Expert Opinion on Drug Metabolism & Toxicology, Volume 6, Issue 12 (2010)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 6, Issue 12 (2010)

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Perspective

Article
Are rats the appropriate experimental model to understand age-related renal drug metabolism and toxicity?
Andrea Trevisan, Annamaria Nicolli & Federica Chiara
Pages: 1451-1459
Published online: 11 Nov 2010
AbstractforAre rats the appropriate experimental model to understand age-related renal drug metabolism and toxicity? | Full Text | References | PDF (193.7 KB)
  • 132 Views
  • 7 CrossRef citations
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Reviews

Article
Cardiac slices as a predictive tool for arrhythmogenic potential of drugs and chemicals
Thomas Meyer, Katharina Stuerz, Elke Guenther, Mitsuhiro Edamura & Udo Kraushaar
Pages: 1461-1475
Published online: 11 Nov 2010
AbstractforCardiac slices as a predictive tool for arrhythmogenic potential of drugs and chemicals | Full Text | References | PDF (783.2 KB)
  • 290 Views
  • 13 CrossRef citations
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Article
Microdialysis for assessing intratumoral drug disposition in brain cancers: a tool for rational drug development
Jaishri Blakeley (Assistant Professor of Neurology) MD & Jana Portnow (Assistant Professor of Oncology) MD
Pages: 1477-1491
Published online: 23 Oct 2010
AbstractforMicrodialysis for assessing intratumoral drug disposition in brain cancers: a tool for rational drug development | Full Text | References | PDF (470.9 KB)
  • 275 Views
  • 33 CrossRef citations
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Article
Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA
Christopher A Koczor (Postdoctoral Fellow) PhD & William Lewis MD
Pages: 1493-1504
Published online: 07 Oct 2010
AbstractforNucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA | Full Text | References | PDF (313.5 KB)
  • 563 Views
  • 71 CrossRef citations
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Article
Thiopurines in Crohn's disease, is there something new?
Pal Miheller MD PhD & Peter Laszlo Lakatos MD PhD
Pages: 1505-1514
Published online: 05 Oct 2010
AbstractforThiopurines in Crohn's disease, is there something new? | Full Text | References | PDF (236 KB)
  • 267 Views
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Article
Herb–drug pharmacokinetic interactions reviewed
Clemence Tarirai, Alvaro M Viljoen (Professor) & Josias H Hamman (Professor) PhD
Pages: 1515-1538
Published online: 11 Nov 2010
AbstractforHerb–drug pharmacokinetic interactions reviewed | Full Text | References | PDF (350.8 KB)
  • 892 Views
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Article
Challenges and solutions to metabolites in safety testing: impact of the International Conference on Harmonization M3(R2) guidance
Hongbin Yu (Principal Scientist) PhD, Daniel Bischoff (Head of Laboratory) PhD & Donald Tweedie (Director) PhD
Pages: 1539-1549
Published online: 11 Nov 2010
AbstractforChallenges and solutions to metabolites in safety testing: impact of the International Conference on Harmonization M3(R2) guidance | Full Text | References | PDF (454.1 KB)
  • 377 Views
  • 27 CrossRef citations
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Drug Evaluations

Article
Iloperidone: chemistry, pharmacodynamics, pharmacokinetics and metabolism, clinical efficacy, safety and tolerability, regulatory affairs, and an opinion
Leslie Citrome (Professor of Psychiatry) (Director (Clinical Research and Evaluation Facility)) MD MPH
Pages: 1551-1564
Published online: 01 Nov 2010
AbstractforIloperidone: chemistry, pharmacodynamics, pharmacokinetics and metabolism, clinical efficacy, safety and tolerability, regulatory affairs, and an opinion | Full Text | References | PDF (274.3 KB)
  • 485 Views
  • 34 CrossRef citations
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Article
Desvenlafaxine for major depressive disorder: incremental clinical benefits from a second-generation serotonin–norepinephrine reuptake inhibitor
Alice I Nichols PhD, Karen A Tourian MD, Susanna Y Tse PhD & Jeffrey Paul PhD
Pages: 1565-1574
Published online: 11 Nov 2010
AbstractforDesvenlafaxine for major depressive disorder: incremental clinical benefits from a second-generation serotonin–norepinephrine reuptake inhibitor | Full Text | References | PDF (445.6 KB)
  • 463 Views
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Article
Pharmacokinetic evaluation of etravirine
Laura Dickinson, Saye Khoo (Professor) & David Back (Professor)
Pages: 1575-1585
Published online: 16 Nov 2010
AbstractforPharmacokinetic evaluation of etravirine | Full Text | References | PDF (267 KB)
  • 216 Views
  • 7 CrossRef citations
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Article
Pharmacokinetic evaluation of continuous intravenous epoprostenol
Marie-Camille Chaumais PharmD, Marion Jobard PharmD, Alice Huertas MD, Claire Vignand-Courtin PharmD, Marc Humbert MD PhD, Olivier Sitbon MD PhD, André Rieutord PharmD PhD & David Montani MD PhD
Pages: 1587-1598
Published online: 16 Nov 2010
AbstractforPharmacokinetic evaluation of continuous intravenous epoprostenol | Full Text | References | PDF (539.8 KB)
  • 287 Views
  • 14 CrossRef citations
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Meeting Highlights

Article
Current and future directions of pharmacokinetic and pharmacokinetic–pharmacodynamic modelling and simulation: Population Approach Group in Europe 19th annual meeting
8 – 11 June, 2010 Berlin, Germany
Charlotte Kloft & Italo Poggesi
Pages: 1599-1604
Published online: 24 Oct 2010
AbstractforCurrent and future directions of pharmacokinetic and pharmacokinetic–pharmacodynamic modelling and simulation: Population Approach Group in Europe 19th annual meeting | Full Text | References | PDF (188.4 KB)
  • 102 Views
  • 1 CrossRef citations
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