Pharmaceutical Biology, Volume 60, Issue 1 (2022)

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Pharmaceutical Biology, Volume 60, Issue 1 (2022)

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In Memoriam

Article
A tribute to Prof. em. Dr. Dr. h.c. mult. Hildebert Wagner
Rudolf Bauer (Univ.-Prof. Dr. DDr.h.c.)
Pages: (i)-(iii)
Published online: 10 Mar 2022
First Page PreviewforA tribute to Prof. em. Dr. Dr. h.c. mult. Hildebert Wagner | Full Text | References | PDF (581.3 KB) | EPUB
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Research Article

Article
Effect of quercetin on the pharmacokinetics of selexipag and its active metabolite in beagles
Shun-bin Luo, Er-min Gu, Yu-ao Chen, Shi-chen Zhou, Chen Fan & Ren-ai Xu
Pages: 1-8
Published online: 03 Dec 2021
AbstractforEffect of quercetin on the pharmacokinetics of selexipag and its active metabolite in beagles | Full Text | References | PDF (1.5 MB) | EPUB
  • 3366 Views
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Review

Review
The pharmacological properties and corresponding mechanisms of farrerol: a comprehensive review
Xiaojiang Qin, Xinrong Xu, Xiaomin Hou, Ruifeng Liang, Liangjing Chen, Yuxuan Hao, Anqi Gao, Xufeng Du, Liangyuan Zhao, Yiwei Shi & Qingshan Li
Pages: 9-16
Published online: 30 Nov 2021
AbstractforThe pharmacological properties and corresponding mechanisms of farrerol: a comprehensive review | Full Text | References | PDF (1.3 MB) | EPUB
  • 5508 Views
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Research Article

Article
Aspirin relieves the calcification of aortic smooth muscle cells by enhancing the heat shock response
Quanquan Shen, Qian Chen, Yang Liu, Xiang Xue, Xiaogang Shen, Qiang He, Guokun Wang & Fei Han
Pages: 17-24
Published online: 30 Nov 2021
AbstractforAspirin relieves the calcification of aortic smooth muscle cells by enhancing the heat shock response | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 3830 Views
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Article
Ellagic acid protects against non-alcoholic fatty liver disease in streptozotocin-diabetic rats by activating AMPK
Jozaa Z. ALTamimi, Ghedeir M. Alshammari, Nora A. AlFaris, Reham I. Alagal, Dalal H. Aljabryn, Norah A. Albekairi, Mahmoud Ahmad Alkhateeb & Mohammed Abdo Yahya
Pages: 25-37
Published online: 06 Dec 2021
AbstractforEllagic acid protects against non-alcoholic fatty liver disease in streptozotocin-diabetic rats by activating AMPK | Full Text | References | PDF (3.4 MB) | EPUB
  • 6627 Views
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Article
Britanin relieves ferroptosis-mediated myocardial ischaemia/reperfusion damage by upregulating GPX4 through activation of AMPK/GSK3β/Nrf2 signalling
Haoyang Lu, Hui Xiao, Manyu Dai, Yangcheng Xue & Ren Zhao
Pages: 38-45
Published online: 03 Dec 2021
AbstractforBritanin relieves ferroptosis-mediated myocardial ischaemia/reperfusion damage by upregulating GPX4 through activation of AMPK/GSK3β/Nrf2 signalling | Full Text | References | PDF (1.9 MB) | EPUB
  • 6875 Views
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Article
Efficacy of Yougui pill combined with Buzhong Yiqi decoction in alleviating the sexual dysfunction in female rats through modulation of the gut microbiota
Yangyun Wang, Chaoliang Shi, Wandong Yu, Wei Jiao & Guowei Shi
Pages: 46-55
Published online: 14 Dec 2021
AbstractforEfficacy of Yougui pill combined with Buzhong Yiqi decoction in alleviating the sexual dysfunction in female rats through modulation of the gut microbiota | Full Text | References | PDF (2.5 MB) | EPUB
  • 3150 Views
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Article
Myristicin regulates proliferation and apoptosis in oxidized low-density lipoprotein-stimulated human vascular smooth muscle cells and human umbilical vein endothelial cells by regulating the PI3K/Akt/NF-κB signalling pathway
Liang Luo, Huiying Liang & Luoying Liu
Pages: 56-64
Published online: 14 Dec 2021
AbstractforMyristicin regulates proliferation and apoptosis in oxidized low-density lipoprotein-stimulated human vascular smooth muscle cells and human umbilical vein endothelial cells by regulating the PI3K/Akt/NF-κB signalling pathway | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Concanavalin A promotes angiogenesis and proliferation in endothelial cells through the Akt/ERK/Cyclin D1 axis
Jing-Zhou Li, Xiao-Xia Zhou, Wei-Yin Wu, Hai-Feng Qiang, Guo-Sheng Xiao, Yan Wang & Gang Li
Pages: 65-74
Published online: 16 Dec 2021
AbstractforConcanavalin A promotes angiogenesis and proliferation in endothelial cells through the Akt/ERK/Cyclin D1 axis | Full Text | References | PDF (2.8 MB) | EPUB
  • 2652 Views
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Article
Deciphering the molecular mechanism of tetrandrine in inhibiting hepatocellular carcinoma and increasing sorafenib sensitivity by combining network pharmacology and experimental evaluation
Biao Niu, Sidong Wei, Jianjun Sun, Huibo Zhao, Bing Wang & Guoyong Chen
Pages: 75-86
Published online: 28 Dec 2021
AbstractforDeciphering the molecular mechanism of tetrandrine in inhibiting hepatocellular carcinoma and increasing sorafenib sensitivity by combining network pharmacology and experimental evaluation | Full Text | References | PDF (4.4 MB) | EPUB
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Article
Mechanism of Elian granules in the treatment of precancerous lesions of gastric cancer in rats through the MAPK signalling pathway based on network pharmacology
Zhirong Yi, Qingling Jia, Yili Lin, Yujiao Wang, Jun Cong, Zhijian Gu, Jianghong Ling & Gan Cai
Pages: 87-95
Published online: 28 Dec 2021
AbstractforMechanism of Elian granules in the treatment of precancerous lesions of gastric cancer in rats through the MAPK signalling pathway based on network pharmacology | Full Text | References | PDF (3.3 MB) | EPUB
  • 4049 Views
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Article
The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats
Jirakrit Saetang, Aman Tedasen, Surasak Sangkhathat, Natnaree Sangkaew, Sirinapa Dokduang, Napat Prompat, Siriporn Taraporn & Potchanapond Graidist
Pages: 96-107
Published online: 28 Dec 2021
AbstractforThe attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 2589 Views
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Article
Effect of Huangqin decoction on regulating intestinal flora in colitis mice characterized as inhibition of the NOD2-dependent pathway
Shaowei Huang, Jinrong He, Yanping Chen, Xiaojing Wang, Yanyang Li, Yulin Su, Ruyan Wen, Xiuling Li, Guanghua Yang, Shuang Luo, Lian Zhou & Xia Luo
Pages: 108-118
Published online: 30 Dec 2021
AbstractforEffect of Huangqin decoction on regulating intestinal flora in colitis mice characterized as inhibition of the NOD2-dependent pathway | Full Text | References | PDF (3 MB) | EPUB
  • 4459 Views
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Article
Network pharmacology and in vitro experimental verification to explore the mechanism of Sanhua decoction in the treatment of ischaemic stroke
Wei Zhang, Li Zhang, Wen jun Wang, Shanbo Ma, Mingming Wang, Minna Yao, Ruili Li, Wei wei Li, Xian Zhao, Dongmei Hu, Yi Ding & Jingwen Wang
Pages: 119-130
Published online: 05 Jan 2022
AbstractforNetwork pharmacology and in vitro experimental verification to explore the mechanism of Sanhua decoction in the treatment of ischaemic stroke | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
  • 6408 Views
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Article
A comprehensive study on the relieving effect of Lilium brownii on the intestinal flora and metabolic disorder in p-chlorphenylalanine induced insomnia rats
Yanpo Si, Wenjun Wei, Xiaohui Chen, Xiaolong Xie, Tao Guo, Yohei Sasaki, Youbo Zhang, Lili Wang, Fei Zhang & Shuying Feng
Pages: 131-143
Published online: 03 Jan 2022
AbstractforA comprehensive study on the relieving effect of Lilium brownii on the intestinal flora and metabolic disorder in p-chlorphenylalanine induced insomnia rats | Full Text | References | PDF (3.2 MB) | EPUB
  • 5317 Views
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Article
Suchilactone inhibits the growth of acute myeloid leukaemia by inactivating SHP2
Jingjing Wu, Yuan Deng, Xin Zhang, Jingjing Ma, Xinqi Zheng & Yue Chen
Pages: 144-153
Published online: 28 Dec 2021
AbstractforSuchilactone inhibits the growth of acute myeloid leukaemia by inactivating SHP2 | Full Text | References | PDF (2.9 MB) | EPUB
  • 2985 Views
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Article
Cucurbitacin B regulates lung cancer cell proliferation and apoptosis via inhibiting the IL-6/STAT3 pathway through the lncRNA XIST/miR-let-7c axis
Jian-Hua Liu, Chen Li, Liang Cao, Chang-Hong Zhang & Zhi-Hua Zhang
Pages: 154-162
Published online: 30 Dec 2021
AbstractforCucurbitacin B regulates lung cancer cell proliferation and apoptosis via inhibiting the IL-6/STAT3 pathway through the lncRNA XIST/miR-let-7c axis | Full Text | References | PDF (3.1 MB) | EPUB
  • 4719 Views
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Article
Yi Shen An, a Chinese traditional prescription, ameliorates membranous glomerulonephritis induced by cationic bovine serum albumin in rats
Yun-Li Zhao, Xiang-Hua Zhang, Feng Guo, Ying Wei, Jian-Hua Shang & Xiao-Dong Luo
Pages: 163-174
Published online: 08 Jan 2022
AbstractforYi Shen An, a Chinese traditional prescription, ameliorates membranous glomerulonephritis induced by cationic bovine serum albumin in rats | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 2968 Views
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Article
The antithrombosis effect of dehydroandrographolide succinate: in vitro and in vivo studies
Bowen Yin, Shuhua Zhang, Yuxi Huang, Yuanzhu Long, Yiguo Chen, Shiyun Zhao, Aiqun Zhou, Minghua Cao, Xiaoming Yin & Daya Luo
Pages: 175-184
Published online: 11 Jan 2022
AbstractforThe antithrombosis effect of dehydroandrographolide succinate: in vitro and in vivo studies | Full Text | References | PDF (2.5 MB) | EPUB
  • 2951 Views
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Article
QiShenYiQi pills, a Chinese patent medicine, increase bioavailability of atorvastatin by inhibiting Mrp2 expression in rats
Congyang Ding, Yajing Li, Xiao Li, Lu Meng, Ran Fu, Xiaonan Wang, Ying Li, Yinling Ma & Zhanjun Dong
Pages: 185-194
Published online: 08 Jan 2022
AbstractforQiShenYiQi pills, a Chinese patent medicine, increase bioavailability of atorvastatin by inhibiting Mrp2 expression in rats | Full Text | References | PDF (1.6 MB) | EPUB
  • 2649 Views
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Article
Folium Ginkgo extract and tetramethylpyrazine sodium chloride injection (Xingxiong injection) protects against focal cerebral ischaemia/reperfusion injury via activating the Akt/Nrf2 pathway and inhibiting NLRP3 inflammasome activation
Ting Zhu, Bin-Yu Fang, Xiang-Bao Meng, Shu-Xia Zhang, Hong Wang, Ge Gao, Fei Liu, Yu Wu, Jin Hu, Gui-Bo Sun & Xiao-Bo Sun
Pages: 195-205
Published online: 21 Jan 2022
AbstractforFolium Ginkgo extract and tetramethylpyrazine sodium chloride injection (Xingxiong injection) protects against focal cerebral ischaemia/reperfusion injury via activating the Akt/Nrf2 pathway and inhibiting NLRP3 inflammasome activation | Full Text | References | PDF (2.8 MB) | EPUB
  • 4220 Views
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Brief Report

Brief Report
Chemical composition, enantiomeric analysis and anticholinesterase activity of Lepechinia betonicifolia essential oil from Ecuador
James Calva, Luis Cartuche, Salomé González, José Vinicio Montesinos & Vladimir Morocho
Pages: 206-211
Published online: 20 Jan 2022
AbstractforChemical composition, enantiomeric analysis and anticholinesterase activity of Lepechinia betonicifolia essential oil from Ecuador | Full Text | References | PDF (1 MB) | EPUB
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Research Article

