Expert Opinion on Drug Metabolism & Toxicology, Volume 17, Issue 6 (2021)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 17, Issue 6 (2021)

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Review

Update on drug-drug interaction at organic cation transporters: mechanisms, clinical impact, and proposal for advanced in vitro testing
Hermann Koepsell
Pages: 635-653
Published online: 09 Jun 2021
AbstractforUpdate on drug-drug interaction at organic cation transporters: mechanisms, clinical impact, and proposal for advanced in vitro testing | Full Text | References | PDF (2.7 MB) | EPUB
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Open Access
Current strategies for predicting side effects from second generation antipsychotics in youth
Jacob T. Brown, Claudia Campo-Soria & Jeffrey R. Bishop
Pages: 655-664
Published online: 02 May 2021
AbstractforCurrent strategies for predicting side effects from second generation antipsychotics in youth | Full Text | References | PDF (370.1 KB) | EPUB
  • 365 Views
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The impact of age on antiretroviral drug pharmacokinetics in the treatment of adults living with HIV
Andrea Calcagno, Mattia Trunfio, Antonio D’Avolio, Giovanni Di Perri & Stefano Bonora
Pages: 665-676
Published online: 29 Apr 2021
AbstractforThe impact of age on antiretroviral drug pharmacokinetics in the treatment of adults living with HIV | Full Text | References | PDF (2.7 MB) | EPUB
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How close are we to personalized mitotane dosing in the treatment of adrenocortical carcinoma? State of the art and future perspectives
Rebecca V. Steenaard, Madeleine H.T. Ettaieb, Thomas M.A. Kerkhofs & Harm R. Haak
Pages: 677-683
Published online: 04 May 2021
AbstractforHow close are we to personalized mitotane dosing in the treatment of adrenocortical carcinoma? State of the art and future perspectives | Full Text | References | PDF (321.8 KB) | EPUB
  • 200 Views
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Polymorphisms of genes related to phase-I metabolic enzymes affecting the clinical efficacy and safety of clopidogrel treatment
Abdullah Alkattan & Eman Alsalameen
Pages: 685-695
Published online: 15 May 2021
AbstractforPolymorphisms of genes related to phase-I metabolic enzymes affecting the clinical efficacy and safety of clopidogrel treatment | Full Text | References | PDF (398 KB) | EPUB
  • 317 Views
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Potential drug-drug interaction between sodium-glucose co-transporter 2 inhibitors and statins: pharmacological and clinical evidence
Panagiotis-Nikolaos Lalagkas, Georgios Poulentzas, Christos Kontogiorgis & Antonios Douros
Pages: 697-705
Published online: 26 May 2021
AbstractforPotential drug-drug interaction between sodium-glucose co-transporter 2 inhibitors and statins: pharmacological and clinical evidence | Full Text | References | PDF (415.4 KB) | EPUB
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Han Chinese specific cytochrome P450 polymorphisms and their impact on the metabolism of anti-hypertensive drugs with adrenoreceptor blocking properties
Jian-Chang Qian, Jian-Ping Cai & Guo-Xin Hu
Pages: 707-716
Published online: 03 May 2021
AbstractforHan Chinese specific cytochrome P450 polymorphisms and their impact on the metabolism of anti-hypertensive drugs with adrenoreceptor blocking properties | Full Text | References | PDF (1.4 MB) | EPUB
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Original Research

Article
Development and evaluation of a physiologically based pharmacokinetic model to predict carvedilol-paroxetine metabolic drug–drug interaction in healthy adults and its extrapolation to virtual chronic heart failure patients for dose optimization
Muhammad Fawad Rasool & Stephanie Läer
Pages: 717-724
Published online: 04 May 2021
AbstractforDevelopment and evaluation of a physiologically based pharmacokinetic model to predict carvedilol-paroxetine metabolic drug–drug interaction in healthy adults and its extrapolation to virtual chronic heart failure patients for dose optimization | Full Text | References | PDF (821.3 KB) | EPUB | Supplemental
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Article
Safety and pharmacokinetic interaction between fotagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin in healthy subjects
Yanhua Ding, Hong Zhang, Cuiyun Li, WenBo Zheng, Meng Wang, Ying Li, HaiGang Sun & Min Wu
Pages: 725-731
Published online: 26 Apr 2021
AbstractforSafety and pharmacokinetic interaction between fotagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin in healthy subjects | Full Text | References | PDF (533.8 KB) | EPUB
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