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Expert Opinion on Drug Metabolism & Toxicology

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Review

Review Article

Recent progress in machine learning approaches for predicting carcinogenicity in drug development

Nguyen Quoc Khanh Le, Thi-Xuan Tran, Phung-Anh Nguyen, Trang-Thi Ho & Van-Nui Nguyen

Published online: 27 May 2024

17 Views
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Review

Review Article

New-generation androgen receptor signaling inhibitors (ARSIs) in metastatic hormone-sensitive prostate cancer (mHSPC): pharmacokinetics, drug-drug interactions (DDIs), and clinical impact

Lorenzo Gasperoni, Emilio Francesco Giunta, Daniela Montanari, Carla Masini & Ugo De Giorgi

Published online: 22 May 2024

180 Views
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Open Access

Drug Evaluation

Review Article

Pharmacokinetic evaluation of donanemab for the treatment of Alzheimer’s

Tanya Song, Yunfei Wang, Bret David Silverglate & George T. Grossberg

Published online: 20 May 2024

72 Views
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Review

Review Article

The role of the circadian timing system on drug metabolism and detoxification: an update

Alper Okyar, Dilek Ozturk Civelek, Yasemin Kubra Akyel, Saliha Surme, Zeliha Pala Kara & İ. Halil Kavakli

Published online: 20 May 2024

56 Views
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Review

Review Article

Pharmacokinetic and toxicological considerations affecting antiretroviral drug dosing in pregnant women

Zoran Todorović, Gordana Dragović & Relja Lukić

Published online: 14 May 2024

27 Views
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Special Report

Report

New approach methods on the bench side to accelerate clinical trials during pregnancy

Ramkumar Menon, Lauren Richardson & Ananth Kumar Kammala

Published online: 13 May 2024

23 Views
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Original Research

Article

Induction effect of antiretroviral bictegravir on the expression of Abcb1, Abcg2 and Abcc1 genes associated with P-gp, BCRP and MRP1 transporters present in rat peripheral blood mononuclear cells

Tarang Jadav, Niraj Rajput, Hemant Kumar, Santosh Kumar Behera & Pinaki Sengupta

Published online: 13 May 2024

36 Views
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Editorial

Editorial

In NAMs we trust – an innovative paradigm-shift in risk-based chemicals management for globally harmonized protection goals

Camilla Alexander-White

Published online: 09 May 2024

80 Views
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Free Access

Editorial

Editorial

Bioactivity descriptors for in vivo toxicity prediction: now and the future

Palle Helmke, Barbara Füzi & Gerhard F. Ecker

Published online: 04 Apr 2024

298 Views
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Free Access

Review

Review Article

Beyond the hype and toward application: liver complex in vitro models in preclinical drug safety

Sushma Jadalannagari & Lorna Ewart

Published online: 13 Mar 2024

1277 Views
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Open Access

Review

Review Article

In-silico approaches to assessing multiple high-level drug-drug and drug-disease adverse drug effects

Xuan Xu, Jim E Riviere, Shahzad Raza, Nuwan Indika Millagaha Gedara, Remya Ampadi Ramachandran, Lisa A Tell, Gerald J. Wyckoff & Majid Jaberi-Douraki

Published online: 01 Feb 2024

670 Views
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Open Access

Review

Review Article

Where developmental toxicity meets explainable artificial intelligence: state-of-the-art and perspectives

Maria Vittoria Togo, Fabrizio Mastrolorito, Angelica Orfino, Elisabetta Anna Graps, Anna Rita Tondo, Cosimo Damiano Altomare, Fulvio Ciriaco, Daniela Trisciuzzi, Orazio Nicolotti & Nicola Amoroso

Published online: 23 Dec 2023

147 Views
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Editorial

Editorial

Overcoming barriers to machine learning applications in toxicity prediction

Abdallah Abou Hajal & Ahmad Z. Al Meslamani

Published online: 13 Dec 2023

722 Views
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Free Access

Research Article

Article

In-depth mechanistic analysis including high-throughput RNA sequencing in the prediction of functional and structural cardiotoxicants using hiPSC cardiomyocytes

Alicia Rosell-Hidalgo, Christopher Bruhn, Emma Shardlow, Ryan Barton, Stephanie Ryder, Timur Samatov, Alexandra Hackmann, Gerald Ryan Aquino, Micael Fernandes Dos Reis, Vladimir Galatenko, Ruediger Fritsch, Cord Dohrmann & Paul A Walker

Published online: 23 Nov 2023

1604 Views
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Open Access

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