Article
Protective effects of Forsythiae fructus and Cassiae semen water extract against memory deficits through the gut-microbiome-brain axis in an Alzheimer’s disease model
Da Sol Kim, Ting Zhang & Sunmin Park
Pages: 212-224
Published online: 25 Jan 2022
AbstractforProtective effects of Forsythiae fructus and Cassiae semen water extract against memory deficits through the gut-microbiome-brain axis in an Alzheimer’s disease model | Full Text | References | PDF (2 MB) | EPUB
  • 4391 Views
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Article
Comparison of chemical profiles, antioxidation, inhibition of skin extracellular matrix degradation, and anti-tyrosinase activity between mycelium and fruiting body of Cordyceps militaris and Isaria tenuipes
Adchara Prommaban, Suwannee Sriyab, Pachabadee Marsup, Waranya Neimkhum, Jakkapan Sirithunyalug, Songyot Anuchapreeda, Chaiwat To-anun & Wantida Chaiyana
Pages: 225-234
Published online: 22 Jan 2022
AbstractforComparison of chemical profiles, antioxidation, inhibition of skin extracellular matrix degradation, and anti-tyrosinase activity between mycelium and fruiting body of Cordyceps militaris and Isaria tenuipes | Full Text | References | PDF (1.5 MB) | EPUB
  • 4102 Views
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Article
Bioactive peptides from broccoli stems strongly enhance regenerative keratinocytes by stimulating controlled proliferation
Juan Nicolas-Espinosa, Lucía Yepes-Molina & Micaela Carvajal
Pages: 235-246
Published online: 27 Jan 2022
AbstractforBioactive peptides from broccoli stems strongly enhance regenerative keratinocytes by stimulating controlled proliferation | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 3060 Views
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Article
Delphinidin-3-O-glucoside, an active compound of Hibiscus sabdariffa calyces, inhibits oxidative stress and inflammation in rabbits with atherosclerosis
Bo Sun, Fangda Li, Xu Zhang, Wei Wang, Jiang Shao & Yuehong Zheng
Pages: 247-254
Published online: 07 Feb 2022
AbstractforDelphinidin-3-O-glucoside, an active compound of Hibiscus sabdariffa calyces, inhibits oxidative stress and inflammation in rabbits with atherosclerosis | Full Text | References | PDF (2.5 MB) | EPUB
  • 3004 Views
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Article
Integrated chemical profiling, network pharmacology and pharmacological evaluation to explore the potential mechanism of Xinbao pill against myocardial ischaemia–reperfusion injury
Ying Yang, Ting Chen, Jiaming Liu, Sixuan Chen, Rongqing Cai, Liqiong Wu, Jiexiong Hu, Qiongying Lin, Xiaoxiao Qi, Zhongqiu Liu & Yuanyuan Cheng
Pages: 255-273
Published online: 11 Feb 2022
AbstractforIntegrated chemical profiling, network pharmacology and pharmacological evaluation to explore the potential mechanism of Xinbao pill against myocardial ischaemia–reperfusion injury | Full Text | References | PDF (4.5 MB) | EPUB
  • 4575 Views
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Article
Jinlida granules ameliorate the high-fat-diet induced liver injury in mice by antagonising hepatocytes pyroptosis
Yuan-yuan Hao, Wen-wen Cui, Huai-lin Gao, Ming-ye Wang, Yan Liu, Cui-ru Li, Yun-long Hou & Zhen-hua Jia
Pages: 274-281
Published online: 09 Feb 2022
AbstractforJinlida granules ameliorate the high-fat-diet induced liver injury in mice by antagonising hepatocytes pyroptosis | Full Text | References | PDF (2.4 MB) | EPUB
  • 5289 Views
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Article
Sperm quality and testicular histopathology of Wistar albino male rats treated with hydroethanolic extract of Cordia dichotoma fruits
Samah A. El-Newary, Mohamed S. Aly, Amal R. Abd El Hameed, Mohamed S. Kotp, Abdelghany A. Youssef & Naglaa A. Ali
Pages: 282-293
Published online: 09 Feb 2022
AbstractforSperm quality and testicular histopathology of Wistar albino male rats treated with hydroethanolic extract of Cordia dichotoma fruits | Full Text | References | PDF (2.7 MB) | EPUB
  • 2224 Views
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Article
Anti-inflammatory action of geniposide promotes wound healing in diabetic rats
Xiao-yan Chen, Wen-wen Jiang, Yan-ling Liu, Zhao-xia Ma & Jian-qiang Dai
Pages: 294-299
Published online: 07 Feb 2022
AbstractforAnti-inflammatory action of geniposide promotes wound healing in diabetic rats | Full Text | References | PDF (1.6 MB) | EPUB
  • 4096 Views
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Article
Ranunculus ternatus Thunb extract attenuates renal fibrosis of diabetic nephropathy via inhibiting SMYD2
Weiwei Xu, Rui Peng, Siyu Chen, Congcong Wu, Xiaoxiao Wang, Ting Yu, Jiuying Jian, Ni Zhang, Siyang Zuo, Min Chen, Bing Guo & Lirong Liu
Pages: 300-307
Published online: 10 Feb 2022
AbstractforRanunculus ternatus Thunb extract attenuates renal fibrosis of diabetic nephropathy via inhibiting SMYD2 | Full Text | References | PDF (2.1 MB) | EPUB
  • 4033 Views
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Article
Response surface optimization of enzymatic hydrolysis and ROS scavenging activity of silk sericin hydrolysates
Keerati Joyjamras, Chatchai Chaotham & Pithi Chanvorachote
Pages: 308-318
Published online: 11 Feb 2022
AbstractforResponse surface optimization of enzymatic hydrolysis and ROS scavenging activity of silk sericin hydrolysates | Full Text | References | PDF (2.1 MB) | EPUB
  • 2815 Views
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Article
Peptides from the croceine croaker (Larimichthys crocea) swim bladder attenuate busulfan-induced oligoasthenospermia in mice
Xi Zhao, Mengmeng Sang, Ping Han, Jie Gao, Zhenhua Liu, Hu Li, Yayun Gu, Chengniu Wang & Fei Sun
Pages: 319-325
Published online: 11 Feb 2022
AbstractforPeptides from the croceine croaker (Larimichthys crocea) swim bladder attenuate busulfan-induced oligoasthenospermia in mice | Full Text | References | PDF (1.6 MB) | EPUB
  • 2570 Views
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Article
Tanshinone IIA alleviates ovalbumin-induced allergic rhinitis symptoms by inhibiting Th2 cytokine production and mast cell histamine release in mice
Qing Chen, Liping Shao, Yong Li, Mian Dai, He Liu, Nan Xiang & Hui Chen
Pages: 326-333
Published online: 15 Feb 2022
AbstractforTanshinone IIA alleviates ovalbumin-induced allergic rhinitis symptoms by inhibiting Th2 cytokine production and mast cell histamine release in mice | Full Text | References | PDF (2.1 MB) | EPUB
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Article
Wasp venom from Vespa magnifica acts as a neuroprotective agent to alleviate neuronal damage after stroke in rats
Hairong Zhao, Mei Wang, Xi Huang, Xiumei Wu, Huai Xiao, Fanmao Jin, Jiaming Lv, Jidong Cheng, Yu Zhao & Chenggui Zhang
Pages: 334-346
Published online: 16 Feb 2022
AbstractforWasp venom from Vespa magnifica acts as a neuroprotective agent to alleviate neuronal damage after stroke in rats | Full Text | References | PDF (4.1 MB) | EPUB
  • 3760 Views
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Article
Nrf2 regulates downstream genes by targeting miR-29b in severe asthma and the role of grape seed proanthocyanidin extract in a murine model of steroid-insensitive asthma
Yan Qian, Yun Sun, Yi Chen, Zhengdao Mao, Yujia Shi, Di Wu, Bin Gu, Zhiguang Liu & Qian Zhang
Pages: 347-358
Published online: 16 Feb 2022
AbstractforNrf2 regulates downstream genes by targeting miR-29b in severe asthma and the role of grape seed proanthocyanidin extract in a murine model of steroid-insensitive asthma | Full Text | References | PDF (2.5 MB) | EPUB
  • 3565 Views
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Article
Evodiamine decreased the systemic exposure of pravastatin in non-alcoholic steatohepatitis rats due to the up-regulation of hepatic OATPs
Ruifeng Liang, Wenjing Ge, Bingjie Li, Weifeng Cui, Xiaofan Ma, Yuying Pan & Gengsheng Li
Pages: 359-373
Published online: 16 Feb 2022
AbstractforEvodiamine decreased the systemic exposure of pravastatin in non-alcoholic steatohepatitis rats due to the up-regulation of hepatic OATPs | Full Text | References | PDF (4.2 MB) | EPUB
  • 2249 Views
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Article
Seed extract of Thai Mucuna pruriens reduced male reproductive damage in rats induced by chronic stress
Natthapol Lapyuneyong, Nareelak Tangsrisakda, Pannawat Choowong-In, Kowit Chaisiwamongkol, Nongnut Uabundit, Tarinee Sawatpanich, Supatcharee Arun, Alexander Tsang-Hsien Wu & Sitthichai Iamsaard
Pages: 374-383
Published online: 18 Feb 2022
AbstractforSeed extract of Thai Mucuna pruriens reduced male reproductive damage in rats induced by chronic stress | Full Text | References | PDF (4.6 MB) | EPUB | Supplemental
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Article
M2b macrophages stimulate lymphangiogenesis to reduce myocardial fibrosis after myocardial ischaemia/reperfusion injury
Cuiping Wang, Yuan Yue, Suiqing Huang, Keke Wang, Xiao Yang, Jiantao Chen, Jiaxing Huang & Zhongkai Wu
Pages: 384-393
Published online: 21 Feb 2022
AbstractforM2b macrophages stimulate lymphangiogenesis to reduce myocardial fibrosis after myocardial ischaemia/reperfusion injury | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Pterostilbene pre-treatment reduces LPS-induced acute lung injury through activating NR4A1
Ying Li, Shu-Min Wang, Xing Li, Chang-Jun Lv, Ling-Yun Peng, Xiao-Feng Yu, Ying-Jian Song & Cong-Jie Wang
Pages: 394-403
Published online: 10 Mar 2022
AbstractforPterostilbene pre-treatment reduces LPS-induced acute lung injury through activating NR4A1 | Full Text | References | PDF (3.7 MB) | EPUB
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Article
Cordycepin mitigates spermatogenic and redox related expression in H2O2-exposed Leydig cells and regulates testicular oxidative apoptotic signalling in aged rats
Spandana Rajendra Kopalli, Kyu-Min Cha, Jae Youl Cho, Si-Kwan Kim & Sushruta Koppula
Pages: 404-416
Published online: 17 Feb 2022
AbstractforCordycepin mitigates spermatogenic and redox related expression in H2O2-exposed Leydig cells and regulates testicular oxidative apoptotic signalling in aged rats | Full Text | References | PDF (2.6 MB) | EPUB
  • 3564 Views
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Article
Osthole exhibits an antitumor effect in retinoblastoma through inhibiting the PI3K/AKT/mTOR pathway via regulating the hsa_circ_0007534/miR-214-3p axis
Xiufang Lv, Haojiang Yang, Hui Zhong, Li He & Li Wang
Pages: 417-426
Published online: 17 Feb 2022
AbstractforOsthole exhibits an antitumor effect in retinoblastoma through inhibiting the PI3K/AKT/mTOR pathway via regulating the hsa_circ_0007534/miR-214-3p axis | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Cyanidin attenuates the apoptosis of rat nucleus pulposus cells and the degeneration of intervertebral disc via the JAK2/STAT3 signal pathway in vitro and in vivo
Xiaoliang Bai, Meichao Jiang, Jie Wang, Shuai Yang, Zhiwei Liu, Hongxin Zhang & Xiaojuan Zhu
Pages: 427-436
Published online: 17 Feb 2022
AbstractforCyanidin attenuates the apoptosis of rat nucleus pulposus cells and the degeneration of intervertebral disc via the JAK2/STAT3 signal pathway in vitro and in vivo | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Ocimum sanctum, Zingiber officinale, and Piper nigrum extracts and their effects on gut microbiota modulations (prebiotic potential), basal inflammatory markers and lipid levels: oral supplementation study in healthy rats
Narendra Babu Kondapalli, Rajkumar Hemalatha, Satyanarayana Uppala, Srinivas Reddy Yathapu, Shujauddin Mohammed, Mullapudi Venkata Surekha, Ananthan Rajendran & Dinesh Kumar Bharadwaj
Pages: 437-450
Published online: 19 Feb 2022
AbstractforOcimum sanctum, Zingiber officinale, and Piper nigrum extracts and their effects on gut microbiota modulations (prebiotic potential), basal inflammatory markers and lipid levels: oral supplementation study in healthy rats | Full Text | References | PDF (4.4 MB) | EPUB
  • 4333 Views
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Article
Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription JieZe-1 in protecting against HSV-2 infection
Tong Liu, Qingqing Shao, Wenjia Wang, Yonggui Ma, Tianli Liu, Ximing Jin, Jianguo Fang, Guangying Huang & Zhuo Chen
Pages: 451-466
Published online: 18 Feb 2022
AbstractforIntegrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription JieZe-1 in protecting against HSV-2 infection | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
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Article
FAEE exerts a protective effect against osteoporosis by regulating the MAPK signalling pathway
Ming‑Yue Wang, Meng‑Fei An, Mao-Si Fan, Shao-Shi Zhang, Ze‑Rui Sun, Yun‑Li Zhao, Ze-Min Xiang & Jun Sheng
Pages: 467-478
Published online: 18 Feb 2022
AbstractforFAEE exerts a protective effect against osteoporosis by regulating the MAPK signalling pathway | Full Text | References | PDF (2.7 MB) | EPUB
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Review

Review
Phytochemicals with protective effects against acute pancreatitis: a review of recent literature
Yao Tang, Mingli Sun & Zhenning Liu
Pages: 479-490
Published online: 18 Feb 2022
AbstractforPhytochemicals with protective effects against acute pancreatitis: a review of recent literature | Full Text | References | PDF (1.5 MB) | EPUB
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Research Article

Article
Curcumin protects rats against gentamicin-induced nephrotoxicity by amelioration of oxidative stress, endoplasmic reticulum stress and apoptosis
Pongrapee Laorodphun, Rada Cherngwelling, Aussara Panya & Phatchawan Arjinajarn
Pages: 491-500
Published online: 21 Feb 2022
AbstractforCurcumin protects rats against gentamicin-induced nephrotoxicity by amelioration of oxidative stress, endoplasmic reticulum stress and apoptosis | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Enhancing osteogenic potential of hDPSCs by resveratrol through reducing oxidative stress via the Sirt1/Nrf2 pathway
Jingying Zhang, Rui Li, Kenny Man & Xuebin B. Yang
Pages: 501-508
Published online: 21 Feb 2022
AbstractforEnhancing osteogenic potential of hDPSCs by resveratrol through reducing oxidative stress via the Sirt1/Nrf2 pathway | Full Text | References | PDF (2.3 MB) | EPUB
  • 4073 Views
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Review Article

Review
The vital role of animal, marine, and microbial natural products against COVID-19
Aljawharah A. Alqathama, Rizwan Ahmad, Ruba B. Alsaedi, Raghad A. Alghamdi, Ekram H. Abkar, Rola H. Alrehaly & Ashraf N. Abdalla
Pages: 509-524
Published online: 02 Mar 2022
AbstractforThe vital role of animal, marine, and microbial natural products against COVID-19 | Full Text | References | PDF (2.8 MB) | EPUB
  • 4966 Views
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Research Article

