Expert Opinion on Drug Metabolism & Toxicology, Volume 12, Issue 12 (2016)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 12, Issue 12 (2016)

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Editorial

Editorial
Pharmacotherapy in pediatric epilepsy: rational drug and dose selection
Alberto Verrotti, Alessandra Piccorossi, Stefania Lasorella & Renato Tambucci
Pages: 1393-1396
Published online: 10 Nov 2016
First Page PreviewforPharmacotherapy in pediatric epilepsy: rational drug and dose selection | Full Text | References | PDF (361.5 KB)
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Review

Review
BRAF and MEK inhibitors in pediatric glioma: new therapeutic strategies, new toxicities
Daniela Rizzo, Antonio Ruggiero, Maria Amato, Palma Maurizi & Riccardo Riccardi
Pages: 1397-1405
Published online: 05 Aug 2016
AbstractforBRAF and MEK inhibitors in pediatric glioma: new therapeutic strategies, new toxicities | Full Text | References | PDF (700.7 KB)
  • 803 Views
  • 13 CrossRef citations
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Review
DPP-4 inhibitor plus SGLT-2 inhibitor as combination therapy for type 2 diabetes: from rationale to clinical aspects
André J. Scheen
Pages: 1407-1417
Published online: 29 Jul 2016
AbstractforDPP-4 inhibitor plus SGLT-2 inhibitor as combination therapy for type 2 diabetes: from rationale to clinical aspects | Full Text | References | PDF (1.1 MB)
  • 2343 Views
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Review
ATP-binding cassette transmembrane transporters and their epigenetic control in cancer: an overview
Elena Arrigoni, Sara Galimberti, Mario Petrini, Romano Danesi & Antonello Di Paolo
Pages: 1419-1432
Published online: 03 Aug 2016
AbstractforATP-binding cassette transmembrane transporters and their epigenetic control in cancer: an overview | Full Text | References | PDF (1.2 MB)
  • 557 Views
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Review
Clinical pharmacology, drug-drug interactions and safety of pazopanib: a review
Pascaline Boudou-Rouquette, Camille Tlemsani, Benoit Blanchet, Olivier Huillard, Anne Jouinot, Jennifer Arrondeau, Audrey Thomas-Schoemann, Michel Vidal, Jérôme Alexandre & François Goldwasser
Pages: 1433-1444
Published online: 24 Aug 2016
AbstractforClinical pharmacology, drug-drug interactions and safety of pazopanib: a review | Full Text | References | PDF (931.5 KB)
  • 791 Views
  • 19 CrossRef citations
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Review
Drug-drug interactions of non-vitamin K oral anticoagulants
Christos Voukalis, Gregory Y. H. Lip & Eduard Shantsila
Pages: 1445-1461
Published online: 26 Aug 2016
AbstractforDrug-drug interactions of non-vitamin K oral anticoagulants | Full Text | References | PDF (1.5 MB)
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Review
The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors
David E. Amacher
Pages: 1463-1477
Published online: 22 Aug 2016
AbstractforThe regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors | Full Text | References | PDF (1 MB)
  • 422 Views
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Review
Preventing oxaliplatin-induced neurotoxicity: rationale and design of phase Ib randomized, double-blind, placebo-controlled, cross-over trials for early clinical evaluation of investigational therapeutics
Catherine H. Han, Dean H. Kilfoyle, Andrew G. Hill, Michael B. Jameson & Mark J. McKeage
Pages: 1479-1490
Published online: 23 Aug 2016
AbstractforPreventing oxaliplatin-induced neurotoxicity: rationale and design of phase Ib randomized, double-blind, placebo-controlled, cross-over trials for early clinical evaluation of investigational therapeutics | Full Text | References | PDF (1.6 MB) | Supplemental
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Drug Evaluation

Article
Pharmacokinetics and pharmacodynamics of ticagrelor in the treatment of cardiac ischemia
Gian Marco Rosa, Daniele Bianco, Alberto Valbusa, Laura Massobrio, Francesco Chiarella & Claudio Brunelli
Pages: 1491-1502
Published online: 24 Oct 2016
AbstractforPharmacokinetics and pharmacodynamics of ticagrelor in the treatment of cardiac ischemia | Full Text | References | PDF (929.6 KB)
  • 526 Views
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Article
Pharmacokinetics, pharmacodynamics and clinical efficacy of omalizumab for the treatment of asthma
Maxime Luu, Marc Bardou, Philippe Bonniaud & Françoise Goirand
Pages: 1503-1511
Published online: 27 Oct 2016
AbstractforPharmacokinetics, pharmacodynamics and clinical efficacy of omalizumab for the treatment of asthma | Full Text | References | PDF (745.1 KB)
  • 1229 Views
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Article
Pharmacokinetic drug evaluation of selexipag for the treatment of pulmonary arterial hypertension
Mayank Sardana, Matthew Moll & Harrison W Farber
Pages: 1513-1520
Published online: 04 Nov 2016
AbstractforPharmacokinetic drug evaluation of selexipag for the treatment of pulmonary arterial hypertension | Full Text | References | PDF (825.9 KB)
  • 460 Views
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Article
Pharmacodynamic and pharmacokinetic evaluation of insulin glargine U300 for the treatment of type 1 diabetes
Kathryn M. Hurren & Jessica L. O’Neill
Pages: 1521-1526
Published online: 18 Oct 2016
AbstractforPharmacodynamic and pharmacokinetic evaluation of insulin glargine U300 for the treatment of type 1 diabetes | Full Text | References | PDF (501.2 KB)
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Letter to the Editor

Letter
Comment on “Inositols: from physiology to rational therapy in gynecological clinical practice”
Antonio Simone Laganà, Fabrizio Sapia, Valentina Lucia La Rosa & Salvatore Giovanni Vitale
Page: 1527
Published online: 21 Oct 2016
CitationforComment on “Inositols: from physiology to rational therapy in gynecological clinical practice” | Full Text | References | PDF (270.2 KB)
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