Expert Opinion on Drug Metabolism & Toxicology, Volume 15, Issue 2 (2019)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 15, Issue 2 (2019)

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Drug Evaluation

Article
Pharmacokinetic drug evaluation of abemaciclib for advanced breast cancer
Marie Robert, Jean-Sébastien Frenel, Emmanuelle Bourbouloux, Dominique Berton Rigaud, Anne Patsouris, Paule Augereau, Carole Gourmelon & Mario Campone
Pages: 85-91
Published online: 05 Jan 2019
AbstractforPharmacokinetic drug evaluation of abemaciclib for advanced breast cancer | Full Text | References | PDF (611.9 KB) | EPUB
  • 637 Views
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Article
Pharmacokinetic and pharmacodynamic considerations for the clinical efficacy of perampanel in focal onset seizures
Stefano de Biase, Gian Luigi Gigli, Annacarmen Nilo, Giorgia Romano & Mariarosaria Valente
Pages: 93-102
Published online: 26 Dec 2018
AbstractforPharmacokinetic and pharmacodynamic considerations for the clinical efficacy of perampanel in focal onset seizures | Full Text | References | PDF (792 KB) | EPUB
  • 489 Views
  • 15 CrossRef citations
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Review

Article
Overcoming barriers to optimal drug dosing during ECMO in critically ill adult patients
Vesa Cheng, Mohd H. Abdul-Aziz, Jason A. Roberts & Kiran Shekar
Pages: 103-112
Published online: 03 Jan 2019
AbstractforOvercoming barriers to optimal drug dosing during ECMO in critically ill adult patients | Full Text | References | PDF (1.2 MB) | EPUB
  • 1110 Views
  • 16 CrossRef citations
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Article
Pharmacokinetics and pharmacodynamics of monoclonal antibodies for asthma treatment
Diego Bagnasco, Enrico Heffler, Elisa Testino, Giovanni Passalacqua & Giorgio Walter Canonica
Pages: 113-120
Published online: 24 Jan 2019
AbstractforPharmacokinetics and pharmacodynamics of monoclonal antibodies for asthma treatment | Full Text | References | PDF (655.9 KB) | EPUB
  • 574 Views
  • 13 CrossRef citations
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Article
Pharmacodynamics of the agents used for the treatment of erectile dysfunction
Tan V. Le, Peter Tsambarlis & Wayne J. G. Hellstrom
Pages: 121-131
Published online: 22 Dec 2018
AbstractforPharmacodynamics of the agents used for the treatment of erectile dysfunction | Full Text | References | PDF (955.7 KB) | EPUB
  • 177 Views
  • 6 CrossRef citations
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Article
Novel β-lactam-β-lactamase inhibitor combinations: expectations for the treatment of carbapenem-resistant Gram-negative pathogens
Ilias Karaiskos, Irene Galani, Maria Souli & Helen Giamarellou
Pages: 133-149
Published online: 10 Jan 2019
AbstractforNovel β-lactam-β-lactamase inhibitor combinations: expectations for the treatment of carbapenem-resistant Gram-negative pathogens | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 1273 Views
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Article
An update on polyphenol disposition via coupled metabolic pathways
Liping Wang, Rongjin Sun, Qisong Zhang, Qing Luo, Sijing Zeng, Xiaoyan Li, Xia Gong, Yuhuan Li, Linlin Lu, Ming Hu & Zhongqiu Liu
Pages: 151-165
Published online: 24 Dec 2018
AbstractforAn update on polyphenol disposition via coupled metabolic pathways | Full Text | References | PDF (1.8 MB) | EPUB
  • 295 Views
  • 14 CrossRef citations
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Article
Pharmacokinetic mechanisms underlying the detoxification effect of Glycyrrhizae Radix et Rhizoma (Gancao): drug metabolizing enzymes, transporters, and beyond
Na Li, Ting Zhou, Fei Wu, Rui Wang, Qing Zhao, Ji-Quan Zhang, Bai-Can Yang & Bing-Liang Ma
Pages: 167-177
Published online: 07 Jan 2019
AbstractforPharmacokinetic mechanisms underlying the detoxification effect of Glycyrrhizae Radix et Rhizoma (Gancao): drug metabolizing enzymes, transporters, and beyond | Full Text | References | PDF (933 KB) | EPUB
  • 330 Views
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Original Research

Article
All-cause mortality and antipsychotic use among elderly persons with high baseline cardiovascular and cerebrovascular risk: a multi-center retrospective cohort study in Italy
Janet Sultana, Francesco Giorgianni, Federico Rea, Ersilia Lucenteforte, Niccolò Lombardi, Alessandro Mugelli, Alfredo Vannacci, Rosa Liperoti, Ursula Kirchmayer, Cristiana Vitale, Alessandro Chinellato, Giuseppe Roberto, Giovanni Corrao, Gianluca Trifirò & on the behalf of the Italian Group for Appropriate Drug prescription in the Elderly (I-GrADE)
Pages: 179-188
Published online: 04 Jan 2019
AbstractforAll-cause mortality and antipsychotic use among elderly persons with high baseline cardiovascular and cerebrovascular risk: a multi-center retrospective cohort study in Italy | Full Text | References | PDF (1 MB) | EPUB | Supplemental
  • 230 Views
  • 6 CrossRef citations
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