Article
Metabolomics coupled with network pharmacology study on the protective effect of Keguan-1 granules in LPS-induced acute lung injury
Shuaishuai Chen, Mingxi Zhou, Xu Zhao, Yanzhong Han, Ying Huang, Long Zhang, Jiabo Wang, Xiaohe Xiao & Pengyan Li
Pages: 525-534
Published online: 07 Mar 2022
AbstractforMetabolomics coupled with network pharmacology study on the protective effect of Keguan-1 granules in LPS-induced acute lung injury | Full Text | References | PDF (3.3 MB) | EPUB
  • 4176 Views
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Article
Senkyunolide A inhibits the progression of osteoarthritis by inhibiting the NLRP3 signalling pathway
Minglei Shao, Dongwei Lv, Kai Zhou, Haijun Sun & Zhitao Wang
Pages: 535-542
Published online: 27 Feb 2022
AbstractforSenkyunolide A inhibits the progression of osteoarthritis by inhibiting the NLRP3 signalling pathway | Full Text | References | PDF (2.1 MB) | EPUB
  • 3139 Views
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Article
Protective role of crocin against sepsis-induced injury in the liver, kidney and lungs via inhibition of p38 MAPK/NF-κB and Bax/Bcl-2 signalling pathways
Jun Gao, Feng Zhao, Shaona Yi, Shuhang Li, Aiqing Zhu, Yingxiu Tang & Aiqun Li
Pages: 543-552
Published online: 27 Feb 2022
AbstractforProtective role of crocin against sepsis-induced injury in the liver, kidney and lungs via inhibition of p38 MAPK/NF-κB and Bax/Bcl-2 signalling pathways | Full Text | References | PDF (3.1 MB) | EPUB
  • 2877 Views
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Article
Acacetin alleviates myocardial ischaemia/reperfusion injury by inhibiting oxidative stress and apoptosis via the Nrf-2/HO-1 pathway
Chan Wu, Ruo-Lan Chen, Yan Wang, Wei-Yin Wu & Gang Li
Pages: 553-561
Published online: 04 Mar 2022
AbstractforAcacetin alleviates myocardial ischaemia/reperfusion injury by inhibiting oxidative stress and apoptosis via the Nrf-2/HO-1 pathway | Full Text | References | PDF (2.3 MB) | EPUB
  • 3299 Views
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Article
Paeonol attenuates heart failure induced by transverse aortic constriction via ERK1/2 signalling
Xu Chen, Zhiyu Zhang, Xiaowei Zhang, Zhi Jia, Jun Liu, Xinpei Chen, Aiqing Xu, Xue Liang & Guangping Li
Pages: 562-569
Published online: 07 Mar 2022
AbstractforPaeonol attenuates heart failure induced by transverse aortic constriction via ERK1/2 signalling | Full Text | References | PDF (1.9 MB) | EPUB
  • 3513 Views
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Article
Injection of YiQiFuMai powder protects against heart failure via inhibiting p38 and ERK1/2 MAPKs activation
Yongwei Nie, Yanxin Zhang, Zhi Li, Meixu Wan & Dekun Li
Pages: 570-578
Published online: 04 Mar 2022
AbstractforInjection of YiQiFuMai powder protects against heart failure via inhibiting p38 and ERK1/2 MAPKs activation | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 2584 Views
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Article
Yunpi Heluo decoction reduces ectopic deposition of lipids by regulating the SIRT1-FoxO1 autophagy pathway in diabetic rats
Zhujun Mao, Shiyu Liu, Tao Yu, Jinglan Su, Kefu Chai & Siying Weng
Pages: 579-588
Published online: 04 Mar 2022
AbstractforYunpi Heluo decoction reduces ectopic deposition of lipids by regulating the SIRT1-FoxO1 autophagy pathway in diabetic rats | Full Text | References | PDF (3.1 MB) | EPUB
  • 3096 Views
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Article
Epigallocatechin-3-O-gallate promotes extracellular matrix and inhibits inflammation in IL-1β stimulated chondrocytes by the PTEN/miRNA-29b pathway
Dong Yang, Guanghua Cao, Xiaorong Ba & Haibo Jiang
Pages: 589-599
Published online: 09 Mar 2022
AbstractforEpigallocatechin-3-O-gallate promotes extracellular matrix and inhibits inflammation in IL-1β stimulated chondrocytes by the PTEN/miRNA-29b pathway | Full Text | References | PDF (2.8 MB) | EPUB
  • 2532 Views
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Article
Gastroprotective effects of water extract of domesticated Amauroderma rugosum against several gastric ulcer models in rats
Yanzhen Mai, Siyuan Xu, Ru Shen, Bairu Feng, Hong He & Yifei Xu
Pages: 600-608
Published online: 11 Mar 2022
AbstractforGastroprotective effects of water extract of domesticated Amauroderma rugosum against several gastric ulcer models in rats | Full Text | References | PDF (2.8 MB) | EPUB
  • 2788 Views
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Article
Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia
Ji-Xian Song, Ya-Shuo Zhao, Ya-Qin Zhen, Xin-Yue Yang, Qi Chen, Ji-Ren An & En-Sheng Ji
Pages: 609-620
Published online: 14 Mar 2022
AbstractforBanxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia | Full Text | References | PDF (3.9 MB) | EPUB
  • 4239 Views
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Article
Evaluation of the inhibitory effect of quercetin on the pharmacokinetics of tucatinib in rats by a novel UPLC–MS/MS assay
Ying Zhang, Ya-nan Liu, Saili Xie, Xuegu Xu & Ren-ai Xu
Pages: 621-626
Published online: 15 Mar 2022
AbstractforEvaluation of the inhibitory effect of quercetin on the pharmacokinetics of tucatinib in rats by a novel UPLC–MS/MS assay | Full Text | References | PDF (1.2 MB) | EPUB
  • 2941 Views
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Article
Spirulina extract improves age-induced vascular dysfunction
Michal Majewski, Mercedes Klett-Mingo, Carlos M. Verdasco-Martín, Cristina Otero & Mercedes Ferrer
Pages: 627-637
Published online: 16 Mar 2022
AbstractforSpirulina extract improves age-induced vascular dysfunction | Full Text | References | PDF (1.6 MB) | EPUB
  • 2992 Views
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Article
In vivo and in vitro protective effects of shengmai injection against doxorubicin-induced cardiotoxicity
Peng Zhou, Ge Gao, Chun-chun Zhao, Jing-ya Li, Jian-fei Peng, Shu-shu Wang, Rui Song, Hui Shi & Liang Wang
Pages: 638-651
Published online: 17 Mar 2022
AbstractforIn vivo and in vitro protective effects of shengmai injection against doxorubicin-induced cardiotoxicity | Full Text | References | PDF (4.2 MB) | EPUB
  • 4186 Views
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Article
Berberine alleviates myocardial ischemia–reperfusion injury by inhibiting inflammatory response and oxidative stress: the key function of miR-26b-5p-mediated PTGS2/MAPK signal transduction
Xiaojing Jia, Wei Shao & Suqing Tian
Pages: 652-663
Published online: 20 Mar 2022
AbstractforBerberine alleviates myocardial ischemia–reperfusion injury by inhibiting inflammatory response and oxidative stress: the key function of miR-26b-5p-mediated PTGS2/MAPK signal transduction | Full Text | References | PDF (3.2 MB) | EPUB
  • 2913 Views
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Review

Review
Phytochemical and biological activities of some Iranian medicinal plants
Salome Dini, Qihe Chen, Faezeh Fatemi & Younes Asri
Pages: 664-689
Published online: 29 Mar 2022
AbstractforPhytochemical and biological activities of some Iranian medicinal plants | Full Text | References | PDF (2.6 MB) | EPUB
  • 3391 Views
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Research Article

Article
Polygalae Radix shortens the circadian period through activation of the CaMKII pathway
Atsushi Haraguchi, Keisuke Saito, Yu Tahara & Shigenobu Shibata
Pages: 690-699
Published online: 17 Mar 2022
AbstractforPolygalae Radix shortens the circadian period through activation of the CaMKII pathway | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 1863 Views
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Article
Stachydrine is effective and selective against blast phase chronic myeloid leukaemia through inhibition of multiple receptor tyrosine kinases
Ruixin Gu, Wei Zhang & Dandan Xu
Pages: 700-707
Published online: 29 Mar 2022
AbstractforStachydrine is effective and selective against blast phase chronic myeloid leukaemia through inhibition of multiple receptor tyrosine kinases | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 1996 Views
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Article
Sericin-mediated improvement of dysmorphic cardiac mitochondria from hypercholesterolaemia is associated with maintaining mitochondrial dynamics, energy production, and mitochondrial structure
Kitiya Rujimongkon, Sumate Ampawong, Duangnate Isarangkul, Onrapak Reamtong & Pornanong Aramwit
Pages: 708-721
Published online: 29 Mar 2022
AbstractforSericin-mediated improvement of dysmorphic cardiac mitochondria from hypercholesterolaemia is associated with maintaining mitochondrial dynamics, energy production, and mitochondrial structure | Full Text | References | PDF (3.5 MB) | EPUB
  • 2407 Views
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Article
QiShenYiQi pill for myocardial collagen metabolism and apoptosis in rats of autoimmune cardiomyopathy
Shichao Lv, Wanqin Zhang, Peng Yuan, Chunmiao Lu, Jianping Dong & Junping Zhang
Pages: 722-728
Published online: 01 Apr 2022
AbstractforQiShenYiQi pill for myocardial collagen metabolism and apoptosis in rats of autoimmune cardiomyopathy | Full Text | References | PDF (1.8 MB) | EPUB
  • 2221 Views
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Article
β-Hydroxyisovalerylshikonin regulates macrophage polarization via the AMPK/Nrf2 pathway and ameliorates sepsis in mice
Tao Pan, Yabin Chang, Min He, Zehui He, Jun Jiang, Xinling Ren & Fang Zhang
Pages: 729-742
Published online: 30 Mar 2022
Abstractforβ-Hydroxyisovalerylshikonin regulates macrophage polarization via the AMPK/Nrf2 pathway and ameliorates sepsis in mice | Full Text | References | PDF (3.7 MB) | EPUB
  • 3392 Views
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Article
Systematic identification of the interventional mechanism of Qingfei Xiaoyan Wan (QFXYW) in treatment of the cytokine storm in acute lung injury using transcriptomics-based system pharmacological analyses
Jing-Yi Hou, Jia-Rong Wu, Yi-Bing Chen, Dong Xu, Shu Liu, Dan-dan Shang, Guan-Wei Fan & Yuan-Lu Cui
Pages: 743-754
Published online: 31 Mar 2022
AbstractforSystematic identification of the interventional mechanism of Qingfei Xiaoyan Wan (QFXYW) in treatment of the cytokine storm in acute lung injury using transcriptomics-based system pharmacological analyses | Full Text | References | PDF (3.5 MB) | EPUB
  • 2782 Views
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Article
C-Phycocyanin prevents acute myocardial infarction-induced oxidative stress, inflammation and cardiac damage
Vanessa Blas-Valdivia, Daniela Nikita Moran-Dorantes, Placido Rojas-Franco, Margarita Franco-Colin, Neda Mirhosseini, Reza Davarnejad, Ahmad Halajisani, Omid Tavakoli & Edgar Cano-Europa
Pages: 755-763
Published online: 02 Apr 2022
AbstractforC-Phycocyanin prevents acute myocardial infarction-induced oxidative stress, inflammation and cardiac damage | Full Text | References | PDF (2.5 MB) | EPUB
  • 3439 Views
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Article
Caudatin blocks the proliferation, stemness and glycolysis of non-small cell lung cancer cells through the Raf/MEK/ERK pathway
Juan Hou, Qing Chen, Yufeng Huang, Zhiwei Wu & De Ma
Pages: 764-773
Published online: 06 Apr 2022
AbstractforCaudatin blocks the proliferation, stemness and glycolysis of non-small cell lung cancer cells through the Raf/MEK/ERK pathway | Full Text | References | PDF (2.5 MB) | EPUB
  • 2611 Views
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Review Article

Review
The traditional ethnic herb Tadehagi triquetrum from China: a review of its phytochemistry and pharmacological activities
Hong-Xia Tang, Wen-Bing Sheng, Xin-Yi Liu, Pei-Wu Cui, Li-Min Gong, Qing-Ling Xie, Wen-Mao Wang, Bin Li, Wei Wang & Xu-Dong Zhou
Pages: 774-784
Published online: 01 Apr 2022
AbstractforThe traditional ethnic herb Tadehagi triquetrum from China: a review of its phytochemistry and pharmacological activities | Full Text | References | PDF (1.4 MB) | EPUB
  • 3079 Views
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Research Article

Article
Gut microbiota and metabonomics used to explore the mechanism of Qing’e Pills in alleviating osteoporosis
Hui Xie, Zhengying Hua, Mengyu Guo, Shangyang Lin, Yaqian Zhou, Zebin Weng, Li Wu, Zhipeng Chen, Zisheng Xu & Weidong Li
Pages: 785-800
Published online: 06 Apr 2022
AbstractforGut microbiota and metabonomics used to explore the mechanism of Qing’e Pills in alleviating osteoporosis | Full Text | References | PDF (3.8 MB) | EPUB
  • 4490 Views
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Article
1α, 25-Dihydroxyvitamin D3 protects gastric mucosa epithelial cells against Helicobacter pylori-infected apoptosis through a vitamin D receptor-dependent c-Raf/MEK/ERK pathway
Shuai Zhao, Daihong Wan, Yaoyao Zhong & Xiwei Xu
Pages: 801-809
Published online: 19 May 2022
Abstractfor1α, 25-Dihydroxyvitamin D3 protects gastric mucosa epithelial cells against Helicobacter pylori-infected apoptosis through a vitamin D receptor-dependent c-Raf/MEK/ERK pathway | Full Text | References | PDF (2.4 MB) | EPUB
  • 1900 Views
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Article
Moringa oleifera seed ethanol extract and its active component kaempferol potentiate pentobarbital-induced sleeping behaviours in mice via a GABAergic mechanism
Wei-Liang Liu, Bai-Fen Wu, Jian-Hua Shang, Xue-Feng Wang, Yun-Li Zhao & Ai-Xiang Huang
Pages: 810-824
Published online: 19 May 2022
AbstractforMoringa oleifera seed ethanol extract and its active component kaempferol potentiate pentobarbital-induced sleeping behaviours in mice via a GABAergic mechanism | Full Text | References | PDF (4 MB) | EPUB
  • 3114 Views
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Article
Astragalus injection ameliorates lipopolysaccharide-induced cognitive decline via relieving acute neuroinflammation and BBB damage and upregulating the BDNF-CREB pathway in mice
Ke Liu, Guoran Wan, Ruhong Jiang, Li Zou, Dong Wan, Huifeng Zhu & Shan Feng
Pages: 825-839
Published online: 19 May 2022
AbstractforAstragalus injection ameliorates lipopolysaccharide-induced cognitive decline via relieving acute neuroinflammation and BBB damage and upregulating the BDNF-CREB pathway in mice | Full Text | References | PDF (4.8 MB) | EPUB
  • 2462 Views
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Article
Pharmacological effects of Artocarpus lakoocha methanol extract on inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway
Shafaq, Tasleem Akhtar, Hafiz Muhammad Ishaq & Muhammad Shahzad
Pages: 840-845
Published online: 19 May 2022
AbstractforPharmacological effects of Artocarpus lakoocha methanol extract on inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway | Full Text | References | PDF (745.8 KB) | EPUB
  • 1728 Views
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Article
Effect of Er Miao San on peritoneal macrophage polarisation through the miRNA-33/NLRP3 signalling pathway in a rat model of adjuvant arthritis
Min Liu, Xiangwen Meng, Zihua Xuan, Simeng Chen, Jin Wang, Zhiluo Chen, Jiayu Wang & Xiaoyi Jia
Pages: 846-853
Published online: 24 May 2022
AbstractforEffect of Er Miao San on peritoneal macrophage polarisation through the miRNA-33/NLRP3 signalling pathway in a rat model of adjuvant arthritis | Full Text | References | PDF (2.1 MB) | EPUB
  • 2285 Views
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Article
Curcumin inhibits cerebral ischaemia–reperfusion injury and cell apoptosis in rats through the ERK–CHOP–caspase-11 pathway
Yue Chen, Lixia Zhang, Zengtai Yang & Jie Yu
Pages: 854-861
Published online: 20 May 2022
AbstractforCurcumin inhibits cerebral ischaemia–reperfusion injury and cell apoptosis in rats through the ERK–CHOP–caspase-11 pathway | Full Text | References | PDF (2.2 MB) | EPUB
  • 1826 Views
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Article
Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein
Yu-meng Chen, Jin-lai Wei, Rui-si Qin, Jin-ping Hou, Guang-chao Zang, Guang-yuan Zhang & Ting-ting Chen
Pages: 862-878
Published online: 20 May 2022
AbstractforFolic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
  • 3004 Views
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Article
Flaxseed extract reduces tissue accumulation and enhances urinary excretion of chondroitin sulphate in the rat: a possible new path in substrate reduction therapy for mucopolysaccharidosis
Sabir Es-said, Karima Lafhal, Abdelaati Elkhiat, Miloud Hammoud, Noureddine Regbaoui, Aicha Ezoubeiri, Rachida Makbal, Safia Sbyea, Omar Elhiba, Souad Sellami, Hanane Rais, Abdallah Karim, Halima Gamrani, Noureddine Rada, Mohammed Bouskraoui & Naima Fdil
Pages: 879-888
Published online: 30 May 2022
AbstractforFlaxseed extract reduces tissue accumulation and enhances urinary excretion of chondroitin sulphate in the rat: a possible new path in substrate reduction therapy for mucopolysaccharidosis | Full Text | References | PDF (2.4 MB) | EPUB
  • 1715 Views
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Article
Quercetin improves contrast-induced acute kidney injury through the HIF-1α/lncRNA NEAT1/HMGB1 pathway
Min Luo, Ziyu Liu, Zongren Hu & Qinghu He
Pages: 889-898
Published online: 19 May 2022
AbstractforQuercetin improves contrast-induced acute kidney injury through the HIF-1α/lncRNA NEAT1/HMGB1 pathway | Full Text | References | PDF (2.8 MB) | EPUB
  • 2877 Views
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Article
Pseudolycorine chloride ameliorates Th17 cell-mediated central nervous system autoimmunity by restraining myeloid-derived suppressor cell expansion
Gan Zhang, Xinying Zhu, Fan Yang, Juan Li, Xiao Leng, Chunfen Mo, Limei Li & Yantang Wang
Pages: 899-908
Published online: 09 Sep 2022
AbstractforPseudolycorine chloride ameliorates Th17 cell-mediated central nervous system autoimmunity by restraining myeloid-derived suppressor cell expansion | Full Text | References | PDF (4 MB) | EPUB | Supplemental
  • 1305 Views
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Article
Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis
Feng-guo Zhai, Qi-chao Liang, Yi-yan Wu, Jia-qi Liu & Jia-wei Liu
Pages: 909-914
Published online: 16 May 2022
AbstractforRed ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis | Full Text | References | PDF (1.3 MB) | EPUB
  • 5419 Views
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Article
Gnetum montanum extract induces apoptosis by inhibiting the activation of AKT in SW480 human colon cancer cells
Xianglong Pan, Xiaotao Hou, Fan Zhang, Peiling Tang, Wanruo Wan, Zixia Su, Yeguo Yang, Wei Wei, Zhengcai Du, Jiagang Deng & Erwei Hao
Pages: 915-930
Published online: 19 May 2022
AbstractforGnetum montanum extract induces apoptosis by inhibiting the activation of AKT in SW480 human colon cancer cells | Full Text | References | PDF (4.6 MB) | EPUB
  • 2571 Views
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Review

