Expert Opinion on Drug Discovery, Volume 15, Issue 1 (2020)

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Expert Opinion on Drug Discovery, Volume 15, Issue 1 (2020)

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Editorial

Editorial
How plausible is an Alzheimer’s disease vaccine?
Ramón Cacabelos
Pages: 1-6
Published online: 17 Sep 2019
AbstractforHow plausible is an Alzheimer’s disease vaccine? | Full Text | References | PDF (508 KB) | EPUB
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Editorial
What are the challenges in commercial non-tuberculous mycobacteria (NTM) drug discovery and how should we move forward?
Graham S Timmins
Pages: 7-9
Published online: 30 Sep 2019
AbstractforWhat are the challenges in commercial non-tuberculous mycobacteria (NTM) drug discovery and how should we move forward? | Full Text | References | PDF (319.3 KB) | EPUB
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Drug Discovery Case History

Article
Lenvatinib for thyroid cancer treatment: discovery, pre-clinical development and clinical application
Rosa Maria Paragliola, Andrea Corsello, Valeria Del Gatto, Giampaolo Papi, Alfredo Pontecorvi & Salvatore Maria Corsello
Pages: 11-26
Published online: 13 Oct 2019
AbstractforLenvatinib for thyroid cancer treatment: discovery, pre-clinical development and clinical application | Full Text | References | PDF (1.2 MB) | EPUB
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Perspective

Article
Streamlining drug discovery assays for cardiovascular disease using zebrafish
Alexander Pott, Wolfgang Rottbauer & Steffen Just
Pages: 27-37
Published online: 01 Oct 2019
AbstractforStreamlining drug discovery assays for cardiovascular disease using zebrafish | Full Text | References | PDF (1 MB) | EPUB
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Open Access

Review

Review
Using Xenopus oocytes in neurological disease drug discovery
Steven L. Zeng, Leland C. Sudlow & Mikhail Y. Berezin
Pages: 39-52
Published online: 01 Nov 2019
AbstractforUsing Xenopus oocytes in neurological disease drug discovery | Full Text | References | PDF (1.5 MB) | EPUB
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Review
Cheminformatics and virtual screening studies of COMT inhibitors as potential Parkinson’s disease therapeutics
Kalliopi Moschovou, Georgia Melagraki, Thomas Mavromoustakos, Lefteris C. Zacharia & Antreas Afantitis
Pages: 53-62
Published online: 20 Nov 2019
AbstractforCheminformatics and virtual screening studies of COMT inhibitors as potential Parkinson’s disease therapeutics | Full Text | References | PDF (1.4 MB) | EPUB
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Review
Advances in the discovery of microRNA-based anticancer therapeutics: latest tools and developments
Kenneth K.W. To, Winnie Fong, Christy W.S. Tong, Mingxia Wu, Wei Yan & William C.S. Cho
Pages: 63-83
Published online: 19 Nov 2019
AbstractforAdvances in the discovery of microRNA-based anticancer therapeutics: latest tools and developments | Full Text | References | PDF (1.9 MB) | EPUB
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Review
The evolution in our understanding of the genetics of rheumatoid arthritis and the impact on novel drug discovery
Filip Machaj, Jakub Rosik, Bartosz Szostak & Andrzej Pawlik
Pages: 85-99
Published online: 29 Oct 2019
AbstractforThe evolution in our understanding of the genetics of rheumatoid arthritis and the impact on novel drug discovery | Full Text | References | PDF (1.3 MB) | EPUB
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Review
Design and optimization strategies for the development of new drugs that treat chronic kidney disease
Adrián M. Ramos, Beatriz Fernández-Fernández, María Vanessa Pérez-Gómez, Sol María Carriazo Julio, María Dolores Sanchez-Niño, Ana Sanz, Marta Ruiz-Ortega & Alberto Ortiz
Pages: 101-115
Published online: 18 Nov 2019
AbstractforDesign and optimization strategies for the development of new drugs that treat chronic kidney disease | Full Text | References | PDF (1.4 MB) | EPUB
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Review
Thermodynamic profiling for fragment-based lead discovery and optimization
György G. Ferenczy & György M. Keserű
Pages: 117-129
Published online: 19 Nov 2019
AbstractforThermodynamic profiling for fragment-based lead discovery and optimization | Full Text | References | PDF (1.9 MB) | EPUB
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