Expert Opinion on Drug Discovery, Volume 12, Issue 2 (2017)

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Expert Opinion on Drug Discovery, Volume 12, Issue 2 (2017)

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Editorial

Editorial
Drug discovery beyond the rule of 5 - Opportunities and challenges
Bradley C. Doak & Jan Kihlberg
Pages: 115-119
Published online: 08 Dec 2016
First Page PreviewforDrug discovery beyond the rule of 5 - Opportunities and challenges | Full Text | References | PDF (839.5 KB)
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Review

Review
The structural modification of natural products for novel drug discovery
Hong Yao, Junkai Liu, Shengtao Xu, Zheying Zhu & Jinyi Xu
Pages: 121-140
Published online: 22 Dec 2016
AbstractforThe structural modification of natural products for novel drug discovery | Full Text | References | PDF (3.7 MB)
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Review
MicroRNA-targeted therapeutics for lung cancer treatment
Jing Xue, Jiali Yang, Meihui Luo, William C. Cho & Xiaoming Liu
Pages: 141-157
Published online: 28 Nov 2016
AbstractforMicroRNA-targeted therapeutics for lung cancer treatment | Full Text | References | PDF (1.5 MB)
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Review
Designing small molecule CXCR3 antagonists
James E. Pease
Pages: 159-168
Published online: 30 Dec 2016
AbstractforDesigning small molecule CXCR3 antagonists | Full Text | References | PDF (1.1 MB)
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Review
Developing drugs that target the Wnt pathway: recent approaches in cancer and neurodegenerative diseases
Annalucia Serafino, Gianluca Sferrazza, Arianna Colini Baldeschi, Giuseppe Nicotera, Federica Andreola, Eugenia Pittaluga & Pasquale Pierimarchi
Pages: 169-186
Published online: 26 Dec 2016
AbstractforDeveloping drugs that target the Wnt pathway: recent approaches in cancer and neurodegenerative diseases | Full Text | References | PDF (2.2 MB)
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Review
Non human primate models for Alzheimer’s disease-related research and drug discovery
Debby Van Dam & Peter Paul De Deyn
Pages: 187-200
Published online: 25 Dec 2016
AbstractforNon human primate models for Alzheimer’s disease-related research and drug discovery | Full Text | References | PDF (1.4 MB)
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Review
Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies
Maria Teresa Donato, Maria José Gómez-Lechón & Laia Tolosa
Pages: 201-211
Published online: 21 Dec 2016
AbstractforUsing high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies | Full Text | References | PDF (1.1 MB)
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Review
Advances in capillary electrophoresis and the implications for drug discovery
Claire M. Ouimet, Cara I. D’amico & Robert T. Kennedy
Pages: 213-224
Published online: 09 Dec 2016
AbstractforAdvances in capillary electrophoresis and the implications for drug discovery | Full Text | References | PDF (1.3 MB)
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Drug Discovery Case History

Article
The preclinical discovery and development of bortezomib for the treatment of mantle cell lymphoma
Richard Arkwright, Tri Minh Pham, Jeffrey A. Zonder & Q. Ping Dou
Pages: 225-235
Published online: 20 Dec 2016
AbstractforThe preclinical discovery and development of bortezomib for the treatment of mantle cell lymphoma | Full Text | References | PDF (1.5 MB)
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