Review
Advances in research on the protective mechanisms of traditional Chinese medicine (TCM) in myocardial ischaemia-reperfusion injury
Jiexin Zhang, Yonghe Hu, Han Wang, Jun Hou, Wenjing Xiao, Xudong Wen, Tingting Wang, Pan Long, Hezhong Jiang, Zhanhao Wang, Huawei Liu & Xin Chen
Pages: 931-948
Published online: 19 May 2022
AbstractforAdvances in research on the protective mechanisms of traditional Chinese medicine (TCM) in myocardial ischaemia-reperfusion injury | Full Text | References | PDF (1.9 MB) | EPUB
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Research Article

Article
Patchouli alcohol protects against myocardial ischaemia–reperfusion injury by regulating the Notch1/Hes1 pathway
Ying Lu, Shou-ye Li & Hui Lou
Pages: 949-957
Published online: 19 May 2022
AbstractforPatchouli alcohol protects against myocardial ischaemia–reperfusion injury by regulating the Notch1/Hes1 pathway | Full Text | References | PDF (2.6 MB) | EPUB
  • 2214 Views
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Article
Schisandra chinensis essential oil attenuates acetaminophen-induced liver injury through alleviating oxidative stress and activating autophagy
Jing Zhao, Kaixin Ding, Manting Hou, Yuanhua Li, Xiaorong Hou, Wenzhang Dai, Zhiyong Li, Jun Zhao, Wenlong Liu & Zhaofang Bai
Pages: 958-967
Published online: 19 May 2022
AbstractforSchisandra chinensis essential oil attenuates acetaminophen-induced liver injury through alleviating oxidative stress and activating autophagy | Full Text | References | PDF (2.3 MB) | EPUB
  • 3012 Views
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Article
Protective effects of lavender oil on sepsis-induced acute lung injury via regulation of the NF-κB pathway
Qian Xie, Yi Wang & Guo-Liang Zou
Pages: 968-978
Published online: 19 May 2022
AbstractforProtective effects of lavender oil on sepsis-induced acute lung injury via regulation of the NF-κB pathway | Full Text | References | PDF (2.7 MB) | EPUB
  • 2040 Views
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Article
Fraxinol attenuates LPS-induced acute lung injury by equilibrating ACE-Ang II-AT1R and ACE2-Ang (1-7)-Mas and inhibiting NLRP3
Yan Wu, Xin Yang, Yuanyuan Ju & Fei Zhao
Pages: 979-989
Published online: 19 May 2022
AbstractforFraxinol attenuates LPS-induced acute lung injury by equilibrating ACE-Ang II-AT1R and ACE2-Ang (1-7)-Mas and inhibiting NLRP3 | Full Text | References | PDF (3.3 MB) | EPUB
  • 2026 Views
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Article
Calycosin plays a protective role in diabetic kidney disease through the regulation of ferroptosis
Di Huang, Peicheng Shen, Chen Wang, Jiandong Gao, Chaoyang Ye & Feng Wu
Pages: 990-996
Published online: 19 May 2022
AbstractforCalycosin plays a protective role in diabetic kidney disease through the regulation of ferroptosis | Full Text | References | PDF (1.8 MB) | EPUB
  • 4227 Views
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Article
Study on the mechanism of lupenone for treating type 2 diabetes by integrating pharmacological evaluation and network pharmacology
Feng Xu, Mei Zhang, Hongmei Wu, Yuanmin Wang, Ye Yang & Xiangpei Wang
Pages: 997-1010
Published online: 28 May 2022
AbstractforStudy on the mechanism of lupenone for treating type 2 diabetes by integrating pharmacological evaluation and network pharmacology | Full Text | References | PDF (5.8 MB) | EPUB
  • 2880 Views
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Article
Cardamonin suppressed the migration, invasion, epithelial mesenchymal transition (EMT) and lung metastasis of colorectal cancer cells by down-regulating ADRB2 expression
Ting Lu, Chunju Zheng & Zhimin Fan
Pages: 1011-1021
Published online: 28 May 2022
AbstractforCardamonin suppressed the migration, invasion, epithelial mesenchymal transition (EMT) and lung metastasis of colorectal cancer cells by down-regulating ADRB2 expression | Full Text | References | PDF (3.9 MB) | EPUB
  • 2882 Views
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Article
Combination of puerarin and tanshinone IIA alleviates ischaemic stroke injury in rats via activating the Nrf2/ARE signalling pathway
Qing Miao, Ruihai Wang, Xiaoxin Sun, Song Du & Limei Liu
Pages: 1022-1031
Published online: 30 May 2022
AbstractforCombination of puerarin and tanshinone IIA alleviates ischaemic stroke injury in rats via activating the Nrf2/ARE signalling pathway | Full Text | References | PDF (3 MB) | EPUB
  • 2397 Views
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Article
Alpinetin suppresses CYP3A4, 2C9, and 2E1 activity in vitro
Hongming Song, Chuankui Wei, Wu Yang, Zhaohe Niu, Mingkai Gong, Haiyan Hu & Haibo Wang
Pages: 1032-1037
Published online: 28 May 2022
AbstractforAlpinetin suppresses CYP3A4, 2C9, and 2E1 activity in vitro | Full Text | References | PDF (1.2 MB) | EPUB
  • 1631 Views
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Article
Ginsenoside Rc attenuates myocardial ischaemic injury through antioxidative and anti-inflammatory effects
Lei Shi, Wenwen Fu, Huali Xu, Shihui Li, Xinyu Yang, Wei Yang, Dayun Sui & Quanwei Wang
Pages: 1038-1046
Published online: 28 May 2022
AbstractforGinsenoside Rc attenuates myocardial ischaemic injury through antioxidative and anti-inflammatory effects | Full Text | References | PDF (2.4 MB) | EPUB
  • 1997 Views
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Article
Ellagic acid attenuates beryllium sulphate-induced oxidative stress and histopathological alterations of spleen in rats
Yuandi Lei, Tianyi Jiang, Liqin He, Yanping Liu, Zhanbing Sun, Weihua Deng, Lian Huang & Zhaohui Zhang
Pages: 1047-1054
Published online: 01 Jun 2022
AbstractforEllagic acid attenuates beryllium sulphate-induced oxidative stress and histopathological alterations of spleen in rats | Full Text | References | PDF (1.5 MB) | EPUB
  • 1472 Views
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Article
Antiperspirant effects and mechanism investigation of Mulisan decoction in rats based on plasma metabolomics
Shan-Peng Ma, Wei-Ping Ma, Shi-Ning Yin, Xiang-Yue Chen, Xiao-Qing Ma, Bao-Hong Wei, Jing-Guang Lu & Hong-Bing Liu
Pages: 1055-1062
Published online: 28 May 2022
AbstractforAntiperspirant effects and mechanism investigation of Mulisan decoction in rats based on plasma metabolomics | Full Text | References | PDF (1.8 MB) | EPUB
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Review Article

Review
Research progress on antiviral constituents in traditional Chinese medicines and their mechanisms of action
Zhi Chen & Si-yong Ye
Pages: 1063-1076
Published online: 28 May 2022
AbstractforResearch progress on antiviral constituents in traditional Chinese medicines and their mechanisms of action | Full Text | References | PDF (1.5 MB) | EPUB
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Research Article

Article
Deer antler based active ingredients have protective effects on LPS/d-GalN-induced acute liver injury in mice through MAPK and NF-κB signalling pathways
Guixiang He, Quanmin Zhao, Yan Zhao, Ying Zong, Shigang Gu, Mengjie Li, Renjie Li & Jiaxin Sun
Pages: 1077-1087
Published online: 28 May 2022
AbstractforDeer antler based active ingredients have protective effects on LPS/d-GalN-induced acute liver injury in mice through MAPK and NF-κB signalling pathways | Full Text | References | PDF (3.2 MB) | EPUB
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Review

Review
Research progress on the protective effects of aucubin in neurological diseases
Ping Yang, Qiaoyue Zhang, Hengyan Shen, Xinyu Bai, Ping Liu & Tao Zhang
Pages: 1088-1094
Published online: 28 May 2022
AbstractforResearch progress on the protective effects of aucubin in neurological diseases | Full Text | References | PDF (1.4 MB) | EPUB
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Research Article

