)

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Editorial

Editorial
Computer-aided drug design: time to play with novel chemical matter
Xavier Barril
Pages: 977-980
Published online: 03 Aug 2017
First Page PreviewforComputer-aided drug design: time to play with novel chemical matter | Full Text | References | PDF (405.8 KB)
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Review

Review
An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery
Glenn R. Masson, Meredith L. Jenkins & John E. Burke
Pages: 981-994
Published online: 17 Aug 2017
AbstractforAn overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery | Full Text | References | PDF (1.7 MB)
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Review
Animal inflammation-based models of depression and their application to drug discovery
Li Ma, Konstantin A. Demin, Tatyana O. Kolesnikova, Sergey L. Kharsko, Xiaokang Zhu, Xiaodong Yuan, Cai Song, Darya A. Meshalkina, Brian E. Leonard, Li Tian & Allan V. Kalueff
Pages: 995-1009
Published online: 17 Aug 2017
AbstractforAnimal inflammation-based models of depression and their application to drug discovery | Full Text | References | PDF (1.2 MB) | Supplemental
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Review
Organotypic cultures of cerebellar slices as a model to investigate demyelinating disorders
Frédéric Doussau, Jean-Luc Dupont, Dorine Neel, Aline Schneider, Bernard Poulain & Jean Louis Bossu
Pages: 1011-1022
Published online: 20 Jul 2017
AbstractforOrganotypic cultures of cerebellar slices as a model to investigate demyelinating disorders | Full Text | References | PDF (1.7 MB)
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Review
Novel approaches to the design of bioavailable melanotropins
Yang Zhou & Minying Cai
Pages: 1023-1030
Published online: 12 Jul 2017
AbstractforNovel approaches to the design of bioavailable melanotropins | Full Text | References | PDF (833.5 KB)
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Review
Targeting intrinsic apoptosis and other forms of cell death by BH3-mimetics in glioblastoma
Georg Karpel-Massler, Chiaki Tsuge Ishida, Yiru Zhang, Marc-Eric Halatsch, M.-Andrew Westhoff & Markus D. Siegelin
Pages: 1031-1040
Published online: 20 Jul 2017
AbstractforTargeting intrinsic apoptosis and other forms of cell death by BH3-mimetics in glioblastoma | Full Text | References | PDF (1,015.5 KB)
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Review
New drug discovery approaches targeting recurrent mutations in chronic lymphocytic leukemia
Rupal Tripathi, Eriong Lee-Verges, Morihiro Higashi, Neus Gimenez, Laia Rosich, Monica Lopez-Guerra & Dolors Colomer
Pages: 1041-1052
Published online: 04 Aug 2017
AbstractforNew drug discovery approaches targeting recurrent mutations in chronic lymphocytic leukemia | Full Text | References | PDF (1.4 MB)
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Review
Therapeutic targeting of leukemic stem cells in acute myeloid leukemia – the biological background for possible strategies
Øystein Bruserud, Elise Aasebø, Maria Hernandez-Valladares, Galina Tsykunova & Håkon Reikvam
Pages: 1053-1065
Published online: 27 Jul 2017
AbstractforTherapeutic targeting of leukemic stem cells in acute myeloid leukemia – the biological background for possible strategies | Full Text | References | PDF (1.1 MB)
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Drug Discovery Case History

Article
The preclinical discovery and development of brexpiprazole for the treatment of major depressive disorder
Awais Aftab & Keming Gao
Pages: 1067-1081
Published online: 18 Jul 2017
AbstractforThe preclinical discovery and development of brexpiprazole for the treatment of major depressive disorder | Full Text | References | PDF (1.3 MB)
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