Expert Opinion on Drug Metabolism & Toxicology, Volume 19, Issue 10 (2023)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 19, Issue 10 (2023)

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Perspective

Improving on in-silico prediction of oral drug bioavailability
Saeed Alqahtani
Pages: 665-670
Published online: 27 Oct 2023
AbstractforImproving on in-silico prediction of oral drug bioavailability | Full Text | References | PDF (851 KB) | EPUB
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Review

Review Article
Pharmacology of viable mechanism agnostic respiratory stimulants for the reversal of drug-induced respiratory depression in humans
Maarten van Lemmen, Rutger van der Schrier, Albert Dahan, Monique van Velzen, Elise Sarton & Marieke Niesters
Pages: 671-679
Published online: 27 Oct 2023
AbstractforPharmacology of viable mechanism agnostic respiratory stimulants for the reversal of drug-induced respiratory depression in humans | Full Text | References | PDF (319.8 KB) | EPUB
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Open Access
Review Article
What is the most effective and safest Non-steroidal anti-inflammatory drug for treating osteoarthritis in patients with comorbidities?
Quentin E Geczy, Aricia J Thirumaran, Peter R Carroll, Andrew J McLachlan & David J Hunter
Pages: 681-695
Published online: 27 Oct 2023
AbstractforWhat is the most effective and safest Non-steroidal anti-inflammatory drug for treating osteoarthritis in patients with comorbidities? | Full Text | References | PDF (3.1 MB) | EPUB
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Review Article
Clinical pharmacology of selatogrel for self-administration by patients with suspected acute myocardial infarction
Martine Gehin, Robert F. Storey, Corine Bernaud & Jasper Dingemanse
Pages: 697-708
Published online: 27 Oct 2023
AbstractforClinical pharmacology of selatogrel for self-administration by patients with suspected acute myocardial infarction | Full Text | References | PDF (1.9 MB) | EPUB
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Open Access

Original Research

Article
The safety and toxicity profile of SPL84, an inhaled antisense oligonucleotide for treatment of cystic fibrosis patients with the 3849 +10kb C->T mutation, supports a Phase 1/2 clinical study
Lital Friedman, Ofra-Barchad Avitzur, Efrat Ozeri Galai, Nicolay Ferrari, Asa Choen, Sara Dahan, Tamar Mordechai & Gili Hart
Pages: 709-720
Published online: 27 Oct 2023
AbstractforThe safety and toxicity profile of SPL84, an inhaled antisense oligonucleotide for treatment of cystic fibrosis patients with the 3849 +10kb C->T mutation, supports a Phase 1/2 clinical study | Full Text | References | PDF (5.9 MB) | EPUB | Supplemental
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Article
Enhancing drug-drug Interaction Prediction by Integrating Physiologically-Based Pharmacokinetic Model with Fraction Metabolized by CYP3A4
Pin Jiang, Tao Chen, Lin-Feng Chu, Ren-Peng Xu, Jin-Ting Gao, Li Wang, Qiang Liu, Lily Tang, Hong Wan, Ming Li & Hong-Can Ren
Pages: 721-731
Published online: 27 Oct 2023
AbstractforEnhancing drug-drug Interaction Prediction by Integrating Physiologically-Based Pharmacokinetic Model with Fraction Metabolized by CYP3A4 | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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