Article
Protective effect of valerian extract capsule (VEC) on ethanol- and indomethacin-induced gastric mucosa injury and ameliorative effect of VEC on gastrointestinal motility disorder
Yuan Feng, Wan Dai, Junyu Ke, Yong Cui, Shuang Li, Jingjing Ma, Wenfeng Guo, Gang Chen, Ning Li & Yanwu Li
Pages: 1095-1105
Published online: 04 Jun 2022
AbstractforProtective effect of valerian extract capsule (VEC) on ethanol- and indomethacin-induced gastric mucosa injury and ameliorative effect of VEC on gastrointestinal motility disorder | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Article
Myostain is involved in ginsenoside Rb1-mediated anti-obesity
Hong-Shi Li, Jiang-Ying Kuang, Gui-Jun Liu, Wei-Jie Wu, Xian-Lun Yin, Hao-Dong Li, Lei Wang, Tao Qin, Wen-Cheng Zhang & Yuan-Yuan Sun
Pages: 1106-1115
Published online: 31 May 2022
AbstractforMyostain is involved in ginsenoside Rb1-mediated anti-obesity | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 2644 Views
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Article
Prevention of ulcerative colitis by Huangqin decoction: reducing the intestinal epithelial cell apoptosis rate through the IFN-γ/JAK/ETS signalling pathway
Xiaowei Mo, Kairui Tang, Lijing Deng, Xingyi Zhou, Xiaojuan Li, Yupei Zhang & Jing Wang
Pages: 1116-1125
Published online: 02 Jun 2022
AbstractforPrevention of ulcerative colitis by Huangqin decoction: reducing the intestinal epithelial cell apoptosis rate through the IFN-γ/JAK/ETS signalling pathway | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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Article
Ethanol extract of the mushroom Coprinus comatus exhibits antidiabetic and antioxidant activities in streptozotocin-induced diabetic rats
Nuniek Ina Ratnaningtyas, Hernayanti Hernayanti, Nuraeni Ekowati & Fajar Husen
Pages: 1126-1136
Published online: 08 Jun 2022
AbstractforEthanol extract of the mushroom Coprinus comatus exhibits antidiabetic and antioxidant activities in streptozotocin-induced diabetic rats | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Article
Camel milk protein hydrosylate alleviates hepatic steatosis and hypertension in high fructose-fed rats
Mohammad A. Alshuniaber, Ghedeir M. Alshammari, Samy M. Eleawa, Abu ElGasim A. Yagoub, Abdullrahman S. Al-Khalifah, Maha H. Alhussain, Laila Naif Al-Harbi & Mohammed Abdo Yahya
Pages: 1137-1147
Published online: 07 Jun 2022
AbstractforCamel milk protein hydrosylate alleviates hepatic steatosis and hypertension in high fructose-fed rats | Full Text | References | PDF (2.5 MB) | EPUB
  • 3012 Views
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Article
Extract of Pinus densiflora needles suppresses acute inflammation by regulating inflammatory mediators in RAW264.7 macrophages and mice
Seul-Yong Jeong, Won Seok Choi, Oh Seong Kwon, Jong Seok Lee, Su Young Son, Choong Hwan Lee, Sarah Lee, Jin Yong Song, Yeon Jin Lee & Ji-Yun Lee
Pages: 1148-1159
Published online: 12 Jun 2022
AbstractforExtract of Pinus densiflora needles suppresses acute inflammation by regulating inflammatory mediators in RAW264.7 macrophages and mice | Full Text | References | PDF (2 MB) | EPUB
  • 2460 Views
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Article
Rhodiola rosea polysaccharides promote the proliferation of bone marrow haematopoietic progenitor cells and stromal cells in mice with aplastic anaemia
Jing Li & Yongfeng Chen
Pages: 1160-1168
Published online: 12 Jun 2022
AbstractforRhodiola rosea polysaccharides promote the proliferation of bone marrow haematopoietic progenitor cells and stromal cells in mice with aplastic anaemia | Full Text | References | PDF (2.8 MB) | EPUB
  • 1846 Views
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Article
S-Propargyl-cysteine prevents concanavalin A-induced immunological liver injury in mice
Beilei Ma, Yicheng Mao, Lingling Chang, Tao Dai, Xiaoming Xin, Fenfen Ma, Zhijun Wang, Zhuqing Shen, Qibing Mei & Yizhun Zhu
Pages: 1169-1176
Published online: 14 Jun 2022
AbstractforS-Propargyl-cysteine prevents concanavalin A-induced immunological liver injury in mice | Full Text | References | PDF (2.2 MB) | EPUB
  • 1902 Views
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Review
A comprehensive review of the ethnomedicine, phytochemistry, pharmacological activities of the genus Kniphofia
Gashaw Nigussie, Metasebia Tegegn, Dessalegn Abeje & Haregua Melak
Pages: 1177-1189
Published online: 14 Jun 2022
AbstractforA comprehensive review of the ethnomedicine, phytochemistry, pharmacological activities of the genus Kniphofia | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Effects of ginkgo leaf tablet on the pharmacokinetics of rosiglitazone in rats and its potential mechanism
Xueting Xing, Mengzhu Kong, Qiaoyu Hou, Jiaqi Li, Wen Qian, Xijing Chen, Hanhan Li & Changqing Yang
Pages: 1190-1197
Published online: 25 Jun 2022
AbstractforEffects of ginkgo leaf tablet on the pharmacokinetics of rosiglitazone in rats and its potential mechanism | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Anti-EMT and anti-fibrosis effects of protocatechuic aldehyde in renal proximal tubular cells and the unilateral ureteral obstruction animal model
Yu-Teng Chang, Mu-Chi Chung, Chi-Hao Chang, Kuan-Hsun Chiu, Jeng-Jer Shieh & Ming-Ju Wu
Pages: 1198-1206
Published online: 25 Jun 2022
AbstractforAnti-EMT and anti-fibrosis effects of protocatechuic aldehyde in renal proximal tubular cells and the unilateral ureteral obstruction animal model | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Gastroprotective activity of (E)-ethyl-12-cyclohexyl-4,5-dihydroxydodec-2-enoate, a compound isolated from Heliotropium indicum: role of nitric oxide, prostaglandins, and sulfhydryls in its mechanism of action
Yaraset López-Lorenzo, María Elena Sánchez-Mendoza, Daniel Arrieta-Baez, Adriana Guadalupe Perez-Ruiz & Jesús Arrieta
Pages: 1207-1213
Published online: 28 Jun 2022
AbstractforGastroprotective activity of (E)-ethyl-12-cyclohexyl-4,5-dihydroxydodec-2-enoate, a compound isolated from Heliotropium indicum: role of nitric oxide, prostaglandins, and sulfhydryls in its mechanism of action | Full Text | References | PDF (1,000.4 KB) | EPUB
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Article
Investigation of cell cytotoxic activity and molecular mechanism of 5β,19-epoxycucurbita-6,23(E)-diene-3β,19(R),25-triol isolated from Momordica charantia on hepatoma cells
Mei-Kang Yuan, Ju-Wen Kao, Wen-Tung Wu, Chiy-Rong Chen, Chi-I Chang & Yu-Jen Wu
Pages: 1214-1223
Published online: 27 Jun 2022
AbstractforInvestigation of cell cytotoxic activity and molecular mechanism of 5β,19-epoxycucurbita-6,23(E)-diene-3β,19(R),25-triol isolated from Momordica charantia on hepatoma cells | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Network pharmacology-based analysis of the mechanism of Saposhnikovia divaricata for the treatment of type I allergy
Xiangsheng Li, Hui Li, Tingting Wang, Yang Zhao, Yuxin Shao, Yizhao Sun, Yanfen Zhang & Zhongcheng Liu
Pages: 1224-1236
Published online: 27 Jun 2022
AbstractforNetwork pharmacology-based analysis of the mechanism of Saposhnikovia divaricata for the treatment of type I allergy | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Comparative study on the gastrointestinal- and immune- regulation functions of Hedysari Radix Praeparata Cum Melle and Astragali Radix Praeparata cum Melle in rats with spleen-qi deficiency, based on fuzzy matter-element analysis
Yugui Zhang, Jiangtao Niu, Shujuan Zhang, Xinlei Si, Tian-Tian Bian, Hongwei Wu, Donghui Li, Yujing Sun, Jing Jia, Erdan Xin, Xingke Yan & Yuefeng Li
Pages: 1237-1254
Published online: 28 Jun 2022
AbstractforComparative study on the gastrointestinal- and immune- regulation functions of Hedysari Radix Praeparata Cum Melle and Astragali Radix Praeparata cum Melle in rats with spleen-qi deficiency, based on fuzzy matter-element analysis | Full Text | References | PDF (5.8 MB) | EPUB | Supplemental
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The complex lipid, SPPCT-800, reduces lung damage, improves pulmonary function and decreases pro-inflammatory cytokines in the murine LPS-induced acute respiratory distress syndrome (ARDS) model
Peter P. Sordillo, Andrea Allaire, Annie Bouchard, Dan Salvail & Sebastien M. Labbe
Pages: 1255-1263
Published online: 03 Jul 2022
AbstractforThe complex lipid, SPPCT-800, reduces lung damage, improves pulmonary function and decreases pro-inflammatory cytokines in the murine LPS-induced acute respiratory distress syndrome (ARDS) model | Full Text | References | PDF (1.5 MB) | EPUB
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Anti-liver fibrosis effects of the total flavonoids of litchi semen on CCl4-induced liver fibrosis in rats associated with the upregulation of retinol metabolism
Jiongyi Yan, Yinyi Feng, Xuewan Fang, Xiaojuan Cui, Xing Xia, Fang Li, Weisheng Luo, Jianqin Liang, Jianfang Feng & Kai Yu
Pages: 1264-1277
Published online: 05 Jul 2022
AbstractforAnti-liver fibrosis effects of the total flavonoids of litchi semen on CCl4-induced liver fibrosis in rats associated with the upregulation of retinol metabolism | Full Text | References | PDF (4.8 MB) | EPUB | Supplemental
  • 1897 Views
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Article
Isolation, characterisation and complement fixation activity of acidic polysaccharides from Argemone mexicana used as antimalarials in Mali
Adama Dénou, Adiaratou Togola, Kari Tvete Inngjerdingen, Nastaran Moussavi, Frode Rise, Yuan Feng Zou, Dalen G. Dafam, Elijah I. Nep, Abubakar Ahmed, Taiwo E. Alemika, Drissa Diallo, Rokia Sanogo & Berit Smestad Paulsen
Pages: 1278-1285
Published online: 07 Jul 2022
AbstractforIsolation, characterisation and complement fixation activity of acidic polysaccharides from Argemone mexicana used as antimalarials in Mali | Full Text | References | PDF (965.9 KB) | EPUB
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Repair mechanism of Wuwei Fuzheng Yijing formula in di-2-ethylhexyl phthalate-induced sperm DNA fragmentation in mice
Chenming Zhang, Shiqi Wang, Zulong Wang, Qi Zhang, Rubing Chen, Hao Zhang, Zhong Hua & Sicheng Ma
Pages: 1286-1302
Published online: 07 Jul 2022
AbstractforRepair mechanism of Wuwei Fuzheng Yijing formula in di-2-ethylhexyl phthalate-induced sperm DNA fragmentation in mice | Full Text | References | PDF (6.7 MB) | EPUB | Supplemental
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Morinda officinalis polysaccharide enable suppression of osteoclastic differentiation by exosomes derived from rat mesenchymal stem cells
Peiyu Wu, Feng Jiao, He Huang, Donghua Liu, Wang Tang, Jie Liang & Wen Chen
Pages: 1303-1316
Published online: 08 Jul 2022
AbstractforMorinda officinalis polysaccharide enable suppression of osteoclastic differentiation by exosomes derived from rat mesenchymal stem cells | Full Text | References | PDF (4.5 MB) | EPUB
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Article
Solanaceae glycoalkaloids: α-solanine and α-chaconine modify the cardioinhibitory activity of verapamil
Szymon Chowański, Magdalena Winkiel, Monika Szymczak-Cendlak, Paweł Marciniak, Dominika Mańczak, Karolina Walkowiak-Nowicka, Marta Spochacz, Sabino A. Bufo, Laura Scrano & Zbigniew Adamski
Pages: 1317-1330
Published online: 10 Jul 2022
AbstractforSolanaceae glycoalkaloids: α-solanine and α-chaconine modify the cardioinhibitory activity of verapamil | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Qiangli Wuhu mixture alleviates LPS-induced pneumonia by inhibiting the TLR4/NF-κB/NLRP3 pathway: a study based on network pharmacology
Jie Tian, Xiao-Long Wang, Long-Cheng Wang, Fei Chen, Yun Tian, Li Ma, Chao-Yun Pan & Yan-Ping Wang
Pages: 1331-1340
Published online: 12 Jul 2022
AbstractforQiangli Wuhu mixture alleviates LPS-induced pneumonia by inhibiting the TLR4/NF-κB/NLRP3 pathway: a study based on network pharmacology | Full Text | References | PDF (4.5 MB) | EPUB
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Sleep-promoting activity of lotus (Nelumbo nucifera) rhizome water extract via GABAA receptors
Yejin Ahn, Singeun Kim, Chunwoong Park, Jung Eun Kim, Hyung Joo Suh & Kyungae Jo
Pages: 1341-1348
Published online: 15 Jul 2022
AbstractforSleep-promoting activity of lotus (Nelumbo nucifera) rhizome water extract via GABAA receptors | Full Text | References | PDF (1.3 MB) | EPUB
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An integrated strategy for the comprehensive profiling of the chemical constituents of Aspongopus chinensis using UPLC-QTOF-MS combined with molecular networking
Fengyu Zhang, Bichen Li, Ying Wen, Yanyang Liu, Rong Liu, Jing Liu, Shao Liu & Yueping Jiang
Pages: 1349-1364
Published online: 22 Jul 2022
AbstractforAn integrated strategy for the comprehensive profiling of the chemical constituents of Aspongopus chinensis using UPLC-QTOF-MS combined with molecular networking | Full Text | References | PDF (3.7 MB) | EPUB
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Improvement of irradiation-induced fibroblast damage by α2-macroglobulin through alleviating mitochondrial dysfunction
Chaoji Huangfu, Nan Tang, Xiaokun Yang, Zhanwei Gong, Junzheng Li, Junting Jia, Jingang Zhang, Yan Huang & Yuyuan Ma
Pages: 1365-1373
Published online: 26 Jul 2022
AbstractforImprovement of irradiation-induced fibroblast damage by α2-macroglobulin through alleviating mitochondrial dysfunction | Full Text | References | PDF (3 MB) | EPUB
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Cytotoxic effects of extracts obtained from plants of the Oleaceae family: bio-guided isolation and molecular docking of new secoiridoids from Jasminum humile
Khaled Ahmed Mansour, Ahmed Elbermawi, Ahmed A. Al-Karmalawy, Mohamed-Farid Lahloub & Mona El-Neketi
Pages: 1374-1383
Published online: 12 Aug 2022
AbstractforCytotoxic effects of extracts obtained from plants of the Oleaceae family: bio-guided isolation and molecular docking of new secoiridoids from Jasminum humile | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Article
Evaluation of the toxicology, anti-lipase, and antioxidant effects of Callistemon citrinus in rats fed with a high fat-fructose diet
Luis Gerardo Ortega-Pérez, Jonathan Saúl Piñón-Simental, Oliver Rafid Magaña-Rodríguez, Alejandro Lopéz-Mejía, Luis Alberto Ayala-Ruiz, Aram Josué García-Calderón, Daniel Godínez-Hernández & Patricia Rios-Chavez
Pages: 1384-1393
Published online: 07 Aug 2022
AbstractforEvaluation of the toxicology, anti-lipase, and antioxidant effects of Callistemon citrinus in rats fed with a high fat-fructose diet | Full Text | References | PDF (1.5 MB) | EPUB
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Network pharmacology approach to investigate the multitarget mechanisms of Zhishi Rhubarb Soup on acute cerebral infarction
Yuejia Shao, Yue Zhang, Rongrong Wu, Lurui Dou, Fengjiao Cao, Yuqing Yan, Yuming Tang, Chi Huang, Yang Zhao & Jinghua Zhang
Pages: 1394-1406
Published online: 07 Aug 2022
AbstractforNetwork pharmacology approach to investigate the multitarget mechanisms of Zhishi Rhubarb Soup on acute cerebral infarction | Full Text | References | PDF (3.6 MB) | EPUB
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Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway
Hui Wang, Qingtao Jiang & Lizhu Zhang
Pages: 1407-1416
Published online: 07 Aug 2022
AbstractforBaicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway | Full Text | References | PDF (3 MB) | EPUB
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Integrated serum pharmacochemistry and investigation of the anti-gastric ulcer effect of Zuojin pill in rats induced by ethanol
Jiaying Zhang, Yi Yin, Qianqian Xu, Xiaoqing Che, Chen Yu, Yan Ren, Dongsheng Li & Juanjuan Zhao
Pages: 1417-1435
Published online: 07 Aug 2022
AbstractforIntegrated serum pharmacochemistry and investigation of the anti-gastric ulcer effect of Zuojin pill in rats induced by ethanol | Full Text | References | PDF (4.1 MB) | EPUB
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Antidepressant effects of total alkaloids of Fibraurea recisa on improving corticosterone-induced apoptosis of HT-22 cells and chronic unpredictable mild stress-induced depressive-like behaviour in mice
Zhongmei He, He Yu, Hong Wu, Lili Su, Kun Shi, Yan Zhao, Ying Zong, Weijia Chen & Rui Du
Pages: 1436-1448
Published online: 07 Aug 2022
AbstractforAntidepressant effects of total alkaloids of Fibraurea recisa on improving corticosterone-induced apoptosis of HT-22 cells and chronic unpredictable mild stress-induced depressive-like behaviour in mice | Full Text | References | PDF (3.8 MB) | EPUB
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A novobiocin derivative, XN4, triggers ferroptosis in gastric cancer cells via the activation of NOX4
Rongrong Li, Bin Yin, Deyu Zeng & Zhenyang Liu
Pages: 1449-1457
Published online: 07 Aug 2022
AbstractforA novobiocin derivative, XN4, triggers ferroptosis in gastric cancer cells via the activation of NOX4 | Full Text | References | PDF (2 MB) | EPUB
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Salvianolic acid B inhibits myocardial I/R-induced ROS generation and cell apoptosis by regulating the TRIM8/GPX1 pathway
Bo Lu, Jianhua Li, MingTai Gui, Lei Yao, Mingsong Fan, Xunjie Zhou & Deyu Fu
Pages: 1458-1468
Published online: 14 Aug 2022
AbstractforSalvianolic acid B inhibits myocardial I/R-induced ROS generation and cell apoptosis by regulating the TRIM8/GPX1 pathway | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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Article
Combination of paeoniflorin and calycosin-7-glucoside alleviates ischaemic stroke injury via the PI3K/AKT signalling pathway
Peng-Cheng Wang, Sheng-Xin Wang, Xiang-Li Yan, Ying-Ying He, Min-Chun Wang, Hao-Zhen Zheng, Xu-Guang Shi, Yong-Heng Tan & Li-Sheng Wang
Pages: 1469-1477
Published online: 07 Aug 2022
AbstractforCombination of paeoniflorin and calycosin-7-glucoside alleviates ischaemic stroke injury via the PI3K/AKT signalling pathway | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Network pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss
Yi-Fang Yang, Xi-Rui Yan, Rui-Xin Wu, Ning Li, Min Chu, Yang Dong, Shu-Ping Fu, Jian-Rong Shi & Qing Liu
Pages: 1478-1490
Published online: 07 Aug 2022
AbstractforNetwork pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss | Full Text | References | PDF (4.4 MB) | EPUB
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Antiproliferative activity, cell-cycle arrest, apoptotic induction and LC-HRMS/MS analyses of extracts from two Linum species
Ryma Mouna, Alexis Broisat, Abdalwahab Ahmed, Marlène Debiossat, Ahcène Boumendjel, Catherine Ghezzi & Zahia Kabouche
Pages: 1491-1501
Published online: 09 Aug 2022
AbstractforAntiproliferative activity, cell-cycle arrest, apoptotic induction and LC-HRMS/MS analyses of extracts from two Linum species | Full Text | References | PDF (2.2 MB) | EPUB
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Aaptamine – a dual acetyl – and butyrylcholinesterase inhibitor as potential anti-Alzheimer’s disease agent
Shuang Miao, Qianqian He, Chen Li, Yan Wu, Mengshan Liu, Yongshou Chen, Shizhou Qi & Kaikai Gong
Pages: 1502-1510
Published online: 14 Aug 2022
AbstractforAaptamine – a dual acetyl – and butyrylcholinesterase inhibitor as potential anti-Alzheimer’s disease agent | Full Text | References | PDF (1.7 MB) | EPUB
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Antiproliferative and cytotoxic effects of sesquiterpene lactones isolated from Ambrosia artemisiifolia on human adenocarcinoma and normal cell lines
Balázs Kovács, Nikoletta Szemerédi, Norbert Kúsz, Tivadar Kiss, Boglárka Csupor-Löffler, Yu-Chi Tsai, Bálint Rácz, Gabriella Spengler & Dezső Csupor
Pages: 1511-1519
Published online: 11 Aug 2022
AbstractforAntiproliferative and cytotoxic effects of sesquiterpene lactones isolated from Ambrosia artemisiifolia on human adenocarcinoma and normal cell lines | Full Text | References | PDF (969.1 KB) | EPUB
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Louki Zupa decoction attenuates the airway inflammation in acute asthma mice induced by ovalbumin through IL-33/ST2-NF-κB/GSK3β/mTOR signalling pathway
Xi Huang, Hang Yu, Cong Xie, Yao-Long Zhou, Meng-Meng Chen, Han-Lin Shi, Wei-Feng Tang, Jing-Cheng Dong & Qing-Li Luo
Pages: 1520-1532
Published online: 11 Aug 2022
AbstractforLouki Zupa decoction attenuates the airway inflammation in acute asthma mice induced by ovalbumin through IL-33/ST2-NF-κB/GSK3β/mTOR signalling pathway | Full Text | References | PDF (2.9 MB) | EPUB
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Effect of Wuzi Yanzong prescription on oligoasthenozoospermia rats based on UPLC-Q-TOF-MS metabolomics
Zhimin Chen, Baohua Dong, Yunxiu Jiang, Ying Peng, Wenbing Li, Lingying Yu, Yongxiang Gao & Changjiang Hu
Pages: 1533-1541
Published online: 09 Aug 2022
AbstractforEffect of Wuzi Yanzong prescription on oligoasthenozoospermia rats based on UPLC-Q-TOF-MS metabolomics | Full Text | References | PDF (1.5 MB) | EPUB
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Jiedutongluotiaogan formula restores pancreatic function by suppressing excessive autophagy and endoplasmic reticulum stress
Jinli Luo, Wenqi Jin, Meiying Jin, Weiwei Pan, Shengnan Gao, Xiaohua Zhao, Xingrong Lai, Liwei Sun & Chunli Piao
Pages: 1542-1555
Published online: 09 Aug 2022
AbstractforJiedutongluotiaogan formula restores pancreatic function by suppressing excessive autophagy and endoplasmic reticulum stress | Full Text | References | PDF (3.4 MB) | EPUB
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Paclitaxel induces cognitive impairment via necroptosis, decreased synaptic plasticity and M1 polarisation of microglia
Miao Tang, Shuang Zhao, Jia-Xin Liu, Xin Liu, Yue-Xian Guo, Gui-Ying Wang & Xiu-Li Wang
Pages: 1556-1565
Published online: 09 Aug 2022
AbstractforPaclitaxel induces cognitive impairment via necroptosis, decreased synaptic plasticity and M1 polarisation of microglia | Full Text | References | PDF (3.2 MB) | EPUB
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Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro
Yang Yang, Zhen-Zhen Ren, Wu-Jun Wei, Zhi-Long He, You-Lin Deng, Zhuan Wang, Yu-Chun Fan, Jie Zhou & Li-He Jiang
Pages: 1566-1577
Published online: 11 Aug 2022
AbstractforStudy on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro | Full Text | References | PDF (3.6 MB) | EPUB
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Assessing potential liver injury induced by Polygonum multiflorum using potential biomarkers via targeted sphingolipidomics
Zhixin Jia, Lirong Liu, Jie Liu, Cong Fang, Mingxia Pan, Jingxuan Zhang, Yueting Li, Zhong Xian & Hongbin Xiao
Pages: 1578-1590
Published online: 10 Aug 2022
AbstractforAssessing potential liver injury induced by Polygonum multiflorum using potential biomarkers via targeted sphingolipidomics | Full Text | References | PDF (2.4 MB) | EPUB
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Article
In vitro differences in toddalolactone metabolism in various species and its effect on cytochrome P450 expression
Lina Shan, Xianbao Shi, Tingting Hu, Jiayin Hu, Zhe Guo, Yonggui Song, Dan Su & Xiaoyong Zhang
Pages: 1591-1605
Published online: 09 Aug 2022
AbstractforIn vitro differences in toddalolactone metabolism in various species and its effect on cytochrome P450 expression | Full Text | References | PDF (3.5 MB) | EPUB
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Article
Danggui Niantong granules ameliorate rheumatoid arthritis by regulating intestinal flora and promoting mitochondrial apoptosis
Qi-Jin Lu, Jia-Yu Li, Hong-Xin Lin, Yi-Si Cai, Chang-Shun Liu, Li-Ping Fu, Gang Liu & Li-Xia Yuan
Pages: 1606-1615
Published online: 12 Aug 2022
AbstractforDanggui Niantong granules ameliorate rheumatoid arthritis by regulating intestinal flora and promoting mitochondrial apoptosis | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Aidi injection reduces doxorubicin-induced cardiotoxicity by inhibiting carbonyl reductase 1 expression
Yuan Lu, Wen Liu, Ting Lv, Yanli Wang, Ting Liu, Yi Chen, Yang Jin, Jin Huang, Lin Zheng, Yong Huang, Yan He & Yongjun Li
Pages: 1616-1624
Published online: 18 Aug 2022
AbstractforAidi injection reduces doxorubicin-induced cardiotoxicity by inhibiting carbonyl reductase 1 expression | Full Text | References | PDF (2.3 MB) | EPUB
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Review Article

