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Volume 9, Issue 2

Expert Opinion on Drug Metabolism & Toxicology

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Expert Opinion on Drug Metabolism & Toxicology, Volume 9, Issue 2 (2013)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 9, Issue 2 (2013)

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Original Research

Article

Evaluation of toxicity and single-dose pharmacokinetics of intravenous ursolic acid liposomes in healthy adult volunteers and patients with advanced solid tumors

Xian-Huo Wang MD, Shi-Yong Zhou MD, Zheng-Zi Qian MD, Hui-Lai Zhang MD, Li-Hua Qiu (Master) , Zheng Song (Master) , Jing Zhao (Master) , Ping Wang (Professor) MD, Xi-Shan Hao (Professor) MD & Hua-Qing Wang (Professor) MD

Pages: 117-125

Published online: 08 Nov 2012

AbstractforEvaluation of toxicity and single-dose pharmacokinetics of intravenous ursolic acid liposomes in healthy adult volunteers and patients with advanced solid tumors | Full Text | References | PDF (490.7 KB)

342 Views
60 CrossRef citations
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Reviews

Review Article

Animal models of toxicology testing: the role of pigs

Kristi L Helke (Assistant Professor) DVM PhD Diplomate ACVP & Marvin Michael Swindle (Professor) DVM Diplomate ACLAM

Pages: 127-139

Published online: 10 Dec 2012

AbstractforAnimal models of toxicology testing: the role of pigs | Full Text | References | PDF (246.8 KB)

966 Views
86 CrossRef citations
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Review Article

Cytokines as molecular targets for aryl hydrocarbon receptor ligands: implications for toxicity and xenobiotic detoxification

Olivier Fardel PharmD PhD

Pages: 141-152

Published online: 12 Dec 2012

AbstractforCytokines as molecular targets for aryl hydrocarbon receptor ligands: implications for toxicity and xenobiotic detoxification | Full Text | References | PDF (299.8 KB)

387 Views
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Review Article

Strategies for a comprehensive understanding of metabolism by aldehyde oxidase

James Matthew Hutzler (Senior Principal Scientist) PhD, Ronald Scott Obach (Senior Research Fellow) PhD, Deepak Dalvie (Research Fellow) PhD & Michael A Zientek (Senior Principal Scientist)

Pages: 153-168

Published online: 12 Dec 2012

AbstractforStrategies for a comprehensive understanding of metabolism by aldehyde oxidase | Full Text | References | PDF (810.3 KB)

1830 Views
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Review Article

Clinical pharmacokinetics of second generation antisense oligonucleotides

Rosie Z Yu (Executive Director) PhD, John S Grundy (Vice President) PhD & Richard S Geary (Senior Vice President) PhD

Pages: 169-182

Published online: 12 Dec 2012

AbstractforClinical pharmacokinetics of second generation antisense oligonucleotides | Full Text | References | PDF (519.3 KB)

2069 Views
106 CrossRef citations
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Review Article

Pharmacogenetics of antipsychotics: recent progress and methodological issues

Jian-Ping Zhang MD PhD & Anil K Malhotra MD

Pages: 183-191

Published online: 01 Dec 2012

AbstractforPharmacogenetics of antipsychotics: recent progress and methodological issues | Full Text | References | PDF (395.7 KB)

428 Views
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Drug Evaluations

Cariprazine: chemistry, pharmacodynamics, pharmacokinetics, and metabolism, clinical efficacy, safety, and tolerability

Leslie Citrome (Clinical Professor of Psychiatry & Behavioral Sciences) MD MPH

Pages: 193-206

Published online: 15 Jan 2013

Abstractfor Cariprazine: chemistry, pharmacodynamics, pharmacokinetics, and metabolism, clinical efficacy, safety, and tolerability | Full Text | References | PDF (380.6 KB)

1889 Views
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Pharmacokinetic evaluation of olanzapine + fluoxetine for the treatment of bipolar depression

Steven L Dubovsky (Professor and Chair) MD

Pages: 207-214

Published online: 08 Jan 2013

AbstractforPharmacokinetic evaluation of olanzapine + fluoxetine for the treatment of bipolar depression | Full Text | References | PDF (213.1 KB)

353 Views
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A pharmacokinetic evaluation of topotecan as a cervical cancer therapy

Fernanda Musa (Fellow in Gynecologic Oncology) , Stephanie Blank (Associate Professor) & Franco Muggia (Professor) MD

Pages: 215-224

Published online: 15 Jan 2013

AbstractforA pharmacokinetic evaluation of topotecan as a cervical cancer therapy | Full Text | References | PDF (291.5 KB)

240 Views
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Pharmacokinetic evaluation of capecitabine in breast cancer

Gennaro Daniele, Marianna Gallo, Maria Carmela Piccirillo, Pasqualina Giordano, Amelia D'Alessio, Antonia Del Giudice, Maria Libera La Porta, Francesco Perrone, Nicola Normanno & Antonella De Luca

Pages: 225-235

Published online: 10 Jan 2013

AbstractforPharmacokinetic evaluation of capecitabine in breast cancer | Full Text | References | PDF (344 KB)

397 Views
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Research Article

Article

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Page: i

Published online: 15 Jan 2013

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