Expert Opinion on Drug Metabolism & Toxicology, Volume 13, Issue 1 (2017)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 13, Issue 1 (2017)

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Editorial

Editorial
Utility of the adverse outcome pathway concept in drug development
Thomas Hartung
Pages: 1-3
Published online: 21 Oct 2016
First Page PreviewforUtility of the adverse outcome pathway concept in drug development | Full Text | References | PDF (301.9 KB)
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Review

Review
Unraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling
Isoude A. Kuijper, Huan Yang, Bob Van De Water & Joost B. Beltman
Pages: 5-17
Published online: 23 Sep 2016
AbstractforUnraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling | Full Text | References | PDF (1.3 MB)
  • 2744 Views
  • 14 CrossRef citations
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Review
Epigenetic regulation of drug transporter expression in human tissues
Takeshi Hirota, Toshihiro Tanaka, Hiroaki Takesue & Ichiro Ieiri
Pages: 19-30
Published online: 07 Sep 2016
AbstractforEpigenetic regulation of drug transporter expression in human tissues | Full Text | References | PDF (982.9 KB)
  • 576 Views
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Review
Kinase inhibitor pharmacokinetics: comprehensive summary and roadmap for addressing inter-individual variability in exposure
Andrew Rowland, Madelé van Dyk, Arduino A. Mangoni, John O. Miners, Ross A. McKinnon, Michael D. Wiese, Angela Rowland, Ganessan Kichenadasse, Howard Gurney & Michael J. Sorich
Pages: 31-49
Published online: 01 Sep 2016
AbstractforKinase inhibitor pharmacokinetics: comprehensive summary and roadmap for addressing inter-individual variability in exposure | Full Text | References | PDF (1.9 MB)
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Review
The toxicity of methotrexate in male fertility and paternal teratogenicity
Jennifer Christine Gutierrez & Kathleen Hwang
Pages: 51-58
Published online: 09 Sep 2016
AbstractforThe toxicity of methotrexate in male fertility and paternal teratogenicity | Full Text | References | PDF (575 KB)
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Review
Colistin: still a lifesaver for the 21st century?
Ilias Karaiskos, Maria Souli, Irene Galani & Helen Giamarellou
Pages: 59-71
Published online: 14 Sep 2016
AbstractforColistin: still a lifesaver for the 21st century? | Full Text | References | PDF (1.5 MB)
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Review
Advances and challenges in hereditary cancer pharmacogenetics
Ingolf Cascorbi & Anneke Nina Werk
Pages: 73-82
Published online: 16 Sep 2016
AbstractforAdvances and challenges in hereditary cancer pharmacogenetics | Full Text | References | PDF (750.8 KB)
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Review
Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters
Aleksi Tornio, Pertti J. Neuvonen, Mikko Niemi & Janne T. Backman
Pages: 83-95
Published online: 31 Aug 2016
AbstractforRole of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters | Full Text | References | PDF (1.2 MB)
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Drug Evaluation

Article
Plasma-derived human factor X concentrate for on-demand and perioperative treatment in factor X-deficient patients: pharmacology, pharmacokinetics, efficacy, and safety
Amy Shapiro
Pages: 97-104
Published online: 02 Nov 2016
AbstractforPlasma-derived human factor X concentrate for on-demand and perioperative treatment in factor X-deficient patients: pharmacology, pharmacokinetics, efficacy, and safety | Full Text | References | PDF (781.9 KB)
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Article
Pharmacokinetics and pharmacodynamics of sofosbuvir and ledipasvir for the treatment of hepatitis C
Francisca Cuenca-Lopez, Antonio Rivero & Antonio Rivero-Juárez
Pages: 105-112
Published online: 14 Nov 2016
AbstractforPharmacokinetics and pharmacodynamics of sofosbuvir and ledipasvir for the treatment of hepatitis C | Full Text | References | PDF (792.5 KB)
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Article
Clinical relevance of pharmacokinetic and pharmacodynamic properties of edoxaban when treating patients with atrial fibrillation and heart failure
Nadia Aspromonte & Furio Colivicchi
Pages: 113-122
Published online: 18 Nov 2016
AbstractforClinical relevance of pharmacokinetic and pharmacodynamic properties of edoxaban when treating patients with atrial fibrillation and heart failure | Full Text | References | PDF (884.4 KB)
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Letter to the Editor

Letter
Polymorphisms of genes related to metotrexate response and toxicity in high-grade osteosarcoma
Massimo Serra & Claudia Maria Hattinger
Page: 123
Published online: 21 Nov 2016
CitationforPolymorphisms of genes related to metotrexate response and toxicity in high-grade osteosarcoma | Full Text | References | PDF (165.9 KB)
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