Review
Effects of osthole on osteoporotic rats: a systematic review and meta-analysis
Bin Wu, Xiu-Fang Zhu, Xiao-Qiang Yang, Wei-Yi Wang & Jian-Hua Lu
Pages: 1625-1634
Published online: 18 Aug 2022
AbstractforEffects of osthole on osteoporotic rats: a systematic review and meta-analysis | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Asiaticoside reverses M2 phenotype macrophage polarization-evoked osteosarcoma cell malignant behaviour by TRAF6/NF-κB inhibition
Dang-ke Li & Guang-hui Wang
Pages: 1635-1645
Published online: 22 Aug 2022
AbstractforAsiaticoside reverses M2 phenotype macrophage polarization-evoked osteosarcoma cell malignant behaviour by TRAF6/NF-κB inhibition | Full Text | References | PDF (3.4 MB) | EPUB
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Article
Chlorogenic acid promotes angiogenesis and attenuates apoptosis following cerebral ischaemia-reperfusion injury by regulating the PI3K-Akt signalling
Yong Fan, Yongkun Li, Yongkai Yang, Kunzhe Lin, Qingqiang Lin, Shenghui Luo, Xiaohui Zhou, Qun Lin & Fan Zhang
Pages: 1646-1655
Published online: 18 Aug 2022
AbstractforChlorogenic acid promotes angiogenesis and attenuates apoptosis following cerebral ischaemia-reperfusion injury by regulating the PI3K-Akt signalling | Full Text | References | PDF (2.3 MB) | EPUB
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Article
New insights on the phytochemical intervention for the treatment of neuropsychiatric disorders using the leaves of Michelia champaca: an in vivo and in silico approach
Pushpa V. H.Jayanthi M. K.Rashmi H. R.Veeresh Kumar N. Shivamurthy, Shashank M. Patil, Prithvi S. Shirahatti & Ramith Ramu
Pages: 1656-1668
Published online: 02 Sep 2022
AbstractforNew insights on the phytochemical intervention for the treatment of neuropsychiatric disorders using the leaves of Michelia champaca: an in vivo and in silico approach | Full Text | References | PDF (1.6 MB) | EPUB
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Correction

Correction
Correction
Page: 1669
Published online: 29 Aug 2022
CitationforCorrection | Full Text | PDF (143.9 KB) | EPUB
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Article
Effects of Bushen Yiyuan recipe on testosterone synthesis in Leydig cells of rats with exercise-induced low serum testosterone levels
Yirong Wang, Xiyang Peng, Zhihong Zhou, Changfa Tang & Wenfeng Liu
Pages: 1670-1678
Published online: 05 Sep 2022
AbstractforEffects of Bushen Yiyuan recipe on testosterone synthesis in Leydig cells of rats with exercise-induced low serum testosterone levels | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Kuhuang injection exerts a protective effect by activating PPAR-γ in an in vitro model of chlorpromazine-induced cholestatic liver injury constructed by tissue engineering
Qiao Wu, Zhongping Duan, Long Huang & Zhijie Li
Pages: 1679-1689
Published online: 05 Sep 2022
AbstractforKuhuang injection exerts a protective effect by activating PPAR-γ in an in vitro model of chlorpromazine-induced cholestatic liver injury constructed by tissue engineering | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Kirenol alleviates diabetic nephropathy via regulating TGF-β/Smads and the NF-κB signal pathway
Jialin Li, Jiawen Zhang, Meng Yang, Xiaocui Huang, Meng Zhang, Xiansong Fang & Suzhen Wu
Pages: 1690-1700
Published online: 08 Sep 2022
AbstractforKirenol alleviates diabetic nephropathy via regulating TGF-β/Smads and the NF-κB signal pathway | Full Text | References | PDF (2.9 MB) | EPUB
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Article
The changes of hepatic bile acid synthesis and transport and bile acids profiles in isopsoralen-induced liver injury C57BL/6J mice
Wei-jie Men, Zhao-jun Meng, Qin Wang, Meng-ying Chen, Yu-xia Zhai, Hong Shi, An-hong Wang & Kun Zhou
Pages: 1701-1709
Published online: 06 Sep 2022
AbstractforThe changes of hepatic bile acid synthesis and transport and bile acids profiles in isopsoralen-induced liver injury C57BL/6J mice | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Astragalus polysaccharide (APS) attenuated PD-L1-mediated immunosuppression via the miR-133a-3p/MSN axis in HCC
Lihua He, Kecheng Xu, Lizhi Niu & Lizhu Lin
Pages: 1710-1720
Published online: 09 Sep 2022
AbstractforAstragalus polysaccharide (APS) attenuated PD-L1-mediated immunosuppression via the miR-133a-3p/MSN axis in HCC | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
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Article
Modified Taohong Siwu decoction improves cardiac function after myocardial ischaemia and reperfusion in rats by promoting endogenous stem cell mobilization and regulating metabolites
Wan-ting Meng, Zhong-Xin Xiao, Han Li, Ya-chao Wang, Yue Zhao, Yan Zhu & Hai-dong Guo
Pages: 1721-1731
Published online: 09 Sep 2022
AbstractforModified Taohong Siwu decoction improves cardiac function after myocardial ischaemia and reperfusion in rats by promoting endogenous stem cell mobilization and regulating metabolites | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
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Article
Protective effect of salidroside on streptozotocin-induced diabetic nephropathy by inhibiting oxidative stress and inflammation in rats via the Akt/GSK-3β signalling pathway
Delong Pei, Shengri Tian, Yanqiu Bao, Jun Zhang, Dongyuan Xu & Minhu Piao
Pages: 1732-1738
Published online: 09 Sep 2022
AbstractforProtective effect of salidroside on streptozotocin-induced diabetic nephropathy by inhibiting oxidative stress and inflammation in rats via the Akt/GSK-3β signalling pathway | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Tao-Hong-Si-Wu decoction improves depressive symptoms in model rats via amelioration of BDNF-CREB-arginase I axis disorders
Xiaoping Zhang, Zeng Li, Chuanpu Shen, Jinzhi He, Longfei Wang, Lei Di, Bin Rui, Ning Li & Zhicheng Liu
Pages: 1739-1750
Published online: 10 Sep 2022
AbstractforTao-Hong-Si-Wu decoction improves depressive symptoms in model rats via amelioration of BDNF-CREB-arginase I axis disorders | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
Acteoside and ursolic acid synergistically protects H2O2-induced neurotrosis by regulation of AKT/mTOR signalling: from network pharmacology to experimental validation
Yan-Jie Qu, Min-Rui Ding, Chao Gu, Li-Min Zhang, Rong-Rong Zhen, Jin-Fang Chen, Bing Hu & Hong-Mei An
Pages: 1751-1761
Published online: 14 Sep 2022
AbstractforActeoside and ursolic acid synergistically protects H2O2-induced neurotrosis by regulation of AKT/mTOR signalling: from network pharmacology to experimental validation | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Small ubiquitin-related modifier (SUMO)ylation of SIRT1 mediates (-)-epicatechin inhibited- differentiation of cardiac fibroblasts into myofibroblasts
Yingchun Luo, Jing Lu, Zeng Wang, Lu Wang, Guodong Wu, Yuanyuan Guo & Zengxiang Dong
Pages: 1762-1770
Published online: 09 Sep 2022
AbstractforSmall ubiquitin-related modifier (SUMO)ylation of SIRT1 mediates (-)-epicatechin inhibited- differentiation of cardiac fibroblasts into myofibroblasts | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Antioxidant properties of polyphenols from snow chrysanthemum (Coreopsis tinctoria) and the modulation on intestinal microflora in vitro
Minghao Zhang, Naiyu Zhao, Minhao Xie, Deqiao Dong, Weilin Chen, Yuanpeng He, Dalin Yan, Haiyan Fu, Xinlin Liang & Li Zhou
Pages: 1771-1780
Published online: 10 Sep 2022
AbstractforAntioxidant properties of polyphenols from snow chrysanthemum (Coreopsis tinctoria) and the modulation on intestinal microflora in vitro | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
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Polyphyllin II induced apoptosis of NSCLC cells by inhibiting autophagy through the mTOR pathway
Yuhan Jiao, Ming Xin, Juanjuan Xu, Xindong Xiang, Xuan Li, Jingjing Jiang & Xiuqin Jia
Pages: 1781-1789
Published online: 14 Sep 2022
AbstractforPolyphyllin II induced apoptosis of NSCLC cells by inhibiting autophagy through the mTOR pathway | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Jing-an oral liquid alleviates Tourette syndrome via the NMDAR/MAPK/CREB pathway in vivo and in vitro
Leying Xi, Xixi Ji, Wenxiu Ji, Yue’e Yang, Yajie Zhang & Hongyan Long
Pages: 1790-1800
Published online: 14 Sep 2022
AbstractforJing-an oral liquid alleviates Tourette syndrome via the NMDAR/MAPK/CREB pathway in vivo and in vitro | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
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Article
Cinobufagin induces acute promyelocytic leukaemia cell apoptosis and PML-RARA degradation in a caspase-dependent manner by inhibiting the β-catenin signalling pathway
Yaoyao Bian, Mei Xue, Xinlong Guo, Wenjuan Jiang, Ye Zhao, Zhaofeng Zhang, Xian Wang, Yongkang Hu, Qi Zhang, Wenliang Dun & Liang Zhang
Pages: 1801-1811
Published online: 19 Sep 2022
AbstractforCinobufagin induces acute promyelocytic leukaemia cell apoptosis and PML-RARA degradation in a caspase-dependent manner by inhibiting the β-catenin signalling pathway | Full Text | References | PDF (3.1 MB) | EPUB
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Article
The BCL2/BAX/ROS pathway is involved in the inhibitory effect of astragaloside IV on pyroptosis in human umbilical vein endothelial cells
Yi Su, Xin Yin, Xin Huang, Qianqian Guo, Mingyuan Ma & Liheng Guo
Pages: 1812-1818
Published online: 19 Sep 2022
AbstractforThe BCL2/BAX/ROS pathway is involved in the inhibitory effect of astragaloside IV on pyroptosis in human umbilical vein endothelial cells | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Integrated strategy of RNA-sequencing and network pharmacology for exploring the protective mechanism of Shen-Shi-Jiang-Zhuo formula in rat with non-alcoholic fatty liver disease
Zheng Xu, Fan-Wei Wu, Xuan Niu, Xiao-Peng Lu, Yan-Rong Li, Shu-Ting Zhang, Jun-Zhao Ou & Xue-Mei Wang
Pages: 1819-1838
Published online: 20 Sep 2022
AbstractforIntegrated strategy of RNA-sequencing and network pharmacology for exploring the protective mechanism of Shen-Shi-Jiang-Zhuo formula in rat with non-alcoholic fatty liver disease | Full Text | References | PDF (4.2 MB) | EPUB
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Correction

