Expert Opinion on Drug Metabolism & Toxicology, Volume 14, Issue 8 (2018)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 14, Issue 8 (2018)

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Editorial

Editorial
Liquid biopsies to optimize therapeutic efficacy in unresponsive lung cancer patients
Mariacarmela Santarpia, Niccola Funel, Asif Ali & Elisa Giovannetti
Pages: 761-763
Published online: 04 Jul 2018
First Page PreviewforLiquid biopsies to optimize therapeutic efficacy in unresponsive lung cancer patients | Full Text | References | PDF (319.8 KB)
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Drug Evaluation

Article
Necitumumab: a new option for first-line treatment of squamous cell lung cancer
Elizabeth Jiménez Aguilar, Jon Zugazagoitia Fraile & Luis Paz-Ares Rodríguez
Pages: 765-772
Published online: 31 Jul 2018
AbstractforNecitumumab: a new option for first-line treatment of squamous cell lung cancer | Full Text | References | PDF (650.2 KB)
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Article
The pharmacokinetics, pharmacodynamics, and clinical role of fixed dose combination of tenofovir disoproxil fumarate, lamivudine and reduced dose efavirenz (TLE-400) in treating HIV-1 infection
Gueorgui Dubrocq & Natella Rakhmanina
Pages: 773-779
Published online: 23 Jul 2018
AbstractforThe pharmacokinetics, pharmacodynamics, and clinical role of fixed dose combination of tenofovir disoproxil fumarate, lamivudine and reduced dose efavirenz (TLE-400) in treating HIV-1 infection | Full Text | References | PDF (584.6 KB)
  • 195 Views
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Review

Review
Quantitation of intracellular triphosphate metabolites of antiretroviral agents in peripheral blood mononuclear cells (PBMCs) and corresponding cell count determinations: review of current methods and challenges
Deqing Xiao, Kah Hiing John Ling, Joseph Custodio, Sophia R. Majeed & Thomas Tarnowski
Pages: 781-802
Published online: 25 Jul 2018
AbstractforQuantitation of intracellular triphosphate metabolites of antiretroviral agents in peripheral blood mononuclear cells (PBMCs) and corresponding cell count determinations: review of current methods and challenges | Full Text | References | PDF (2.3 MB)
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Review
Pharmacokinetics–pharmacodynamics of antifungal agents in the central nervous system
Katharine E Stott & William Hope
Pages: 803-815
Published online: 09 Jul 2018
AbstractforPharmacokinetics–pharmacodynamics of antifungal agents in the central nervous system | Full Text | References | PDF (997.4 KB)
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Review
An update on expression and function of P-gp/ABCB1 and BCRP/ABCG2 in the placenta and fetus
Lyrialle W. Han, Chunying Gao & Qingcheng Mao
Pages: 817-829
Published online: 03 Aug 2018
AbstractforAn update on expression and function of P-gp/ABCB1 and BCRP/ABCG2 in the placenta and fetus | Full Text | References | PDF (1.1 MB)
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Review
Personalized therapy when tackling nonalcoholic fatty liver disease: a focus on sex, genes, and drugs
Cene Skubic, Živa Drakulić & Damjana Rozman
Pages: 831-841
Published online: 03 Jul 2018
AbstractforPersonalized therapy when tackling nonalcoholic fatty liver disease: a focus on sex, genes, and drugs | Full Text | References | PDF (1,003.7 KB)
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Review
Misconceptions and issues regarding allometric scaling during the drug development process
Iftekhar Mahmood
Pages: 843-854
Published online: 19 Jul 2018
AbstractforMisconceptions and issues regarding allometric scaling during the drug development process | Full Text | References | PDF (907.3 KB)
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Review
The dark side of ibuprofen in the treatment of patent ductus arteriosus: could paracetamol be the solution?
Laura Cuzzolin, Flamina Bardanzellu & Vassilios Fanos
Pages: 855-868
Published online: 02 Jul 2018
AbstractforThe dark side of ibuprofen in the treatment of patent ductus arteriosus: could paracetamol be the solution? | Full Text | References | PDF (1 MB)
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Original Research

Article
A randomized study investigating the effect of omeprazole on the pharmacokinetics of oral semaglutide
Tine A. Bækdal, Astrid Breitschaft, Andrea Navarria & Cilie W. Hansen
Pages: 869-877
Published online: 30 Jun 2018
AbstractforA randomized study investigating the effect of omeprazole on the pharmacokinetics of oral semaglutide | Full Text | References | PDF (1.2 MB) | Supplemental
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Article
Interaction between CYP2D6 inhibitor antidepressants and codeine: is this relevant?
Lucie Cazet, Samuel Bulteau, Adrien Evin, Andrew Spiers, Pascal Caillet, Emmanuelle Kuhn, Jacques Pivette, Anicet Chaslerie, Pascale Jolliet & Caroline Victorri-Vigneau
Pages: 879-886
Published online: 12 Jul 2018
AbstractforInteraction between CYP2D6 inhibitor antidepressants and codeine: is this relevant? | Full Text | References | PDF (749.1 KB)
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