Expert Opinion on Drug Metabolism & Toxicology, Volume 3, Issue 1 (2007)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 3, Issue 1 (2007)

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Review

Article
Genetic polymorphisms of drug-metabolizing enzymes and the susceptibility to antituberculosis drug-induced liver injury
Yi-Shin Huang
Pages: 1-8
Published online: 01 Feb 2007
AbstractforGenetic polymorphisms of drug-metabolizing enzymes and the susceptibility to antituberculosis drug-induced liver injury | Full Text | References | PDF (103.8 KB)
  • 358 Views
  • 45 CrossRef citations
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Article
Antipsychotic drugs and QTc prolongation: the potential role of CYP2D6 genetic polymorphism
Pedro Dorado, Roland Berecz, Eva M Peñas-LLedó & Adrián LLerena
Pages: 9-19
Published online: 01 Feb 2007
AbstractforAntipsychotic drugs and QTc prolongation: the potential role of CYP2D6 genetic polymorphism | Full Text | References | PDF (184.1 KB)
  • 220 Views
  • 15 CrossRef citations
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Article
The impact of CYP allelic variation on antidepressant metabolism: a review
John L Black III, Dennis J O’Kane & David A Mrazek
Pages: 21-31
Published online: 01 Feb 2007
AbstractforThe impact of CYP allelic variation on antidepressant metabolism: a review | Full Text | References | PDF (112.2 KB)
  • 311 Views
  • 36 CrossRef citations
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Article
Cellular proteolytic systems in P450 degradation: evolutionary conservation from Saccharomycescerevisiae to mammalian liver
Maria Almira Correia & Mingxiang Liao
Pages: 33-49
Published online: 01 Feb 2007
AbstractforCellular proteolytic systems in P450 degradation: evolutionary conservation from Saccharomycescerevisiae to mammalian liver | Full Text | References | PDF (408.7 KB)
  • 169 Views
  • 17 CrossRef citations
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Article
Time-dependent CYP inhibition
Robert J Riley, Ken Grime & Richard Weaver
Pages: 51-66
Published online: 01 Feb 2007
AbstractforTime-dependent CYP inhibition | Full Text | References | PDF (368.4 KB)
  • 4770 Views
  • 110 CrossRef citations
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Article
Clinical relevance of the small intestine as an organ of drug elimination: drug–fruit juice interactions
Mary F Paine & Nicholas H Oberlies
Pages: 67-80
Published online: 01 Feb 2007
AbstractforClinical relevance of the small intestine as an organ of drug elimination: drug–fruit juice interactions | Full Text | References | PDF (185.1 KB)
  • 283 Views
  • 49 CrossRef citations
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Article
Transporter-mediated drug interactions: clinical implications and in vitro assessment
Jiunn H Lin
Pages: 81-92
Published online: 01 Feb 2007
AbstractforTransporter-mediated drug interactions: clinical implications and in vitro assessment | Full Text | References | PDF (133.5 KB)
  • 403 Views
  • 79 CrossRef citations
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Article
Intestinal UGTs as potential modifiers of pharmacokinetics and biological responses to drugs and xenobiotics
Joseph K Ritter
Pages: 93-107
Published online: 01 Feb 2007
AbstractforIntestinal UGTs as potential modifiers of pharmacokinetics and biological responses to drugs and xenobiotics | Full Text | References | PDF (153 KB)
  • 781 Views
  • 81 CrossRef citations
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Article
Toxicological and clinical computational analysis and the US FDA/CDER
R Daniel Benz
Pages: 109-124
Published online: 01 Feb 2007
AbstractforToxicological and clinical computational analysis and the US FDA/CDER | Full Text | References | PDF (196.2 KB)
  • 114 Views
  • 26 CrossRef citations
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Article
In silico approaches to explore toxicity end points: issues and concerns for estimating human health effects
Edwin J Matthews & Joseph F Contrera
Pages: 125-134
Published online: 01 Feb 2007
AbstractforIn silico approaches to explore toxicity end points: issues and concerns for estimating human health effects | Full Text | References | PDF (111.4 KB)
  • 112 Views
  • 30 CrossRef citations
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Drug Evaluation

Article
A brief review of the pharmacologic and therapeutic aspects of memantine in Alzheimer’s disease
Frederick Schmitt, Melody Ryan & Gregory Cooper
Pages: 135-141
Published online: 01 Feb 2007
AbstractforA brief review of the pharmacologic and therapeutic aspects of memantine in Alzheimer’s disease | Full Text | References | PDF (94.1 KB)
  • 255 Views
  • 22 CrossRef citations
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