Correction
Correction
Page: 1839
Published online: 06 Oct 2022
CitationforCorrection | Full Text | PDF (375.8 KB) | EPUB
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Article
Bullatine A exerts anti-inflammatory effects by inhibiting the ROS/JNK/NF-κB pathway and attenuating systemic inflammatory responses in mice
Shuhan Liu, Na Che, Wen Ou, Meichen Yan, Yajin Liao & Yong Cheng
Pages: 1840-1849
Published online: 06 Oct 2022
AbstractforBullatine A exerts anti-inflammatory effects by inhibiting the ROS/JNK/NF-κB pathway and attenuating systemic inflammatory responses in mice | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Mechanism of lily bulb and Rehmannia decoction in the treatment of lipopolysaccharide-induced depression-like rats based on metabolomics study and network pharmacology
Xiansu Chi, Xiaoyan Xue, Jin Pan, Jiang Wu, Huishan Shi, Yong Wang, Yanting Lu, Zhe Zhang & Ke Ma
Pages: 1850-1864
Published online: 07 Oct 2022
AbstractforMechanism of lily bulb and Rehmannia decoction in the treatment of lipopolysaccharide-induced depression-like rats based on metabolomics study and network pharmacology | Full Text | References | PDF (4.1 MB) | EPUB
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Article
Sasanquasaponin inhibited epithelial to mesenchymal transition in prostate cancer by regulating the PI3K/Akt/mTOR and Smad pathways
Wenfeng Li, Yuanshen Mao, Bao Hua, Xin Gu, Chao Lu, Bin Xu & Weixin Pan
Pages: 1865-1875
Published online: 07 Oct 2022
AbstractforSasanquasaponin inhibited epithelial to mesenchymal transition in prostate cancer by regulating the PI3K/Akt/mTOR and Smad pathways | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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Rapid Communication

Rapid Communication
Genistein-induced mitochondrial dysfunction and FOXO3a/PUMA expression in non-small lung cancer cells
Liujia Chan, Yuheng Pang, Yuji Wang, Di Zhu, Ayijinag Taledaohan, Yijiang Jia, Lichun Zhao & Wenjing Wang
Pages: 1876-1883
Published online: 06 Oct 2022
AbstractforGenistein-induced mitochondrial dysfunction and FOXO3a/PUMA expression in non-small lung cancer cells | Full Text | References | PDF (2.1 MB) | EPUB
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Research Article

Article
Guanxin V attenuates myocardial ischaemia reperfusion injury through regulating iron homeostasis
Fuqiong Zhou, Zhengguang Zhang, Meiyuan Wang, Weina Zhu, Jie Ruan, Hongyan Long, Yajie Zhang & Ning Gu
Pages: 1884-1898
Published online: 10 Oct 2022
AbstractforGuanxin V attenuates myocardial ischaemia reperfusion injury through regulating iron homeostasis | Full Text | References | PDF (4.5 MB) | EPUB
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Article
Thais savignyi tissue extract: bioactivity, chemical composition, and molecular docking
Mohamed R. Habib, Ahmed A. Hamed, Rasha E. M. Ali, Khaled M. Zayed, Rasha M. Gad El-Karim, Rehab Sabour, Hanaa M. Abu El-Einin & Mosad A. Ghareeb
Pages: 1899-1914
Published online: 06 Oct 2022
AbstractforThais savignyi tissue extract: bioactivity, chemical composition, and molecular docking | Full Text | References | PDF (3.2 MB) | EPUB
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Article
Echinatin mitigates sevoflurane-induced hippocampal neurotoxicity and cognitive deficits through mitigation of iron overload and oxidative stress
Zilong Xu, Yanqiu You, Qiuqin Tang, Hui Zeng, Tianshou Zhao, Juan Wang & Fujun Li
Pages: 1915-1924
Published online: 07 Oct 2022
AbstractforEchinatin mitigates sevoflurane-induced hippocampal neurotoxicity and cognitive deficits through mitigation of iron overload and oxidative stress | Full Text | References | PDF (2.7 MB) | EPUB
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Review

Review
Ethnomedicinal plants used for treatment of snakebites in Tanzania – a systematic review
Neema Gideon Mogha, Olivia John Kalokora, Halima Mvungi Amir & David Sylvester Kacholi
Pages: 1925-1934
Published online: 07 Oct 2022
AbstractforEthnomedicinal plants used for treatment of snakebites in Tanzania – a systematic review | Full Text | References | PDF (1.2 MB) | EPUB
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Research Article

Article
Dolichandrone serrulata flower improves seminal biochemical parameters and proteins in T2DM rats induced by a high-fat diet and streptozotocin
Tarinee Sawatpanich, Chadaporn Chaimontri, Alexander Tsang-Hsien Wu, Sitthichai Iamsaard & Supataechasit Yannasithinon
Pages: 1935-1943
Published online: 07 Oct 2022
AbstractforDolichandrone serrulata flower improves seminal biochemical parameters and proteins in T2DM rats induced by a high-fat diet and streptozotocin | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Pharmacokinetic study on the co-administration of abemaciclib and astragaloside IV in rats
Sen Sun, Lu Liu, Hongming Song & Hong Li
Pages: 1944-1948
Published online: 13 Oct 2022
AbstractforPharmacokinetic study on the co-administration of abemaciclib and astragaloside IV in rats | Full Text | References | PDF (855.7 KB) | EPUB
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Article
Gypenosides counteract hepatic steatosis and intestinal barrier injury in rats with metabolic associated fatty liver disease by modulating the adenosine monophosphate activated protein kinase and Toll-like receptor 4/nuclear factor kappa B pathways
Shuhua Shen, Kungen Wang, Yihui Zhi & Yue Dong
Pages: 1949-1959
Published online: 07 Oct 2022
AbstractforGypenosides counteract hepatic steatosis and intestinal barrier injury in rats with metabolic associated fatty liver disease by modulating the adenosine monophosphate activated protein kinase and Toll-like receptor 4/nuclear factor kappa B pathways | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Swertia mussotii prevents high-fat diet-induced non-alcoholic fatty liver disease in rats by inhibiting expression the TLR4/MyD88 and the phosphorylation of NF-κB
Ming Dong Si, Meng Wu, Xi Zhen Cheng, Zhi Hong Ma, Yu Guang Zheng, Jing Li, Si Li, Yong Xing Song & Donglai Ma
Pages: 1960-1968
Published online: 07 Oct 2022
AbstractforSwertia mussotii prevents high-fat diet-induced non-alcoholic fatty liver disease in rats by inhibiting expression the TLR4/MyD88 and the phosphorylation of NF-κB | Full Text | References | PDF (3.2 MB) | EPUB
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Article
In vitro and in silico β-lactamase inhibitory properties and phytochemical profile of Ocimum basilicum cultivated in central delta of Egypt
Nagwa A. Shoeib, Lamiaa A. Al-Madboly & Amany E. Ragab
Pages: 1969-1980
Published online: 13 Oct 2022
AbstractforIn vitro and in silico β-lactamase inhibitory properties and phytochemical profile of Ocimum basilicum cultivated in central delta of Egypt | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Article
Upregulation of claudin‑4 by Chinese traditional medicine Shenfu attenuates lung tissue damage by acute lung injury aggravated by acute gastrointestinal injury
Yueliang Zheng, Mian Zheng, Jing Shao, Chengxing Jiang, Jian Shen, Rujia Tao, Yuqin Deng, Yingge Xu & Yuanqiang Lu
Pages: 1981-1993
Published online: 13 Oct 2022
AbstractforUpregulation of claudin‑4 by Chinese traditional medicine Shenfu attenuates lung tissue damage by acute lung injury aggravated by acute gastrointestinal injury | Full Text | References | PDF (4.4 MB) | EPUB
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Article
Volatile composition, antidiabetic, and anti-obesity potential of Brassica incana leaf and flowering top extracts
Maria Fernanda Taviano, Sonia Núñez, Adrián Millán-Laleona, Concetta Condurso, Antonella Verzera, Maria Merlino, Monica Ragusa, Natalizia Miceli & Víctor López
Pages: 1994-2001
Published online: 11 Oct 2022
AbstractforVolatile composition, antidiabetic, and anti-obesity potential of Brassica incana leaf and flowering top extracts | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Article
TangNaiKang, herbal formulation, alleviates obesity in diabetic SHR/cp rats through modulation of gut microbiota and related metabolic functions
Peng Tian, Lili Wu, Maya Kudo, Misa Hayashi, Lingling Qin, Ming Gao, Anlong Xu & Tonghua Liu
Pages: 2002-2010
Published online: 13 Oct 2022
AbstractforTangNaiKang, herbal formulation, alleviates obesity in diabetic SHR/cp rats through modulation of gut microbiota and related metabolic functions | Full Text | References | PDF (2.2 MB) | EPUB
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Shenlian extract attenuates myocardial ischaemia-reperfusion injury via inhibiting M1 macrophage polarization by silencing miR-155
Min Song, Xihe Cui, Jing Zhang, Yujie Li, Jingjing Li, Yuanlong Zang, Qi Li, Qing Yang, Ying Chen, Weiyan Cai, Xiaogang Weng, Yajie Wang & Xiaoxin Zhu
Pages: 2011-2024
Published online: 14 Oct 2022
AbstractforShenlian extract attenuates myocardial ischaemia-reperfusion injury via inhibiting M1 macrophage polarization by silencing miR-155 | Full Text | References | PDF (4.3 MB) | EPUB
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Article
Bazi Bushen capsule attenuates cognitive deficits by inhibiting microglia activation and cellular senescence
Chuanyuan Ji, Cong Wei, Mengnan Li, Shuang Shen, Shixiong Zhang, Yunlong Hou & Yiling Wu
Pages: 2025-2039
Published online: 20 Oct 2022
AbstractforBazi Bushen capsule attenuates cognitive deficits by inhibiting microglia activation and cellular senescence | Full Text | References | PDF (4.7 MB) | EPUB
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Article
Anti-inflammatory effect of Gyeji-tang in a chronic obstructive pulmonary disease mouse model induced by cigarette smoke and lipopolysaccharide
Eun Bok Baek, Yu Jin Kim, Jin-Hyung Rho, Eun-Ju Hong, Mee-Young Lee & Hyo-Jung Kwun
Pages: 2040-2048
Published online: 20 Oct 2022
AbstractforAnti-inflammatory effect of Gyeji-tang in a chronic obstructive pulmonary disease mouse model induced by cigarette smoke and lipopolysaccharide | Full Text | References | PDF (2 MB) | EPUB
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Article
Natural products from medicinal plants in Asia and the Pacific for RNA viruses: Hercules’ fifth labour
Mazdida Sulaiman, Vladimir Zarubaev, Chandramathi Samudi, Mohammed Rahmatullah, Khoshnur Jannat, Alok Paul, Mogana Rajagopal, Malarvili Selvaraja, Veeranoot Nissapatorn, Monica Suleiman, Mark Butler & Christophe Wiart
Pages: 2049-2087
Published online: 28 Oct 2022
AbstractforNatural products from medicinal plants in Asia and the Pacific for RNA viruses: Hercules’ fifth labour | PDF (3.5 MB)
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Article
The anti-inflammatory activity of resveratrol in acute kidney injury: a systematic review and meta‐analysis of animal studies
Shangmei Cao, Xiuhong Fu, Shaozhe Yang & Shuifu Tang
Pages: 2088-2097
Published online: 21 Oct 2022
AbstractforThe anti-inflammatory activity of resveratrol in acute kidney injury: a systematic review and meta‐analysis of animal studies | Full Text | References | PDF (2.9 MB) | EPUB
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Article
A clinical herbal prescription Gu-Shu-Kang capsule exerted beneficial effects on the musculoskeletal system of dexamethasone-treated mice by acting on tissue IGF-1 signalling pathway
Xiao-Li Li, Liang Wang, Ming-Chao He, Wen-Xiong Li, Jia-Li Zhang, Yong-Fang Fu & Yan Zhang
Pages: 2098-2109
Published online: 21 Oct 2022
AbstractforA clinical herbal prescription Gu-Shu-Kang capsule exerted beneficial effects on the musculoskeletal system of dexamethasone-treated mice by acting on tissue IGF-1 signalling pathway | Full Text | References | PDF (3.9 MB) | EPUB
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Article
The therapeutic role of Jingchuan tablet on ischaemic cerebral stroke via the HIF-1α/EPO/VEGFA signalling pathway
Yan Zhang, Qinghuan Liu, Ting Zhang, Hong Wang, Yu Fu, Wentong Wang & Dongdong Li
Pages: 2110-2123
Published online: 21 Oct 2022
AbstractforThe therapeutic role of Jingchuan tablet on ischaemic cerebral stroke via the HIF-1α/EPO/VEGFA signalling pathway | Full Text | References | PDF (5 MB) | EPUB
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Article
Qushi Huayu decoction attenuated hepatic lipid accumulation via JAK2/STAT3/CPT-1A-related fatty acid β-oxidation in mice with non-alcoholic steatohepatitis
QinMei Sun, Xin Wang, Xin Xin, ZiMing An, YiYang Hu & Qin Feng
Pages: 2124-2133
Published online: 29 Oct 2022
AbstractforQushi Huayu decoction attenuated hepatic lipid accumulation via JAK2/STAT3/CPT-1A-related fatty acid β-oxidation in mice with non-alcoholic steatohepatitis | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Ameliorative effect of chitosan nanoparticles against carbon tetrachloride-induced nephrotoxicity in Wistar rats
Yousra A. Nomier, Saeed Alshahrani, Mahmoud Elsabahy, Gihan F. Asaad, Azza Hassan & Walaa A. El-Dakroury
Pages: 2134-2144
Published online: 28 Oct 2022
AbstractforAmeliorative effect of chitosan nanoparticles against carbon tetrachloride-induced nephrotoxicity in Wistar rats | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Veratramine ameliorates pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway
Yu Zhang, Guangyao Ye, Yuebo Chen, Chaoxu Sheng, Jianlin Wang, Lingsi Kong, Liyong Yuan & Chunyan Lin
Pages: 2145-2154
Published online: 14 Nov 2022
AbstractforVeratramine ameliorates pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway | Full Text | References | PDF (3.8 MB) | EPUB
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Article
Chitooligosaccharide prevents vascular endothelial cell apoptosis by attenuation of endoplasmic reticulum stress via suppression of oxidative stress through Nrf2-SOD1 up-regulation
Zin Zin Ei, Pilaiwanwadee Hutamekalin, Peerada Prommeenate, Avtar Singh, Soottawat Benjakul, Kittichate Visuttijai & Pithi Chanvorachote
Pages: 2155-2166
Published online: 27 Oct 2022
AbstractforChitooligosaccharide prevents vascular endothelial cell apoptosis by attenuation of endoplasmic reticulum stress via suppression of oxidative stress through Nrf2-SOD1 up-regulation | Full Text | References | PDF (3.2 MB) | EPUB
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Review

