The association of Sort1 expression with LDL subfraction and inflammation in patients with coronary artery disease

Abstract

Background

Controversial effect of sortilin on lipoprotein metabolism in the development of atherosclerosis reveals the need for more extensive research

Objectives

The aim of this study was to investigate the association between Sort1 gene expression and lipids, lipoprotein subfractions, and inflammation in CAD.

Methods

The study population included 162 subjects with CAD and 49 healthy individuals. The Sort1 gene expression level was determined by qRT-PCR using Human Sortilin TaqMan Gene Expression Assays. Lipoprotein subclasses were analysed by the Lipoprint system. Serum levels of apolipoprotein and CRP were measured by autoanalyzer.

Results

Sort1 gene expression and atherogenic subfraction (SdLDL) levels were significantly higher (p < 0.001) while atheroprotective subfraction (LbLDL) was lower in the subjects with CAD (p < 0.050). Also, increased Sort1 gene expression levels were observed in those with higher CRP values.

Conclusions

Our findings reveal that the high Sort1 gene expression has a prominent linear relationship with both the atherogenic LDL phenotype and proinflammation, thereby might contribute to the occurrence of CAD.

Keywords:

• CAD
• LDL subfraction
• Sort1 expression
• inflammation

Author contributions

Mehtap ATAK: Conceptualization, Validation, Writing - Original Draft, Writing - Review & Editing. Hatice SEVİM NALKIRAN: Investigation, Writing - Original Draft, Writing - Review & Editing. Mehmet BOSTAN: Investigation, Writing - Original Draft. Hüseyin Avni UYDU: Conceptualization, Formal analysis, Resources, Writing - Original Draft, Writing - Review & Editing- Project administration.

Disclosure statement

No potential conflict of interest was reported by the author(s). The authors proclaim that they have no known conflict financial interests or personal relationships that could have become cleared to affect the work reported in this paper.

Data availability statement

All the required data are present in the article.

Additional information

Funding

This work was supported by the Scientific Research Projects Coordination Unit of Recep Tayyip Erdogan University (project code: 2014.106.01.01).