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Expert Opinion on Drug Metabolism & Toxicology
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Expert Opinion on Drug Metabolism & Toxicology

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Expert Opinion on Drug Metabolism & Toxicology, Volume 1, Issue 1 (2005)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 1, Issue 1 (2005)

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Editorial

Article

From in vivo to in vitro/in silico ADME: progress and challenges

Han Van de Waterbeemd

Pages: 1-4

Published online: 14 Jun 2005

AbstractforFrom in vivo to in vitro/in silico ADME: progress and challenges | References | PDF (56.8 KB)

173 Views
28 CrossRef citations
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Perspective

Article

Human P450s in the metabolism of drugs: molecular modelling of enzyme–substrate interactions

David FV Lewis

Pages: 5-8

Published online: 14 Jun 2005

AbstractforHuman P450s in the metabolism of drugs: molecular modelling of enzyme–substrate interactions | References | PDF (50 KB)

74 Views
11 CrossRef citations
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Review

Article

Role of the aryl hydrocarbon receptor in drug metabolism

Preeti Ramadoss, Craig Marcus & Gary H Perdew

Pages: 9-21

Published online: 14 Jun 2005

AbstractforRole of the aryl hydrocarbon receptor in drug metabolism | References | PDF (154.8 KB)

315 Views
115 CrossRef citations
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Article

The use of accelerator mass spectrometry to obtain early human ADME/PK data

Graham Lappin & R Colin Garner

Pages: 23-31

Published online: 14 Jun 2005

AbstractforThe use of accelerator mass spectrometry to obtain early human ADME/PK data | References | PDF (134.6 KB)

237 Views
43 CrossRef citations
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Article

Pharmacokinetic dosage guidelines for elderly subjects

Klaus Turnheim

Pages: 33-48

Published online: 14 Jun 2005

AbstractforPharmacokinetic dosage guidelines for elderly subjects | References | PDF (170.7 KB)

234 Views
19 CrossRef citations
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Article

In vitro screening of drug metabolism during drug development: can we trust the predictions?

Olavi Pelkonen & Hannu Raunio

Pages: 49-59

Published online: 14 Jun 2005

AbstractforIn vitro screening of drug metabolism during drug development: can we trust the predictions? | References | PDF (116.9 KB)

147 Views
35 CrossRef citations
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Article

Generation of human hepatocytes by stem cell technology: definition of the hepatocyte

Jan G Hengstler, Marc Brulport, Wiebke Schormann, Alexander Bauer, Matthias Hermes, Andreas K Nussler, Fred Fandrich, Maren Ruhnke, Hendrik Ungefroren, Louise Griffin, Ernesto Bockamp, Franz Oesch & Marc-Alexander von Mach

Pages: 61-74

Published online: 14 Jun 2005

AbstractforGeneration of human hepatocytes by stem cell technology: definition of the hepatocyte | References | PDF (178.7 KB)

368 Views
101 CrossRef citations
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Article

Cell-based models to study hepatic drug metabolism and enzyme induction in humans

Marc Vermeir, Pieter Annaert, Rao NVS Mamidi, Dirk Roymans, Willem Meuldermans & Geert Mannens

Pages: 75-90

Published online: 14 Jun 2005

AbstractforCell-based models to study hepatic drug metabolism and enzyme induction in humans | References | PDF (178.9 KB)

272 Views
64 CrossRef citations
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Article

Minimising the potential for metabolic activation in drug discovery

Amit S Kalgutkar & John R Soglia

Pages: 91-142

Published online: 14 Jun 2005

AbstractforMinimising the potential for metabolic activation in drug discovery | References | PDF (548.5 KB)

1104 Views
189 CrossRef citations
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Drug Evaluation

Article

New drugs for chemotherapy-induced nausea and vomiting: focus on palonosetron

Giuseppe Tonini, Bruno Vincenzi & Daniele Santini

Pages: 143-149

Published online: 14 Jun 2005

AbstractforNew drugs for chemotherapy-induced nausea and vomiting: focus on palonosetron | References | PDF (82.5 KB)

66 Views
16 CrossRef citations
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Article

Clinical pharmacology of bimatoprost

Louis B Cantor

Pages: 151-157

Published online: 14 Jun 2005

AbstractforClinical pharmacology of bimatoprost | References | PDF (83.6 KB)

147 Views
12 CrossRef citations
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Technology Evaluation

Article

From physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools

Stefan Willmann, Jörg Lippert & Walter Schmitt

Pages: 159-168

Published online: 14 Jun 2005

AbstractforFrom physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools | References | PDF (237.7 KB)

547 Views
110 CrossRef citations
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