Review
Therapeutic potential of plant iridoids in depression: a review
Yaoyao Kou, Zhihao Li, Tong Yang, Xue Shen, Xin Wang, Haopeng Li, Kun Zhou, Luyao Li, Zhaodi Xia, Xiaohui Zheng & Ye Zhao
Pages: 2167-2181
Published online: 27 Oct 2022
AbstractforTherapeutic potential of plant iridoids in depression: a review | Full Text | References | PDF (2.2 MB) | EPUB
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Research Article

Article
Herbal remedies used by traditional healers to treat haemorrhoids in Tabora region, Tanzania
David Sylvester Kacholi & Halima Mvungi Amir
Pages: 2182-2188
Published online: 28 Oct 2022
AbstractforHerbal remedies used by traditional healers to treat haemorrhoids in Tabora region, Tanzania | Full Text | References | PDF (1.2 MB) | EPUB
  • 1849 Views
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Article
Mechanism of Huangqi–Honghua combination regulating the gut microbiota to affect bile acid metabolism towards preventing cerebral ischaemia–reperfusion injury in rats
Kai Wang, Yue Chen, Jinyi Cao, Ruimin Liang, Yi Qiao, Likun Ding, Xiaojuan Yang & Zhifu Yang
Pages: 2189-2199
Published online: 28 Oct 2022
AbstractforMechanism of Huangqi–Honghua combination regulating the gut microbiota to affect bile acid metabolism towards preventing cerebral ischaemia–reperfusion injury in rats | Full Text | References | PDF (2.9 MB) | EPUB
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Retraction

Retraction
Statement of Retraction: 18β-Glycyrrhetinic acid inhibits the apoptosis of cells infected with rotavirus SA11 via the Fas/FasL pathway
Page: 2200
Published online: 08 Nov 2022
CitationforStatement of Retraction: 18β-Glycyrrhetinic acid inhibits the apoptosis of cells infected with rotavirus SA11 via the Fas/FasL pathway | Full Text | PDF (144.1 KB) | EPUB
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Research Article

Article
Ganoderma lucidum polysaccharides ameliorate lipopolysaccharide-induced acute pneumonia via inhibiting NRP1-mediated inflammation
Xuelian Zhang, Daoshun Wu, Yu Tian, Xiangdong Chen, Jin Lan, Fei Wei, Ye Li, Yun Luo & Xiaobo Sun
Pages: 2201-2209
Published online: 14 Nov 2022
AbstractforGanoderma lucidum polysaccharides ameliorate lipopolysaccharide-induced acute pneumonia via inhibiting NRP1-mediated inflammation | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Catalpol relieved angiotensin II-induced blood–brain barrier destruction via inhibiting the TLR4 pathway in brain endothelial cells
Yu Xia, Yun Wei Lu, Ren Juan Hao & Gu Ran Yu
Pages: 2210-2218
Published online: 12 Nov 2022
AbstractforCatalpol relieved angiotensin II-induced blood–brain barrier destruction via inhibiting the TLR4 pathway in brain endothelial cells | Full Text | References | PDF (2 MB) | EPUB
  • 1647 Views
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Article
Isoorientin ameliorates osteoporosis and oxidative stress in postmenopausal rats
Zhilin Cao, Wei Liu, Benjun Bi, Hao Wu, Gong Cheng & Zhongyuan Zhao
Pages: 2219-2228
Published online: 16 Nov 2022
AbstractforIsoorientin ameliorates osteoporosis and oxidative stress in postmenopausal rats | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Ginsenoside Rb1 reduces oxidative/carbonyl stress damage and ameliorates inflammation in the lung of streptozotocin-induced diabetic rats
Hao Su, Cheng-Ju Tian, Ying Wang, Jiaojiao Shi, Xiaoxiao Chen, Zhong Zhen, Yu Bai, Lan Deng, Chunpeng Feng, Zhuang Ma & Jinfeng Liu
Pages: 2229-2236
Published online: 11 Nov 2022
AbstractforGinsenoside Rb1 reduces oxidative/carbonyl stress damage and ameliorates inflammation in the lung of streptozotocin-induced diabetic rats | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Deciphering the anti-filarial potential of bioactive compounds from Ocimum sanctum: a combined experimental and computational study
Ayushi Mishra, Vipin Kumar & Anchal Singh
Pages: 2237-2252
Published online: 22 Nov 2022
AbstractforDeciphering the anti-filarial potential of bioactive compounds from Ocimum sanctum: a combined experimental and computational study | Full Text | References | PDF (4.5 MB) | EPUB
  • 985 Views
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Article
Rongjin Niantong Fang ameliorates cartilage degeneration by regulating the SDF-1/CXCR4-p38MAPK signalling pathway
Jun Chen, Nan Chen, Ting Zhang, Jie Lin, Yunmei Huang & Guangwen Wu
Pages: 2253-2265
Published online: 25 Nov 2022
AbstractforRongjin Niantong Fang ameliorates cartilage degeneration by regulating the SDF-1/CXCR4-p38MAPK signalling pathway | Full Text | References | PDF (3 MB) | EPUB
  • 1152 Views
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Article
Factors determining the oral absorption and systemic disposition of zeaxanthin in rats: in vitro, in situ, and in vivo evaluations
Seong‑Wook Seo, Dong‑Gyun Han, Eugene Choi, Min‑Jeong Seo, Im‑Sook Song & In‑Soo Yoon
Pages: 2266-2275
Published online: 22 Nov 2022
AbstractforFactors determining the oral absorption and systemic disposition of zeaxanthin in rats: in vitro, in situ, and in vivo evaluations | Full Text | References | PDF (1.8 MB) | EPUB
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Article
13-Acetoxysarcocrassolide induces apoptosis in human hepatocellular carcinoma cells through mitochondrial dysfunction and suppression of the PI3K/AKT/mTOR/p70S6K signalling pathway
Chang-Min Hsu, Jen-Jie Lin, Jui-Hsin Su & Chih-I Liu
Pages: 2276-2285
Published online: 23 Nov 2022
Abstractfor13-Acetoxysarcocrassolide induces apoptosis in human hepatocellular carcinoma cells through mitochondrial dysfunction and suppression of the PI3K/AKT/mTOR/p70S6K signalling pathway | Full Text | References | PDF (2.1 MB) | EPUB
  • 983 Views
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Article
Ferulic acid alleviates alveolar epithelial barrier dysfunction in sepsis-induced acute lung injury by activating the Nrf2/HO-1 pathway and inhibiting ferroptosis
Xianming Tang, Jiqiang Liu, Shuo Yao, Jianfei Zheng, Xun Gong & Bing Xiao
Pages: 2286-2294
Published online: 25 Nov 2022
AbstractforFerulic acid alleviates alveolar epithelial barrier dysfunction in sepsis-induced acute lung injury by activating the Nrf2/HO-1 pathway and inhibiting ferroptosis | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Curcuma longa and Boswellia serrata extract combination for hand osteoarthritis: an open-label pre-post trial
Yves Henrotin, Yvan Dierckxsens, Gaëlle Delisse, Nathalie Maes & Adelin Albert
Pages: 2295-2299
Published online: 23 Nov 2022
AbstractforCurcuma longa and Boswellia serrata extract combination for hand osteoarthritis: an open-label pre-post trial | Full Text | References | PDF (558.9 KB) | EPUB
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Article
Solid lipid nanoparticle as an effective drug delivery system of a novel curcumin derivative: formulation, release in vitro and pharmacokinetics in vivo
Wenmei Zhao, Mingtang Zeng, Ke Li, Chao Pi, Zerong Liu, Chenglin Zhan, Jiyuan Yuan, Zhilian Su, Yuxun Wei, Jie Wen, Fengjuan Pi, Xinjie Song, Robert J. Lee, Yumeng Wei & Ling Zhao
Pages: 2300-2307
Published online: 23 Nov 2022
AbstractforSolid lipid nanoparticle as an effective drug delivery system of a novel curcumin derivative: formulation, release in vitro and pharmacokinetics in vivo | Full Text | References | PDF (1.6 MB) | EPUB
  • 1184 Views
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Article
Yiqi Huoxue Tongluo recipe regulates NR4A1 to improve renal mitochondrial function in unilateral ureteral obstruction (UUO) rats
Zhen He, Mengjuan Zhang, Hepeng Xu, Wenping Zhou, Chang Xu, Zheng Wang, Ming He & Xiangting Wang
Pages: 2308-2318
Published online: 25 Nov 2022
AbstractforYiqi Huoxue Tongluo recipe regulates NR4A1 to improve renal mitochondrial function in unilateral ureteral obstruction (UUO) rats | Full Text | References | PDF (3 MB) | EPUB
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Article
Didymin, a natural flavonoid, relieves the progression of myocardial infarction via inhibiting the NLR family pyrin domain containing 3 inflammasome
Yong Zhang & GuLi RuXian
Pages: 2319-2327
Published online: 23 Nov 2022
AbstractforDidymin, a natural flavonoid, relieves the progression of myocardial infarction via inhibiting the NLR family pyrin domain containing 3 inflammasome | Full Text | References | PDF (3.2 MB) | EPUB
  • 915 Views
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Article
Resveratrol accelerates wound healing by inducing M2 macrophage polarisation in diabetic mice
Youjun Ding, Ping Yang, Shiyan Li, Hao Zhang, Xiaofeng Ding & Qian Tan
Pages: 2328-2337
Published online: 05 Dec 2022
AbstractforResveratrol accelerates wound healing by inducing M2 macrophage polarisation in diabetic mice | Full Text | References | PDF (2.5 MB) | EPUB
  • 2206 Views
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Article
Integration of network pharmacology and intestinal flora to investigate the mechanism of action of Chinese herbal Cichorium intybus formula in attenuating adenine and ethambutol hydrochloride-induced hyperuricemic nephropathy in rats
Na Li, Mukaram Amatjan, Pengke He, Boheng Zhang, Xianyan Mai, Qianle Jiang, Haochen Xie & Xiaoni Shao
Pages: 2338-2354
Published online: 29 Nov 2022
AbstractforIntegration of network pharmacology and intestinal flora to investigate the mechanism of action of Chinese herbal Cichorium intybus formula in attenuating adenine and ethambutol hydrochloride-induced hyperuricemic nephropathy in rats | Full Text | References | PDF (5.9 MB) | EPUB
  • 2212 Views
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Article
XiaoEr LianHuaQinqGan alleviates viral pneumonia in mice infected by influenza A and respiratory syncytial viruses
Wenyan Li, Tongtong Li, Chi Zhao, Tao Song, Yao Mi, Zhang Chuangfeng, Yunlong Hou & Zhenhua Jia
Pages: 2355-2366
Published online: 29 Nov 2022
AbstractforXiaoEr LianHuaQinqGan alleviates viral pneumonia in mice infected by influenza A and respiratory syncytial viruses | Full Text | References | PDF (3.4 MB) | EPUB
  • 1326 Views
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