Journal of Toxicology and Environmental Health, Part B, Volume 13, Issue 2-4 (2010)

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Journal of Toxicology and Environmental Health, Part B, Volume 13, Issue 2-4 (2010)

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The Future of Toxicology Testing

Original Articles

Article
Toxicity Testing in the 21st Century: A Vision and a Strategy
Daniel Krewski, Daniel Acosta Jr., Melvin Andersen, Henry Anderson, John C. Bailar III, Kim Boekelheide, Robert Brent, Gail Charnley, Vivian G. Cheung, Sidney Green Jr., Karl T. Kelsey, Nancy I. Kerkvliet, Abby A. Li, Lawrence McCray, Otto Meyer, Reid D. Patterson, William Pennie, Robert A. Scala, Gina M. Solomon, Martin Stephens, James Yager, Lauren Zeise & Staff of Committee on Toxicity Testing and Assessment of Environmental Agents
Pages: 51-138
Published online: 21 Jun 2010
AbstractforToxicity Testing in the 21st Century: A Vision and a Strategy | Full Text | References | PDF (1.8 MB)
  • 4656 Views
  • 555 CrossRef citations
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Article
The U.S. Environmental Protection Agency Strategic Plan for Evaluating the Toxicity of Chemicals
Michael Firestone, Robert Kavlock, Hal Zenick, Melissa Kramer & the U.S. EPA Working Group on the Future of Toxicity Testing
Pages: 139-162
Published online: 21 Jun 2010
AbstractforThe U.S. Environmental Protection Agency Strategic Plan for Evaluating the Toxicity of Chemicals | Full Text | References | PDF (694.8 KB)
  • 653 Views
  • 37 CrossRef citations
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Article
The Future of Toxicity Testing
Melvin E. Andersen, Mustafa Al-Zoughool, Maxine Croteau, Margit Westphal & Daniel Krewski
Pages: 163-196
Published online: 21 Jun 2010
AbstractforThe Future of Toxicity Testing | Full Text | References | PDF (250 KB)
  • 841 Views
  • 44 CrossRef citations
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Article
Computational Toxicology as Implemented by the U.S. EPA: Providing High Throughput Decision Support Tools for Screening and Assessing Chemical Exposure, Hazard and Risk
Robert Kavlock & David Dix
Pages: 197-217
Published online: 21 Jun 2010
AbstractforComputational Toxicology as Implemented by the U.S. EPA: Providing High Throughput Decision Support Tools for Screening and Assessing Chemical Exposure, Hazard and Risk | Full Text | References | PDF (172.5 KB)
  • 1268 Views
  • 122 CrossRef citations
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Article
Public Databases Supporting Computational Toxicology
Richard Judson
Pages: 218-231
Published online: 21 Jun 2010
AbstractforPublic Databases Supporting Computational Toxicology | Full Text | References | PDF (483.4 KB)
  • 370 Views
  • 29 CrossRef citations
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Article
The Reach Perspective: Toward a New Concept of Toxicity Testing
Greet Schoeters
Pages: 232-241
Published online: 21 Jun 2010
AbstractforThe Reach Perspective: Toward a New Concept of Toxicity Testing | Full Text | References | PDF (117.6 KB)
  • 322 Views
  • 36 CrossRef citations
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Article
Biokinetic Modeling and in Vitro–in Vivo Extrapolations
Bas J. Blaauboer
Pages: 242-252
Published online: 21 Jun 2010
AbstractforBiokinetic Modeling and in Vitro–in Vivo Extrapolations | Full Text | References | PDF (182.1 KB)
  • 924 Views
  • 130 CrossRef citations
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Article
Computational Systems Biology and Dose-Response Modeling in Relation to New Directions in Toxicity Testing
Qiang Zhang, Sudin Bhattacharya, Melvin E. Andersen & Rory B. Conolly
Pages: 253-276
Published online: 21 Jun 2010
AbstractforComputational Systems Biology and Dose-Response Modeling in Relation to New Directions in Toxicity Testing | Full Text | References | PDF (446.8 KB)
  • 667 Views
  • 41 CrossRef citations
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Article
Lessons Learned from Alternative Methods and their Validation for a New Toxicology in the 21st Century
Thomas Hartung
Pages: 277-290
Published online: 21 Jun 2010
AbstractforLessons Learned from Alternative Methods and their Validation for a New Toxicology in the 21st Century | Full Text | References | PDF (244.6 KB)
  • 572 Views
  • 52 CrossRef citations
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Article
An Animal Protection Perspective On 21st Century Toxicology
Martin L. Stephens
Pages: 291-298
Published online: 21 Jun 2010
AbstractforAn Animal Protection Perspective On 21st Century Toxicology | Full Text | References | PDF (106.2 KB)
  • 231 Views
  • 7 CrossRef citations
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Article
Advancing Exposure Characterization for Chemical Evaluation and Risk Assessment
Elaine A. Cohen Hubal, Ann Richard, Lesa Aylward, Steve Edwards, Jane Gallagher, Michael-Rock Goldsmith, Sastry Isukapalli, Rogelio Tornero-Velez, Eric Weber & Robert Kavlock
Pages: 299-313
Published online: 21 Jun 2010
AbstractforAdvancing Exposure Characterization for Chemical Evaluation and Risk Assessment | Full Text | References | PDF (336.5 KB)
  • 785 Views
  • 81 CrossRef citations
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Article
Virtual Tissues in Toxicology
Imran Shah & John Wambaugh
Pages: 314-328
Published online: 21 Jun 2010
AbstractforVirtual Tissues in Toxicology | Full Text | References | PDF (645.1 KB)
  • 344 Views
  • 46 CrossRef citations
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Article
Xenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals
Daniel M. Rotroff, Andrew L. Beam, David J. Dix, Adam Farmer, Kimberly M. Freeman, Keith A. Houck, Richard S. Judson, Edward L. LeCluyse, Matthew T. Martin, David M. Reif & Stephen S. Ferguson
Pages: 329-346
Published online: 21 Jun 2010
AbstractforXenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals | Full Text | References | PDF (908.1 KB) | Supplemental
  • 554 Views
  • 49 CrossRef citations
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Article
Meeting The Common Needs of a More Effective and Efficient Testing and Assessment Paradigm for Chemical Risk Management
Vicki Dellarco, Tala Henry, Phil Sayre, Jennifer Seed & Steven Bradbury
Pages: 347-360
Published online: 21 Jun 2010
AbstractforMeeting The Common Needs of a More Effective and Efficient Testing and Assessment Paradigm for Chemical Risk Management | Full Text | References | PDF (197.3 KB)
  • 266 Views
  • 24 CrossRef citations
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Article
Toxicity Testing in the 21st Century: How will it Affect Risk Assessment?
Lorenz R. Rhomberg
Pages: 361-375
Published online: 21 Jun 2010
AbstractforToxicity Testing in the 21st Century: How will it Affect Risk Assessment? | Full Text | References | PDF (188.2 KB)
  • 254 Views
  • 12 CrossRef citations
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Article
Implementing the National Academy's Vision and Strategy for Toxicity Testing: Opportunities and Challenges Under the U.S. Toxic Substances Control Act
Paul A. Locke & D. Bruce Myers Jr.
Pages: 376-384
Published online: 21 Jun 2010
AbstractforImplementing the National Academy's Vision and Strategy for Toxicity Testing: Opportunities and Challenges Under the U.S. Toxic Substances Control Act | Full Text | References | PDF (112.4 KB)
  • 172 Views
  • 10 CrossRef citations
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